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imatinib (CID 5291) - Compound BioActivity Data
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Filters: All Data » PTKc Abl      
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BioActivity Outcomes:
Active(50)
 
 
Inactive(5)
 
 
Unspecified(8)
 
 
Top Targets:
PTKc Abl(63)
 
 
 
 
BioAssay Types:
Literature(57)
 
 
 
Confirmatory(6)
 
 
 
BioActivity Types:
Kd(34)
 
 
 
IC50(11)
 
 
Ki(3)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 58    Data Row: 63   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103245522]
Kd 0.0011Binding constant for ABL1-nonphosphorylated kinase domain [AID624991, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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2
[SID103245522]
Kd 0.0018Binding constant for ABL1(Q252H)-nonphosphorylated kinase domain [AID624986, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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3
[SID103245522]
Kd 0.0022Average Binding Constant for ABL1 ; NA=Not Active at 10 uM [AID256665, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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4
[SID103245522]
Kd 0.0025Binding constant for ABL1(F317L)-nonphosphorylated kinase domain [AID624981, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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5
[SID103245522]
Kd 0.0059Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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6
[SID103245522]
Kd 0.006Binding affinity to human active site of N-terminal hexahistidine-tagged ABL2 expressed in Trichoplusia ni infected Sf9 cells by isothermal titration calorimetric assay [AID593557, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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7
[SID103245522]
Kd 0.0083Binding constant for ABL1(F317I)-nonphosphorylated kinase domain [AID624979, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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8
[SID103245522]
Kd 0.0085Binding constant for ABL1(M351T) kinase domain [AID435514, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
9
[SID103245522]
Kd 0.01Binding constant for ABL2 kinase domain [AID435777, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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10
[SID103245522]
Kd 0.01Binding constant for ABL2 kinase domain [AID624993, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
View
11
[SID103245522]
IC50 0.0108Inhibition of mouse recombinant N-terminal His6-tagged Abl by radiometric kinase assay [AID497611, Type: Literature]Tyrosine-protein kinase ABL1 [gi:59802613]
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12
[SID103245522]
Kd 0.012Binding constant for ABL1 kinase domain [AID435775, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
13
[SID103245522]
Kd 0.013Average Binding Constant for ABL2 ; NA=Not Active at 10 uM [AID256641, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
View
14
[SID103245522]
Ki 0.013Inhibition of human recombinant Abl [AID317426, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
15
[SID103245522]
Ki 0.013Inhibition of human recombinant Abl by filter-binding assay [AID370599, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
16
[SID103245522]
Ki 0.013Inhibition of human recombinant c-Abl by filter-binding assay [AID595769, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
17
[SID103245522]
Kd 0.014Average Binding Constant for ABL1(M351T) ; NA=Not Active at 10 uM [AID256669, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
18
[SID103245522]
Kd 0.021Binding constant for ABL1(Q252H) kinase domain [AID435515, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
19
[SID103245522]
Kd 0.021Binding constant for ABL1-phosphorylated kinase domain [AID624992, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
20
[SID103245522]
Kd 0.024Average Binding Constant for ABL1(Q252H) ; NA=Not Active at 10 uM [AID256666, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
21
[SID103245522]
Kd 0.035Binding constant for ABL1(H396P) kinase domain [AID435146, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
22
[SID103245522]
IC50 0.038Inhibitory concentration against v-Abl tyrosine kinase [AID254706, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
23
[SID103245522]
IC50 0.04Inhibition of c-Abl [AID291752, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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24
[SID103245522]
Kd 0.044Binding constant for ABL1(Y253F) kinase domain [AID435776, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
25
[SID103245522]
Kd 0.044Average Binding Constant for ABL1(Y253F) ; NA=Not Active at 10 uM [AID256671, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
26
[SID103245522]
Kd 0.044Binding constant for ABL1(M351T)-phosphorylated kinase domain [AID624985, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
27
[SID103245522]
Kd 0.062Average Binding Constant for ABL1(H396P) ; NA=Not Active at 10 uM [AID256668, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
28
[SID103245522]
Kd 0.065Binding constant for ABL1(H396P)-phosphorylated kinase domain [AID624984, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
29
[SID103245522]
Kd 0.077Binding constant for ABL1(E255K) kinase domain [AID435644, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
30
[SID103245522]
Kd 0.092Binding constant for ABL1(Q252H)-phosphorylated kinase domain [AID624987, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
31
[SID103245522]
IC50 0.0982Inhibition of human recombinant wild type ABL1 expressed in insect cells after 30 mins by FRET assay [AID724981, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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32
[SID103245522]
Kd 0.11Binding constant for ABL1(F317L)-phosphorylated kinase domain [AID624982, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
33
[SID103245522]
Kd 0.11Average Binding Constant for ABL1(E255K) ; NA=Not Active at 10 uM [AID256667, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
34
[SID103245522]
Kd 0.13Binding constant for ABL1(Y253F)-phosphorylated kinase domain [AID624990, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
35
[SID103245522]
Kd 0.17Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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36
[SID103245522]
IC50 0.19Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 15 mins by fluorescence assay [AID729373, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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37
[SID103245522]
IC50 0.25Inhibition of Abl1 kinase (unknown origin) [AID729372, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
38
[SID103245522]
IC50 0.319Inhibition of Abl1 kinase (unknown origin) using Tyr 6 peptide as substrate assessed as residual enzyme activity after every 10 secs measured for 10 mins by platform assay [AID729374, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
39
[SID103245522]
IC50 0.47Inhibition of human Abl kinase expressed in Sf9 cells [AID295287, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
40
[SID103245522]
IC50 0.473Inhibition of BCR-ABL1 autophosphorylation in human K562 cells [AID515832, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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41
[SID103245522]
Kd 0.5Binding affinity to human remote site of N-terminal hexahistidine-tagged ABL2 expressed in Trichoplusia ni infected Sf9 cells by isothermal titration calorimetric assay [AID593558, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
View
42
[SID103245522]
Kd 0.58Binding constant for ABL1(F317I)-phosphorylated kinase domain [AID624980, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
43
[SID103245522]
IC50 0.75Inhibition of BCR/ABL p210 autophosphorylation in human K562 cells after 2 hrs by western blot analysis [AID511818, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
44
[SID103245522]
IC50 2.7Inhibition of human wild type ABL1 assessed as [gamma33P]ATP incorporation into poly-Ala-Glu-Lys-Tyr after 60 mins by microplate scintillation counting [AID591854, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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45
[SID103245522]
Kd 6.2Average Binding Constant for ABL1(T315I) ; NA=Not Active at 10 uM [AID256670, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
46
[SID50100104]
8.5Kinase Inhibitor Selectivity Profiling Assay [AID1433_97, Type: confirmatory]tyrosine-protein kinase ABL1 isoform a [Homo sapiens] [gi:62362414]
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47
[SID46392211]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Crystal Structure Of The C-Abl Kinase Domain In Complex With Sti-571. [gi:14278498]
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48
[SID103245522]
Inhibition of BCR-ABL-mediated STAT5 phosphorylation in human K562 cells after 6 hrs by phospho-flowcytometry [AID658699, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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49
[SID103245522]
Inhibition of BCR-ABL-mediated ERK1 phosphorylation in human K562 cells at 40 uM after 6 hrs by phospho-flowcytometry [AID658702, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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50
[SID103245522]
Inhibition of BCR-ABL-mediated ERK2 phosphorylation in human K562 cells at 40 uM after 6 hrs by phospho-flowcytometry [AID658703, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View