Bookmark and Share

Compound Summary for: CID 155557

Neprilysin

Also known as: 4-tert-butyl-N-methyl-N-phenylbenzamide, 70019-98-6, Carboxypeptidase, enkephalin dipeptidyl, AC1L4EID, AC1Q3VS4, MolPort-001-796-246
Molecular Formula: C18H21NO   Molecular Weight: 267.36544   InChIKey: HIYAQBUTHPUUSV-UHFFFAOYSA-N
Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.   From: MeSH
Show subcontent titlesTable of Contents
Identification
Related Records
show all 3 sub-sections (Related Compounds with Annotation, Related Compounds, Related Substances)
Biomedical Effects and Toxicity
Literature
Classification
Chemical and Physical Properties
_ _