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axitinib (CID 6450551) - Compound BioActivity Data
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Filters: All Data » confirmatory      
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BioActivity Outcomes:
Active(513)
 
 
Inactive(46)
 
 
Inconclusive(22)
 
 
Unspecified(535)
 
 
Top Targets:
PKc(48)
 
 
 
PKc like(40)
 
 
 
STKc AGC(19)
 
 
 
PTKc Abl(16)
 
 
PTKc EGFR(12)
 
 
 
BioAssay Types:
Confirmatory(662)
 
 
 
 
 
Literature(454)
 
 
 
BioActivity Types:
IC50(582)
 
 
 
Kd(442)
 
 
 
Potency(86)
 
 
 
 
Ki(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1116    Data Row: 1116   Total Pages: 56   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID123098392]
IC50 5.13e-05SANGER: Inhibition of human EoL-1-cell cell growth in a cell viability assay. [AID742166, Type: confirmatory]
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2
[SID123098392]
IC50 0.00025Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assay [AID538338, Type: Literature]
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3
[SID123098392]
Kd 0.00049Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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4
[SID123098392]
Kd 0.00051Binding constant for PDGFRA kinase domain [AID625034, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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5
[SID123098392]
Kd 0.00057Binding constant for PDGFRB kinase domain [AID624875, Type: Literature]Platelet-derived growth factor receptor beta [gi:129890]
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6
[SID123098392]
IC50 0.000902SANGER: Inhibition of human NCI-H1703 cell growth in a cell viability assay. [AID741708, Type: confirmatory]
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7
[SID123098392]
Kd 0.0013Binding constant for AURKC kinase domain [AID624769, Type: Literature]Aurora kinase C [gi:27805738]
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8
[SID123098392]
Kd 0.0014Binding constant for KIT(V559D,T670I) kinase domain [AID624792, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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9
[SID123098392]
Kd 0.0015Binding constant for ABL1(T315I)-phosphorylated kinase domain [AID624989, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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10
[SID123098392]
Kd 0.0017Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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11
[SID123098392]
Kd 0.0032Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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12
[SID123098392]
Kd 0.0035Binding constant for KIT(V559D,V654A) kinase domain [AID624793, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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13
[SID123098392]
Kd 0.0036Binding constant for ABL1(T315I)-non phosphorylated kinase domain [AID624988, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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14
[SID123098392]
Ki 0.0042Inhibition of human PLK4 [AID762206, Type: Literature]Serine/threonine-protein kinase PLK4 [gi:160113150]
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15
[SID123098392]
Kd 0.0058Binding constant for FLT1 kinase domain [AID624853, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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16
[SID123098392]
Kd 0.0059Binding constant for VEGFR2 kinase domain [AID624860, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:9087218]
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17
[SID123098392]
IC50 0.00682SANGER: Inhibition of human KASUMI-1 cell growth in a cell viability assay. [AID742267, Type: confirmatory]
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18
[SID123098392]
IC50 0.00722SANGER: Inhibition of human CGTH-W-1 cell growth in a cell viability assay. [AID742061, Type: confirmatory]
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19
[SID123098392]
IC50 0.00992SANGER: Inhibition of human A204 cell growth in a cell viability assay. [AID741943, Type: confirmatory]
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20
[SID123098392]
Kd 0.011Binding constant for AURKB kinase domain [AID624772, Type: Literature]Aurora kinase B [gi:317373473]
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