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BioActivity Data for Compound Ethylene Glycol (CID 174)

Filters: All Data » confirmatory      
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BioActivity Outcomes:
Inactive(357)
 
 
Inconclusive(13)
 
 
Unspecified(123)
 
 
Top Targets:
7tm 4(31)
 
 
 
NR LBD PPAR(13)
 
 
 
NR LBD ER(12)
 
 
 
 
p450(11)
 
 
 
NR LBD AR(11)
 
 
 
 
BioAssay Types:
Confirmatory(485)
 
 
 
 
Literature(8)
 
 
 
BioAssay Categories:
Biochemical(2)
 
 
 
Cell-based(6)
 
 
 
Toxicity(39)
 
 
 
 
ADME(3)
 
 
In vitro(1)
 
 
BioActivity Types:
Potency(324)
 
 
 
 
IC50(123)
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 419    Data Row: 493   Total Pages: 25   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103601826]
CC50 221Cytotoxicity against human HL60 cells in presence of RPMI1640 containing 10% fetal bovine serum by trypan blue exclusion test [AID382489, Type: Literature]
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2
[SID103601826]
CC50 385Cytotoxicity against human HSC4 cells by MTT method [AID382488, Type: Literature]
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3
[SID103601826]
CC50 400Cytotoxicity against human HSC2 by MTT method [AID382487, Type: Literature]
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4
[SID103601826]
CC50 400Cytotoxicity against human gingival fibroblast by MTT method [AID382490, Type: Literature]
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5
[SID103601826]
CC50 400Cytotoxicity against human pulp cells by MTT method [AID382491, Type: Literature]
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6
[SID103601826]
CC50 400Cytotoxicity against human periodontal ligament fibroblast by MTT method [AID382492, Type: Literature]
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7
[SID103601826]
IC50 DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) [AID625181, Type: confirmatory]Mitogen-activated protein kinase 1 [gi:119554]
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8
[SID103601826]
IC50 DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) [AID625182, Type: confirmatory]Mitogen-activated protein kinase 14 [gi:2499600]
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9
[SID103601826]
IC50 DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP) [AID625183, Type: confirmatory]Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [gi:1352673]
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10
[SID103601826]
IC50 DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625184, Type: confirmatory]Epidermal growth factor receptor [gi:2811086]
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11
[SID103601826]
IC50 DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625185, Type: confirmatory]Tyrosine-protein kinase Fyn [gi:125370]
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12
[SID103601826]
IC50 DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625186, Type: confirmatory]Receptor tyrosine-protein kinase erbB-2 [gi:119533]
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13
[SID103601826]
IC50 DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625187, Type: confirmatory]Tyrosine-protein kinase Lck [gi:125474]
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14
[SID103601826]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) [AID625190, Type: confirmatory]
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15
[SID103601826]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) [AID625191, Type: confirmatory]5-hydroxytryptamine receptor 1B [gi:112815]
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16
[SID103601826]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: confirmatory]5-hydroxytryptamine receptor 2A [gi:543727]
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17
[SID103601826]
IC50 DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) [AID625193, Type: confirmatory]Acetylcholinesterase [gi:113037]
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18
[SID103601826]
IC50 DRUGMATRIX: Adenosine A1 radioligand binding (ligand: DPCPX) [AID625194, Type: confirmatory]Adenosine receptor A1 [gi:231473]
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19
[SID103601826]
IC50 DRUGMATRIX: Adenosine A2A radioligand binding (ligand: AB-MECA) [AID625195, Type: confirmatory]Adenosine receptor A2a [gi:543740]
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20
[SID103601826]
IC50 DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: confirmatory]Adenosine receptor A3 [gi:1351831]
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