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"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:33302"
}
},
{
"NodeID": "CHEBI:51143",
"ParentID": [
"CHEBI:33302"
],
"Information": {
"Name": "nitrogen molecular entity",
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:51143"
}
},
{
"NodeID": "CHEBI:32988",
"ParentID": [
"CHEBI:51143"
],
"Information": {
"Name": "amide",
"Description": [
"An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:32988"
}
},
{
"NodeID": "CHEBI:33256",
"ParentID": [
"CHEBI:32988"
],
"Information": {
"Name": "primary amide",
"Description": [
"A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:33256"
}
},
{
"NodeID": "CHEBI:33304",
"ParentID": [
"CHEBI:33675"
],
"Information": {
"Name": "chalcogen molecular entity",
"Description": [
"Any p-block molecular entity containing a chalcogen."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:33304"
}
},
{
"NodeID": "CHEBI:25806",
"ParentID": [
"CHEBI:33304"
],
"Information": {
"Name": "oxygen molecular entity",
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:25806"
}
},
{
"NodeID": "CHEBI:33674",
"ParentID": [
"CHEBI:33579"
],
"Information": {
"Name": "s-block molecular entity",
"Description": [
"An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:33674"
}
},
{
"NodeID": "CHEBI:36357",
"ParentID": [
"CHEBI:23367"
],
"Information": {
"Name": "polyatomic entity",
"Description": [
"Any molecular entity consisting of more than one atom."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:36357"
}
},
{
"NodeID": "CHEBI:37577",
"ParentID": [
"CHEBI:36357"
],
"Information": {
"Name": "heteroatomic molecular entity",
"Description": [
"A molecular entity consisting of two or more chemical elements."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:37577"
}
},
{
"NodeID": "CHEBI:50906",
"ParentID": [
"root_node"
],
"Information": {
"Name": "role",
"Description": [
"A role is particular behaviour which a material entity may exhibit."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:50906"
}
},
{
"NodeID": "CHEBI:24432",
"ParentID": [
"CHEBI:50906"
],
"Information": {
"Name": "biological role",
"Description": [
"A role played by the molecular entity or part thereof within a biological context."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:24432"
}
},
{
"NodeID": "CHEBI:52206",
"ParentID": [
"CHEBI:24432"
],
"Information": {
"Name": "biochemical role",
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:52206"
}
},
{
"NodeID": "CHEBI:23924",
"ParentID": [
"CHEBI:52206",
"CHEBI:35222"
],
"Information": {
"Name": "enzyme inhibitor",
"Description": [
"A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:23924"
}
},
{
"NodeID": "CHEBI:35544",
"ParentID": [
"CHEBI:23924"
],
"Information": {
"Name": "cyclooxygenase inhibitor",
"Description": [
"A compound or agent that combines with cyclooxygenases and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:35544"
}
},
{
"NodeID": "CHEBI:50629",
"ParentID": [
"CHEBI:35544"
],
"Information": {
"Name": "cyclooxygenase 2 inhibitor",
"Description": [
"A cyclooxygenase inhibitor with specificity for cyclooxygenase 2."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:50629"
}
},
{
"NodeID": "CHEBI:50630",
"ParentID": [
"CHEBI:35544"
],
"Information": {
"Name": "cyclooxygenase 1 inhibitor",
"Description": [
"A cyclooxygenase inhibitor with specificity for cyclooxygenase 1."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:50630"
}
},
{
"NodeID": "CHEBI:52210",
"ParentID": [
"CHEBI:24432"
],
"Information": {
"Name": "pharmacological role",
"Description": [
"A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:52210"
}
},
{
"NodeID": "CHEBI:35480",
"ParentID": [
"CHEBI:52210",
"CHEBI:23888"
],
"Information": {
"Name": "analgesic",
"Description": [
"An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:35480"
}
},
{
"NodeID": "CHEBI:35481",
"ParentID": [
"CHEBI:35480"
],
"Information": {
"Name": "non-narcotic analgesic",
"Description": [
"A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:35481"
}
},
{
"NodeID": "CHEBI:33232",
"ParentID": [
"CHEBI:50906"
],
"Information": {
"Name": "application",
"Description": [
"Intended use of the molecular entity or part thereof by humans."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:33232"
}
},
{
"NodeID": "CHEBI:52217",
"ParentID": [
"CHEBI:33232"
],
"Information": {
"Name": "pharmaceutical",
"Description": [
"Any substance introduced into a living organism with therapeutic or diagnostic purpose."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:52217"
}
},
{
"NodeID": "CHEBI:23888",
"ParentID": [
"CHEBI:52217"
],
"Information": {
"Name": "drug",
"Description": [
"Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:23888"
}
},
{
"NodeID": "CHEBI:35472",
"ParentID": [
"CHEBI:23888"
],
"Information": {
"Name": "anti-inflammatory drug",
"Description": [
"A substance that reduces or suppresses inflammation."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:35472"
}
},
{
"NodeID": "CHEBI:35475",
"ParentID": [
"CHEBI:35842",
"CHEBI:35472"
],
"Information": {
"Name": "non-steroidal anti-inflammatory drug",
"Description": [
"An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:35475"
}
},
{
"NodeID": "CHEBI:35493",
"ParentID": [
"CHEBI:23888"
],
"Information": {
"Name": "antipyretic",
"Description": [
"A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:35493"
}
},
{
"NodeID": "CHEBI:35842",
"ParentID": [
"CHEBI:23888"
],
"Information": {
"Name": "antirheumatic drug",
"Description": [
"A drug used to treat rheumatoid arthritis."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:35842"
}
},
{
"NodeID": "CHEBI:51086",
"ParentID": [
"CHEBI:50906"
],
"Information": {
"Name": "chemical role",
"Description": [
"A role played by the molecular entity or part thereof within a chemical context."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:51086"
}
},
{
"NodeID": "CHEBI:35222",
"ParentID": [
"CHEBI:51086"
],
"Information": {
"Name": "inhibitor",
"Description": [
"A substance that diminishes the rate of a chemical reaction."
],
"URL": "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:35222"
}
}
]
},
{
"SourceName": "Gene Ontology",
"SourceID": "GO_ROOT_486550",
"RootID": "bsid486550",
"Information": {
"Name": "biological process",
"Description": [
"The Gene Ontology (GO) project provides a controlled vocabulary of terms for describing the functions of gene products, and is divided into three domains. Each term in the biological processes domain, shown here, represents recognized series of events, or a collection of molecular events with a defined beginning and end. Mutant phenotypes often reflect disruptions in biological processes. The terms below apply to the gene/protein target(s) tested by the BioAssay. "
],
"Comments": [
"This Gene Ontology tree was mapped by BioAssays' protein targets shown as leaves of this tree. ",
"GO database release 2012-06-04",
"For any queries contact http://geneontology.org/GO.contacts.shtml"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008150"
},
"Node": [
{
"NodeID": "bsid493742",
"ParentID": [
"bsid493737"
],
"Information": {
"Name": "response to nematode",
"Description": [
"GO:0009624 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode. Synonym: response to nematodes;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009624"
}
},
{
"NodeID": "bsid508743",
"ParentID": [
"bsid507244"
],
"Information": {
"Name": "heterocycle metabolic process",
"Description": [
"GO:0046483 The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). Synonym: heterocycle metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046483"
}
},
{
"NodeID": "bsid510716",
"ParentID": [
"bsid492607"
],
"Information": {
"Name": "positive regulation of smooth muscle cell proliferation",
"Description": [
"GO:0048661 Any process that activates or increases the rate or extent of smooth muscle cell proliferation. Synonyms: activation of smooth muscle cell proliferation; positive regulation of SMC proliferation; stimulation of smooth muscle cell proliferation; up regulation of smooth muscle cell proliferation; up-regulation of smooth muscle cell proliferation; upregulation of smooth muscle cell proliferation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048661"
}
},
{
"NodeID": "bsid518190",
"ParentID": [
"bsid506566"
],
"Information": {
"Name": "regulation of cell migration involved in sprouting angiogenesis",
"Description": [
"GO:0090049 Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090049"
}
},
{
"NodeID": "bsid518502",
"ParentID": [
"bsid487715"
],
"Information": {
"Name": "positive regulation of platelet-derived growth factor production",
"Description": [
"GO:0090362 Any process that increases the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090362"
}
},
{
"NodeID": "bsid504454",
"ParentID": [
"bsid510786"
],
"Information": {
"Name": "endocrine system development",
"Description": [
"GO:0035270 Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035270"
}
},
{
"NodeID": "bsid492607",
"ParentID": [
"bsid510593"
],
"Information": {
"Name": "positive regulation of cell proliferation",
"Description": [
"GO:0008284 Any process that activates or increases the rate or extent of cell proliferation. Synonyms: activation of cell proliferation; stimulation of cell proliferation; up regulation of cell proliferation; up-regulation of cell proliferation; upregulation of cell proliferation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008284"
}
},
{
"NodeID": "bsid502071",
"ParentID": [
"bsid510593"
],
"Information": {
"Name": "positive regulation of cellular pH reduction",
"Description": [
"GO:0032849 Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell. Synonyms: activation of cellular pH reduction; positive regulation of cell pH reduction; positive regulation of cellular acidification; positive regulation of intracellular acidification; positive regulation of intracellular pH reduction; positive regulation of reduction of cellular pH; positive regulation of reduction of pH in cell; stimulation of cellular pH reduction; up regulation of cellular pH reduction; up-regulation of cellular pH reduction; upregulation of cellular pH reduction;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032849"
}
},
{
"NodeID": "bsid507073",
"ParentID": [
"bsid512133"
],
"Information": {
"Name": "regulation of system process",
"Description": [
"GO:0044057 Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044057"
}
},
{
"NodeID": "bsid516242",
"ParentID": [
"bsid516341"
],
"Information": {
"Name": "cellular response to ATP",
"Description": [
"GO:0071318 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. Synonyms: cellular response to adenosine 5'-triphosphate; cellular response to adenosine triphosphate;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071318"
}
},
{
"NodeID": "bsid491097",
"ParentID": [
"bsid751852"
],
"Information": {
"Name": "oxidation-reduction process",
"Description": [
"GO:0055114 A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. Synonyms: oxidation reduction; oxidoreductase process;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0055114"
}
},
{
"NodeID": "bsid500582",
"ParentID": [
"bsid511763"
],
"Information": {
"Name": "regulation of cellular metabolic process",
"Description": [
"GO:0031323 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. Synonym: regulation of cellular metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031323"
}
},
{
"NodeID": "bsid501462",
"ParentID": [
"bsid511771"
],
"Information": {
"Name": "negative regulation of synaptic transmission, dopaminergic",
"Description": [
"GO:0032227 Any process that stops, prevents, or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine. Synonyms: down regulation of synaptic transmission, dopaminergic; down-regulation of synaptic transmission, dopaminergic; downregulation of synaptic transmission, dopaminergic; inhibition of synaptic transmission, dopaminergic;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032227"
}
},
{
"NodeID": "bsid505490",
"ParentID": [
"bsid506085"
],
"Information": {
"Name": "positive regulation of NF-kappaB import into nucleus",
"Description": [
"GO:0042346 Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane. Synonyms: activation of NF-kappaB import into nucleus; positive regulation of NF-kappaB import into cell nucleus; positive regulation of NF-kappaB transport from cytoplasm to nucleus; positive regulation of NF-kappaB-nucleus import; stimulation of NF-kappaB import into nucleus; up regulation of NF-kappaB import into nucleus; up-regulation of NF-kappaB import into nucleus; upregulation of NF-kappaB import into nucleus;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042346"
}
},
{
"NodeID": "bsid491578",
"ParentID": [
"bsid754528"
],
"Information": {
"Name": "icosanoid metabolic process",
"Description": [
"GO:0006690 The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. Synonyms: eicosanoid metabolic process; eicosanoid metabolism; icosanoid metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006690"
}
},
{
"NodeID": "bsid508215",
"ParentID": [
"bsid498081"
],
"Information": {
"Name": "positive regulation of vasoconstriction",
"Description": [
"GO:0045907 Any process that activates or increases the frequency, rate or extent of vasoconstriction. Synonyms: activation of vasoconstriction; stimulation of vasoconstriction; up regulation of vasoconstriction; up-regulation of vasoconstriction; upregulation of vasoconstriction;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045907"
}
},
{
"NodeID": "bsid505998",
"ParentID": [
"bsid505999"
],
"Information": {
"Name": "9-cis-retinoic acid biosynthetic process",
"Description": [
"GO:0042904 The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative. Synonyms: 9-cis-retinoic acid anabolism; 9-cis-retinoic acid biosynthesis; 9-cis-retinoic acid formation; 9-cis-retinoic acid synthesis;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042904"
}
},
{
"NodeID": "bsid500901",
"ParentID": [
"bsid502068"
],
"Information": {
"Name": "positive regulation of heat generation",
"Description": [
"GO:0031652 Any process that activates or increases the rate or extent of heat generation. Synonyms: activation of heat generation; stimulation of heat generation; up regulation of heat generation; up-regulation of heat generation; upregulation of heat generation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031652"
}
},
{
"NodeID": "bsid503202",
"ParentID": [
"bsid494114"
],
"Information": {
"Name": "response to lipid",
"Description": [
"GO:0033993 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033993"
}
},
{
"NodeID": "bsid491522",
"ParentID": [
"bsid502010"
],
"Information": {
"Name": "fatty acid metabolic process",
"Description": [
"GO:0006631 The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. Synonym: fatty acid metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006631"
}
},
{
"NodeID": "bsid498214",
"ParentID": [
"bsid498212"
],
"Information": {
"Name": "cyclooxygenase pathway",
"Description": [
"GO:0019371 The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019371"
}
},
{
"NodeID": "bsid507946",
"ParentID": [
"bsid507943"
],
"Information": {
"Name": "regulation of fat cell differentiation",
"Description": [
"GO:0045598 Any process that modulates the frequency, rate or extent of adipocyte differentiation. Synonyms: regulation of adipocyte cell differentiation; regulation of adipocyte differentiation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045598"
}
},
{
"NodeID": "bsid499461",
"ParentID": [
"bsid511759"
],
"Information": {
"Name": "regulation of signaling",
"Description": [
"GO:0023051 Any process that modulates the frequency, rate or extent of a signaling process. Synonyms: regulation of signaling process; regulation of signalling process;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0023051"
}
},
{
"NodeID": "bsid492315",
"ParentID": [
"bsid751849"
],
"Information": {
"Name": "female pregnancy",
"Description": [
"GO:0007565 The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. Synonyms: carrying of young; gestation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007565"
}
},
{
"NodeID": "bsid507943",
"ParentID": [
"bsid511763"
],
"Information": {
"Name": "regulation of cell differentiation",
"Description": [
"GO:0045595 Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045595"
}
},
{
"NodeID": "bsid493575",
"ParentID": [
"bsid505382"
],
"Information": {
"Name": "response to toxic substance",
"Description": [
"GO:0009636 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. Synonyms: detoxification response; toxin resistance; toxin susceptibility/resistance;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009636"
}
},
{
"NodeID": "bsid493577",
"ParentID": [
"bsid498561"
],
"Information": {
"Name": "toxin metabolic process",
"Description": [
"GO:0009404 The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. Synonym: toxin metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009404"
}
},
{
"NodeID": "bsid498561",
"ParentID": [
"bsid751852"
],
"Information": {
"Name": "secondary metabolic process",
"Description": [
"GO:0019748 The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. Synonyms: secondary metabolism; secondary metabolite metabolic process; secondary metabolite metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019748"
}
},
{
"NodeID": "bsid491302",
"ParentID": [
"bsid491293"
],
"Information": {
"Name": "transcription initiation from RNA polymerase II promoter",
"Description": [
"GO:0006367 Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. Synonym: transcription initiation from Pol II promoter;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006367"
}
},
{
"NodeID": "bsid510590",
"ParentID": [
"bsid511759"
],
"Information": {
"Name": "negative regulation of biological process",
"Description": [
"GO:0048519 Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. Synonyms: GO:0043118; down regulation of biological process; down-regulation of biological process; downregulation of biological process; inhibition of biological process; negative regulation of physiological process;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048519"
}
},
{
"NodeID": "bsid498186",
"ParentID": [
"bsid508928"
],
"Information": {
"Name": "dibenzo-p-dioxin catabolic process",
"Description": [
"GO:0019341 The chemical reactions and pathways resulting in the breakdown of dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Synonyms: dibenzo-p-dioxin breakdown; dibenzo-p-dioxin catabolism; dibenzo-p-dioxin degradation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019341"
}
},
{
"NodeID": "bsid510594",
"ParentID": [
"bsid510590"
],
"Information": {
"Name": "negative regulation of cellular process",
"Description": [
"GO:0048523 Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Synonyms: GO:0051243; down regulation of cellular process; down-regulation of cellular process; downregulation of cellular process; inhibition of cellular process; negative regulation of cellular physiological process;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048523"
}
},
{
"NodeID": "bsid493858",
"ParentID": [
"bsid503487"
],
"Information": {
"Name": "response to hexose stimulus",
"Description": [
"GO:0009746 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009746"
}
},
{
"NodeID": "bsid515915",
"ParentID": [
"bsid515914"
],
"Information": {
"Name": "oxidative demethylation",
"Description": [
"GO:0070989 The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070989"
}
},
{
"NodeID": "bsid491676",
"ParentID": [
"bsid493575"
],
"Information": {
"Name": "response to insecticide",
"Description": [
"GO:0017085 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects. Synonyms: insecticide resistance; insecticide susceptibility/resistance;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017085"
}
},
{
"NodeID": "bsid512816",
"ParentID": [
"bsid511770"
],
"Information": {
"Name": "regulation of synaptic transmission, glutamatergic",
"Description": [
"GO:0051966 Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051966"
}
},
{
"NodeID": "bsid518208",
"ParentID": [
"bsid510593"
],
"Information": {
"Name": "positive regulation of cell cycle process",
"Description": [
"GO:0090068 Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090068"
}
},
{
"NodeID": "bsid511637",
"ParentID": [
"bsid507256"
],
"Information": {
"Name": "hydrogen peroxide biosynthetic process",
"Description": [
"GO:0050665 The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. Synonyms: H2O2 biosynthetic process; hydrogen peroxide anabolism; hydrogen peroxide biosynthesis; hydrogen peroxide formation; hydrogen peroxide generation; hydrogen peroxide synthesis;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050665"
}
},
{
"NodeID": "bsid501331",
"ParentID": [
"bsid505382"
],
"Information": {
"Name": "response to food",
"Description": [
"GO:0032094 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032094"
}
},
{
"NodeID": "bsid496940",
"ParentID": [
"bsid491676"
],
"Information": {
"Name": "insecticide metabolic process",
"Description": [
"GO:0017143 The chemical reactions and pathways involving insecticides, chemicals used to kill insects. Synonyms: GO:0017138; insecticide metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0017143"
}
},
{
"NodeID": "bsid512820",
"ParentID": [
"bsid512819"
],
"Information": {
"Name": "negative regulation of transmission of nerve impulse",
"Description": [
"GO:0051970 Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. Synonyms: down regulation of transmission of nerve impulse; down-regulation of transmission of nerve impulse; downregulation of transmission of nerve impulse; inhibition of transmission of nerve impulse;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051970"
}
},
{
"NodeID": "bsid491680",
"ParentID": [
"bsid512128"
],
"Information": {
"Name": "transport",
"Description": [
"GO:0006810 The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. Synonyms: GO:0015457; GO:0015460; auxiliary transport protein activity; small molecule transport; solute:solute exchange; transport accessory protein activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006810"
}
},
{
"NodeID": "bsid492317",
"ParentID": [
"bsid751849"
],
"Information": {
"Name": "parturition",
"Description": [
"GO:0007567 The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs. Synonyms: egg laying; giving birth;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007567"
}
},
{
"NodeID": "bsid498216",
"ParentID": [
"bsid498212"
],
"Information": {
"Name": "epoxygenase P450 pathway",
"Description": [
"GO:0019373 The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019373"
}
},
{
"NodeID": "bsid488804",
"ParentID": [
"bsid501734"
],
"Information": {
"Name": "developmental process involved in reproduction",
"Description": [
"GO:0003006 A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring. Synonym: reproductive developmental process;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003006"
}
},
{
"NodeID": "bsid516419",
"ParentID": [
"bsid493831"
],
"Information": {
"Name": "cellular response to endogenous stimulus",
"Description": [
"GO:0071495 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071495"
}
},
{
"NodeID": "bsid511759",
"ParentID": [
"bsid514938"
],
"Information": {
"Name": "regulation of biological process",
"Description": [
"GO:0050789 Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. Synonyms: GO:0050791; regulation of physiological process;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050789"
}
},
{
"NodeID": "bsid500872",
"ParentID": [
"bsid500901"
],
"Information": {
"Name": "positive regulation of fever generation",
"Description": [
"GO:0031622 Any process that activates or increases the frequency, rate, or extent of fever generation. Synonyms: activation of fever; positive regulation of pyrexia; stimulation of fever; up regulation of fever; up-regulation of fever; upregulation of fever;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031622"
}
},
{
"NodeID": "bsid498077",
"ParentID": [
"bsid511759"
],
"Information": {
"Name": "regulation of metabolic process",
"Description": [
"GO:0019222 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. Synonym: regulation of metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019222"
}
},
{
"NodeID": "bsid487495",
"ParentID": [
"bsid486550"
],
"Information": {
"Name": "metabolic process",
"Description": [
"GO:0008152 The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. Synonyms: metabolic process resulting in cell growth; metabolism; metabolism resulting in cell growth;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008152"
}
},
{
"NodeID": "bsid516341",
"ParentID": [
"bsid516419"
],
"Information": {
"Name": "cellular response to organic nitrogen",
"Description": [
"GO:0071417 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic nitrogen stimulus. An organic nitrogen compound is formally a compound containing at least one carbon-nitrogen bond. Synonym: cellular response to organonitrogen compound;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071417"
}
},
{
"NodeID": "bsid507985",
"ParentID": [
"bsid507943"
],
"Information": {
"Name": "regulation of myeloid cell differentiation",
"Description": [
"GO:0045637 Any process that modulates the frequency, rate or extent of myeloid cell differentiation."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045637"
}
},
{
"NodeID": "bsid502010",
"ParentID": [
"bsid498565"
],
"Information": {
"Name": "monocarboxylic acid metabolic process",
"Description": [
"GO:0032787 The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). Synonyms: monocarboxylate metabolic process; monocarboxylic acid metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032787"
}
},
{
"NodeID": "bsid493259",
"ParentID": [
"bsid487495"
],
"Information": {
"Name": "biosynthetic process",
"Description": [
"GO:0009058 The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. Synonyms: anabolism; biosynthesis; formation; synthesis;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009058"
}
},
{
"NodeID": "bsid495846",
"ParentID": [
"bsid516626"
],
"Information": {
"Name": "organic anion transport",
"Description": [
"GO:0015711 The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015711"
}
},
{
"NodeID": "bsid493737",
"ParentID": [
"bsid512579"
],
"Information": {
"Name": "response to other organism",
"Description": [
"GO:0051707 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism. Synonyms: GO:0009613; GO:0042828;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051707"
}
},
{
"NodeID": "bsid510292",
"ParentID": [
"bsid511770"
],
"Information": {
"Name": "regulation of synaptic plasticity",
"Description": [
"GO:0048167 A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048167"
}
},
{
"NodeID": "bsid502000",
"ParentID": [
"bsid493260"
],
"Information": {
"Name": "RNA biosynthetic process",
"Description": [
"GO:0032774 The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Synonyms: RNA anabolism; RNA biosynthesis; RNA formation; RNA synthesis;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032774"
}
},
{
"NodeID": "bsid494658",
"ParentID": [
"bsid499734"
],
"Information": {
"Name": "regulation of endothelial cell migration",
"Description": [
"GO:0010594 Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010594"
}
},
{
"NodeID": "bsid505845",
"ParentID": [
"bsid493499"
],
"Information": {
"Name": "exogenous drug catabolic process",
"Description": [
"GO:0042738 The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism. Synonyms: exogenous drug breakdown; exogenous drug catabolism; exogenous drug degradation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042738"
}
},
{
"NodeID": "bsid494072",
"ParentID": [
"bsid486550"
],
"Information": {
"Name": "cellular process",
"Description": [
"GO:0009987 Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Synonyms: GO:0008151; GO:0050875; cell growth and/or maintenance; cell physiology; cellular physiological process;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009987"
}
},
{
"NodeID": "bsid518476",
"ParentID": [
"bsid507948"
],
"Information": {
"Name": "positive regulation of brown fat cell differentiation",
"Description": [
"GO:0090336 Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090336"
}
},
{
"NodeID": "bsid493499",
"ParentID": [
"bsid505382"
],
"Information": {
"Name": "response to drug",
"Description": [
"GO:0042493 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. Synonyms: GO:0017035; drug resistance; drug susceptibility/resistance;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042493"
}
},
{
"NodeID": "bsid493260",
"ParentID": [
"bsid506242"
],
"Information": {
"Name": "macromolecule biosynthetic process",
"Description": [
"GO:0009059 The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. Synonyms: GO:0043284; biopolymer biosynthetic process; macromolecule anabolism; macromolecule biosynthesis; macromolecule formation; macromolecule synthesis;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009059"
}
},
{
"NodeID": "bsid491292",
"ParentID": [
"bsid502000"
],
"Information": {
"Name": "transcription, DNA-dependent",
"Description": [
"GO:0006351 The cellular synthesis of RNA on a template of DNA. Synonyms: DNA-dependent transcription; GO:0006350; GO:0061018; GO:0061022; cellular transcription; cellular transcription, DNA-dependent; transcription; transcription regulator activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006351"
}
},
{
"NodeID": "bsid507786",
"ParentID": [
"bsid507785"
],
"Information": {
"Name": "positive regulation of nitric oxide biosynthetic process",
"Description": [
"GO:0045429 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. Synonyms: activation of nitric oxide biosynthetic process; positive regulation of nitric oxide anabolism; positive regulation of nitric oxide biosynthesis; positive regulation of nitric oxide formation; positive regulation of nitric oxide synthesis; stimulation of nitric oxide biosynthetic process; up regulation of nitric oxide biosynthetic process; up-regulation of nitric oxide biosynthetic process; upregulation of nitric oxide biosynthetic process;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045429"
}
},
{
"NodeID": "bsid498071",
"ParentID": [
"bsid518014"
],
"Information": {
"Name": "regulation of lipid metabolic process",
"Description": [
"GO:0019216 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. Synonym: regulation of lipid metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019216"
}
},
{
"NodeID": "bsid516173",
"ParentID": [
"bsid516166"
],
"Information": {
"Name": "cellular response to metal ion",
"Description": [
"GO:0071248 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. Synonyms: cellular response to heavy metal; cellular response to metal;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071248"
}
},
{
"NodeID": "bsid516626",
"ParentID": [
"bsid491680"
],
"Information": {
"Name": "organic substance transport",
"Description": [
"GO:0071702 The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071702"
}
},
{
"NodeID": "bsid518489",
"ParentID": [
"bsid500583"
],
"Information": {
"Name": "negative regulation of cellular organohalogen metabolic process",
"Description": [
"GO:0090349 Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090349"
}
},
{
"NodeID": "bsid508020",
"ParentID": [
"bsid488636"
],
"Information": {
"Name": "positive regulation of osteoclast differentiation",
"Description": [
"GO:0045672 Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. Synonyms: activation of osteoclast differentiation; stimulation of osteoclast differentiation; up regulation of osteoclast differentiation; up-regulation of osteoclast differentiation; upregulation of osteoclast differentiation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045672"
}
},
{
"NodeID": "bsid512133",
"ParentID": [
"bsid511759"
],
"Information": {
"Name": "regulation of multicellular organismal process",
"Description": [
"GO:0051239 Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051239"
}
},
{
"NodeID": "bsid512579",
"ParentID": [
"bsid486550"
],
"Information": {
"Name": "multi-organism process",
"Description": [
"GO:0051704 A biological process which involves another organism of the same or different species. Synonyms: GO:0051706; interaction between organisms; physiological interaction between organisms; physiological interaction with other organism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051704"
}
},
{
"NodeID": "bsid506085",
"ParentID": [
"bsid506082"
],
"Information": {
"Name": "positive regulation of transcription factor import into nucleus",
"Description": [
"GO:0042993 Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. Synonyms: activation of transcription factor import into nucleus; positive regulation of transcription factor import into cell nucleus; positive regulation of transcription factor transport from cytoplasm to nucleus; positive regulation of transcription factor-nucleus import; stimulation of transcription factor import into nucleus; up regulation of transcription factor import into nucleus; up-regulation of transcription factor import into nucleus; upregulation of transcription factor import into nucleus;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042993"
}
},
{
"NodeID": "bsid488634",
"ParentID": [
"bsid507985"
],
"Information": {
"Name": "regulation of myeloid leukocyte differentiation",
"Description": [
"GO:0002761 Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002761"
}
},
{
"NodeID": "bsid487785",
"ParentID": [
"bsid510585"
],
"Information": {
"Name": "liver development",
"Description": [
"GO:0001889 The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001889"
}
},
{
"NodeID": "bsid510652",
"ParentID": [
"bsid751909"
],
"Information": {
"Name": "developmental growth",
"Description": [
"GO:0048589 The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048589"
}
},
{
"NodeID": "bsid498212",
"ParentID": [
"bsid487587"
],
"Information": {
"Name": "arachidonic acid metabolic process",
"Description": [
"GO:0019369 The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. Synonym: arachidonic acid metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019369"
}
},
{
"NodeID": "bsid502409",
"ParentID": [
"bsid503202"
],
"Information": {
"Name": "response to vitamin A",
"Description": [
"GO:0033189 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus. Synonym: response to retinol;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033189"
}
},
{
"NodeID": "bsid502545",
"ParentID": [
"bsid488804"
],
"Information": {
"Name": "Leydig cell differentiation",
"Description": [
"GO:0033327 The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033327"
}
},
{
"NodeID": "bsid501155",
"ParentID": [
"bsid510292"
],
"Information": {
"Name": "positive regulation of synaptic plasticity",
"Description": [
"GO:0031915 A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. Synonyms: activation of synaptic plasticity; stimulation of synaptic plasticity; up regulation of synaptic plasticity; up-regulation of synaptic plasticity; upregulation of synaptic plasticity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031915"
}
},
{
"NodeID": "bsid504811",
"ParentID": [
"bsid751905"
],
"Information": {
"Name": "maintenance of blood-brain barrier",
"Description": [
"GO:0035633 Preserving the permeability barrier between the blood and the brain in a stable functional or structural state. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier. Synonym: maintenance of BBB;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0035633"
}
},
{
"NodeID": "bsid512128",
"ParentID": [
"bsid486550"
],
"Information": {
"Name": "establishment of localization",
"Description": [
"GO:0051234 The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location. Synonym: establishment of localisation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051234"
}
},
{
"NodeID": "bsid518411",
"ParentID": [
"bsid487715"
],
"Information": {
"Name": "positive regulation of fibroblast growth factor production",
"Description": [
"GO:0090271 Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090271"
}
},
{
"NodeID": "bsid493751",
"ParentID": [
"bsid491797"
],
"Information": {
"Name": "response to herbicide",
"Description": [
"GO:0009635 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants. Synonym: herbicide susceptibility/resistance;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009635"
}
},
{
"NodeID": "bsid518793",
"ParentID": [
"bsid512158"
],
"Information": {
"Name": "regulation of cell motility",
"Description": [
"GO:2000145 Any process that modulates the frequency, rate or extent of cell motility. Synonyms: regulation of cell locomotion; regulation of cell movement; regulation of movement of a cell;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2000145"
}
},
{
"NodeID": "bsid491293",
"ParentID": [
"bsid491292"
],
"Information": {
"Name": "DNA-dependent transcription, initiation",
"Description": [
"GO:0006352 Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription. Synonyms: DNA-dependent RNA polymerase complex assembly at promoter; initiation of DNA-dependent transcription; initiation of transcription, DNA-dependent; transcription initiation factor activity; transcription initiation, DNA-dependent;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006352"
}
},
{
"NodeID": "bsid518014",
"ParentID": [
"bsid498077"
],
"Information": {
"Name": "regulation of primary metabolic process",
"Description": [
"GO:0080090 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0080090"
}
},
{
"NodeID": "bsid494114",
"ParentID": [
"bsid505382"
],
"Information": {
"Name": "response to organic substance",
"Description": [
"GO:0010033 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010033"
}
},
{
"NodeID": "bsid488636",
"ParentID": [
"bsid488634"
],
"Information": {
"Name": "positive regulation of myeloid leukocyte differentiation",
"Description": [
"GO:0002763 Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation. Synonyms: activation of myeloid leukocyte differentiation; stimulation of myeloid leukocyte differentiation; up regulation of myeloid leukocyte differentiation; up-regulation of myeloid leukocyte differentiation; upregulation of myeloid leukocyte differentiation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0002763"
}
},
{
"NodeID": "bsid511771",
"ParentID": [
"bsid512820"
],
"Information": {
"Name": "negative regulation of synaptic transmission",
"Description": [
"GO:0050805 Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Synonyms: down regulation of synaptic transmission; down-regulation of synaptic transmission; downregulation of synaptic transmission; inhibition of synaptic transmission;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050805"
}
},
{
"NodeID": "bsid505451",
"ParentID": [
"bsid498072"
],
"Information": {
"Name": "regulation of fatty acid biosynthetic process",
"Description": [
"GO:0042304 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Synonyms: regulation of fatty acid anabolism; regulation of fatty acid biosynthesis; regulation of fatty acid formation; regulation of fatty acid synthesis;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042304"
}
},
{
"NodeID": "bsid499462",
"ParentID": [
"bsid516420"
],
"Information": {
"Name": "cellular response to mechanical stimulus",
"Description": [
"GO:0071260 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. Synonym: cellular mechanical stimulus response;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071260"
}
},
{
"NodeID": "bsid499459",
"ParentID": [
"bsid512589"
],
"Information": {
"Name": "cellular response to chemical stimulus",
"Description": [
"GO:0070887 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070887"
}
},
{
"NodeID": "bsid518490",
"ParentID": [
"bsid518489"
],
"Information": {
"Name": "negative regulation of cellular organofluorine metabolic process",
"Description": [
"GO:0090350 Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090350"
}
},
{
"NodeID": "bsid498565",
"ParentID": [
"bsid516628"
],
"Information": {
"Name": "carboxylic acid metabolic process",
"Description": [
"GO:0019752 The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). Synonym: carboxylic acid metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019752"
}
},
{
"NodeID": "bsid501733",
"ParentID": [
"bsid486550"
],
"Information": {
"Name": "multicellular organismal process",
"Description": [
"GO:0032501 Any biological process, occurring at the level of a multicellular organism, pertinent to its function. Synonyms: GO:0050874; organismal physiological process;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032501"
}
},
{
"NodeID": "bsid491797",
"ParentID": [
"bsid511833"
],
"Information": {
"Name": "response to stress",
"Description": [
"GO:0006950 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). Synonyms: response to abiotic stress; response to biotic stress;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006950"
}
},
{
"NodeID": "bsid515914",
"ParentID": [
"bsid751852"
],
"Information": {
"Name": "demethylation",
"Description": [
"GO:0070988 The process of removing one or more methyl groups from a molecule."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070988"
}
},
{
"NodeID": "bsid503309",
"ParentID": [
"bsid512133"
],
"Information": {
"Name": "regulation of tissue remodeling",
"Description": [
"GO:0034103 Any process that modulates the frequency, rate, or extent of tissue remodeling."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034103"
}
},
{
"NodeID": "bsid508117",
"ParentID": [
"bsid509072"
],
"Information": {
"Name": "positive regulation of bone resorption",
"Description": [
"GO:0045780 Any process that activates or increases the frequency, rate or extent of bone resorption. Synonyms: activation of bone resorption; stimulation of bone resorption; up regulation of bone resorption; up-regulation of bone resorption; upregulation of bone resorption;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045780"
}
},
{
"NodeID": "bsid502297",
"ParentID": [
"bsid508743"
],
"Information": {
"Name": "isoquinoline alkaloid metabolic process",
"Description": [
"GO:0033076 The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin. Synonyms: ipecac alkaloid metabolism; isoquinoline alkaloid metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033076"
}
},
{
"NodeID": "bsid516420",
"ParentID": [
"bsid493730"
],
"Information": {
"Name": "cellular response to external stimulus",
"Description": [
"GO:0071496 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. Synonym: cellular response to environmental stimulus;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071496"
}
},
{
"NodeID": "bsid507785",
"ParentID": [
"bsid500585"
],
"Information": {
"Name": "regulation of nitric oxide biosynthetic process",
"Description": [
"GO:0045428 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide. Synonyms: regulation of nitric oxide anabolism; regulation of nitric oxide biosynthesis; regulation of nitric oxide formation; regulation of nitric oxide synthesis;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045428"
}
},
{
"NodeID": "bsid499726",
"ParentID": [
"bsid504454"
],
"Information": {
"Name": "adrenal gland development",
"Description": [
"GO:0030325 The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. Synonym: interrenal gland;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030325"
}
},
{
"NodeID": "bsid505382",
"ParentID": [
"bsid511833"
],
"Information": {
"Name": "response to chemical stimulus",
"Description": [
"GO:0042221 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. Synonym: response to chemical substance;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042221"
}
},
{
"NodeID": "bsid494640",
"ParentID": [
"bsid487715"
],
"Information": {
"Name": "positive regulation vascular endothelial growth factor production",
"Description": [
"GO:0010575 Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0010575"
}
},
{
"NodeID": "bsid509072",
"ParentID": [
"bsid509070"
],
"Information": {
"Name": "positive regulation of bone remodeling",
"Description": [
"GO:0046852 Any process that activates or increases the frequency, rate or extent of bone remodeling. Synonyms: activation of bone remodeling; stimulation of bone remodeling; up regulation of bone remodeling; up-regulation of bone remodeling; upregulation of bone remodeling;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046852"
}
},
{
"NodeID": "bsid516200",
"ParentID": [
"bsid516173"
],
"Information": {
"Name": "cellular response to cadmium ion",
"Description": [
"GO:0071276 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. Synonym: cellular response to cadmium;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071276"
}
},
{
"NodeID": "bsid492316",
"ParentID": [
"bsid492315"
],
"Information": {
"Name": "embryo implantation",
"Description": [
"GO:0007566 Attachment of the blastocyst to the uterine lining. Synonym: blastocyst implantation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007566"
}
},
{
"NodeID": "bsid487587",
"ParentID": [
"bsid491522"
],
"Information": {
"Name": "long-chain fatty acid metabolic process",
"Description": [
"GO:0001676 The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. Synonym: long-chain fatty acid metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001676"
}
},
{
"NodeID": "bsid507262",
"ParentID": [
"bsid507244"
],
"Information": {
"Name": "cellular lipid metabolic process",
"Description": [
"GO:0044255 The chemical reactions and pathways involving lipids, as carried out by individual cells. Synonym: cellular lipid metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044255"
}
},
{
"NodeID": "bsid505701",
"ParentID": [
"bsid502010"
],
"Information": {
"Name": "retinoic acid metabolic process",
"Description": [
"GO:0042573 The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. Synonyms: retinoic acid metabolism; vitamin A1 acid metabolic process; vitamin A1 acid metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042573"
}
},
{
"NodeID": "bsid516166",
"ParentID": [
"bsid499459"
],
"Information": {
"Name": "cellular response to inorganic substance",
"Description": [
"GO:0071241 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071241"
}
},
{
"NodeID": "bsid501734",
"ParentID": [
"bsid486550"
],
"Information": {
"Name": "developmental process",
"Description": [
"GO:0032502 A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. Synonym: development;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032502"
}
},
{
"NodeID": "bsid507256",
"ParentID": [
"bsid493259"
],
"Information": {
"Name": "cellular biosynthetic process",
"Description": [
"GO:0044249 The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. Synonyms: cellular anabolism; cellular biosynthesis; cellular formation; cellular synthesis;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044249"
}
},
{
"NodeID": "bsid508928",
"ParentID": [
"bsid508743"
],
"Information": {
"Name": "heterocycle catabolic process",
"Description": [
"GO:0046700 The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). Synonyms: heterocycle breakdown; heterocycle catabolism; heterocycle degradation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046700"
}
},
{
"NodeID": "bsid493730",
"ParentID": [
"bsid511833"
],
"Information": {
"Name": "response to external stimulus",
"Description": [
"GO:0009605 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. Synonym: response to environmental stimulus;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009605"
}
},
{
"NodeID": "bsid496191",
"ParentID": [
"bsid491607"
],
"Information": {
"Name": "monoterpenoid metabolic process",
"Description": [
"GO:0016098 The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton. Synonym: monoterpenoid metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016098"
}
},
{
"NodeID": "bsid498081",
"ParentID": [
"bsid507073"
],
"Information": {
"Name": "regulation of vasoconstriction",
"Description": [
"GO:0019229 Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019229"
}
},
{
"NodeID": "bsid514938",
"ParentID": [
"bsid486550"
],
"Information": {
"Name": "biological regulation",
"Description": [
"GO:0065007 Any process that modulates a measurable attribute of any biological process, quality or function. Synonym: regulation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0065007"
}
},
{
"NodeID": "bsid493576",
"ParentID": [
"bsid493577"
],
"Information": {
"Name": "toxin biosynthetic process",
"Description": [
"GO:0009403 The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. Synonyms: toxin anabolism; toxin biosynthesis; toxin formation; toxin synthesis;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009403"
}
},
{
"NodeID": "bsid491606",
"ParentID": [
"bsid507262"
],
"Information": {
"Name": "isoprenoid metabolic process",
"Description": [
"GO:0006720 The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. Synonyms: GO:0016096; isoprenoid metabolism; polyisoprenoid metabolic process; polyisoprenoid metabolism; polyterpene metabolic process; polyterpene metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006720"
}
},
{
"NodeID": "bsid499734",
"ParentID": [
"bsid518793"
],
"Information": {
"Name": "regulation of cell migration",
"Description": [
"GO:0030334 Any process that modulates the frequency, rate or extent of cell migration."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030334"
}
},
{
"NodeID": "bsid487713",
"ParentID": [
"bsid512133"
],
"Information": {
"Name": "regulation of cytokine production",
"Description": [
"GO:0001817 Any process that modulates the frequency, rate, or extent of production of a cytokine."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001817"
}
},
{
"NodeID": "bsid493925",
"ParentID": [
"bsid493923"
],
"Information": {
"Name": "alkaloid catabolic process",
"Description": [
"GO:0009822 The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). Synonyms: alkaloid breakdown; alkaloid catabolism; alkaloid degradation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009822"
}
},
{
"NodeID": "bsid512158",
"ParentID": [
"bsid511763"
],
"Information": {
"Name": "regulation of cellular component movement",
"Description": [
"GO:0051270 Any process that modulates the frequency, rate or extent of the movement of a cellular component. Synonyms: regulation of cell movement; regulation of cellular component motion;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051270"
}
},
{
"NodeID": "bsid511770",
"ParentID": [
"bsid512819"
],
"Information": {
"Name": "regulation of synaptic transmission",
"Description": [
"GO:0050804 Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050804"
}
},
{
"NodeID": "bsid512589",
"ParentID": [
"bsid511833"
],
"Information": {
"Name": "cellular response to stimulus",
"Description": [
"GO:0051716 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051716"
}
},
{
"NodeID": "bsid499574",
"ParentID": [
"bsid510918"
],
"Information": {
"Name": "cell differentiation",
"Description": [
"GO:0030154 The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030154"
}
},
{
"NodeID": "bsid513695",
"ParentID": [
"bsid492317"
],
"Information": {
"Name": "maternal process involved in parturition",
"Description": [
"GO:0060137 A reproductive process occurring in the mother that results in birth."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060137"
}
},
{
"NodeID": "bsid510585",
"ParentID": [
"bsid510906"
],
"Information": {
"Name": "organ development",
"Description": [
"GO:0048513 Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. Synonyms: development of an organ; organogenesis;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048513"
}
},
{
"NodeID": "bsid506566",
"ParentID": [
"bsid494658"
],
"Information": {
"Name": "regulation of blood vessel endothelial cell migration",
"Description": [
"GO:0043535 Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043535"
}
},
{
"NodeID": "bsid508927",
"ParentID": [
"bsid488804"
],
"Information": {
"Name": "decidualization",
"Description": [
"GO:0046697 The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. Synonym: decidual cell reaction;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046697"
}
},
{
"NodeID": "bsid500585",
"ParentID": [
"bsid500582"
],
"Information": {
"Name": "regulation of cellular biosynthetic process",
"Description": [
"GO:0031326 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. Synonyms: regulation of cellular anabolism; regulation of cellular biosynthesis; regulation of cellular formation; regulation of cellular synthesis;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031326"
}
},
{
"NodeID": "bsid500643",
"ParentID": [
"bsid755385"
],
"Information": {
"Name": "regulation of prostaglandin biosynthetic process",
"Description": [
"GO:0031392 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin. Synonyms: regulation of prostaglandin anabolism; regulation of prostaglandin biosynthesis; regulation of prostaglandin formation; regulation of prostaglandin synthesis;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031392"
}
},
{
"NodeID": "bsid510786",
"ParentID": [
"bsid510906"
],
"Information": {
"Name": "system development",
"Description": [
"GO:0048731 The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048731"
}
},
{
"NodeID": "bsid508089",
"ParentID": [
"bsid518208"
],
"Information": {
"Name": "positive regulation of S phase of mitotic cell cycle",
"Description": [
"GO:0045750 Any process that activates or increases the frequency, rate or extent of S phase of mitotic cell cycle activity. Synonyms: activation of S phase of mitotic cell cycle; positive regulation of S-phase of mitotic cell cycle; stimulation of S phase of mitotic cell cycle; up regulation of S phase of mitotic cell cycle; up-regulation of S phase of mitotic cell cycle; upregulation of S phase of mitotic cell cycle;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045750"
}
},
{
"NodeID": "bsid509070",
"ParentID": [
"bsid503309"
],
"Information": {
"Name": "regulation of bone remodeling",
"Description": [
"GO:0046850 Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046850"
}
},
{
"NodeID": "bsid506082",
"ParentID": [
"bsid505453"
],
"Information": {
"Name": "regulation of transcription factor import into nucleus",
"Description": [
"GO:0042990 Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus. Synonyms: regulation of transcription factor import into cell nucleus; regulation of transcription factor transport from cytoplasm to nucleus; regulation of transcription factor-nucleus import;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042990"
}
},
{
"NodeID": "bsid516539",
"ParentID": [
"bsid491097"
],
"Information": {
"Name": "oxidative deethylation",
"Description": [
"GO:0071615 The process of removing one or more ethyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071615"
}
},
{
"NodeID": "bsid510589",
"ParentID": [
"bsid511759"
],
"Information": {
"Name": "positive regulation of biological process",
"Description": [
"GO:0048518 Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. Synonyms: GO:0043119; activation of biological process; positive regulation of physiological process; stimulation of biological process; up regulation of biological process; up-regulation of biological process; upregulation of biological process;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048518"
}
},
{
"NodeID": "bsid493831",
"ParentID": [
"bsid511833"
],
"Information": {
"Name": "response to endogenous stimulus",
"Description": [
"GO:0009719 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009719"
}
},
{
"NodeID": "bsid507798",
"ParentID": [
"bsid499574"
],
"Information": {
"Name": "fat cell differentiation",
"Description": [
"GO:0045444 The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. Synonyms: adipocyte cell differentiation; adipocyte differentiation; adipogenesis; adipose cell differentiation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045444"
}
},
{
"NodeID": "bsid512818",
"ParentID": [
"bsid512816"
],
"Information": {
"Name": "positive regulation of synaptic transmission, glutamatergic",
"Description": [
"GO:0051968 Any process that activates, maintains or increases the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. Synonyms: activation of synaptic transmission, glutamatergic; stimulation of synaptic transmission, glutamatergic; up regulation of synaptic transmission, glutamatergic; up-regulation of synaptic transmission, glutamatergic; upregulation of synaptic transmission, glutamatergic;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051968"
}
},
{
"NodeID": "bsid510593",
"ParentID": [
"bsid510589"
],
"Information": {
"Name": "positive regulation of cellular process",
"Description": [
"GO:0048522 Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Synonyms: GO:0051242; activation of cellular process; positive regulation of cellular physiological process; stimulation of cellular process; up regulation of cellular process; up-regulation of cellular process; upregulation of cellular process;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048522"
}
},
{
"NodeID": "bsid493923",
"ParentID": [
"bsid754524"
],
"Information": {
"Name": "alkaloid metabolic process",
"Description": [
"GO:0009820 The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). Synonym: alkaloid metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009820"
}
},
{
"NodeID": "bsid506242",
"ParentID": [
"bsid516628"
],
"Information": {
"Name": "macromolecule metabolic process",
"Description": [
"GO:0043170 The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. Synonyms: GO:0043283; biopolymer metabolic process; macromolecule metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043170"
}
},
{
"NodeID": "bsid510906",
"ParentID": [
"bsid501734"
],
"Information": {
"Name": "anatomical structure development",
"Description": [
"GO:0048856 The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. Synonym: development of an anatomical structure;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048856"
}
},
{
"NodeID": "bsid511833",
"ParentID": [
"bsid486550"
],
"Information": {
"Name": "response to stimulus",
"Description": [
"GO:0050896 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. Synonyms: GO:0051869; physiological response to stimulus;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050896"
}
},
{
"NodeID": "bsid513897",
"ParentID": [
"bsid511763"
],
"Information": {
"Name": "regulation of cellular localization",
"Description": [
"GO:0060341 Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. Synonym: regulation of cellular localisation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0060341"
}
},
{
"NodeID": "bsid487715",
"ParentID": [
"bsid487713"
],
"Information": {
"Name": "positive regulation of cytokine production",
"Description": [
"GO:0001819 Any process that activates or increases the frequency, rate or extent of production of a cytokine. Synonyms: activation of cytokine production; stimulation of cytokine production; up regulation of cytokine production; up-regulation of cytokine production; upregulation of cytokine production;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0001819"
}
},
{
"NodeID": "bsid505999",
"ParentID": [
"bsid505701"
],
"Information": {
"Name": "9-cis-retinoic acid metabolic process",
"Description": [
"GO:0042905 The chemical reactions and pathways involving 9-cis-retinoic acid, a metabolically active vitamin A derivative. Synonym: 9-cis-retinoic acid metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042905"
}
},
{
"NodeID": "bsid507948",
"ParentID": [
"bsid507946"
],
"Information": {
"Name": "positive regulation of fat cell differentiation",
"Description": [
"GO:0045600 Any process that activates or increases the frequency, rate or extent of adipocyte differentiation. Synonyms: activation of fat cell differentiation; positive regulation of adipocyte cell differentiation; positive regulation of adipocyte differentiation; stimulation of fat cell differentiation; up regulation of fat cell differentiation; up-regulation of fat cell differentiation; upregulation of fat cell differentiation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0045600"
}
},
{
"NodeID": "bsid515297",
"ParentID": [
"bsid487785"
],
"Information": {
"Name": "hepatocyte differentiation",
"Description": [
"GO:0070365 The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver. Synonym: liver cell differentiation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070365"
}
},
{
"NodeID": "bsid505453",
"ParentID": [
"bsid753173"
],
"Information": {
"Name": "regulation of protein import into nucleus",
"Description": [
"GO:0042306 Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus. Synonyms: regulation of protein import into cell nucleus; regulation of protein transport from cytoplasm to nucleus; regulation of protein-nucleus import;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042306"
}
},
{
"NodeID": "bsid511815",
"ParentID": [
"bsid507798"
],
"Information": {
"Name": "brown fat cell differentiation",
"Description": [
"GO:0050873 The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. Synonyms: brown adipocyte cell differentiation; brown adipocyte differentiation;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050873"
}
},
{
"NodeID": "bsid495836",
"ParentID": [
"bsid495846"
],
"Information": {
"Name": "bicarbonate transport",
"Description": [
"GO:0015701 The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015701"
}
},
{
"NodeID": "bsid498072",
"ParentID": [
"bsid498071"
],
"Information": {
"Name": "regulation of fatty acid metabolic process",
"Description": [
"GO:0019217 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. Synonyms: GO:0006632; regulation of fatty acid metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019217"
}
},
{
"NodeID": "bsid505754",
"ParentID": [
"bsid510652"
],
"Information": {
"Name": "anagen",
"Description": [
"GO:0042640 The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair. Synonym: hair growth;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042640"
}
},
{
"NodeID": "bsid500645",
"ParentID": [
"bsid500643"
],
"Information": {
"Name": "positive regulation of prostaglandin biosynthetic process",
"Description": [
"GO:0031394 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin. Synonyms: activation of prostaglandin biosynthetic process; positive regulation of prostaglandin anabolism; positive regulation of prostaglandin biosynthesis; positive regulation of prostaglandin formation; positive regulation of prostaglandin synthesis; stimulation of prostaglandin biosynthetic process; up regulation of prostaglandin biosynthetic process; up-regulation of prostaglandin biosynthetic process; upregulation of prostaglandin biosynthetic process;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031394"
}
},
{
"NodeID": "bsid500583",
"ParentID": [
"bsid510594"
],
"Information": {
"Name": "negative regulation of cellular metabolic process",
"Description": [
"GO:0031324 Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. Synonyms: down regulation of cellular metabolic process; down-regulation of cellular metabolic process; downregulation of cellular metabolic process; inhibition of cellular metabolic process; negative regulation of cellular metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031324"
}
},
{
"NodeID": "bsid503487",
"ParentID": [
"bsid493855"
],
"Information": {
"Name": "response to monosaccharide stimulus",
"Description": [
"GO:0034284 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034284"
}
},
{
"NodeID": "bsid495807",
"ParentID": [
"bsid498566"
],
"Information": {
"Name": "carbon dioxide transport",
"Description": [
"GO:0015670 The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015670"
}
},
{
"NodeID": "bsid491607",
"ParentID": [
"bsid491606"
],
"Information": {
"Name": "terpenoid metabolic process",
"Description": [
"GO:0006721 The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups. Synonym: terpenoid metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0006721"
}
},
{
"NodeID": "bsid498215",
"ParentID": [
"bsid491578"
],
"Information": {
"Name": "lipoxygenase pathway",
"Description": [
"GO:0019372 The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019372"
}
},
{
"NodeID": "bsid507244",
"ParentID": [
"bsid494072"
],
"Information": {
"Name": "cellular metabolic process",
"Description": [
"GO:0044237 The chemical reactions and pathways by which individual cells transform chemical substances. Synonyms: cellular metabolism; intermediary metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044237"
}
},
{
"NodeID": "bsid511763",
"ParentID": [
"bsid511759"
],
"Information": {
"Name": "regulation of cellular process",
"Description": [
"GO:0050794 Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Synonyms: GO:0051244; regulation of cellular physiological process;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050794"
}
},
{
"NodeID": "bsid512819",
"ParentID": [
"bsid499461"
],
"Information": {
"Name": "regulation of transmission of nerve impulse",
"Description": [
"GO:0051969 Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051969"
}
},
{
"NodeID": "bsid510918",
"ParentID": [
"bsid501734"
],
"Information": {
"Name": "cellular developmental process",
"Description": [
"GO:0048869 A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0048869"
}
},
{
"NodeID": "bsid502068",
"ParentID": [
"bsid510589"
],
"Information": {
"Name": "positive regulation of homeostatic process",
"Description": [
"GO:0032846 Any process that activates or increases the frequency, rate, or extent of a homeostatic process. Synonyms: activation of homeostatic process; stimulation of homeostatic process; up regulation of homeostatic process; up-regulation of homeostatic process; upregulation of homeostatic process;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032846"
}
},
{
"NodeID": "bsid493855",
"ParentID": [
"bsid754651"
],
"Information": {
"Name": "response to carbohydrate stimulus",
"Description": [
"GO:0009743 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009743"
}
},
{
"NodeID": "bsid493862",
"ParentID": [
"bsid493858"
],
"Information": {
"Name": "response to fructose stimulus",
"Description": [
"GO:0009750 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009750"
}
},
{
"NodeID": "bsid518191",
"ParentID": [
"bsid518190"
],
"Information": {
"Name": "positive regulation of cell migration involved in sprouting angiogenesis",
"Description": [
"GO:0090050 Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0090050"
}
},
{
"NodeID": "gi116241312",
"ParentID": [
"bsid493925",
"bsid496191",
"bsid505845",
"bsid515915"
],
"Information": {
"Name": "Cytochrome P450 3A4",
"Description": [
"Cytochrome P450 3A4"
],
"Comments": [
"RecName: Full=Cytochrome P450 3A4; AltName: Full=1,8-cineole 2-exo-monooxygenase; AltName: Full=Albendazole monooxygenase; AltName: Full=Albendazole sulfoxidase; AltName: Full=CYPIIIA3; AltName: Full=CYPIIIA4; AltName: Full=Cytochrome P450 3A3; AltName: Full=Cytochrome P450 HLp; AltName: Full=Cytochrome P450 NF-25; AltName: Full=Cytochrome P450-PCN1; AltName: Full=Nifedipine oxidase; AltName: Full=Quinine 3-monooxygenase; AltName: Full=Taurochenodeoxycholate 6-alpha-hydroxylase"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/116241312"
},
"XRefs": {
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}
},
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"bsid494640",
"bsid498214",
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"bsid499462",
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"bsid500872",
"bsid501155",
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"bsid505490",
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"bsid507786",
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"bsid511815",
"bsid512818",
"bsid516242",
"bsid518191",
"bsid518411",
"bsid518476",
"bsid518502"
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"Information": {
"Name": "Prostaglandin G/H synthase 2",
"Description": [
"Prostaglandin G/H synthase 2"
],
"Comments": [
"RecName: Full=Prostaglandin G/H synthase 2; AltName: Full=Cyclooxygenase-2; Short=COX-2; AltName: Full=PHS II; AltName: Full=Prostaglandin H2 synthase 2; Short=PGH synthase 2; Short=PGHS-2; AltName: Full=Prostaglandin-endoperoxide synthase 2; Flags: Precursor"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/3915797"
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"bsid516539",
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"Information": {
"Name": "Cytochrome P450 1A2",
"Description": [
"Cytochrome P450 1A2"
],
"Comments": [
"RecName: Full=Cytochrome P450 1A2; AltName: Full=CYPIA2; AltName: Full=Cytochrome P(3)450; AltName: Full=Cytochrome P450 4; AltName: Full=Cytochrome P450-P3"
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"URL": "http://www.ncbi.nlm.nih.gov/protein/117144"
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"NodeID": "gi317373262",
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"Information": {
"Name": "Prostaglandin G/H synthase 1",
"Description": [
"Prostaglandin G/H synthase 1"
],
"Comments": [
"RecName: Full=Prostaglandin G/H synthase 1; AltName: Full=Cyclooxygenase-1; Short=COX-1; AltName: Full=Prostaglandin H2 synthase 1; Short=PGH synthase 1; Short=PGHS-1; Short=PHS 1; AltName: Full=Prostaglandin-endoperoxide synthase 1; Flags: Precursor"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/317373262"
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"Information": {
"Name": "Cytochrome P450 2C9",
"Description": [
"Cytochrome P450 2C9"
],
"Comments": [
"RecName: Full=Cytochrome P450 2C9; AltName: Full=(R)-limonene 6-monooxygenase; AltName: Full=(S)-limonene 6-monooxygenase; AltName: Full=(S)-limonene 7-monooxygenase; AltName: Full=CYPIIC9; AltName: Full=Cytochrome P-450MP; AltName: Full=Cytochrome P450 MP-4; AltName: Full=Cytochrome P450 MP-8; AltName: Full=Cytochrome P450 PB-1; AltName: Full=S-mephenytoin 4-hydroxylase"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/6686268"
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"Information": {
"Name": "Carbonic anhydrase 2",
"Description": [
"Carbonic anhydrase 2"
],
"Comments": [
"RecName: Full=Carbonic anhydrase 2; AltName: Full=Carbonate dehydratase II; AltName: Full=Carbonic anhydrase C; Short=CAC; AltName: Full=Carbonic anhydrase II; Short=CA-II"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/115456"
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"NodeID": "gi60416369",
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"Information": {
"Name": "Cytochrome P450 2C19",
"Description": [
"Cytochrome P450 2C19"
],
"Comments": [
"RecName: Full=Cytochrome P450 2C19; AltName: Full=(R)-limonene 6-monooxygenase; AltName: Full=(S)-limonene 6-monooxygenase; AltName: Full=(S)-limonene 7-monooxygenase; AltName: Full=CYPIIC17; AltName: Full=CYPIIC19; AltName: Full=Cytochrome P450-11A; AltName: Full=Cytochrome P450-254C; AltName: Full=Mephenytoin 4-hydroxylase"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/60416369"
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},
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"NodeID": "gi117139",
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"bsid505998",
"bsid508089",
"bsid511637",
"bsid513695",
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"Information": {
"Name": "Cytochrome P450 1A1",
"Description": [
"Cytochrome P450 1A1"
],
"Comments": [
"RecName: Full=Cytochrome P450 1A1; AltName: Full=CYPIA1; AltName: Full=Cytochrome P450 form 6; AltName: Full=Cytochrome P450-C; AltName: Full=Cytochrome P450-P1"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/117139"
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}
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"NodeID": "gi5016090",
"ParentID": [
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"Information": {
"Name": "NR0B1 gene product [Homo sapiens]",
"Description": [
"NR0B1 gene product [Homo sapiens]"
],
"Comments": [
"NR0B1 gene product [Homo sapiens]"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/5016090"
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"XRefs": {
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}
},
{
"NodeID": "gi115465",
"ParentID": [
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"Information": {
"Name": "Carbonic anhydrase 4",
"Description": [
"Carbonic anhydrase 4"
],
"Comments": [
"RecName: Full=Carbonic anhydrase 4; AltName: Full=Carbonate dehydratase IV; AltName: Full=Carbonic anhydrase IV; Short=CA-IV; Flags: Precursor"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/115465"
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"NodeID": "gi84028191",
"ParentID": [
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"bsid515915",
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],
"Information": {
"Name": "Cytochrome P450 2D6",
"Description": [
"Cytochrome P450 2D6"
],
"Comments": [
"RecName: Full=Cytochrome P450 2D6; AltName: Full=CYPIID6; AltName: Full=Cytochrome P450-DB1; AltName: Full=Debrisoquine 4-hydroxylase"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/84028191"
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"XRefs": {
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}
},
{
"NodeID": "gi134047703",
"ParentID": [
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"Information": {
"Name": "Carbonic anhydrase 3",
"Description": [
"Carbonic anhydrase 3"
],
"Comments": [
"RecName: Full=Carbonic anhydrase 3; AltName: Full=Carbonate dehydratase III; AltName: Full=Carbonic anhydrase III; Short=CA-III"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/134047703"
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"XRefs": {
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}
},
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"NodeID": "gi5915866",
"ParentID": [
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"Information": {
"Name": "Carbonic anhydrase 12",
"Description": [
"Carbonic anhydrase 12"
],
"Comments": [
"RecName: Full=Carbonic anhydrase 12; AltName: Full=Carbonate dehydratase XII; AltName: Full=Carbonic anhydrase XII; Short=CA-XII; AltName: Full=Tumor antigen HOM-RCC-3.1.3; Flags: Precursor"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/5915866"
},
"XRefs": {
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}
},
{
"NodeID": "gi115449",
"ParentID": [
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],
"Information": {
"Name": "Carbonic anhydrase 1",
"Description": [
"Carbonic anhydrase 1"
],
"Comments": [
"RecName: Full=Carbonic anhydrase 1; AltName: Full=Carbonate dehydratase I; AltName: Full=Carbonic anhydrase B; Short=CAB; AltName: Full=Carbonic anhydrase I; Short=CA-I"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/115449"
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"XRefs": {
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}
},
{
"NodeID": "gi1168744",
"ParentID": [
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],
"Information": {
"Name": "Carbonic anhydrase 7",
"Description": [
"Carbonic anhydrase 7"
],
"Comments": [
"RecName: Full=Carbonic anhydrase 7; AltName: Full=Carbonate dehydratase VII; AltName: Full=Carbonic anhydrase VII; Short=CA-VII"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/1168744"
},
"XRefs": {
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}
},
{
"NodeID": "gi8928036",
"ParentID": [
"bsid495836"
],
"Information": {
"Name": "Carbonic anhydrase 14",
"Description": [
"Carbonic anhydrase 14"
],
"Comments": [
"RecName: Full=Carbonic anhydrase 14; AltName: Full=Carbonate dehydratase XIV; AltName: Full=Carbonic anhydrase XIV; Short=CA-XIV; Flags: Precursor"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/8928036"
},
"XRefs": {
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}
},
{
"NodeID": "bsid751852",
"ParentID": [
"bsid487495"
],
"Information": {
"Name": "single-organism metabolic process",
"Description": [
"GO:0044710 A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves a single organism."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044710"
}
},
{
"NodeID": "bsid498566",
"ParentID": [
"bsid516626"
],
"Information": {
"Name": "one-carbon compound transport",
"Description": [
"GO:0019755 The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Synonym: one carbon compound transport;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019755"
}
},
{
"NodeID": "bsid751909",
"ParentID": [
"bsid501734"
],
"Information": {
"Name": "single-organism developmental process",
"Description": [
"GO:0044767 A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, involving only one organism."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044767"
}
},
{
"NodeID": "bsid516628",
"ParentID": [
"bsid487495"
],
"Information": {
"Name": "organic substance metabolic process",
"Description": [
"GO:0071704 The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. Synonyms: organic molecular entity metabolic process; organic molecular entity metabolism; organic substance metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0071704"
}
},
{
"NodeID": "bsid751905",
"ParentID": [
"bsid494072"
],
"Information": {
"Name": "single-organism cellular process",
"Description": [
"GO:0044763 Any process that is carried out at the cellular level, occurring within a single organism."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044763"
}
},
{
"NodeID": "bsid754651",
"ParentID": [
"bsid505382"
],
"Information": {
"Name": "response to oxygen-containing compound",
"Description": [
"GO:1901700 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. Synonym: response to oxygen molecular entity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901700"
}
},
{
"NodeID": "bsid751849",
"ParentID": [
"bsid501733"
],
"Information": {
"Name": "multi-multicellular organism process",
"Description": [
"GO:0044706 A multicellular organism process which involves another multicellular organism of the same or different species."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044706"
}
},
{
"NodeID": "bsid755385",
"ParentID": [
"bsid505451"
],
"Information": {
"Name": "regulation of unsaturated fatty acid biosynthetic process",
"Description": [
"GO:2001279 Any process that modulates the frequency, rate or extent of unsaturated fatty acid biosynthetic process. Synonyms: regulation of fatty acid desaturation; regulation of polyunsaturated fatty acid biosynthesis; regulation of unsaturated fatty acid anabolism; regulation of unsaturated fatty acid biosynthesis; regulation of unsaturated fatty acid formation; regulation of unsaturated fatty acid synthesis;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:2001279"
}
},
{
"NodeID": "bsid753173",
"ParentID": [
"bsid513897"
],
"Information": {
"Name": "regulation of protein localization to nucleus",
"Description": [
"GO:1900180 Any process that modulates the frequency, rate or extent of protein localization to nucleus. Synonyms: regulation of protein localisation to nucleus; regulation of protein localization in cell nucleus; regulation of protein localization in nucleus;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1900180"
}
},
{
"NodeID": "bsid754524",
"ParentID": [
"bsid516628"
],
"Information": {
"Name": "organonitrogen compound metabolic process",
"Description": [
"GO:1901564 The chemical reactions and pathways involving organonitrogen compound. Synonym: organonitrogen compound metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901564"
}
},
{
"NodeID": "bsid754528",
"ParentID": [
"bsid516628"
],
"Information": {
"Name": "fatty acid derivative metabolic process",
"Description": [
"GO:1901568 The chemical reactions and pathways involving fatty acid derivative. Synonym: fatty acid derivative metabolism;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:1901568"
}
},
{
"NodeID": "bsid752768",
"ParentID": [
"bsid498212"
],
"Information": {
"Name": "omega-hydroxylase P450 pathway",
"Description": [
"GO:0097267 The chemical reactions and pathways by which arachidonic acid is converted to other compounds initially by omega-hydroxylation. Synonym: P450 omega-hydroxylase pathway;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097267"
}
}
]
},
{
"SourceName": "Gene Ontology",
"SourceID": "GO_ROOT_486551",
"RootID": "bsid486551",
"Information": {
"Name": "cellular component",
"Description": [
"The Gene Ontology (GO) project provides a controlled vocabulary of terms for describing the functions of gene products, and is divided into three domains. The cellular components domain, shown here, describes locations, at the levels of subcellular structures and macromolecular complexes. An example of a cellular component is the nuclear inner membrane, with the synonym inner envelope. Generally, a gene product is located in or is a subcomponent of a particular cellular component. The terms below apply to the gene/protein target(s) tested by the BioAssay. "
],
"Comments": [
"This Gene Ontology tree was mapped by BioAssays' protein targets shown as leaves of this tree. ",
"GO database release 2012-06-04",
"For any queries contact http://geneontology.org/GO.contacts.shtml"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005575"
},
"Node": [
{
"NodeID": "bsid507374",
"ParentID": [
"bsid489309"
],
"Information": {
"Name": "membrane part",
"Description": [
"GO:0044425 Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044425"
}
},
{
"NodeID": "bsid507411",
"ParentID": [
"bsid490692"
],
"Information": {
"Name": "cell part",
"Description": [
"GO:0044464 Any constituent part of a cell, the basic structural and functional unit of all organisms. Synonym: protoplast;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044464"
}
},
{
"NodeID": "bsid507406",
"ParentID": [
"bsid507374"
],
"Information": {
"Name": "plasma membrane part",
"Description": [
"GO:0044459 Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044459"
}
},
{
"NodeID": "bsid500494",
"ParentID": [
"bsid500487"
],
"Information": {
"Name": "intrinsic to external side of plasma membrane",
"Description": [
"GO:0031233 Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031233"
}
},
{
"NodeID": "bsid489274",
"ParentID": [
"bsid507373"
],
"Information": {
"Name": "ribonucleoprotein complex",
"Description": [
"GO:0030529 A macromolecular complex containing both protein and RNA molecules. Synonyms: RNA-protein complex; RNP; protein-RNA complex; ribonucleoprotein;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030529"
}
},
{
"NodeID": "bsid489309",
"ParentID": [
"bsid486551"
],
"Information": {
"Name": "membrane",
"Description": [
"GO:0016020 Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016020"
}
},
{
"NodeID": "bsid496364",
"ParentID": [
"bsid507406"
],
"Information": {
"Name": "apical plasma membrane",
"Description": [
"GO:0016324 The region of the plasma membrane located at the apical end of the cell."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016324"
}
},
{
"NodeID": "bsid486779",
"ParentID": [
"bsid507411"
],
"Information": {
"Name": "intracellular",
"Description": [
"GO:0005622 The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. Synonyms: internal to cell; nucleocytoplasm; protoplasm; protoplast;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005622"
}
},
{
"NodeID": "bsid505893",
"ParentID": [
"bsid490860"
],
"Information": {
"Name": "polysomal ribosome",
"Description": [
"GO:0042788 A ribosome bound to mRNA that forms part of a polysome. Synonym: active ribosome;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042788"
}
},
{
"NodeID": "bsid490692",
"ParentID": [
"bsid486551"
],
"Information": {
"Name": "cell",
"Description": [
"GO:0005623 The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005623"
}
},
{
"NodeID": "bsid500512",
"ParentID": [
"bsid507406"
],
"Information": {
"Name": "cell projection membrane",
"Description": [
"GO:0031253 The portion of the plasma membrane surrounding a cell surface projection. Synonyms: membrane extension; membrane projection;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031253"
}
},
{
"NodeID": "bsid500621",
"ParentID": [
"bsid500494"
],
"Information": {
"Name": "anchored to external side of plasma membrane",
"Description": [
"GO:0031362 Tethered to the plasma membrane by a covalently attached anchor, such as a lipid group, that is embedded in the membrane, with the bulk of the gene product located on the side opposite to the side that faces the cytoplasm. When used to describe a protein, indicates that the peptide sequence does not span the membrane."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031362"
}
},
{
"NodeID": "bsid500486",
"ParentID": [
"bsid507374"
],
"Information": {
"Name": "intrinsic to membrane",
"Description": [
"GO:0031224 Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031224"
}
},
{
"NodeID": "bsid490860",
"ParentID": [
"bsid489274"
],
"Information": {
"Name": "polysome",
"Description": [
"GO:0005844 Several ribosomes bound to one mRNA. Synonym: polyribosome;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005844"
}
},
{
"NodeID": "bsid500487",
"ParentID": [
"bsid500486"
],
"Information": {
"Name": "intrinsic to plasma membrane",
"Description": [
"GO:0031226 Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031226"
}
},
{
"NodeID": "bsid507373",
"ParentID": [
"bsid486779"
],
"Information": {
"Name": "intracellular part",
"Description": [
"GO:0044424 Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0044424"
}
},
{
"NodeID": "bsid500777",
"ParentID": [
"bsid500512"
],
"Information": {
"Name": "brush border membrane",
"Description": [
"GO:0031526 The portion of the plasma membrane surrounding the brush border."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0031526"
}
},
{
"NodeID": "gi5016090",
"ParentID": [
"bsid505893"
],
"Information": {
"Name": "NR0B1 gene product [Homo sapiens]",
"Description": [
"NR0B1 gene product [Homo sapiens]"
],
"Comments": [
"NR0B1 gene product [Homo sapiens]"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/5016090"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi115465",
"ParentID": [
"bsid496364",
"bsid500621",
"bsid500777"
],
"Information": {
"Name": "Carbonic anhydrase 4",
"Description": [
"Carbonic anhydrase 4"
],
"Comments": [
"RecName: Full=Carbonic anhydrase 4; AltName: Full=Carbonate dehydratase IV; AltName: Full=Carbonic anhydrase IV; Short=CA-IV; Flags: Precursor"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/115465"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
}
]
},
{
"SourceName": "Gene Ontology",
"SourceID": "GO_ROOT_486552",
"RootID": "bsid486552",
"Information": {
"Name": "molecular function",
"Description": [
"The Gene Ontology (GO) project provides a controlled vocabulary of terms for describing the functions of gene products, and is divided into three domains. Each term in the molecular functions domain, shown here, represent a protein's jobs or abilities. These may include transporting things around, binding to things, holding things together and changing one thing into another. This is different from the biological processes the gene product is involved in, which involve more than one activity. The terms below apply to the gene/protein target(s) tested by the BioAssay. "
],
"Comments": [
"This Gene Ontology tree was mapped by BioAssays' protein targets shown as leaves of this tree. ",
"GO database release 2012-06-04",
"For any queries contact http://geneontology.org/GO.contacts.shtml"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003674"
},
"Node": [
{
"NodeID": "bsid511453",
"ParentID": [
"bsid496624"
],
"Information": {
"Name": "arachidonate 15-lipoxygenase activity",
"Description": [
"GO:0050473 Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate. Synonyms: 15-lipoxygenase activity; arachidonate omega(6) lipoxygenase activity; arachidonate omega6 lipoxygenase activity; arachidonate:oxygen 15-oxidoreductase activity; linoleic acid omega6-lipoxygenase activity; omega6 lipoxygenase activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050473"
}
},
{
"NodeID": "bsid489231",
"ParentID": [
"bsid489230"
],
"Information": {
"Name": "DNA binding",
"Description": [
"GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). Synonyms: microtubule/chromatin interaction; plasmid binding;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003677"
}
},
{
"NodeID": "bsid492693",
"ParentID": [
"bsid489846"
],
"Information": {
"Name": "steroid hydroxylase activity",
"Description": [
"GO:0008395 Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. Synonyms: GO:0008394; cytochrome P450 CYP2G1; olfactory-specific steroid hydroxylase activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008395"
}
},
{
"NodeID": "bsid509119",
"ParentID": [
"bsid490614"
],
"Information": {
"Name": "transition metal ion binding",
"Description": [
"GO:0046914 Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046914"
}
},
{
"NodeID": "bsid486738",
"ParentID": [
"bsid506597"
],
"Information": {
"Name": "DNA secondary structure binding",
"Description": [
"GO:0000217 Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0000217"
}
},
{
"NodeID": "bsid506241",
"ParentID": [
"bsid506239"
],
"Information": {
"Name": "cation binding",
"Description": [
"GO:0043169 Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043169"
}
},
{
"NodeID": "bsid489995",
"ParentID": [
"bsid496626"
],
"Information": {
"Name": "prostaglandin-endoperoxide synthase activity",
"Description": [
"GO:0004666 Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. Synonyms: (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity; (PG)H synthase activity; PG synthetase activity; fatty acid cyclooxygenase activity; prostaglandin G/H synthase activity; prostaglandin endoperoxide synthetase activity; prostaglandin synthase activity; prostaglandin synthetase activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004666"
}
},
{
"NodeID": "bsid496645",
"ParentID": [
"bsid491098"
],
"Information": {
"Name": "oxidoreductase activity, acting on CH or CH2 groups",
"Description": [
"GO:0016725 Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Synonym: oxidoreductase activity, acting on CH or CH2 groups, other acceptors;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016725"
}
},
{
"NodeID": "bsid511563",
"ParentID": [
"bsid496630"
],
"Information": {
"Name": "quinine 3-monooxygenase activity",
"Description": [
"GO:0050591 Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+). Synonyms: nifedipine oxidase activity; quinine 3-hydroxylase activity; quinine,NADPH:oxygen oxidoreductase activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050591"
}
},
{
"NodeID": "bsid489846",
"ParentID": [
"bsid491098"
],
"Information": {
"Name": "monooxygenase activity",
"Description": [
"GO:0004497 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. Synonym: hydroxylase activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004497"
}
},
{
"NodeID": "bsid497592",
"ParentID": [
"bsid497504"
],
"Information": {
"Name": "(S)-limonene 7-monooxygenase activity",
"Description": [
"GO:0018676 Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (4S)-perillyl alcohol + H(2)O + NADP(+). Synonyms: (-)-limonene 7-monooxygenase activity; (-)-limonene hydroxylase activity; (-)-limonene monooxygenase activity; (-)-limonene,NADPH:oxygen oxidoreductase (7-hydroxylating) activity; (S)-limonene,NADPH:oxygen oxidoreductase (7-hydroxylating); limonene hydroxylase activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018676"
}
},
{
"NodeID": "bsid511621",
"ParentID": [
"bsid492693"
],
"Information": {
"Name": "testosterone 6-beta-hydroxylase activity",
"Description": [
"GO:0050649 Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O. Synonym: testosterone 6b-hydroxylase activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050649"
}
},
{
"NodeID": "bsid490614",
"ParentID": [
"bsid506241"
],
"Information": {
"Name": "metal ion binding",
"Description": [
"GO:0046872 Interacting selectively and non-covalently with any metal ion. Synonyms: heavy metal binding; metal binding;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046872"
}
},
{
"NodeID": "bsid489230",
"ParentID": [
"bsid752660"
],
"Information": {
"Name": "nucleic acid binding",
"Description": [
"GO:0003676 Interacting selectively and non-covalently with any nucleic acid."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003676"
}
},
{
"NodeID": "bsid506239",
"ParentID": [
"bsid490605"
],
"Information": {
"Name": "ion binding",
"Description": [
"GO:0043167 Interacting selectively and non-covalently with ions, charged atoms or groups of atoms. Synonym: atom binding;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043167"
}
},
{
"NodeID": "bsid489557",
"ParentID": [
"bsid496732"
],
"Information": {
"Name": "carbonate dehydratase activity",
"Description": [
"GO:0004089 Catalysis of the reaction: H2CO3 = CO2 + H2O. Synonyms: anhydrase activity; carbonate anhydrase activity; carbonate hydro-lyase (carbon-dioxide-forming); carbonate hydro-lyase activity; carbonic acid anhydrase activity; carbonic anhydrase A; carbonic anhydrase activity; carbonic dehydratase activity; carboxyanhydrase activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0004089"
}
},
{
"NodeID": "bsid504074",
"ParentID": [
"bsid502912"
],
"Information": {
"Name": "caffeine oxidase activity",
"Description": [
"GO:0034875 Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0034875"
}
},
{
"NodeID": "bsid505906",
"ParentID": [
"bsid509172"
],
"Information": {
"Name": "protein homodimerization activity",
"Description": [
"GO:0042803 Interacting selectively and non-covalently with an identical protein to form a homodimer. Synonym: dimerization activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0042803"
}
},
{
"NodeID": "bsid486595",
"ParentID": [
"bsid486552"
],
"Information": {
"Name": "electron carrier activity",
"Description": [
"GO:0009055 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. Synonyms: 2Fe-2S electron transfer carrier; 3Fe-4S/4Fe-4S electron transfer carrier; GO:0009053; GO:0009054; adrenodoxin-type ferredoxin; amicyanin; azurin; bacterial-type ferredoxin; chloroplast-type ferredoxin; copper electron carrier; dicluster bacterial-type ferredoxin; electron acceptor activity; electron carrier, chlorophyll electron transport system; electron donor activity; electron transfer flavoprotein; electron transfer flavoprotein, group I; electron transfer flavoprotein, group II; electron transporter activity; high-potential iron-sulfur carrier; iron-sulfur electron transfer carrier; monocluster bacterial-type ferredoxin; mononuclear iron electron carrier; polyferredoxin; redox-active disulfide bond electron carrier; rubredoxin; small blue copper electron carrier; thioredoxin-like 2Fe-2S ferredoxin;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0009055"
}
},
{
"NodeID": "bsid506597",
"ParentID": [
"bsid489231"
],
"Information": {
"Name": "structure-specific DNA binding",
"Description": [
"GO:0043566 Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding. Synonym: structure specific DNA binding;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0043566"
}
},
{
"NodeID": "bsid496241",
"ParentID": [
"bsid509119"
],
"Information": {
"Name": "nickel cation binding",
"Description": [
"GO:0016151 Interacting selectively and non-covalently with nickel (Ni) cations. Synonym: nickel binding;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016151"
}
},
{
"NodeID": "bsid496624",
"ParentID": [
"bsid512109"
],
"Information": {
"Name": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen",
"Description": [
"GO:0016702 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016702"
}
},
{
"NodeID": "bsid495328",
"ParentID": [
"bsid486561"
],
"Information": {
"Name": "protein disulfide oxidoreductase activity",
"Description": [
"GO:0015035 Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. Synonyms: GO:0008895; haem lyase disulphide oxidoreductase activity; heme lyase disulfide oxidoreductase activity; protein disulphide oxidoreductase activity; thioredoxin activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015035"
}
},
{
"NodeID": "bsid498681",
"ParentID": [
"bsid486730"
],
"Information": {
"Name": "protein domain specific binding",
"Description": [
"GO:0019904 Interacting selectively and non-covalently with a specific domain of a protein. Synonym: protein domain-specific binding;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019904"
}
},
{
"NodeID": "bsid497504",
"ParentID": [
"bsid496630"
],
"Information": {
"Name": "limonene monooxygenase activity",
"Description": [
"GO:0019113 Catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0019113"
}
},
{
"NodeID": "bsid502991",
"ParentID": [
"bsid496630"
],
"Information": {
"Name": "taurochenodeoxycholate 6alpha-hydroxylase activity",
"Description": [
"GO:0033780 Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O. Synonyms: CYP3A4; CYP4A21; taurochenodeoxycholate 6alpha-monooxygenase activity; taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033780"
}
},
{
"NodeID": "bsid499743",
"ParentID": [
"bsid515573"
],
"Information": {
"Name": "vitamin D3 25-hydroxylase activity",
"Description": [
"GO:0030343 Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O. Synonym: cholecalciferol 25-hydroxylase activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0030343"
}
},
{
"NodeID": "bsid509172",
"ParentID": [
"bsid486730"
],
"Information": {
"Name": "protein dimerization activity",
"Description": [
"GO:0046983 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046983"
}
},
{
"NodeID": "bsid486730",
"ParentID": [
"bsid490605"
],
"Information": {
"Name": "protein binding",
"Description": [
"GO:0005515 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). Synonyms: GO:0045308; alpha-2 macroglobulin receptor-associated protein activity; protein amino acid binding; protein degradation tagging activity; protein folding chaperone; protein tagging activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005515"
}
},
{
"NodeID": "bsid496632",
"ParentID": [
"bsid496630"
],
"Information": {
"Name": "flavonoid 3'-monooxygenase activity",
"Description": [
"GO:0016711 Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O. Synonyms: NADPH:flavonoid-3'-hydroxylase activity; flavonoid 3'-hydroxylase activity; flavonoid 3-hydroxylase (erroneous); flavonoid 3-monooxygenase (erroneous); flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating);"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016711"
}
},
{
"NodeID": "bsid515262",
"ParentID": [
"bsid496633"
],
"Information": {
"Name": "aromatase activity",
"Description": [
"GO:0070330 Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. Synonym: estrogen synthetase activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070330"
}
},
{
"NodeID": "bsid497591",
"ParentID": [
"bsid497504"
],
"Information": {
"Name": "(S)-limonene 6-monooxygenase activity",
"Description": [
"GO:0018675 Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O. Synonyms: (-)-limonene 6-hydroxylase activity; (-)-limonene 6-monooxygenase activity; (-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity; (S)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating); limonene 6-hydroxylase activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0018675"
}
},
{
"NodeID": "bsid509113",
"ParentID": [
"bsid752660"
],
"Information": {
"Name": "tetrapyrrole binding",
"Description": [
"GO:0046906 Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. Synonym: porphyrin binding;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0046906"
}
},
{
"NodeID": "bsid491098",
"ParentID": [
"bsid489325"
],
"Information": {
"Name": "oxidoreductase activity",
"Description": [
"GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. Synonyms: oxidoreductase activity, acting on other substrates; redox activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016491"
}
},
{
"NodeID": "bsid496732",
"ParentID": [
"bsid496731"
],
"Information": {
"Name": "hydro-lyase activity",
"Description": [
"GO:0016836 Catalysis of the cleavage of a carbon-oxygen bond by elimination of water."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016836"
}
},
{
"NodeID": "bsid486561",
"ParentID": [
"bsid496599"
],
"Information": {
"Name": "disulfide oxidoreductase activity",
"Description": [
"GO:0015036 Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. Synonym: disulphide oxidoreductase activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0015036"
}
},
{
"NodeID": "bsid496599",
"ParentID": [
"bsid491098"
],
"Information": {
"Name": "oxidoreductase activity, acting on a sulfur group of donors",
"Description": [
"GO:0016667 Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. Synonyms: oxidoreductase activity, acting on sulfur group of donors, other acceptors; oxidoreductase activity, acting on sulphur group of donors;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016667"
}
},
{
"NodeID": "bsid492594",
"ParentID": [
"bsid509119"
],
"Information": {
"Name": "zinc ion binding",
"Description": [
"GO:0008270 Interacting selectively and non-covalently with zinc (Zn) ions. Synonym: zinc binding;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008270"
}
},
{
"NodeID": "bsid496626",
"ParentID": [
"bsid491098"
],
"Information": {
"Name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen",
"Description": [
"GO:0016705 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. Synonym: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016705"
}
},
{
"NodeID": "bsid496731",
"ParentID": [
"bsid496726"
],
"Information": {
"Name": "carbon-oxygen lyase activity",
"Description": [
"GO:0016835 Catalysis of the breakage of a carbon-oxygen bond. Synonym: other carbon-oxygen lyase activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016835"
}
},
{
"NodeID": "bsid509813",
"ParentID": [
"bsid496630"
],
"Information": {
"Name": "albendazole monooxygenase activity",
"Description": [
"GO:0047638 Catalysis of the reaction: albendazole + H(+) + NADPH + O(2) = albendazole S-oxide + H(2)O + NADP(+). Synonyms: albendazole oxidase activity; albendazole sulfoxidase activity; albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming);"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0047638"
}
},
{
"NodeID": "bsid498782",
"ParentID": [
"bsid509113"
],
"Information": {
"Name": "heme binding",
"Description": [
"GO:0020037 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. Synonym: haem binding;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0020037"
}
},
{
"NodeID": "bsid496726",
"ParentID": [
"bsid489325"
],
"Information": {
"Name": "lyase activity",
"Description": [
"GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. Synonym: other lyase activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016829"
}
},
{
"NodeID": "bsid515573",
"ParentID": [
"bsid491098"
],
"Information": {
"Name": "vitamin D 25-hydroxylase activity",
"Description": [
"GO:0070643 Catalysis of the hydroxylation of C-25 of any form of vitamin D. Synonyms: calciferol 25-hydroxylase activity; cholecalciferol 25-hydroxylase activity; ergocalciferol 25-hydroxylase activity; vitamin D2 25-hydroxylase activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0070643"
}
},
{
"NodeID": "bsid511654",
"ParentID": [
"bsid498681"
],
"Information": {
"Name": "AF-2 domain binding",
"Description": [
"GO:0050682 Interacting selectively and non-covalently with the AF-2 domain of a protein, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0050682"
}
},
{
"NodeID": "bsid501680",
"ParentID": [
"bsid486738"
],
"Information": {
"Name": "DNA hairpin binding",
"Description": [
"GO:0032448 Interacting selectively and non-covalently with DNA containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0032448"
}
},
{
"NodeID": "bsid492451",
"ParentID": [
"bsid489751"
],
"Information": {
"Name": "growth factor activity",
"Description": [
"GO:0008083 The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0008083"
}
},
{
"NodeID": "bsid489751",
"ParentID": [
"bsid486730"
],
"Information": {
"Name": "receptor binding",
"Description": [
"GO:0005102 Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. Synonyms: receptor ligand; receptor-associated protein activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005102"
}
},
{
"NodeID": "bsid489325",
"ParentID": [
"bsid486552"
],
"Information": {
"Name": "catalytic activity",
"Description": [
"GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. Synonym: enzyme activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0003824"
}
},
{
"NodeID": "bsid496814",
"ParentID": [
"bsid496602"
],
"Information": {
"Name": "thiol oxidase activity",
"Description": [
"GO:0016972 Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O. Synonyms: sulfhydryl oxidase activity; thiol:oxygen oxidoreductase activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016972"
}
},
{
"NodeID": "bsid490605",
"ParentID": [
"bsid486552"
],
"Information": {
"Name": "binding",
"Description": [
"GO:0005488 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. Synonym: ligand;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0005488"
}
},
{
"NodeID": "bsid496602",
"ParentID": [
"bsid496599"
],
"Information": {
"Name": "oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor",
"Description": [
"GO:0016670 Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen. Synonym: oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016670"
}
},
{
"NodeID": "bsid502912",
"ParentID": [
"bsid496645"
],
"Information": {
"Name": "oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor",
"Description": [
"GO:0033695 Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0033695"
}
},
{
"NodeID": "bsid512109",
"ParentID": [
"bsid491098"
],
"Information": {
"Name": "dioxygenase activity",
"Description": [
"GO:0051213 Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051213"
}
},
{
"NodeID": "bsid496633",
"ParentID": [
"bsid489846"
],
"Information": {
"Name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen",
"Description": [
"GO:0016712 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. Synonyms: GO:0008402; GO:0050381; aryl hydrocarbon hydroxylase activity; aryl-4-monooxygenase activity; cytochrome P450 CYP19; cytochrome p450 activity; flavoprotein monooxygenase activity; flavoprotein-linked monooxygenase activity; microsomal P-450; microsomal monooxygenase activity; microsomal p450 activity; substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing); unspecific monooxygenase activity; xenobiotic monooxygenase activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016712"
}
},
{
"NodeID": "bsid496630",
"ParentID": [
"bsid489846"
],
"Information": {
"Name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen",
"Description": [
"GO:0016709 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. Synonym: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016709"
}
},
{
"NodeID": "gi134047703",
"ParentID": [
"bsid489557",
"bsid492594",
"bsid496241"
],
"Information": {
"Name": "Carbonic anhydrase 3",
"Description": [
"Carbonic anhydrase 3"
],
"Comments": [
"RecName: Full=Carbonic anhydrase 3; AltName: Full=Carbonate dehydratase III; AltName: Full=Carbonic anhydrase III; Short=CA-III"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/134047703"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi30580362",
"ParentID": [
"bsid489557"
],
"Information": {
"Name": "Carbonic anhydrase 15",
"Description": [
"Carbonic anhydrase 15"
],
"Comments": [
"RecName: Full=Carbonic anhydrase 15; AltName: Full=Carbonate dehydratase XV; AltName: Full=Carbonic anhydrase XV; Short=CA-XV; Flags: Precursor"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/30580362"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi116241312",
"ParentID": [
"bsid486595",
"bsid498782",
"bsid499743",
"bsid502991",
"bsid504074",
"bsid509813",
"bsid511563",
"bsid511621"
],
"Information": {
"Name": "Cytochrome P450 3A4",
"Description": [
"Cytochrome P450 3A4"
],
"Comments": [
"RecName: Full=Cytochrome P450 3A4; AltName: Full=1,8-cineole 2-exo-monooxygenase; AltName: Full=Albendazole monooxygenase; AltName: Full=Albendazole sulfoxidase; AltName: Full=CYPIIIA3; AltName: Full=CYPIIIA4; AltName: Full=Cytochrome P450 3A3; AltName: Full=Cytochrome P450 HLp; AltName: Full=Cytochrome P450 NF-25; AltName: Full=Cytochrome P450-PCN1; AltName: Full=Nifedipine oxidase; AltName: Full=Quinine 3-monooxygenase; AltName: Full=Taurochenodeoxycholate 6-alpha-hydroxylase"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/116241312"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi3915797",
"ParentID": [
"bsid489995",
"bsid498782",
"bsid505906",
"bsid511453"
],
"Information": {
"Name": "Prostaglandin G/H synthase 2",
"Description": [
"Prostaglandin G/H synthase 2"
],
"Comments": [
"RecName: Full=Prostaglandin G/H synthase 2; AltName: Full=Cyclooxygenase-2; Short=COX-2; AltName: Full=PHS II; AltName: Full=Prostaglandin H2 synthase 2; Short=PGH synthase 2; Short=PGHS-2; AltName: Full=Prostaglandin-endoperoxide synthase 2; Flags: Precursor"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/3915797"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi117144",
"ParentID": [
"bsid486595",
"bsid498782",
"bsid504074",
"bsid515262"
],
"Information": {
"Name": "Cytochrome P450 1A2",
"Description": [
"Cytochrome P450 1A2"
],
"Comments": [
"RecName: Full=Cytochrome P450 1A2; AltName: Full=CYPIA2; AltName: Full=Cytochrome P(3)450; AltName: Full=Cytochrome P450 4; AltName: Full=Cytochrome P450-P3"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/117144"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi317373262",
"ParentID": [
"bsid489995",
"bsid498782"
],
"Information": {
"Name": "Prostaglandin G/H synthase 1",
"Description": [
"Prostaglandin G/H synthase 1"
],
"Comments": [
"RecName: Full=Prostaglandin G/H synthase 1; AltName: Full=Cyclooxygenase-1; Short=COX-1; AltName: Full=Prostaglandin H2 synthase 1; Short=PGH synthase 1; Short=PGHS-1; Short=PHS 1; AltName: Full=Prostaglandin-endoperoxide synthase 1; Flags: Precursor"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/317373262"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi6686268",
"ParentID": [
"bsid486595",
"bsid497591",
"bsid497592",
"bsid498782",
"bsid504074",
"bsid751943"
],
"Information": {
"Name": "Cytochrome P450 2C9",
"Description": [
"Cytochrome P450 2C9"
],
"Comments": [
"RecName: Full=Cytochrome P450 2C9; AltName: Full=(R)-limonene 6-monooxygenase; AltName: Full=(S)-limonene 6-monooxygenase; AltName: Full=(S)-limonene 7-monooxygenase; AltName: Full=CYPIIC9; AltName: Full=Cytochrome P-450MP; AltName: Full=Cytochrome P450 MP-4; AltName: Full=Cytochrome P450 MP-8; AltName: Full=Cytochrome P450 PB-1; AltName: Full=S-mephenytoin 4-hydroxylase"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/6686268"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi5915866",
"ParentID": [
"bsid489557",
"bsid492594"
],
"Information": {
"Name": "Carbonic anhydrase 12",
"Description": [
"Carbonic anhydrase 12"
],
"Comments": [
"RecName: Full=Carbonic anhydrase 12; AltName: Full=Carbonate dehydratase XII; AltName: Full=Carbonic anhydrase XII; Short=CA-XII; AltName: Full=Tumor antigen HOM-RCC-3.1.3; Flags: Precursor"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/5915866"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi115449",
"ParentID": [
"bsid489557",
"bsid492594"
],
"Information": {
"Name": "Carbonic anhydrase 1",
"Description": [
"Carbonic anhydrase 1"
],
"Comments": [
"RecName: Full=Carbonic anhydrase 1; AltName: Full=Carbonate dehydratase I; AltName: Full=Carbonic anhydrase B; Short=CAB; AltName: Full=Carbonic anhydrase I; Short=CA-I"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/115449"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi1168744",
"ParentID": [
"bsid489557",
"bsid492594"
],
"Information": {
"Name": "Carbonic anhydrase 7",
"Description": [
"Carbonic anhydrase 7"
],
"Comments": [
"RecName: Full=Carbonic anhydrase 7; AltName: Full=Carbonate dehydratase VII; AltName: Full=Carbonic anhydrase VII; Short=CA-VII"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/1168744"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi115456",
"ParentID": [
"bsid489557",
"bsid492594"
],
"Information": {
"Name": "Carbonic anhydrase 2",
"Description": [
"Carbonic anhydrase 2"
],
"Comments": [
"RecName: Full=Carbonic anhydrase 2; AltName: Full=Carbonate dehydratase II; AltName: Full=Carbonic anhydrase C; Short=CAC; AltName: Full=Carbonic anhydrase II; Short=CA-II"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/115456"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi60416369",
"ParentID": [
"bsid486595",
"bsid497591",
"bsid497592",
"bsid498782",
"bsid751943"
],
"Information": {
"Name": "Cytochrome P450 2C19",
"Description": [
"Cytochrome P450 2C19"
],
"Comments": [
"RecName: Full=Cytochrome P450 2C19; AltName: Full=(R)-limonene 6-monooxygenase; AltName: Full=(S)-limonene 6-monooxygenase; AltName: Full=(S)-limonene 7-monooxygenase; AltName: Full=CYPIIC17; AltName: Full=CYPIIC19; AltName: Full=Cytochrome P450-11A; AltName: Full=Cytochrome P450-254C; AltName: Full=Mephenytoin 4-hydroxylase"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/60416369"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi117139",
"ParentID": [
"bsid486595",
"bsid496632",
"bsid498782",
"bsid515262"
],
"Information": {
"Name": "Cytochrome P450 1A1",
"Description": [
"Cytochrome P450 1A1"
],
"Comments": [
"RecName: Full=Cytochrome P450 1A1; AltName: Full=CYPIA1; AltName: Full=Cytochrome P450 form 6; AltName: Full=Cytochrome P450-C; AltName: Full=Cytochrome P450-P1"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/117139"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi5016090",
"ParentID": [
"bsid501680",
"bsid505906",
"bsid511654"
],
"Information": {
"Name": "NR0B1 gene product [Homo sapiens]",
"Description": [
"NR0B1 gene product [Homo sapiens]"
],
"Comments": [
"NR0B1 gene product [Homo sapiens]"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/5016090"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi115465",
"ParentID": [
"bsid489557",
"bsid492594"
],
"Information": {
"Name": "Carbonic anhydrase 4",
"Description": [
"Carbonic anhydrase 4"
],
"Comments": [
"RecName: Full=Carbonic anhydrase 4; AltName: Full=Carbonate dehydratase IV; AltName: Full=Carbonic anhydrase IV; Short=CA-IV; Flags: Precursor"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/115465"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi84028191",
"ParentID": [
"bsid486595",
"bsid498782",
"bsid515262"
],
"Information": {
"Name": "Cytochrome P450 2D6",
"Description": [
"Cytochrome P450 2D6"
],
"Comments": [
"RecName: Full=Cytochrome P450 2D6; AltName: Full=CYPIID6; AltName: Full=Cytochrome P450-DB1; AltName: Full=Debrisoquine 4-hydroxylase"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/84028191"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi54112432",
"ParentID": [
"bsid492451",
"bsid495328",
"bsid496814"
],
"Information": {
"Name": "FAD-linked sulfhydryl oxidase ALR [Homo sapiens]",
"Description": [
"FAD-linked sulfhydryl oxidase ALR [Homo sapiens]"
],
"Comments": [
"FAD-linked sulfhydryl oxidase ALR [Homo sapiens]"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/54112432"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi8928036",
"ParentID": [
"bsid489557"
],
"Information": {
"Name": "Carbonic anhydrase 14",
"Description": [
"Carbonic anhydrase 14"
],
"Comments": [
"RecName: Full=Carbonic anhydrase 14; AltName: Full=Carbonate dehydratase XIV; AltName: Full=Carbonic anhydrase XIV; Short=CA-XIV; Flags: Precursor"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/8928036"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "gi30580372",
"ParentID": [
"bsid489557",
"bsid492594"
],
"Information": {
"Name": "Carbonic anhydrase 13",
"Description": [
"Carbonic anhydrase 13"
],
"Comments": [
"RecName: Full=Carbonic anhydrase 13; AltName: Full=Carbonate dehydratase XIII; AltName: Full=Carbonic anhydrase XIII; Short=CA-XIII"
],
"URL": "http://www.ncbi.nlm.nih.gov/protein/30580372"
},
"XRefs": {
"XRef_PubChemCID": [
1983
]
}
},
{
"NodeID": "bsid751943",
"ParentID": [
"bsid497504"
],
"Information": {
"Name": "(R)-limonene 6-monooxygenase activity",
"Description": [
"GO:0052741 Catalysis of the reaction: (4R)-limonene + H+ + NADPH + O2 = (1R,5S)-carveol + H2O + NADP+. Synonyms: (+)-limonene 6-monooxygenase activity; (+)-limonene-6-hydroxylase activity; (R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity;"
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0052741"
}
},
{
"NodeID": "bsid752660",
"ParentID": [
"bsid490605"
],
"Information": {
"Name": "organic cyclic compound binding",
"Description": [
"GO:0097159 Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure."
],
"URL": "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0097159"
}
}
]
}
]
}
}