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MLS002702491 (CID 404406) - Compound BioActivity Data
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Filters: All Data » confirmatory      
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BioActivity Outcomes:
Active(32)
 
 
Inactive(54)
 
 
Inconclusive(15)
 
 
Unspecified(1)
 
 
Top Targets:
RasGEF(4)
 
 
 
Tryp SPc(2)
 
 
Snurportin-1..(2)
 
 
Pyr redox dim(2)
 
 
 
PTZ00435(2)
 
 
 
BioAssay Types:
Confirmatory(102)
 
 
 
 
 
BioActivity Types:
Potency(74)
 
 
 
 
 
IC50(13)
 
 
 
AC50(2)
 
 
EC50(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 96    Data Row: 102   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID92764869]
AbsAC35_uM 0.15Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (3D7 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-05_Inhibitor_Dose_CherryPick_Activity [AID652047, Type: confirmatory]
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2
[SID92764869]
AbsAC35_uM 0.228Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (HB3 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-06_Inhibitor_Dose_CherryPick_Activity [AID652041, Type: confirmatory]
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3
[SID92764869]
Potency 0.3264qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID92764869]
Potency 0.4109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID92764869]
AC50_uM 0.914FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity [AID652116, Type: confirmatory]DNA repair protein RAD52 homolog [Homo sapiens] [gi:109637798]
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6
[SID92764869]
IC50 1.314Fluorescence-based cell-based primary high throughput dose response assay to identify antagonists of the Galanin Receptor 3 (GalR3). [AID687013, Type: confirmatory]galanin receptor type 3 [Homo sapiens] [gi:4503907]
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7
[SID92764869]
AbsAC35_uM 1.9Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_Dose_CherryPick_Activity [AID686920, Type: confirmatory]
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8
[SID92764869]
AbsAC35_uM 2.08HEK293 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-01_Inhibitor_Dose_CherryPick_Activity_Set3 [AID720588, Type: confirmatory]
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9
[SID92764869]
AbsAC35_uM 2.14HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_CherryPick_Activity_Set3 [AID720589, Type: confirmatory]
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10
[SID92764869]
Potency 2.5119qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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11
[SID92764869]
AbsAC1000_uM 2.635In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_Dose_CherryPick_Activity [AID540271, Type: confirmatory]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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12
[SID92764869]
AbsAC35_uM 2.82Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent A673 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-03_Inhibitor_Dose_CherryPick_Activity [AID720587, Type: confirmatory]
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13
[SID92764869]
Potency 3.1623qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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14
[SID92764869]
Potency 4.4668qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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15
[SID92764869]
Potency 6.3096qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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16
[SID92764869]
Potency 6.5131Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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17
[SID92764869]
Potency 6.5131qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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18
[SID92764869]
AbsAC35_uM 6.52Fluorescence polarization acridine orange assay to identify DNA binding small molcules Measured in Biochemical System Using Plate Reader - 7014-02_Inhibitor_Dose_CherryPick_Activity [AID720586, Type: confirmatory]EWS/FLI fusion protein [Homo sapiens] [gi:169655958]
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19
[SID92764869]
AC50_uM 6.93RAD52: DNA binders Measured in Biochemical System Using Plate Reader - 7018-02_Inhibitor_Dose_CherryPick_Activity [AID652128, Type: confirmatory]
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20
[SID92764869]
Potency 7.9433qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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21
[SID92764869]
IC50 10.973Discovery of Small Molecule Probes for H1N1 Influenza NS1A [AID504329, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/California/07/2009(H1N1))] [gi:227977143]
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22
[SID92764869]
CC50 16.921Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - HeLa Cytotoxicity [AID624300, Type: confirmatory]
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23
[SID92764869]
Potency 20.5962Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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24
[SID92764869]
Potency 22.3872qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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25
[SID92764869]
Potency 22.3872qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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26
[SID92764869]
Potency 22.3872qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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27
[SID92764869]
Max_Activity_Conc_uM 26Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent TC71 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-04_Inhibitor_Dose_CherryPick_Activity [AID720570, Type: confirmatory]
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28
[SID92764869]
Potency 28.1838qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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29
[SID92764869]
Potency 30.1313qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds [AID720498, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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30
[SID92764869]
AbsAC35_uM 33.3Mammalian cell toxicity counterscreen to identify toxic HSP40 inhibitor compounds in NIH3T3 cells Measured in Cell-Based System Using Plate Reader - 2120-03_Inhibitor_Dose_CherryPick_Activity_Set2 [AID624265, Type: confirmatory]
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31
[SID92764869]
IC50 38.31Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens [AID624330, Type: confirmatory]rac GTPase-activating protein 1 [Homo sapiens] [gi:21361397]
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32
[SID92764869]
IC50 100Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Counter Screen Coupled Enzyme [AID624351, Type: confirmatory]
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33
[SID92764869]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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34
[SID92764869]
Potency 0.1122qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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35
[SID92764869]
Potency 7.9433qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
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36
[SID92764869]
Potency 19.9526Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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37
[SID92764869]
EC50 29.913Counterscreen for antagonists of the galanin Receptor 3 (GalR3): Fluorescence-based cell-based high throughput dose response assay to identify non specific activators of the parental HEK-CNG cells. [AID687015, Type: confirmatory]
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38
[SID92764869]
Potency 31.6228qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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39
[SID92764869]
IC50 71.101QFRET-based biochemical high throughput dose response assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2) [AID743457, Type: confirmatory]phospholipase A2, group III [Homo sapiens] [gi:119580345]
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40
[SID92764869]
IC50_MT1-MMP(HT1080)_Mean 80Dose Response confirmation of uHTS hits for a small molecule inhibitors of MT1-MMP activation in a fluorescence assay set 1 [AID652244, Type: confirmatory]matrix metalloproteinase-14 preproprotein [Homo sapiens] [gi:4826834]
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41
[SID92764869]
IC50_HT1080_Mean 80Dose Response confirmation of uHTS hits for a small molecule inhibitors of MT1-MMP activation in a luminescence assay set 1 [AID652252, Type: confirmatory]
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42
[SID92764869]
IC50 121.843Counterscreen for inhibitors of the HGIII-SPLA2: QFRET-based biochemical high throughput dose response assay to identify inhibitors that optically interfere with 535nm fluorescence [AID743455, Type: confirmatory]
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43
[SID92764869]
IC50 Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition [AID588689, Type: confirmatory]Chain A, Crystal Structure Of Dengue-2 Virus Methyltransferase Complexed With S-Adenosyl-L-Homocysteine [gi:219689243]
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44
[SID92764869]
IC50 Discovery of Small Molecule Probes for H1N1 NS1a - H1N1 (KY136) Influenza Antiviral Screen [AID540257, Type: confirmatory]
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45
[SID92764869]
IC50 A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 [AID588727, Type: confirmatory]
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46
[SID92764869]
IC50 Primary and Confirmatory Screening for Inhibitors of Bacterial Capsule Biogenesis [AID488966, Type: confirmatory]
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47
[SID92764869]
IC50 Discovery of Small Molecule Probes for H1N1 NS1a - H1N1 (KY180) Influenza Antiviral Screen [AID540254, Type: confirmatory]
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48
[SID92764869]
Potency qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation [AID540253, Type: confirmatory]snurportin-1 [Homo sapiens] [gi:5031833]
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49
[SID92764869]
Potency qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation [AID540263, Type: confirmatory]snurportin-1 [Homo sapiens] [gi:5031833]
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50
[SID92764869]
Potency qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation [AID540253, Type: confirmatory]GTP-binding nuclear protein Ran [Homo sapiens] [gi:5453555]
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