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BioActivity Data for Compound Ethylene Glycol (CID 174)

Filters: All Data » confirmatory      
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BioActivity Outcomes:
Inactive(368)
 
 
Inconclusive(14)
 
 
Unspecified(123)
 
 
Top Targets:
7tm 4(30)
 
 
 
NR LBD PPAR(13)
 
 
 
NR LBD ER(12)
 
 
 
 
p450(11)
 
 
 
NR LBD AR(11)
 
 
 
 
BioAssay Types:
Confirmatory(497)
 
 
 
 
Literature(8)
 
 
 
BioAssay Categories:
Biochemical(117)
 
 
 
Cell-based(79)
 
 
 
Toxicity(39)
 
 
 
 
ADME(3)
 
 
In vitro(116)
 
 
BioActivity Types:
Potency(336)
 
 
 
 
IC50(123)
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 425    Data Row: 505   Total Pages: 26   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103601826]
CC50 221Cytotoxicity against human HL60 cells in presence of RPMI1640 containing 10% fetal bovine serum by trypan blue exclusion test [AID382489, Type: Literature]
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2
[SID103601826]
CC50 385Cytotoxicity against human HSC4 cells by MTT method [AID382488, Type: Literature]
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3
[SID103601826]
CC50 400Cytotoxicity against human HSC2 by MTT method [AID382487, Type: Literature]
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4
[SID103601826]
CC50 400Cytotoxicity against human gingival fibroblast by MTT method [AID382490, Type: Literature]
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5
[SID103601826]
CC50 400Cytotoxicity against human pulp cells by MTT method [AID382491, Type: Literature]
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6
[SID103601826]
CC50 400Cytotoxicity against human periodontal ligament fibroblast by MTT method [AID382492, Type: Literature]
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7
[SID85272555]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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8
[SID103601826]
IC50 DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) [AID625168, Type: confirmatory]Platelet-activating factor receptor [gi:129557]
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9
[SID103601826]
IC50 DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) [AID625173, Type: confirmatory]Angiotensin-converting enzyme [gi:2822103]
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10
[SID103601826]
IC50 DRUGMATRIX: Protease, Caspase 1 enzyme inhibition (substrate: Ac-YVAD-AMC) [AID625174, Type: confirmatory]Caspase-1 [gi:266321]
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11
[SID103601826]
IC50 DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) [AID625175, Type: confirmatory]Cathepsin G [gi:115725]
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12
[SID103601826]
IC50 DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) [AID625177, Type: confirmatory]Interstitial collagenase [gi:116852]
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13
[SID103601826]
IC50 DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) [AID625178, Type: confirmatory]Matrix metalloproteinase-9 [gi:269849668]
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14
[SID103601826]
IC50 DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) [AID625180, Type: confirmatory]Mitogen-activated protein kinase 3 [gi:232066]
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15
[SID103601826]
IC50 DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) [AID625181, Type: confirmatory]Mitogen-activated protein kinase 1 [gi:119554]
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16
[SID103601826]
IC50 DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) [AID625182, Type: confirmatory]Mitogen-activated protein kinase 14 [gi:2499600]
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17
[SID103601826]
IC50 DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) [AID625183, Type: confirmatory]Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [gi:1352673]
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18
[SID103601826]
IC50 DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625184, Type: confirmatory]Epidermal growth factor receptor [gi:2811086]
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19
[SID103601826]
IC50 DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625185, Type: confirmatory]Tyrosine-protein kinase Fyn [gi:125370]
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20
[SID103601826]
IC50 DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625186, Type: confirmatory]Receptor tyrosine-protein kinase erbB-2 [gi:119533]
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