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Succinic Acid (CID 1110) - Compound BioActivity Data
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Filters: All Data » Literature      
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BioActivity Outcomes:
Active(5)
 
 
Inactive(63)
 
 
Inconclusive(1)
 
 
Unspecified(21)
 
 
Top Targets:
P4Hc(6)
 
 
 
 
AAT like(3)
 
 
MFS(1)
 
 
NAD bind 1 ma..(1)
 
 
SWIB(1)
 
 
BioAssay Types:
Literature(90)
 
 
 
 
 
BioActivity Types:
IC50(8)
 
 
 
Kd(5)
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 28    Data Row: 90   Total Pages: 5   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179217]
IC50 0.0013Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition assay [AID216185, Type: Literature]
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2
[SID103179217]
IC50 3Inhibition of 2-oxoglutarate-dependent human recombinant HIF PHD2 preincubated for 1 hr [AID344926, Type: Literature]Egl nine homolog 1 [gi:32129514]
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3
[SID46391683]
Kd 2400Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Aspartate Aminotransferase Mutant Atb17139S142N WITH SUCCINIC ACID [gi:7245555]
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4
[SID46391683]
Kd 2400Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Aspartate Aminotransferase Mutant Atb17139S142N WITH SUCCINIC ACID [gi:7245555]
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5
[SID46391683]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Aspartate Aminotransferase Mutant Atb17139S142N WITH SUCCINIC ACID [gi:7245555]
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6
[SID103179217]
IC50 85.3Inhibition of human PHD2 at 293K temperature by solvent relaxation technique [AID446353, Type: Literature]Egl nine homolog 1 [gi:32129514]
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7
[SID103179217]
IC50 85.3Destabilizing effect on human recombinant PHD2 (181-426) expressed in Escherichia coli BL21 (DE3) assessed as half life by limited trypsinolysis/MALDI-MS analysis in presence of ferrous ion [AID349748, Type: Literature]
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8
[SID103179217]
Kd 100Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature [AID446356, Type: Literature]Egl nine homolog 1 [gi:32129514]
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9
[SID103179217]
Kd 100Binding affinity to human PHD2 by nondenaturing ESI-MS [AID446352, Type: Literature]Egl nine homolog 1 [gi:32129514]
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10
[SID103179217]
IC50 320Inhibition of 2-oxoglutarate-dependent human JMJD2E preincubated for 30 mins by FDH coupled assay [AID344918, Type: Literature]
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11
[SID103179217]
IC50 710Inhibition of 2-oxoglutarate-dependent human JMJD2E in presence of excess H3K9me3 peptide and 10 uM Fe2 by FDH coupled assay [AID344917, Type: Literature]
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12
[SID103179217]
Kd 1450Binding affinity to Pyrococcus horikoshii sodium-coupled aspartate transporter [AID328866, Type: Literature]
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13
[SID103179217]
IC50 10000Inhibition of 2-oxoglutarate-dependent human JMJD2E in presence of excess 2-oxoglutarate and 10 uM Fe2 by FDH coupled assay [AID344916, Type: Literature]
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14
[SID103179217]
IC50 10000Inhibition of PHD2 (unknown origin) [AID721521, Type: Literature]Egl nine homolog 1 [gi:32129514]
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15
[SID103179217]
Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset [AID588220, Type: Literature]
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16
[SID103179217]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681141, Type: Literature]Solute carrier family 22 member 8 [gi:74730587]
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17
[SID103179217]
Aqueous solubility [AID19262, Type: Literature]
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18
[SID103179217]
Protein interaction energy by using binding affinity towards human L-xylulose reductase enzyme [AID95754, Type: Literature]
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19
[SID103179217]
Antileukemic activity of compound against the P-388 lymphocytic leukemic BDF1 male mice at 0.6(mg/kg)/day, administered intraperitoneally; 10.7/9.66 (Treated/control) [AID110255, Type: Literature]
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20
[SID103179217]
In vivo antileukemic activity against P-388 lymphocytic leukemia in BDF1 male mice at 60 mg/kg/day intraperitoneal dose expressed as T/C [AID121647, Type: Literature]
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