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Aminolevulinic Acid (CID 137) - Compound BioActivity Data
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Filters: All Data » Literature      
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BioActivity Outcomes:
Active(11)
 
 
Inactive(8)
 
 
Unspecified(62)
 
 
Top Targets:
Anthrax-tox M(1)
 
 
MFS(1)
 
 
Neur chan LBD(1)
 
 
PTR2(1)
 
 
Toxin trans(1)
 
 
BioAssay Types:
Literature(81)
 
 
 
 
BioActivity Types:
IC50(7)
 
 
 
Ki(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 81    Data Row: 81   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103182993]
IC50 12.9Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method [AID406571, Type: Literature]Gamma-aminobutyric acid receptor subunit rho-1 [gi:223590210]
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2
[SID103182993]
Increase in heme level in human U251 cells assessed as porphobilinogen deaminase level at 100 uM after 2 hrs by western blot in presence of cycloheximide [AID347405, Type: Literature]
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3
[SID103182993]
Induction of apoptosis in human U251 cells assessed as increase in full length caspase 8 level after 24 hrs by western blot [AID347584, Type: Literature]
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4
[SID103182993]
Increase in ROS production in human U251 cells at 100 uM after 4 hrs by FACS [AID347396, Type: Literature]
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5
[SID103182993]
Inhibition of 26S proteasome activity in human U251 cells at 1 mM after 48 hrs [AID347411, Type: Literature]
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6
[SID103182993]
Antibacterial activity against Escherichia coli K-12 assessed as reduction in microbial viability incubated at 0.1 mM followed by irradiation at 120 J.cm2 light [AID519379, Type: Literature]
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7
[SID103182993]
Antibacterial activity against Escherichia coli K-12 assessed as reduction in microbial viability incubated at 40 mM followed by irradiation at 120 J.cm2 light [AID519380, Type: Literature]
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8
[SID103182993]
Induction of photoactive porphyrins in Escherichia coli K-12 exposed to irradiation at 120 J.cm2 light by HPLC [AID519381, Type: Literature]
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9
[SID103182993]
Induction of photoactive porphyrins in Escherichia coli K-12 assessed as uroporphyrin level exposed to irradiation at 120 J.cm2 light by HPLC [AID519382, Type: Literature]
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10
[SID103182993]
Induction of photoactive porphyrins in Escherichia coli K-12 assessed as protoporphyrin level exposed to irradiation at 120 J.cm2 light by HPLC [AID519383, Type: Literature]
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11
[SID103182993]
Antibacterial activity against Escherichia coli K-12 assessed as reduction in microbial viability incubated at 40 mM for 4 hrs under dark condition [AID519389, Type: Literature]
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12
[SID103182993]
Ki 790Inhibition constant (Ki) for human intestinal peptide carrier [AID92023, Type: Literature]
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13
[SID103182993]
IC50 1570Cytotoxicity against human HL60 cells after 72 hrs by MTT assay [AID347393, Type: Literature]
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14
[SID103182993]
IC50 1735Cytotoxicity against human MCF7 cells after 72 hrs by Hoechst test [AID347394, Type: Literature]
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15
[SID103182993]
IC50 2665Cytotoxicity against human U251 cells after 72 hrs by Hoechst test [AID347392, Type: Literature]
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16
[SID103182993]
IC50 2715Antiproliferative activity against human U251 cells assessed as PpIX release pretreated 72 hrs before 360-410 nm light photosensitization measured after 48 hrs by Hoechst test [AID347409, Type: Literature]
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17
[SID103182993]
IC50 2719Antiproliferative activity against human U251 cells assessed as PpIX release after 72 hrs by Hoechst test [AID347408, Type: Literature]
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18
[SID103182993]
IC50 3475Cytotoxicity against human MCF7/DX cells after 72 hrs by Hoechst test [AID347395, Type: Literature]
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19
[SID103182993]
Increase in heme level in human U251 cells at 100 uM after 48 hrs by western blot relative to control [AID347403, Type: Literature]
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20
[SID103182993]
Increase in heme level in human U251 cells assessed as porphobilinogen deaminase level at 100 uM after 2 hrs by western blot relative to control [AID347404, Type: Literature]
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21
[SID103182993]
Inhibition of 26S proteasome activity in human U251 cells at 100 uM after 48 hrs relative to control [AID347412, Type: Literature]
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22
[SID103182993]
Inhibition of 26S proteasome activity in human U251 cells at 100 uM after 48 hrs in presence of N-acetyl-L-cysteine relative to control [AID347413, Type: Literature]
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23
[SID103182993]
Induction of apoptosis in human U251 cells assessed as early apoptotic cells at 100 uM after 48 hrs using annexin-V FITC and PI staining by flow cytometry in presence of Ac-LEHD-CHO [AID347416, Type: Literature]
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24
[SID103182993]
Induction of necrosis in human U251 cells assessed as necrotic cells at 100 uM after 48 hrs using annexin-V FITC and PI staining by flow cytometry in presence of Ac-LEHD-CHO [AID347417, Type: Literature]
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25
[SID103182993]
Induction of apoptosis in human U251 cells assessed as viable cells at 100 uM after 48 hrs using annexin-V FITC and PI staining by flow cytometry in presence of Ac-LEHD-CHO [AID347418, Type: Literature]
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26
[SID103182993]
Induction of apoptosis in human U251 cells assessed as viable cells at 100 uM after 48 hrs using annexin-V FITC and PI staining by flow cytometry [AID347419, Type: Literature]
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27
[SID103182993]
Induction of necrosis in human U251 cells assessed as necrotic cells at 100 uM after 48 hrs using annexin-V FITC and PI staining by flow cytometry [AID347420, Type: Literature]
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28
[SID103182993]
Induction of apoptosis in human U251 cells assessed as early apoptotic cells at 100 uM after 48 hrs using annexin-V FITC and PI staining by flow cytometry [AID347421, Type: Literature]
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29
[SID103182993]
Induction of apoptosis in human U251 cells assessed as late apoptotic cells at 100 uM after 48 hrs using annexin-V FITC and PI staining by flow cytometry [AID347422, Type: Literature]
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30
[SID103182993]
Induction of apoptosis in human U251 cells assessed as late apoptotic cells at 100 uM after 48 hrs using annexin-V FITC and PI staining by flow cytometry in presence of Ac-LEHD-CHO [AID347423, Type: Literature]
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31
[SID103182993]
Induction of apoptosis in human U251 cells assessed as viable cells at 100 uM after 48 hrs using annexin-V FITC and PI staining by flow cytometry in presence of Z-Asp-2,6-dichlorobenzoyloxymethylketone [AID347424, Type: Literature]
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32
[SID103182993]
Induction of necrosis in human U251 cells assessed as necrotic cells at 100 uM after 48 hrs using annexin-V FITC and PI staining by flow cytometry in presence of Z-Asp-2,6-dichlorobenzoyloxymethylketone [AID347425, Type: Literature]
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33
[SID103182993]
Induction of apoptosis in human U251 cells assessed as early apoptotic cells at 100 uM after 48 hrs using annexin-V FITC and PI staining by flow cytometry in presence of Z-Asp-2,6-dichlorobenzoyloxymethylketone [AID347426, Type: Literature]
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34
[SID103182993]
Induction of apoptosis in human U251 cells assessed as late apoptotic cells at 100 uM after 48 hrs using annexin-V FITC and PI staining by flow cytometry in presence of Z-Asp-2,6-dichlorobenzoyloxymethylketone [AID347583, Type: Literature]
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35
[SID103182993]
Increase in protoporphyrin 9 levels in human U251 cells at 100 uM after 24 hrs relative to control [AID347406, Type: Literature]
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36
[SID103182993]
Increase in protoporphyrin 9 levels in human U251 cells at 200 uM after 24 hrs relative to control [AID347407, Type: Literature]
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37
[SID103182993]
Drug uptake in mouse PAM212 cells assessed as intracellular 5-aminolaevulinic acid level per mg of protein at 0.1 mM after 4 hrs [AID371985, Type: Literature]
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38
[SID103182993]
Drug uptake in mouse PAM212 cells assessed as PpIX production per mg of protein at 0.1 mM after 4 hrs [AID371986, Type: Literature]
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39
[SID103182993]
Drug uptake in mouse PAM212 cells assessed as intracellular 5-aminolaevulinic acid level per mg of protein at 1 mM after 4 hrs [AID371987, Type: Literature]
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40
[SID103182993]
Drug uptake in mouse PAM212 cells assessed as PpIX production per mg of protein at 1 mM after 4 hrs [AID371988, Type: Literature]
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41
[SID103182993]
Drug uptake in human A549 cells assessed as intracellular 5-aminolaevulinic acid level per mg of protein at 0.1 mM after 4 hrs [AID371989, Type: Literature]
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42
[SID103182993]
Drug uptake in human A549 cells assessed as PpIX production per mg of protein at 0.1 mM after 4 hrs [AID371990, Type: Literature]
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43
[SID103182993]
Drug uptake in human Caco-2 cells assessed as intracellular 5-aminolaevulinic acid level per mg of protein at 1 mM after 4 hrs [AID371991, Type: Literature]
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44
[SID103182993]
Drug uptake in human Caco-2 cells assessed as PpIX production per mg of protein at 1 mM after 4 hrs [AID371992, Type: Literature]
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45
[SID103182993]
Phototoxicity against mouse PAM212 cells assessed as cell viability at 0.1 mM after 4 hrs irradiated with 2.5 J/cm2 blue light by MTT assay relative to control [AID371993, Type: Literature]
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46
[SID103182993]
Antibacterial activity against Escherichia coli K-12 assessed as microbial survival fraction incubated at 0.1 mM followed by irradiation at 120 J.cm2 light relative to untreated control [AID519391, Type: Literature]
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47
[SID103182993]
Antibacterial activity against Escherichia coli Ti05 assessed as microbial survival fraction incubated at 1 mM followed by irradiation at 120 J.cm2 light relative to untreated control [AID519392, Type: Literature]
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48
[SID103182993]
Antibacterial activity against Pseudomonas aeruginosa assessed as microbial survival fraction incubated at 1 mM followed by irradiation at 120 J.cm2 light relative to untreated control [AID519393, Type: Literature]
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49
[SID103182993]
Antibacterial activity against methicillin resistant Staphylococcus aureus assessed as microbial survival fraction incubated at 10 mM followed by irradiation at 120 J.cm2 light relative to untreated control [AID519394, Type: Literature]
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50
[SID103182993]
Induction of photoactive porphyrins in Escherichia coli K-12 assessed as porphyrin level per 10'-6 CFU microbial load incubated at 0.1 mM followed by irradiation at 120 J.cm2 light relative to untreated control [AID519395, Type: Literature]
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