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Adenosine Diphosphate (CID 6022) - Compound BioActivity Data
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Filters: All Data » Literature      
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BioActivity Outcomes:
Active(49)
 
 
Inactive(3)
 
 
Inconclusive(4)
 
 
Unspecified(49)
 
 
Top Targets:
HSP90(5)
 
 
 
RNase A canon..(3)
 
 
Pyruvate Kina..(3)
 
 
SecA SW(1)
 
 
PurL repeat1(1)
 
 
BioAssay Types:
Literature(105)
 
 
 
 
 
BioActivity Types:
EC50(18)
 
 
 
Kd(11)
 
 
 
Ki(5)
 
 
 
IC50(3)
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 92    Data Row: 105   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176960]
Ki 0.00091Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis method [AID461575, Type: Literature]5'-nucleotidase [gi:112826]
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2
[SID103176960]
EC50 0.014Agonist activity at G-protein coupled P2Y1 receptor expressed in human 1321N1 cells assessed as increase in calcium by Fura2 assay [AID462811, Type: Literature]
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3
[SID103176960]
EC50 0.069Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12) [AID150495, Type: Literature]
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4
[SID103176960]
EC50 0.1Agonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis [AID373705, Type: Literature]P2Y purinoceptor 1 [gi:1352693]
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5
[SID103176960]
Kd 0.11Binding affinity to bovine Hsc70 by filter binding assay [AID527446, Type: Literature]
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6
[SID103176960]
Km 0.11Binding affinity to Hsp70 [AID527447, Type: Literature]
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7
[SID103176960]
Ki 0.11Inhibition of HSP70 by fluorescence polarization assay [AID600787, Type: Literature]
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8
[SID103176960]
Kd 0.26Binding affinity to human Hsc70 by isothermal calorimetry assay [AID527455, Type: Literature]
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9
[SID103176960]
Kd 0.5Binding affinity to HSP70 by surface plasmon resonance analysis [AID600786, Type: Literature]
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10
[SID103176960]
IC50 0.5Displacement of fluorescein labeled N6-(6-amino)hexyl-ATP-5-FAM from HSP70 by fluorescence polarization assay [AID393506, Type: Literature]
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11
[SID103176960]
Kd 0.5Binding affinity to HSP70 by Biocore direct binding assay [AID393507, Type: Literature]
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12
[SID103176960]
Kd 2.17Binding affinity to histidine-tagged Grp78 by surface plasmon resonance analysis [AID600785, Type: Literature]
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13
[SID103176960]
Kd 3.83Binding affinity to Grp78 by isothermal titration calorimetric analysis [AID600788, Type: Literature]
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14
[SID103176960]
Kd 4.3Binding affinity to Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase assessed as S-sulfocysteine formation at pH 7.5 by single turnover method in absence of MgCl2 [AID440581, Type: Literature]
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15
[SID103176960]
Kd 7.3Binding affinity to Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase assessed as S-sulfocysteine formation at pH 7.5 by single turnover method in presence of 0.5 mM MgCl2 [AID440582, Type: Literature]
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16
[SID103176960]
EC50 8Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytes [AID150470, Type: Literature]P2Y purinoceptor 1 [gi:1352693]
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17
[SID103176960]
Kd 10Affinity for mouse cyclic-AMP dependent Ser/Thr Kinase [AID219831, Type: Literature]
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18
[SID103176960]
EC50 10Antagonist activity against recombinant human P2X purinoceptor 1 (P2X1 ) [AID152476, Type: Literature]
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19
[SID103176960]
EC50 11Antagonist activity against recombinant rat P2X purinoceptor 6 (P2X6 ) [AID150172, Type: Literature]
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20
[SID103176960]
EC50 18Antagonist activity against recombinant rat P2X purinoceptor 5 (P2X5) [AID150170, Type: Literature]
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21
[SID103176960]
Kd 20Binding affinity to Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase assessed as S-sulfocysteine formation at pH 7.5 by single turnover method in presence of 2 mM MgCl2 [AID440583, Type: Literature]
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22
[SID103176960]
EC50 21Inhibition of BODIPY-AG binding to dog Grp94 [AID266547, Type: Literature]Endoplasmin [gi:729425]
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23
[SID103176960]
EC50 28Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 30 uM,expressed in Xenopus oocytes [AID150166, Type: Literature]
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24
[SID103176960]
Km 33Tested for inhibition of Nucleoside Triphosphate Diphosphohydrolase (NTPDase) from bovine spleen. [AID146705, Type: Literature]
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25
[SID103176960]
Km 34Compound was tested for ribonucleotide reductase (RR) activity by inhibition of dGTP-activated ADP reduction [AID198128, Type: Literature]
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26
[SID103176960]
Inhibition of Escherichia coli KPR at 1 mM [AID269131, Type: Literature]
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27
[SID46391451]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Adp Binding Site In The Hsp90 Molecular Chaperone [gi:157829974]
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28
[SID46391453]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Glutamine Phosphoribosylpyrophosphate (Prpp) Amidotransferase From B. Subtilis Complexed With Adp And Gmp [gi:2624597]
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29
[SID46391776]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Structure Of The H61t Mutant Of The Flavoenzyme Vanillyl- Alcohol Oxidase In The Apo Form Complexed By Adp [gi:10835629]
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30
[SID46392119]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Eosinophil-Derived Neurotoxin (Edn)-Adenosine-5'- Diphosphate Complex [gi:14488650]
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31
[SID46392442]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Motor Domain Of Myoe, A Class-I Myosin [gi:21730748]
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32
[SID46392494]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Mg-Adp-Bound Seca From Bacillus Subtilis [gi:24158967]
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33
[SID46392673]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Ribonuclease A In Complex With 5'-Adp [gi:40889149]
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34
[SID46393196]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Structure Of Formylglycinamide Synthetase [gi:55669841]
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35
[SID46393302]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, X-Ray Structure Of Human Nucleoside Diphosphate Kinase A Complexed With Adp At 2 A Resolution [gi:37928159]
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36
[SID46393633]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of The Pdk3-L2 Complex [gi:67463897]
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37
[SID46393675]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of Ksp In Complex With Inhibitor 1 [gi:66361184]
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38
[SID46393893]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, The Macro Domain Is An Adp-Ribose Binding Module [gi:58177656]
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39
[SID46393948]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structures Of Eosinophil-Derived Neurotoxin In Complex With The Inhibitors 5'-Atp, Ap3a, Ap4a And Ap5a [gi:88192512]
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40
[SID103176960]
Agonism at turkey erythrocyte P2Y receptor. [AID70544, Type: Literature]
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41
[SID103176960]
Tested for contraction of guinea pig isolated urinary bladder detrussor muscle at 37 degree C; Potency equal to ATP [AID77349, Type: Literature]
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42
[SID103176960]
Tested for contraction of guinea pig vas deferens at 37 degree C; Less potent than or equal to ATP [AID77352, Type: Literature]
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43
[SID103176960]
Tested for relaxation of carbachol-contracted guinea pig taenia coli at 37 degree C; Potency equal to ATP [AID77360, Type: Literature]
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44
[SID103176960]
Reversible aggregation effect at low concentration; Active [AID88903, Type: Literature]
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45
[SID103176960]
Agonistic activity against platelet aggregation; Effective agonist [AID91204, Type: Literature]
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46
[SID103176960]
Biphasic response at low concentration; Active [AID91216, Type: Literature]
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47
[SID103176960]
Ki Binding affinity to Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase assessed as S-sulfocysteine formation at pH 5.5 by single turnover method in absence of thioredoxin [AID440574, Type: Literature]
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48
[SID103176960]
Antioxidant activity in rat brain mitochondria assessed as inhibition of Ca2+/phosphate induced mitochondrial swelling by spectrophotometry [AID728305, Type: Literature]
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49
[SID103176960]
Antioxidant activity in rat liver mitochondria assessed as inhibition of Ca2+/phosphate induced mitochondrial swelling at 50 uM by spectrophotometry [AID728308, Type: Literature]
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50
[SID103176960]
EC50 65Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as PLC-mediated [3H]IP production [AID271163, Type: Literature]P2Y purinoceptor 6 [gi:2495018]
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