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Adenosine Diphosphate (CID 6022) - Compound BioActivity Data
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Filters: All Data » confirmatory      
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BioActivity Outcomes:
Active(32)
 
 
Inactive(29)
 
 
Inconclusive(4)
 
 
Unspecified(22)
 
 
Top Targets:
HSP90(8)
 
 
 
PLDc mTdp1 2(3)
 
 
Tubulin-bindi..(2)
 
 
ANK(2)
 
 
NR LBD TR(2)
 
 
BioAssay Types:
Literature(54)
 
 
 
Confirmatory(33)
 
 
 
BioActivity Types:
Potency(30)
 
 
 
EC50(20)
 
 
 
IC50(11)
 
 
 
Kd(11)
 
 
 
Ki(5)
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 85    Data Row: 87   Total Pages: 5   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176960]
Ki 0.00091Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis method [AID461575, Type: Literature]5'-nucleotidase [gi:112826]
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2
[SID103176960]
EC50 0.014Agonist activity at G-protein coupled P2Y1 receptor expressed in human 1321N1 cells assessed as increase in calcium by Fura2 assay [AID462811, Type: Literature]
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3
[SID103176960]
EC50 0.024Agonist activity at human GFP-tagged P2Y1R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay [AID751213, Type: Literature]P2Y purinoceptor 1 [gi:1352692]
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4
[SID103176960]
EC50 0.069Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12) [AID150495, Type: Literature]
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5
[SID103176960]
EC50 0.1Agonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis [AID373705, Type: Literature]P2Y purinoceptor 1 [gi:1352693]
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6
[SID103176960]
Km 0.11Binding affinity to Hsp70 [AID527447, Type: Literature]
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7
[SID103176960]
Ki 0.11Inhibition of HSP70 by fluorescence polarization assay [AID600787, Type: Literature]
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8
[SID103176960]
Kd 0.11Binding affinity to bovine Hsc70 by filter binding assay [AID527446, Type: Literature]
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9
[SID103176960]
Kd 0.26Binding affinity to human Hsc70 by isothermal calorimetry assay [AID527455, Type: Literature]
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10
[SID103176960]
Kd 0.5Binding affinity to HSP70 by surface plasmon resonance analysis [AID600786, Type: Literature]
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11
[SID103176960]
IC50 0.5Displacement of fluorescein labeled N6-(6-amino)hexyl-ATP-5-FAM from HSP70 by fluorescence polarization assay [AID393506, Type: Literature]
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12
[SID103176960]
Kd 0.5Binding affinity to HSP70 by Biocore direct binding assay [AID393507, Type: Literature]
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13
[SID103176960]
EC50 1.7Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay [AID751212, Type: Literature]P2Y purinoceptor 11 [gi:21263830]
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14
[SID103176960]
Kd 2.17Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis [AID600785, Type: Literature]
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15
[SID103176960]
Kd 3.83Binding affinity to Grp78 by isothermal titration calorimetric analysis [AID600788, Type: Literature]
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16
[SID103176960]
Kd 4.3Binding affinity to Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase assessed as S-sulfocysteine formation at pH 7.5 by single turnover method in absence of MgCl2 [AID440581, Type: Literature]
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17
[SID103176960]
Kd 7.3Binding affinity to Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase assessed as S-sulfocysteine formation at pH 7.5 by single turnover method in presence of 0.5 mM MgCl2 [AID440582, Type: Literature]
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18
[SID103176960]
EC50 8Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytes [AID150470, Type: Literature]P2Y purinoceptor 1 [gi:1352693]
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19
[SID103176960]
Kd 10Affinity for mouse cyclic-AMP dependent Ser/Thr Kinase [AID219831, Type: Literature]
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20
[SID103176960]
EC50 10Antagonist activity against recombinant human P2X purinoceptor 1 (P2X1 ) [AID152476, Type: Literature]
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