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DSSTox_CID_28487 (CID 60196441) - Compound BioActivity Data
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Filters: All Data » summary      
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BioActivity Outcomes:
Active(1)
 
 
Inactive(4)
 
 
Inconclusive(19)
 
 
Top Targets:
NR LBD PPAR(4)
 
 
 
NR LBD AR(3)
 
 
 
NR LBD ER(3)
 
 
NR LBD Fxr(2)
 
 
NR LBD GR(2)
 
 
BioAssay Types:
Summary(24)
 
 
 
 
BioActivity Types:
Potency(18)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 24    Data Row: 24   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144213906]
Ratio Potency (uM) 9.5398qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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2
[SID144213906]
AhR Potency (uM) qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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3
[SID144213906]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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4
[SID144213906]
qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743199, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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5
[SID144213906]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway: Summary [AID743241, Type: summary]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
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6
[SID144213906]
TR Potency (uM) 10.3008qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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7
[SID144213906]
Ratio Potency (uM) 16.4684qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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8
[SID144213906]
Ratio Potency (uM) 16.4684qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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9
[SID144213906]
Ratio Potency (uM) 25.8745qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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10
[SID144213906]
Ratio Potency (uM) 28.1828qHTS assay for small molecule activators of the heat shock response signaling pathway: Summary [AID743228, Type: summary]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
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11
[SID144213906]
Ratio Potency (uM) 30.4311qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway: Summary [AID743227, Type: summary]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
View
12
[SID144213906]
Ratio Potency (uM) 30.4311qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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13
[SID144213906]
Ratio Potency (uM) 30.4311qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
View
14
[SID144213906]
Ratio Potency (uM) 35.48qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway: Summary [AID743239, Type: summary]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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15
[SID144213906]
AR Potency (uM) 37.9786qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary [AID743054, Type: summary]AR protein [Homo sapiens] [gi:124375976]
View
16
[SID144213906]
ATAD5 Potency (uM) 44.2798qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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17
[SID144213906]
Ratio Potency (uM) 44.2798qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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18
[SID144213906]
Ratio Potency (uM) 48.201qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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19
[SID144213906]
ER Potency (uM) 53.6462qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line: Summary [AID743091, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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20
[SID144213906]
qHTS assay to identify aromatase inhibitors: Summary [AID743139, Type: summary]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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21
[SID144213906]
qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway: Summary [AID743226, Type: summary]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
View
22
[SID144213906]
qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720725, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
View
23
[SID144213906]
qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway: Summary [AID743240, Type: summary]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
View
24
[SID144213906]
qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway: Summary [AID743242, Type: summary]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
View