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Cyclic AMP (CID 6076) - Compound BioActivity Data
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Filters: All Data » Literature      
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BioActivity Outcomes:
Active(11)
 
 
Inactive(8)
 
 
Unspecified(25)
 
 
Top Targets:
CAP ED(3)
 
 
 
STKc PKA(2)
 
 
alcohol DH cl..(2)
 
 
ABCC MRP doma..(1)
 
 
Avidin(1)
 
 
BioAssay Types:
Literature(44)
 
 
 
 
BioActivity Types:
IC50(2)
 
 
Ki(2)
 
 
Potency(2)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 40    Data Row: 44   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103317043]
Km 0.05Inhibition of Phosphodiesterase 8 [AID158285, Type: Literature]CAMP-specific cyclic nucleotide phosphodiesterase PDE8 [gi:81864950]
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2
[SID103317043]
Km 0.2Inhibition of Phosphodiesterase 7 [AID158280, Type: Literature]
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3
[SID103317043]
Km 0.53Affinity for bovine heart phosphodiesterase [AID158420, Type: Literature]
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4
[SID103317043]
Km 0.56Affinity for rabbit lung phosphodiesterase [AID158735, Type: Literature]
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5
[SID103317043]
Km 0.56Inhibition of rabbit lung cAMP Phosphodiesterase [AID219819, Type: Literature]
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6
[SID103317043]
Km 0.79Affinity for rabbit kidney phosphodiesterase [AID158734, Type: Literature]
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7
[SID103317043]
Km 1.3Inhibition of bovine brain cAMP Phosphodiesterase [AID219691, Type: Literature]
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8
[SID103317043]
IC50 40Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay [AID723507, Type: Literature]Rap guanine nucleotide exchange factor 4 [gi:32171491]
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9
[SID103317043]
IC50 48Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis [AID663168, Type: Literature]
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10
[SID103317043]
Activity of bovine aortic PDE4 [AID628762, Type: Literature]
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11
[SID103317043]
Activation of olfactory CNG A2A41b channel expressed in HEK293 cells assessed as effect on half maximal current [AID297178, Type: Literature]
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12
[SID103317043]
Km 150Inhibition of Phosphodiesterase 5 [AID158111, Type: Literature]cGMP-specific 3',5'-cyclic phosphodiesterase [gi:5921804]
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13
[SID103317043]
Ki 780Inhibition constant was evaluated against horse liver alcohol dehydrogenase [AID33710, Type: Literature]Alcohol dehydrogenase S chain [gi:113406]
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14
[SID103317043]
Ki 780Inhibition constant was evaluated against horse liver alcohol dehydrogenase [AID33710, Type: Literature]Alcohol dehydrogenase E chain [gi:113397]
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15
[SID103317043]
ED50 5000Antiviral activity against Herpes simplex virus -2 strain MS was evaluated in african green monkey kidney [AID84938, Type: Literature]
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16
[SID103317043]
ED50 5000Antiviral activity against Herpes simplex virus -1 strain KOS was evaluated in african green monkey kidney [AID86027, Type: Literature]
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17
[SID103317043]
ED50 5000Antiviral activity against Para influenza virus type 3 strain C243 was evaluated in african green monkey kidney [AID155571, Type: Literature]
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18
[SID103317043]
ED50 5000Antiviral activity against Vaccinia virus strain Elstree was evaluated in african green monkey kidney [AID217820, Type: Literature]
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19
[SID103317043]
In vitro antiviral activity against Vaccinia virus strain Elstree was evaluated in african green monkey kidney [AID217969, Type: Literature]
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20
[SID103317043]
Compound was evaluated for activation of bovine heart protein kinase. [AID164454, Type: Literature]
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21
[SID103317043]
In vitro antiviral activity against Para influenza virus type 3 strain C243 was evaluated in african green monkey kidney [AID155572, Type: Literature]
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22
[SID103317043]
Percent inhibition against L1210 cell line in mice. [AID97751, Type: Literature]
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23
[SID103317043]
Percent inhibition against P388 cell line in mice. [AID154165, Type: Literature]
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24
[SID103317043]
In vitro antiviral activity against Herpes simplex virus -2 strain MS was evaluated in african green monkey kidney [AID85090, Type: Literature]
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25
[SID103317043]
In vitro antiviral activity against Herpes simplex virus -1 strain KOS was evaluated in african green monkey kidney [AID84060, Type: Literature]
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26
[SID103317043]
Substrates of transporters of clinical importance in the absorption and dispostion of drugs, MRP4 [AID588979, Type: Literature]Multidrug resistance-associated protein 4 [gi:206729914]
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27
[SID103317043]
Inhibition of bovine heart cAMP Phosphodiesterase [AID219685, Type: Literature]
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28
[SID103317043]
Activate a partially purified type II cAMP-dependent protein kinase from bovine brain [AID219827, Type: Literature]
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29
[SID103317043]
Susceptibility to be hydrolysed by a partially purified cAMP phosphodiesterase from rabbit kidney [AID219982, Type: Literature]
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30
[SID103317043]
Activation of cAMP-dependent protein kinase type I [AID220152, Type: Literature]
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31
[SID103317043]
Specificity for protein kinase-I and protein kinase-II [AID220153, Type: Literature]
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32
[SID103317043]
Activation of cAMP-dependent protein kinase type II [AID220154, Type: Literature]cAMP-dependent protein kinase catalytic subunit beta [gi:125209]
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33
[SID103317043]
Activation of cAMP-dependent protein kinase type II [AID220154, Type: Literature]cAMP-dependent protein kinase catalytic subunit alpha [gi:1346363]
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34
[SID103317043]
Activation of cAMP-dependent protein kinase type II [AID220154, Type: Literature]cAMP-dependent protein kinase type II-beta regulatory subunit [gi:400114]
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35
[SID103317043]
Activation of cAMP-dependent protein kinase type II [AID220154, Type: Literature]cAMP-dependent protein kinase type II-alpha regulatory subunit [gi:145559487]
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36
[SID103317043]
Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis relative to cAMP [AID663169, Type: Literature]
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37
[SID103317043]
Binding affinity to Streptomyces avidinii streptavidin at 4 mM using dye labeled Streptavidin binding aptamer by fluorescence spectral analysis method [AID717236, Type: Literature]Streptavidin [gi:134951]
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38
[SID163564038]
Fluorescence polarization based primary biochemical high throughput screening assay of LOPAC1280 to identify inhibitors of hepatitis C non-structural protein 3 helicase [AID687035, Type: Literature]NS3 [Hepatitis C virus] [gi:125541954]
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39
[SID163564038]
Fluorescence-based counterscreen assay of HCV NS3 helicase-DNA binding inhibitors in LOPAC1280: biochemical high-throughput screening assay to identify compounds that enhance or quench fluorescence of a Cy5-DNA-NS3h complex [AID687037, Type: Literature]
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40
[SID50105813]
Potency qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]potassium voltage-gated channel subfamily H member 2 isoform d [Homo sapiens] [gi:325651834]
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41
[SID90340992]
Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504810, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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42
[SID90340992]
Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504812, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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43
[SID90340992]
Potency Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation [AID504836, Type: Literature]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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44
[SID103317043]
In vitro cytotoxicity against Vero cells. [AID218494, Type: Literature]
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