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imatinib (CID 5291) - Compound BioActivity Data
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Filters: All Data » PTKc Kit      
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BioActivity Outcomes:
Active(23)
 
 
Inactive(5)
 
 
Unspecified(3)
 
 
Top Targets:
PTKc Kit(31)
 
 
 
 
BioAssay Types:
Literature(26)
 
 
 
Confirmatory(5)
 
 
BioActivity Types:
Kd(15)
 
 
IC50(8)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 27    Data Row: 31   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103245522]
Kd 0.013Binding constant for KIT kinase domain [AID624786, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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2
[SID103245522]
Kd 0.014Binding affinity to human KIT incubated for 1 hr by kinase binding assay [AID599957, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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3
[SID103245522]
Kd 0.014Binding constant for KIT(L576P) kinase domain [AID624790, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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4
[SID103245522]
Kd 0.014Binding constant for KIT kinase domain [AID435410, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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5
[SID103245522]
Kd 0.015Binding constant for KIT(V559D) kinase domain [AID624791, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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6
[SID103245522]
Kd 0.015Binding constant for KIT(V559D) kinase domain [AID435167, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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7
[SID103245522]
Kd 0.015Binding constant for KIT(A829P) kinase domain [AID624787, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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8
[SID103245522]
Kd 0.071Binding constant for KIT(V559D,V654A) kinase domain [AID435802, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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9
[SID103245522]
Kd 0.091Binding constant for KIT(V559D,V654A) kinase domain [AID624793, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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10
[SID103245522]
IC50 0.097Inhibition of human KIT autophosphorylation in human GIST882 cells by ELISA [AID515830, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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11
[SID103245522]
IC50 0.1Inhibitory concentration against c-Kit [AID254662, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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12
[SID103245522]
IC50 0.1Inhibitory concentration against c-Kit wild type expressed in recombinant baculovirus [AID255004, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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13
[SID103245522]
IC50 0.219Inhibition of c-kit receptor phosphorylation in M07e cell [AID262702, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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14
[SID103245522]
IC50 0.37Inhibition of human wild type KIT assessed as [gamma33P]ATP incorporation into polyGluTyr after 60 mins by microplate scintillation counting [AID591855, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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15
[SID103245522]
IC50 0.4Inhibitory concentration against IL-3 independent Ba/F3 Kit cell line with SCF (kit-ligand) [AID255987, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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16
[SID103245522]
Kd 0.56Binding constant for KIT(D816H) kinase domain [AID624788, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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17
[SID103245522]
Kd 0.82Binding constant for KIT(D816V) kinase domain [AID435411, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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18
[SID103245522]
Kd 0.83Average Binding Constant for KIT ; NA=Not Active at 10 uM [AID256660, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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19
[SID103245522]
Kd 0.98Binding constant for KIT(D816V) kinase domain [AID624789, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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20
[SID103245522]
Kd 2.5Binding constant for KIT(V559D,T670I) kinase domain [AID624792, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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21
[SID103245522]
Kd 2.9Binding constant for KIT(V559D,T670I) kinase domain [AID435675, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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22
[SID103245522]
IC50 5Inhibitory concentration against IL-3 independent Ba/F3 Kit D816V cell line [AID255976, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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23
[SID103245522]
IC50 10Inhibitory concentration against c-Kit D816V type expressed in recombinant baculovirus [AID256551, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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24
[SID103245522]
Binding affinity to human Kit assessed as residual binding at 10 uM by site dependent competitive binding assay [AID592017, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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25
[SID103245522]
Binding affinity to human Kit cysteine residue assessed as residual binding at 10 uM by site dependent competitive binding assay [AID592112, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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26
[SID103245522]
Inhibition of human c-kit activity at 10 uM by radiometric assay [AID512410, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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27
[SID50100104]
14Kinase Inhibitor Selectivity Profiling Assay [AID1433_36, Type: confirmatory]mast/stem cell growth factor receptor Kit isoform 1 precursor [Homo sapiens] [gi:4557695]
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28
[SID50100104]
15Kinase Inhibitor Selectivity Profiling Assay [AID1433_40, Type: confirmatory]mast/stem cell growth factor receptor Kit isoform 1 precursor [Homo sapiens] [gi:4557695]
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29
[SID50100104]
71Kinase Inhibitor Selectivity Profiling Assay [AID1433_39, Type: confirmatory]mast/stem cell growth factor receptor Kit isoform 1 precursor [Homo sapiens] [gi:4557695]
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30
[SID50100104]
820Kinase Inhibitor Selectivity Profiling Assay [AID1433_37, Type: confirmatory]mast/stem cell growth factor receptor Kit isoform 1 precursor [Homo sapiens] [gi:4557695]
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31
[SID50100104]
2900Kinase Inhibitor Selectivity Profiling Assay [AID1433_38, Type: confirmatory]mast/stem cell growth factor receptor Kit isoform 1 precursor [Homo sapiens] [gi:4557695]
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