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Diflunisal (CID 3059) - Compound BioActivity Data
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Filters: All Data » Literature      
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BioActivity Outcomes:
Active(21)
 
 
Inactive(79)
 
 
Inconclusive(16)
 
 
Unspecified(99)
 
 
Top Targets:
prostaglandin..(10)
 
 
GT1 Gtf like(7)
 
 
ALBUMIN(6)
 
 
 
Anthrax-tox M(3)
 
 
MFS(2)
 
 
BioAssay Types:
Literature(215)
 
 
 
 
 
BioActivity Types:
IC50(23)
 
 
 
 
Kd(2)
 
 
Ki(2)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 137    Data Row: 215   Total Pages: 11   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103235071]
Kd 1.16Binding affinity to human recombinant TTR Y78F mutant after 5 mins by isothermal titration calorimetry [AID1054846, Type: Literature]
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2
[SID103235071]
Kd 1.23027Binding affinity to human serum albumin by PAMPA method [AID327170, Type: Literature]Serum albumin [gi:113576]
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3
[SID103235071]
IC50 2.7Inhibition of human carbonic anhydrase 2 esterase activity by spectrophotometry [AID349141, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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4
[SID103235071]
IC50 3.38Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometry [AID349140, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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5
[SID103235071]
IC50 6.3Inhibition of transthyretin V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of sodium acetate-mediated aggregation preincubated for 30 mins followed by sodium acetate addition measured after 96 hrs by thioflavin T assay [AID1074430, Type: Literature]
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6
[SID103235071]
Ki 8.45Inhibition of human carbonic anhydrase 1 esterase activity by noncompetitive Lineweaver-Burke plot [AID349142, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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7
[SID103235071]
Ki 9.37Inhibition of human carbonic anhydrase 2 esterase activity by non-competitive Lineweaver-Burke plot [AID349145, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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8
[SID103235071]
IC50 18Inhibition of human recombinant TTR Y78F mutant-mediated fibrillogenesis after 30 mins by turbidimetric assay [AID1054848, Type: Literature]
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9
[SID103235071]
The second dissociation constant for binding to WT TTR determined by isothermal titration calorimetry (25 C, pH 8.0) [AID210957, Type: Literature]
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10
[SID103235071]
The first dissociation constant for binding to WT TTR determined by isothermal titration calorimetry (25 C, pH 8.0) [AID210956, Type: Literature]
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11
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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12
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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13
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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14
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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15
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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16
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: Literature]Prostaglandin G/H synthase 1 [gi:317373262]
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17
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: Literature]Prostaglandin G/H synthase 1 [gi:317373262]
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18
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: Literature]Prostaglandin G/H synthase 1 [gi:317373262]
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19
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: Literature]Prostaglandin G/H synthase 1 [gi:317373262]
View
20
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: Literature]Prostaglandin G/H synthase 1 [gi:317373262]
View