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Arachidonic Acid (CID 444899) - Compound BioActivity Data
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Filters: All Data » Literature      
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BioActivity Outcomes:
Active(19)
 
 
Inactive(6)
 
 
Unspecified(41)
 
 
Top Targets:
p450(3)
 
 
 
Lipocalin(2)
 
 
RNA dep RNAP(2)
 
 
prostaglandin..(2)
 
 
ALBUMIN(1)
 
 
BioAssay Types:
Literature(66)
 
 
 
 
BioActivity Types:
IC50(20)
 
 
 
EC50(2)
 
 
 
Kd(2)
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 63    Data Row: 66   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103178961]
IC50 0.0047Concentration required to inhibit production of LTC4 from THP-1 cells stimulated with A-23187 [AID209196, Type: Literature]
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2
[SID103178961]
IC50 0.18Concentration required to inhibit production of PGE-2 from THP-1 cells stimulated with A-23187 [AID209197, Type: Literature]
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3
[SID103178961]
Kd 0.18Binding affinity against Adipocyte lipid binding protein [AID32788, Type: Literature]
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4
[SID103178961]
IC50 0.3Inhibition of mPGES1 [AID405533, Type: Literature]
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5
[SID103178961]
IC50 0.94Concentration required to inhibit production of LTB4 from whole blood stimulated with A-23187 [AID223075, Type: Literature]
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6
[SID103178961]
Km 1Activity of COX2 [AID336480, Type: Literature]
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7
[SID103178961]
Km 8.8Activity of bovine seminal microsomal COX1 [AID399408, Type: Literature]Prostaglandin G/H synthase 1 [gi:166897622]
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8
[SID103178961]
Km 9.7Activity of sheep placental cotyledons COX2 [AID399409, Type: Literature]Prostaglandin G/H synthase 2 [gi:3914304]
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9
[SID103178961]
IC50 10Inhibition of hepatitis C virus replication in Huh7-K2040 cells in presence of delipidated fetal calf serum medium by RT-PCR [AID330323, Type: Literature]
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10
[SID103178961]
Km 15Activity of soybean lipooxygenase 1 [AID409935, Type: Literature]
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11
[SID103178961]
EC50 22.1Antiviral activity against HCV assessed as inhibition of HCV RNA replication in OR6 cells after 72 hrs by luciferase reporter assay [AID323922, Type: Literature]
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12
[SID103178961]
IC50 28.2Inhibition of aromatase in human placental microsomes by radiometric method [AID376617, Type: Literature]Aromatase [gi:117293]
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13
[SID103178961]
IC50 40Concentration required to inhibit production of arachidonic acid from THP-1 cells stimulated with A-23187 [AID209198, Type: Literature]
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14
[SID46391417]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Adipocyte Lipid Binding Protein Complexed With Arachidonic Acid: X-Ray Crystallographic And Titration Calorimetry Studies [gi:157829813]
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15
[SID46392023]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Human Serum Albumin Complexed With Cis-5,8,11,14- Eicosatetraenoic Acid (Arachidonic Acid) [gi:18158775]
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16
[SID46393430]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Schistosoma Mansoni Fatty Acid Binding Protein In Complex With Arachidonic Acid [gi:55670478]
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17
[SID103178961]
Reversal of inhibition of hepatitis C virus replication in Huh7-K2040 cells in presence of delipidated fetal calf serum medium assessed as malondialdehyde level at 0.1 mM in presence of vitamin E [AID330318, Type: Literature]
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18
[SID103178961]
Inhibition of hepatitis C virus replication in Huh7-K2040 in presence of delipidated fetal calf serum medium assessed as increase of malondialdehyde at 0.1 mM after 12 to 24 hrs [AID330330, Type: Literature]
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19
[SID103178961]
Binding affinity to enterotoxigenic Escherichia coli 12566 heat-labile enterotoxin assessed as inhibition of heat-labile enterotoxin binding to ganglioside GM1 receptor [AID423137, Type: Literature]
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20
[SID103178961]
IC50 10Concentration required to inhibit production of LDH from whole blood stimulated with A-23187 [AID223074, Type: Literature]
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21
[SID103178961]
IC50 10Concentration required to inhibit production of PGE-2 from whole blood stimulated with A-23187 [AID223076, Type: Literature]
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22
[SID103178961]
IC50 10Concentration required to inhibit production of TXB2 from whole blood stimulated with A-23187 [AID223077, Type: Literature]
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23
[SID103178961]
IC50 10Concentration required to inhibit production of arachidonic acid from whole blood stimulated with A-23187 [AID223078, Type: Literature]
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24
[SID103178961]
IC50 60Inhibitory concentration against PAF (8E-10M) induced aggregation of rabbit platelet at 2.1E-4 M concentration [AID248458, Type: Literature]
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25
[SID103178961]
IC50 60Inhibition of hepatitis C virus replication in Huh7-K2040 cells in presence of fetal calf serum medium by RT-PCR [AID330322, Type: Literature]
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26
[SID103178961]
IC50 100Inhibition of FAAH [AID346660, Type: Literature]
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27
[SID103178961]
IC50 100Concentration required to inhibit human Cytosolic phospholipase A2 [AID55271, Type: Literature]
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28
[SID103178961]
EC50 100Proapoptotic activity in human MDA-MB-468 cells assessed as activation of caspase-3 by luminometry [AID701911, Type: Literature]
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29
[SID103178961]
IC50 100Antiproliferative activity against human MDA-MB-468 cells after 48 hrs by MTT assay [AID701913, Type: Literature]
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30
[SID103178961]
IC50 105Inhibition of amidolytic activity of human tissue factor/human factor 7a [AID402795, Type: Literature]Tissue factor [gi:135666]
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31
[SID103178961]
Kd 180Binding affinity to Vibrio cholerae cholera toxin assessed as quenching of intrinsic fluorescence by two-state binding model assay [AID423131, Type: Literature]
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32
[SID103178961]
IC50 200Inhibition of pig pancreatic trypsin after 15 mins [AID402793, Type: Literature]Trypsin [gi:136429]
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33
[SID103178961]
IC50 200Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assay [AID322753, Type: Literature]Lanosterol 14-alpha demethylase [gi:3915660]
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34
[SID103178961]
IC50 380Binding affinity to Vibrio cholerae cholera toxin assessed as inhibition of cholera toxin binding to ganglioside GM1 receptor treated 15 mins before receptor addition by ELISA [AID423126, Type: Literature]
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35
[SID103178961]
Octanol-water partition coefficient, log P of the compound [AID402794, Type: Literature]
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36
[SID103178961]
Inhibition of mPGES1 at 10 uM [AID405528, Type: Literature]
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37
[SID103178961]
Inhibition of aromatase in human SKBR3 cells at 100 uM relative to control [AID376618, Type: Literature]Aromatase [gi:117293]
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38
[SID103178961]
Ratio of kcat/km for soyabean lipoxygenase 1 [AID409936, Type: Literature]
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39
[SID103178961]
Activity of soybean lipooxygenase 1 assessed as rate of oxidation under diffusion-controlled reaction at 20 deg C [AID409937, Type: Literature]
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40
[SID103178961]
Activity of soybean lipooxygenase 1 assessed as rate of oxidation under diffusion-controlled reaction at 5 deg C [AID409938, Type: Literature]
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41
[SID103178961]
Activity of soyabean lipoxygenase 1 assessed as rate of oxidation under diffusion-controlled reaction at 37 deg C [AID409939, Type: Literature]
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42
[SID103178961]
Inhibition of hepatitis C virus replication in Huh7-K2040 cells in presence of fetal calf serum assessed viral RNA level at 0.1 mM by RT-PCR relative to control [AID330320, Type: Literature]
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43
[SID103178961]
Inhibition of hepatitis C virus replication in Huh7-K2040 cells in presence of delipidated fetal calf serum assessed viral RNA level at 0.1 mM by RT-PCR relative to control [AID330321, Type: Literature]
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44
[SID103178961]
Inhibition of hepatitis C virus replication in Huh7-K2040 cells in presence of fetal calf serum medium assessed as increase of malondialdehyde at 0.1 mM relative to control [AID330316, Type: Literature]
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45
[SID103178961]
Inhibition of hepatitis C virus replication in Huh7-K2040 cells in presence of delipidated fetal calf serum medium assessed as increase of malondialdehyde at 0.1 mM relative to control [AID330317, Type: Literature]
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46
[SID103178961]
Inhibition of aromatase in human placental microsomes at 20 ug/ml by radiometric method relative to control [AID376615, Type: Literature]Aromatase [gi:117293]
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47
[SID103178961]
Inhibition of hepatitis C virus replication in Huh7-K2040 cells in presence of delipidated fetal calf serum medium assessed as reduction in viral RNA level at 0.1 mM after 12 hrs relative to control [AID330332, Type: Literature]
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48
[SID103178961]
Inhibition of hepatitis C virus replication in Huh7-K2040 cells in presence of delipidated fetal calf serum medium assessed as increase of malonaldehyde at 0.1 mM after 72 hrs relative to control [AID330333, Type: Literature]
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49
[SID103178961]
Inhibition of hepatitis C virus replication in Huh7-K2040 cells in presence of delipidated fetal calf serum medium assessed as reduction in viral RNA level at 0.1 mM after 72 hrs relative to control [AID330334, Type: Literature]
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50
[SID103178961]
Cytotoxicity against human Huh7-K2040 cells in delipidated fetal calf serum medium [AID330335, Type: Literature]
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