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Dopamine (CID 681) - Compound BioActivity Data
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Filters: All Data » Literature      
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BioActivity Outcomes:
Active(243)
 
 
Inactive(65)
 
 
Inconclusive(26)
 
 
Unspecified(226)
 
 
Top Targets:
7TM GPCR Srsx(72)
 
 
 
 
alpha CA I II..(23)
 
 
7TM GPCR Srx(22)
 
 
 
 
GT1 Gtf like(6)
 
 
FAM101(5)
 
 
BioAssay Types:
Literature(560)
 
 
 
 
 
BioActivity Types:
Ki(98)
 
 
 
 
IC50(60)
 
 
 
 
EC50(51)
 
 
Kd(8)
 
 
 
Potency(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 490    Data Row: 560   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103167911]
IC50 8e-09Agonist required to inhibit Dopamine receptor D2 photoinactivation by 50% with Iodazidoclebopride using [3H]-Spiperone [AID62635, Type: Literature]
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2
[SID103167911]
EC50 0.0011In vitro effective concentration tested on HEK293 cells co-transfected with rat Dopamine receptor D2 using FLIPR assay [AID61225, Type: Literature]
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3
[SID103167911]
EC50 0.0011Agonist activity at rat D2 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR [AID274445, Type: Literature]D(2) dopamine receptor [gi:47117674]
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4
[SID103167911]
Ki 0.0012Binding Affinity was tested on the high affinity site of Dopamine receptor D4.4 [AID64028, Type: Literature]D(4) dopamine receptor [gi:1345939]
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5
[SID103167911]
Kd 0.00133Displacement of [3H]SCH23390 from dopamine D1-like receptor pig striatal membrane [AID515612, Type: Literature]
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6
[SID103167911]
Ki 0.0018Binding Affinity on high Affinity Site of Bovine dopamine receptor D2. Tested for ability to displace the radioligand [3H]pramipexole was tested [AID62319, Type: Literature]
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7
[SID103167911]
Ki 0.00189Displacement of [3H]quinpirole from Dopamine receptor D2 [AID63075, Type: Literature]
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8
[SID103167911]
Ki 0.00189Displacement of [3H]quinpirole from human dopamine D2A receptors expressed in LtK cells [AID61612, Type: Literature]D(2) dopamine receptor [gi:118206]
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9
[SID103167911]
IC50 0.002Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTN [AID196429, Type: Literature]D(2) dopamine receptor [gi:47117674]
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10
[SID103167911]
IC50 0.002Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTN [AID196429, Type: Literature]D(3) dopamine receptor [gi:118211]
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11
[SID103167911]
IC50 0.002Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTN [AID196429, Type: Literature]D(4) dopamine receptor [gi:6226851]
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12
[SID103167911]
IC50 0.002Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTN [AID196429, Type: Literature]D(1A) dopamine receptor [gi:118229]
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13
[SID103167911]
IC50 0.002Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTN [AID196429, Type: Literature]D(1B) dopamine receptor [gi:118251]
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14
[SID103167911]
IC50 0.0021Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpiride [AID196428, Type: Literature]D(1A) dopamine receptor [gi:118229]
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15
[SID103167911]
IC50 0.0021Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpiride [AID196428, Type: Literature]D(2) dopamine receptor [gi:47117674]
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16
[SID103167911]
IC50 0.0021Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpiride [AID196428, Type: Literature]D(1B) dopamine receptor [gi:118251]
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17
[SID103167911]
IC50 0.0021Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpiride [AID196428, Type: Literature]D(4) dopamine receptor [gi:6226851]
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18
[SID103167911]
IC50 0.0021Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpiride [AID196428, Type: Literature]D(3) dopamine receptor [gi:118211]
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19
[SID103167911]
EC50 0.0022In vitro effective concentration tested on HEK293 cells co-transfected with human Dopamine receptor D4 using FLIPR assay [AID65928, Type: Literature]
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20
[SID103167911]
EC50 0.0022Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR [AID274437, Type: Literature]D(4) dopamine receptor [gi:1345939]
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21
[SID103167911]
EC50 0.0024Agonist activity at rat D4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR [AID274442, Type: Literature]D(4) dopamine receptor [gi:6226851]
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22
[SID103167911]
EC50 0.0024In vitro effective concentration tested on HEK293 cells co-transfected with rat Dopamine receptor D4 using FLIPR assay [AID63828, Type: Literature]
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23
[SID103167911]
EC50 0.0027In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D4 using FLIPR assay [AID63703, Type: Literature]
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24
[SID103167911]
EC50 0.0027Agonist activity at ferret D4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR [AID274441, Type: Literature]
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25
[SID103167911]
Ki 0.0029Displacement of [3H]spiperone from human dopamine D2 receptor at high affinity state expressed in HEK293 cells [AID458633, Type: Literature]D(2) dopamine receptor [gi:118206]
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26
[SID103167911]
IC50 0.0037Tested for binding to dopamine receptor using [3H]- ADTN as radioligand in calf caudate nucleus homogenates. [AID62451, Type: Literature]
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27
[SID103167911]
IC50 0.0045Tested for binding to dopamine receptor using [3H]apomorphine as radioligand in calf caudate nucleus homogenates. [AID62452, Type: Literature]
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28
[SID103167911]
EC50 0.00476Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID461563, Type: Literature]D(3) dopamine receptor [gi:1169206]
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29
[SID103167911]
EC50 0.00476Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID513742, Type: Literature]D(3) dopamine receptor [gi:1169206]
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30
[SID103167911]
EC50 0.005Activity at rat dopamine D2L receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production [AID272396, Type: Literature]D(2) dopamine receptor [gi:47117674]
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31
[SID103167911]
EC50 0.0058Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay [AID712282, Type: Literature]D(3) dopamine receptor [gi:1169206]
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32
[SID103167911]
EC50 0.0061Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay [AID709655, Type: Literature]D(3) dopamine receptor [gi:1169206]
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33
[SID103167911]
Ki 0.0062Displacement of [3H]spiperone from human D4 receptor expressed in CHO cells [AID388670, Type: Literature]D(4) dopamine receptor [gi:1345939]
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34
[SID103167911]
IC50 0.00663Inhibition of [3H]norepinephrine uptake in HEK cells expressing human NET [AID145556, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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35
[SID103167911]
Ki 0.007Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 [AID63176, Type: Literature]
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36
[SID103167911]
EC50 0.008In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D2 using FLIPR assay [AID61221, Type: Literature]
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37
[SID103167911]
EC50 0.008Agonist activity at ferret D2 receptor in HEK293 cells coexpressing Galphaqo5 by FLIPR [AID274444, Type: Literature]
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38
[SID103167911]
EC50 0.00853Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding [AID384700, Type: Literature]D(3) dopamine receptor [gi:1169206]
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39
[SID103167911]
EC50 0.00853Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding [AID446402, Type: Literature]D(3) dopamine receptor [gi:1169206]
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40
[SID103167911]
EC50 0.00853Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding [AID425420, Type: Literature]D(3) dopamine receptor [gi:1169206]
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41
[SID103167911]
EC50 0.00853Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding [AID312287, Type: Literature]D(3) dopamine receptor [gi:1169206]
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42
[SID103167911]
EC50 0.00857Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID690847, Type: Literature]D(3) dopamine receptor [gi:1169206]
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43
[SID103167911]
Ki 0.0089Displacement of [3H]spiperone from human dopamine D4.4 receptor expressed in CHO cells [AID733805, Type: Literature]
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44
[SID103167911]
EC50 0.01Activity at human dopamine D4.4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production [AID272398, Type: Literature]D(4) dopamine receptor [gi:1345939]
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45
[SID103167911]
Ki 0.011Binding affinity which represents concentration giving half-maximal inhibition of [3H]7-OH-DPAT binding to Dopamine receptor D3 in rat tissue homogenate [AID65613, Type: Literature]
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46
[SID103167911]
Ki 0.011Binding Affinity was tested on high Affinity Site of Bovine Dopamine D2 Receptor. Tested for ability to displace the radioligand [3H]spiperone was tested [AID42820, Type: Literature]
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47
[SID103167911]
Ki 0.0132Displacement of [3H]raclopride from Dopamine receptor D3 [AID65128, Type: Literature]D(3) dopamine receptor [gi:1169206]
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48
[SID103167911]
Ki 0.0149Inhibition of [3H]YM-09151-2 binding to bovine retina membrane Dopamine receptor D2, high affinity site [AID64172, Type: Literature]D(2) dopamine receptor [gi:118205]
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49
[SID103167911]
Ki 0.015Binding affinity for dopamine D4-like receptor labelled with [3H]YM-09151-2 in retina [AID63853, Type: Literature]
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50
[SID103167911]
IC50 0.015The IC50 value was reported as apparent, since [3H]NCA was purported to be irreversible. Result indicates the mean of two separate experiments, each performed in triplicate. [AID62573, Type: Literature]
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