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Succinic Acid (CID 1110) - Compound BioActivity Data
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Filters: All Data » confirmatory      
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BioActivity Outcomes:
Active(2)
 
 
Inactive(235)
 
 
Inconclusive(13)
 
 
Unspecified(10)
 
 
Top Targets:
NR LBD PPAR(12)
 
 
 
NR LBD ER(12)
 
 
 
NR LBD AR(12)
 
 
NR LBD TR(8)
 
 
NR LBD VDR(7)
 
 
 
BioAssay Types:
Confirmatory(248)
 
 
 
Literature(12)
 
 
 
BioActivity Types:
Potency(245)
 
 
 
IC50(8)
 
 
 
Kd(3)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 133    Data Row: 260   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179217]
IC50 0.0013Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition assay [AID216185, Type: Literature]
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2
[SID103179217]
IC50 3Inhibition of 2-oxoglutarate-dependent human recombinant HIF PHD2 preincubated for 1 hr [AID344926, Type: Literature]Egl nine homolog 1 [gi:32129514]
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3
[SID103179217]
IC50 85.3Inhibition of human PHD2 at 293K temperature by solvent relaxation technique [AID446353, Type: Literature]Egl nine homolog 1 [gi:32129514]
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4
[SID103179217]
IC50 85.3Destabilizing effect on human recombinant PHD2 (181-426) expressed in Escherichia coli BL21 (DE3) assessed as half life by limited trypsinolysis/MALDI-MS analysis in presence of ferrous ion [AID349748, Type: Literature]
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5
[SID103179217]
Kd 100Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature [AID446356, Type: Literature]Egl nine homolog 1 [gi:32129514]
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6
[SID103179217]
Kd 100Binding affinity to human PHD2 by nondenaturing ESI-MS [AID446352, Type: Literature]Egl nine homolog 1 [gi:32129514]
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7
[SID103179217]
IC50 320Inhibition of 2-oxoglutarate-dependent human JMJD2E preincubated for 30 mins by FDH coupled assay [AID344918, Type: Literature]
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8
[SID103179217]
IC50 710Inhibition of 2-oxoglutarate-dependent human JMJD2E in presence of excess H3K9me3 peptide and 10 uM Fe2 by FDH coupled assay [AID344917, Type: Literature]
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9
[SID103179217]
Kd 1450Binding affinity to Pyrococcus horikoshii sodium-coupled aspartate transporter [AID328866, Type: Literature]
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10
[SID103179217]
IC50 10000Inhibition of 2-oxoglutarate-dependent human JMJD2E in presence of excess 2-oxoglutarate and 10 uM Fe2 by FDH coupled assay [AID344916, Type: Literature]
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11
[SID103179217]
IC50 10000Inhibition of PHD2 (unknown origin) [AID721521, Type: Literature]Egl nine homolog 1 [gi:32129514]
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12
[SID103179217]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681141, Type: Literature]Solute carrier family 22 member 8 [gi:74730587]
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13
[SID144205165]
Potency 0.0251qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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14
[SID144205165]
Potency-Replicate_1 33.4915qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743080, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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15
[SID144209116]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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16
[SID144209116]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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17
[SID144209116]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
18
[SID144209116]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743080, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
19
[SID144213564]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
20
[SID144213564]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View