Bookmark and Share
Diflunisal (CID 3059) - Compound BioActivity Data
.
Filters: All Data » confirmatory      
Filter selected
BioActivity Outcomes:
Active(16)
 
 
Inactive(311)
 
 
Inconclusive(60)
 
 
Unspecified(120)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
 
7TM GPCR Srsx(16)
 
 
 
p450(15)
 
 
 
 
NR LBD TR(8)
 
 
Bromo ALL-1(8)
 
 
 
BioAssay Types:
Confirmatory(480)
 
 
 
 
 
Literature(27)
 
 
 
 
BioActivity Types:
Potency(272)
 
 
 
 
IC50(175)
 
 
 
 
 
EC50(12)
 
 
 
 
Kd(2)
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 399    Data Row: 507   Total Pages: 26   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103235071]
Kd 1.16Binding affinity to human recombinant TTR Y78F mutant after 5 mins by isothermal titration calorimetry [AID1054846, Type: Literature]
View
2
[SID103235071]
Kd 1.23027Binding affinity to human serum albumin by PAMPA method [AID327170, Type: Literature]Serum albumin [gi:113576]
View
3
[SID103235071]
IC50 2.7Inhibition of human carbonic anhydrase 2 esterase activity by spectrophotometry [AID349141, Type: Literature]Carbonic anhydrase 2 [gi:115456]
View
4
[SID103235071]
IC50 3.38Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometry [AID349140, Type: Literature]Carbonic anhydrase 1 [gi:115449]
View
5
[SID103235071]
IC50 6.3Inhibition of transthyretin V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of sodium acetate-mediated aggregation preincubated for 30 mins followed by sodium acetate addition measured after 96 hrs by thioflavin T assay [AID1074430, Type: Literature]
View
6
[SID103235071]
Ki 8.45Inhibition of human carbonic anhydrase 1 esterase activity by noncompetitive Lineweaver-Burke plot [AID349142, Type: Literature]Carbonic anhydrase 1 [gi:115449]
View
7
[SID103235071]
Ki 9.37Inhibition of human carbonic anhydrase 2 esterase activity by non-competitive Lineweaver-Burke plot [AID349145, Type: Literature]Carbonic anhydrase 2 [gi:115456]
View
8
[SID144204149]
Potency-Replicate_1 11.3588qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
View
9
[SID11112675]
Potency 12.5893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
View
10
[SID11112675]
Potency 12.5893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
View
11
[SID170464956]
Potency-Replicate_1 13.3322qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
View
12
[SID855794]
Potency 15.1014qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
View
13
[SID103235071]
IC50 18Inhibition of human recombinant TTR Y78F mutant-mediated fibrillogenesis after 30 mins by turbidimetric assay [AID1054848, Type: Literature]
View
14
[SID855794]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
View
15
[SID855794]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
View
16
[SID855794]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7K cells) [AID431, Type: confirmatory]
View
17
[SID103235071]
IC50 0.85TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells [AID681160, Type: Literature]Solute carrier family 22 member 6 [gi:74762955]
View
18
[SID103235071]
IC50 109Inhibition of mycophenolic acid (1 mM) glucuronidation by human UGT enzymes from liver microsomes [AID624662, Type: Literature]
View
19
[SID103235071]
IC50 122Inhibition of mycophenolic acid (0.5 mM) glucuronidation by human kidney microsomes [AID624661, Type: Literature]
View
20
[SID103235071]
IC50 DRUGMATRIX: Glutamate, NMDA, Agonism radioligand binding (ligand: [3H] CGP-39653) [AID625266, Type: confirmatory]
View