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axitinib (CID 6450551) - Compound BioActivity Data
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Filters: All Data » confirmatory      
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BioActivity Outcomes:
Active(17)
 
 
Inactive(38)
 
 
Inconclusive(28)
 
 
Top Targets:
NR LBD AR(4)
 
 
 
NR LBD ER(4)
 
 
 
NR LBD PPAR(4)
 
 
PLDc mTdp1 2(2)
 
 
NR LBD VDR(2)
 
 
BioAssay Types:
Confirmatory(82)
 
 
 
 
Literature(1)
 
 
BioActivity Types:
Potency(83)
 
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 83    Data Row: 83   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144207146]
Potency-Replicate_1 0.0841qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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2
[SID144207146]
Potency-Replicate_1 0.2371qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
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3
[SID124950168]
Potency 0.5103Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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4
[SID144207146]
Potency 0.6884qHTS for small molecule inhibitors of Yes1 kinase: Primary Screen [AID686947, Type: Literature]tyrosine-protein kinase Yes [Homo sapiens] [gi:4885661]
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5
[SID144207146]
Potency-Replicate_1 0.7498qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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6
[SID144207146]
Potency-Replicate_1 2.1132qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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7
[SID144207146]
Potency-Replicate_1 2.371qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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8
[SID144207146]
Potency-Replicate_1 2.371qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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9
[SID144207146]
Potency-Replicate_1 2.6603qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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10
[SID144207146]
Potency 2.6609qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID144207146]
Potency 4.2172qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID144207146]
Potency-Replicate_1 6.74qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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13
[SID144207146]
Potency-Replicate_1 13.3332qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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14
[SID170466656]
Potency-Replicate_1 18.8322qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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15
[SID170466656]
Potency-Replicate_1 23.9145qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
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16
[SID170466656]
Potency-Replicate_1 26.6011qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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17
[SID170466656]
Potency-Replicate_1 29.847qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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18
[SID144207146]
Potency-Replicate_1 0.5956qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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19
[SID144207146]
Potency-Replicate_1 1.1883qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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20
[SID144207146]
Potency 1.4818Cell Proliferation Assay against the TMD8 Cell Line (Caspase readout at 8 hrs) [AID651713, Type: confirmatory]
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21
[SID144207146]
Potency 1.8655Cell Proliferation Assay against a hMSC Cell Line [AID651696, Type: confirmatory]
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22
[SID144207146]
Potency 16.7744qHTS profiling for inhibitors of Plasmodium falciparum (DD2) proliferation [AID743323, Type: confirmatory]
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23
[SID144207146]
Potency 18.8212qHTS profiling for inhibitors of Plasmodium falciparum (3D7) proliferation [AID743322, Type: confirmatory]
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24
[SID144207146]
Potency 20.931Cell Proliferation Assay against the HBL1 Cell Line [AID651646, Type: confirmatory]
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25
[SID144207146]
Potency Cell Proliferation Assay against the TMD8 Cell Line (Caspase readout at 16 hrs) [AID651712, Type: confirmatory]
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26
[SID144207146]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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27
[SID144207146]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line - cell viability counter screen [AID743041, Type: confirmatory]
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28
[SID144207146]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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29
[SID144207146]
Potency qHTS profiling for inhibitors of Plasmodium falciparum (HB3) proliferation [AID743324, Type: confirmatory]
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30
[SID144207146]
Potency Cell Proliferation Assay against the TMD8 Cell Line [AID651645, Type: confirmatory]
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31
[SID144207146]
Potency-Replicate_1 qHTS assay to identify aromatase inhibitors - cell viability counter screen [AID743084, Type: confirmatory]
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32
[SID144207146]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cells [AID720687, Type: confirmatory]
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33
[SID144207146]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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34
[SID144207146]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HepG2 cells [AID720674, Type: confirmatory]
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35
[SID144207146]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cells [AID720675, Type: confirmatory]
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36
[SID144207146]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cells [AID720678, Type: confirmatory]
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37
[SID144207146]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cells [AID720679, Type: confirmatory]
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38
[SID144207146]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells [AID720680, Type: confirmatory]
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39
[SID144207146]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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40
[SID144207146]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell free culture [AID720682, Type: confirmatory]
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41
[SID144207146]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cell free culture [AID720683, Type: confirmatory]
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42
[SID144207146]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HepG2 cell free culture [AID720684, Type: confirmatory]
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43
[SID144207146]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cell free culture [AID720685, Type: confirmatory]
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44
[SID144207146]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cell free culture [AID720686, Type: confirmatory]
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45
[SID144207146]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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46
[SID124950168]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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47
[SID124950168]
Potency qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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48
[SID124950168]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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49
[SID170466656]
Potency-Replicate_1 qHTS assay for small molecule activators of the heat shock response signaling pathway [AID743210, Type: confirmatory]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
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50
[SID144207146]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the thyroid receptor (TR) signaling pathway [AID743066, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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