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nitromethane (CID 6375) - Compound BioActivity Data
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Filters: All Data » Literature      
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BioActivity Outcomes:
Inactive(10)
 
 
Inconclusive(4)
 
 
Unspecified(17)
 
 
Top Targets:
CAP ED(1)
 
 
MetAP1(1)
 
 
MetAP2(1)
 
 
Tryp SPc(1)
 
 
BioAssay Types:
Literature(31)
 
 
 
 
BioActivity Types:
IC50(12)
 
 
 
Potency(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 31    Data Row: 31   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179179]
IC50 100Cytotoxicity against human SW707 cells after 72 hrs by crystal violet staining method [AID736753, Type: Literature]
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2
[SID103179179]
IC50 100Cytotoxicity against human Capan1 cells after 72 hrs by crystal violet staining method [AID736754, Type: Literature]
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3
[SID103179179]
IC50 100Cytotoxicity against human CaSki cells after 72 hrs by crystal violet staining method [AID736755, Type: Literature]
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4
[SID103179179]
IC50 100Cytotoxicity against human Calu6 cells after 72 hrs by crystal violet staining method [AID736756, Type: Literature]
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5
[SID103179179]
IC50 100Cytotoxicity against human MeWo cells after 72 hrs by crystal violet staining method [AID736757, Type: Literature]
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6
[SID103179179]
IC50 100Cytotoxicity against human A431 cells after 72 hrs by crystal violet staining method [AID736758, Type: Literature]
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7
[SID103179179]
IC50 100Cytotoxicity against human Flow 2002 cells after 72 hrs by crystal violet staining method [AID736759, Type: Literature]
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8
[SID103179179]
IC50 100Cytotoxicity against human HaCaT cells after 72 hrs by crystal violet staining method [AID736760, Type: Literature]
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9
[SID103179179]
Antibacterial activity against methicillin-resistant Staphylococcus aureus NCTC 10442 after 20 to 24 hrs by broth microdilution assay [AID736761, Type: Literature]
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10
[SID103179179]
Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 after 20 to 24 hrs by broth microdilution assay [AID736762, Type: Literature]
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11
[SID103179179]
Aqueous solubility [AID19262, Type: Literature]
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12
[SID103179179]
Partition coefficient (logP) [AID23443, Type: Literature]
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13
[SID103179179]
Toxicity determined using Tadpole Narcosis Test [AID212400, Type: Literature]
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14
[SID103179179]
Octanol-water partition coefficient, log P of the compound [AID343683, Type: Literature]
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15
[SID103179179]
Alkane-water partition coefficient, log P of the compound [AID343684, Type: Literature]
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16
[SID103179179]
Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 20 to 24 hrs by broth microdilution assay [AID736366, Type: Literature]
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17
[SID103179179]
Antibacterial activity against Escherichia coli ATCC 25922 after 20 to 24 hrs by broth microdilution assay [AID736367, Type: Literature]
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18
[SID17389787]
Potency qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]potassium voltage-gated channel subfamily H member 2 isoform d [Homo sapiens] [gi:325651834]
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19
[SID103179179]
Inhibition of Dengue virus NS2B-NS3 protease expressed in Escherichia coli BL21(lamdaDE3) using Abz-NleKRRS-3-(NO2)Y as substrate at 50 uM incubated for 15 mins prior to substrate addition measured for 15 mins by fluorometric analysis [AID736763, Type: Literature]
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20
[SID103179179]
Inhibition of thrombin (unknown origin) expressed in Escherichia coli BL21(lamdaDE3) using Boc-Val-Pro-Arg-AMC as substrate at 25 uM incubated for 15 mins prior to substrate addition measured for 10 mins by fluorometric analysis [AID736764, Type: Literature]Prothrombin [gi:135807]
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21
[SID103179179]
Inhibition of human MetAP2 expressed in Escherichia coli BL21(lamdaDE3) using Met-AMC as substrate at 10 uM incubated for 30 mins prior to substrate addition measured for 15 mins fluorometric analysis [AID736765, Type: Literature]Methionine aminopeptidase 2 [gi:1703273]
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22
[SID103179179]
Inhibition of human MetAP1 expressed in Escherichia coli BL21(lamdaDE3) using Met-AMC as substrate at 10 uM incubated for 30 mins prior to substrate addition measured for 15 mins fluorometric analysis [AID736766, Type: Literature]Methionine aminopeptidase 1 [gi:33302602]
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23
[SID103179179]
Inhibition of Escherichia coli MetAP expressed in Escherichia coli BL21(lamdaDE3) using Met-AMC as substrate at 10 uM incubated for 30 mins prior to substrate addition measured for 15 mins fluorometric analysis [AID736767, Type: Literature]
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24
[SID103179179]
IC50 Inhibition of Staphylococcus aureus MurA2 expressed in Escherichia coli BL21(lamdaDE3) using UNAG and PEP as substrate incubated for 10 mins prior to PEP addition measured after 60 mins by spectrophotometric analysis [AID736768, Type: Literature]
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25
[SID103179179]
IC50 Inhibition of Pseudomonas aeruginosa MurA expressed in Escherichia coli BL21(lamdaDE3) using UNAG and PEP as substrate incubated for 10 mins prior to PEP addition measured after 60 mins by spectrophotometric analysis [AID736769, Type: Literature]
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26
[SID103179179]
IC50 Inhibition of Escherichia coli MurA C115D mutant expressed in Escherichia coli BL21(lamdaDE3) using UNAG and PEP as substrate incubated for 10 mins prior to PEP addition measured after 60 mins by spectrophotometric analysis [AID736770, Type: Literature]
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27
[SID103179179]
IC50 Inhibition of Escherichia coli MurA expressed in Escherichia coli BL21(lamdaDE3) using UNAG and PEP as substrate incubated for 10 mins prior to PEP addition measured after 60 mins by spectrophotometric analysis [AID736771, Type: Literature]
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28
[SID103179179]
Induction of GSSG formation in citrate buffer at 100 uM by RP-LC/MS analysis [AID736374, Type: Literature]
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29
[SID103179179]
Induction of GSH-adduct formation in citrate buffer at100 uM by RP-LC/MS analysis [AID736375, Type: Literature]
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30
[SID103179179]
Half life of the compound in citrate buffer at pH 6 [AID736380, Type: Literature]
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31
[SID103179179]
Half life of the compound in tris buffer at pH 7.8 [AID736381, Type: Literature]
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