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Rutin (CID 5280805) - Compound BioActivity Data
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Filters: All Data » Literature      
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BioActivity Outcomes:
Active(26)
 
 
Inactive(69)
 
 
Inconclusive(2)
 
 
Unspecified(100)
 
 
Top Targets:
Esterase lipa..(6)
 
 
 
NR LBD ER(3)
 
 
 
ABCG EPDR(2)
 
 
Sialidase(2)
 
 
 
7TM GPCR Srsx(1)
 
 
BioAssay Types:
Literature(197)
 
 
 
 
 
BioActivity Types:
IC50(24)
 
 
 
 
Ki(4)
 
 
 
EC50(2)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 136    Data Row: 197   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103516775]
Ki 0.009Binding affinity to adrenergic alpha2c receptor [AID478695, Type: Literature]
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2
[SID103516775]
Ki 0.009Binding affinity to adrenergic alpha2A receptor [AID478696, Type: Literature]
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3
[SID103516775]
IC50 1.17Antioxidant activity assessed as nitric oxide scavenging activity by fluorescent triazofluorescein formation assay [AID453282, Type: Literature]
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4
[SID103516775]
I50 1.886Inhibition of beef heart mitochondrial NADH oxidase assessed per mg of protein [AID338027, Type: Literature]
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5
[SID103516775]
IC50 2.53Antioxidant activity assessed as nitric oxide scavenging activity by spectrophotometry [AID515378, Type: Literature]
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6
[SID103516775]
IC50 3.66Nitric oxide scavenging activity assessed as inhibition of DAF2 oxidation [AID289333, Type: Literature]
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7
[SID103516775]
ID50 7.27Inhibition of Moloney murine leukemia virus reverse transcriptase using (riboadenylic acid)n(deoxythymidylic acid)12-18 as template primer by liquid scintillation counting [AID339056, Type: Literature]
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8
[SID103516775]
ID50 7.33Inhibition of Moloney murine leukemia virus reverse transcriptase using (ribocytidylic acid)n(deoxyguanylic acid)12-18 as template primer by liquid scintillation counting [AID339057, Type: Literature]
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9
[SID103516775]
IC50 10.6Antioxidant activity assessed as superoxide-scavenging activity by nitrite method [AID399341, Type: Literature]
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10
[SID103516775]
IC50 12.3Antioxidant activity assessed as DPPH radical scavenging activity [AID333567, Type: Literature]
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11
[SID103516775]
IC50 12.34Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins [AID356577, Type: Literature]
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12
[SID103516775]
IC50 13Inhibition of aldose reductase in rat lens homogenates by fluorophotometer [AID335838, Type: Literature]Aldose reductase [gi:1168407]
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13
[SID103516775]
IC50 30.9Inhibition of Clostridium perfringens neuraminidase [AID455702, Type: Literature]Sialidase [gi:127825]
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14
[SID103516775]
IC50 34.4Noncompetitive inhibition of recombinant influenza A virus rvH1N1 A/Bervig_Mission/1/18 neuraminidase [AID455703, Type: Literature]
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15
[SID103516775]
IC50 38.7Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by microplate reader [AID736009, Type: Literature]
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16
[SID103516775]
IC50 41.9Inhibition of glycation of bovine serum albumin assessed as advanced glycated end product measured after 7 days by spectrofluorimeter in presence of glucose anhydrous [AID721628, Type: Literature]Serum albumin [gi:1351907]
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17
[SID103516775]
IC50 41.9Antiglycation activity of compound assessed as inhibition of BSA-derived advance glycated end product formation after 7 days by spectrofluorimeter [AID395278, Type: Literature]
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18
[SID103516775]
Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality treated with drug after 2 hrs of TNFalpha treatment [AID402483, Type: Literature]
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19
[SID103516775]
Potentiation of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality treated with drug after 2 hrs of TNFalpha treatment [AID402484, Type: Literature]
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20
[SID103516775]
Stimulation of BALB/c mouse cloned 3T3/A31 cells proliferation at 0.01 to 10 ug/mL [AID379096, Type: Literature]
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21
[SID103516775]
Antioxidant activity assessed as DPPH radical scavenging activity after 20 min [AID293297, Type: Literature]
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22
[SID103516775]
IC50 Antioxidant activity assessed as inhibition of superoxide production by xanthine/xanthine oxidase method [AID293298, Type: Literature]
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23
[SID103516775]
Antioxidant activity in BALB/c mouse BM cells assessed as inhibition of ROS production [AID293299, Type: Literature]
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24
[SID103516775]
Stability in phosphate buffer at pH 7.4 after 90 mins by spectrophotometry [AID441661, Type: Literature]
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25
[SID103516775]
Inhibition of AMPK-mediated adipocyte differentiation in mouse 3T3L1 cells [AID517389, Type: Literature]
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26
[SID103516775]
Inhibition of PPAR-gamma-mediated adipocyte differentiation in mouse 3T3L1 cells [AID517390, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432235]
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27
[SID103516775]
IC50 52.2Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay [AID366285, Type: Literature]
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28
[SID103516775]
IC50 52.2Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry [AID399340, Type: Literature]
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29
[SID103516775]
IC50 80Inhibition of CYP3A4 [AID380506, Type: Literature]
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30
[SID103516775]
IC50 87.7Inhibition of Influenza A Jinan/15/90 H3N2 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay [AID366284, Type: Literature]
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31
[SID103516775]
IC50 100Inhibition of Influenza A Jiangsu/10/2003 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay [AID366286, Type: Literature]
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32
[SID103516775]
IC50 100Cytotoxicity against human LCC-6 cells after 5 days by MTS assay [AID666853, Type: Literature]
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33
[SID103516775]
IC50 100Cytotoxicity against multidrug resistant human LCC-6 cells after 5 days by MTS assay [AID666854, Type: Literature]
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34
[SID103516775]
IC50 100Cytotoxicity against mouse L929 cells after 5 days by MTS assay [AID666855, Type: Literature]
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35
[SID103516775]
IC50 164Growth inhibition of BALB/c mouse cloned 3T3/A31 cells after 72 hrs by nigrosin assay [AID379089, Type: Literature]
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36
[SID103516775]
EC50 250Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by crystal violet staining [AID402473, Type: Literature]
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37
[SID103516775]
EC50 250Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality preincubated for 15 mins before TNFalpha addition measured after 24 hrs by [methyl-3H]thymidine incorporation assay [AID402475, Type: Literature]
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38
[SID103516775]
IC50 294.46Antiglycation activity assessed as inhibition of BSA-derived advance glycated end product formation after 9 days by spectrophotometry [AID452625, Type: Literature]
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39
[SID103516775]
Ki 300Inhibition of human recombinant AChE by Ellman's method [AID441660, Type: Literature]Acetylcholinesterase [gi:113037]
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40
[SID103516775]
Ki 501.2Inhibition of human plasma BChE by Ellman's method [AID441659, Type: Literature]Cholinesterase [gi:116353]
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41
[SID103516775]
Cytotoxicity against human HepG2 cells upto 200 umol/L after 24 hrs by MTS assay [AID441664, Type: Literature]
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42
[SID103516775]
Cytotoxicity against human A549 cells upto 200 umol/L after 24 hrs by MTS assay [AID441665, Type: Literature]
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43
[SID103516775]
ABTS radical scavenging activity assessed as trolox equivalent antioxidant capacity [AID456316, Type: Literature]
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44
[SID103516775]
Antioxidant activity assessed as trolox equivalent by TEAC assay [AID456317, Type: Literature]
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45
[SID103516775]
DPPH radical scavenging activity assessed as trolox equivalent antioxidant capacity [AID456318, Type: Literature]
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46
[SID103516775]
Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 30 uM after 72 hrs [AID462333, Type: Literature]
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47
[SID103516775]
Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 10 uM after 72 hrs [AID462334, Type: Literature]
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48
[SID103516775]
Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 3 uM after 72 hrs [AID462335, Type: Literature]
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49
[SID103516775]
Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 1 uM after 72 hrs [AID462336, Type: Literature]
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50
[SID103516775]
Toxicity in mouse B16-4A5 cells assessed as inhibition of cell proliferation at 30 uM in presence of 1 mM theophylline after 72 hrs by WST8 dye reduction assay [AID462342, Type: Literature]
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