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Compound Summary for: CID 123865

antibiotic G 418

Also known as: geneticin; G418; antibiotic G-418; 49863-47-0
Molecular Formula: C20H40N4O10   Molecular Weight: 496.5524   InChIKey: BRZYSWJRSDMWLG-DJWUNRQOSA-N
G418 (also known as Geneticin) is an aminoglycoside antibiotic similar in structure to gentamicin B1. It is produced by Micromonospora rhodorangea. G418 blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells. Resistance to G418 is conferred by the neo gene from Tn5 encoding an aminoglycoside 3??-phosphotransferase, APH 3?? II. G418 is commonly used in laboratory research to select genetically engineered cells.   From: DrugBank
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Biomedical Effects and Toxicity
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Chemical and Physical Properties
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