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Diflunisal (CID 3059) - Compound BioActivity Data
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Filters: All Data » Literature      
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BioActivity Outcomes:
Active(8)
 
 
Inactive(73)
 
 
Inconclusive(16)
 
 
Unspecified(70)
 
 
Top Targets:
GT1 Gtf like(7)
 
 
ALBUMIN(6)
 
 
 
alpha CA I II..(4)
 
 
NAD binding 8(2)
 
 
RNA dep RNAP(2)
 
 
BioAssay Types:
Literature(167)
 
 
 
 
 
BioActivity Types:
IC50(20)
 
 
 
 
Ki(2)
 
 
Kd(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 104    Data Row: 167   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103235071]
Kd 1.23027Binding affinity to human serum albumin by PAMPA method [AID327170, Type: Literature]Serum albumin [gi:113576]
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2
[SID103235071]
IC50 2.7Inhibition of human carbonic anhydrase 2 esterase activity by spectrophotometry [AID349141, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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3
[SID103235071]
IC50 3.38Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometry [AID349140, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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4
[SID103235071]
Ki 8.45Inhibition of human carbonic anhydrase 1 esterase activity by noncompetitive Lineweaver-Burke plot [AID349142, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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5
[SID103235071]
Ki 9.37Inhibition of human carbonic anhydrase 2 esterase activity by non-competitive Lineweaver-Burke plot [AID349145, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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6
[SID103235071]
The first dissociation constant for binding to WT TTR determined by isothermal titration calorimetry (25 C, pH 8.0) [AID210956, Type: Literature]
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7
[SID103235071]
The second dissociation constant for binding to WT TTR determined by isothermal titration calorimetry (25 C, pH 8.0) [AID210957, Type: Literature]
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8
[SID103235071]
Inhibition of TNF-alpha-induced NF-kappaB activation in human HCT116 cells at 1 mM after 6 hrs by luciferase reporter gene assay [AID639952, Type: Literature]
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9
[SID103235071]
IC50 109Inhibition of mycophenolic acid (1 mM) glucuronidation by human UGT enzymes from liver microsomes [AID624662, Type: Literature]
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10
[SID103235071]
IC50 122Inhibition of mycophenolic acid (0.5 mM) glucuronidation by human kidney microsomes [AID624661, Type: Literature]
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11
[SID103235071]
Dissociation constant, pKa of the compound [AID677462, Type: Literature]
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12
[SID103235071]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia [AID625279, Type: Literature]
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13
[SID103235071]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis [AID625280, Type: Literature]
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14
[SID103235071]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis [AID625281, Type: Literature]
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15
[SID103235071]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis [AID625282, Type: Literature]
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16
[SID103235071]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests [AID625283, Type: Literature]
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17
[SID103235071]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure [AID625284, Type: Literature]
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18
[SID103235071]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis [AID625285, Type: Literature]
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19
[SID103235071]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis [AID625286, Type: Literature]
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20
[SID103235071]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly [AID625287, Type: Literature]
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21
[SID103235071]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice [AID625288, Type: Literature]
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22
[SID103235071]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease [AID625289, Type: Literature]
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23
[SID103235071]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty [AID625290, Type: Literature]
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24
[SID103235071]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal [AID625291, Type: Literature]
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25
[SID103235071]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score [AID625292, Type: Literature]
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26
[SID103235071]
Inhibition of wild type-TTR expressed in Escherichia coli assessed as amyloid fibril formation at pH 4.4 at 7. 2 uM after 72 hrs by acid-mediated aggregation assay relative to control [AID574422, Type: Literature]
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27
[SID103235071]
Displacement of 4-fluorophenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzoate from recombinant TTR assessed as fluorescence at 37 degC after 3 hrs [AID574423, Type: Literature]
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28
[SID103235071]
Displacement of S-phenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzothioate from human TTR assessed as fluorescence at 37 degC after 3 hrs [AID574424, Type: Literature]Transthyretin [gi:136464]
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29
[SID103235071]
Literature-mined public compounds from Lowe et al phospholipidosis modelling dataset [AID588208, Type: Literature]
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30
[SID103235071]
Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset [AID588209, Type: Literature]
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31
[SID103235071]
Human drug-induced liver injury (DILI) modelling dataset from Ekins et al [AID588210, Type: Literature]
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32
[SID103235071]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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33
[SID103235071]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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34
[SID103235071]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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35
[SID103235071]
FDA HLAED, liver enzyme composite activity [AID588214, Type: Literature]
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36
[SID103235071]
FDA HLAED, alkaline phosphatase increase [AID588215, Type: Literature]
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37
[SID103235071]
FDA HLAED, serum glutamic oxaloacetic transaminase (SGOT) increase [AID588216, Type: Literature]
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38
[SID103235071]
FDA HLAED, serum glutamic pyruvic transaminase (SGPT) increase [AID588217, Type: Literature]
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39
[SID103235071]
FDA HLAED, lactate dehydrogenase (LDH) increase [AID588218, Type: Literature]
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40
[SID103235071]
FDA HLAED, gamma-glutamyl transferase (GGT) increase [AID588219, Type: Literature]
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41
[SID103235071]
Displacement of radiolabeled warfarin from fatty acid-free human serum albumin site 1 in phosphate buffer at pH 7.4 at 12 uM by fluorescence spectroscopy [AID604741, Type: Literature]Serum albumin [gi:113576]
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42
[SID103235071]
Displacement of radiolabeled dansylsarcosine from fatty acid-free human serum albumin site 2 in phosphate buffer at pH 7.4 at 12 uM by fluorescence spectroscopy [AID604742, Type: Literature]Serum albumin [gi:113576]
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43
[SID103235071]
Displacement of radiolabeled warfarin from fatty acid containing human serum albumin site 1 in phosphate buffer at pH 7.4 at 12 uM by fluorescence spectroscopy [AID604743, Type: Literature]Serum albumin [gi:113576]
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44
[SID103235071]
Displacement of radiolabeled dansylsarcosine from fatty acid containing human serum albumin site 2 in phosphate buffer at pH 7.4 at 12 uM by fluorescence spectroscopy [AID604744, Type: Literature]Serum albumin [gi:113576]
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45
[SID103235071]
Specific activity of expressed human recombinant UGT1A4 [AID624608, Type: Literature]UDP-glucuronosyltransferase 1-4 [gi:136731]
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46
[SID103235071]
Specific activity of expressed human recombinant UGT1A8 [AID624611, Type: Literature]UDP-glucuronosyltransferase 1-8 [gi:29839637]
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47
[SID103235071]
Specific activity of expressed human recombinant UGT1A9 [AID624612, Type: Literature]UDP-glucuronosyltransferase 1-9 [gi:29839451]
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48
[SID103235071]
Specific activity of expressed human recombinant UGT1A10 [AID624613, Type: Literature]UDP-glucuronosyltransferase 1-10 [gi:29839636]
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49
[SID103235071]
Specific activity of expressed human recombinant UGT2B10 [AID624615, Type: Literature]UDP-glucuronosyltransferase 2B10 [gi:549155]
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50
[SID103235071]
Specific activity of expressed human recombinant UGT2B4 [AID624618, Type: Literature]UDP-glucuronosyltransferase 2B4 [gi:6175083]
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