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imatinib (CID 5291) - Compound BioActivity Data
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Filters: All Data » PTKc Abl      
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BioActivity Outcomes:
Active(57)
 
 
Inactive(5)
 
 
Unspecified(8)
 
 
Top Targets:
PTKc Abl(70)
 
 
 
 
BioAssay Types:
Literature(64)
 
 
 
Confirmatory(6)
 
 
 
BioActivity Types:
Kd(34)
 
 
 
IC50(18)
 
 
Ki(3)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 64    Data Row: 70   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103245522]
Kd 0.0011Binding constant for ABL1-non phosphorylated kinase domain [AID624991, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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2
[SID103245522]
Kd 0.0018Binding constant for ABL1(Q252H)-non phosphorylated kinase domain [AID624986, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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3
[SID103245522]
Kd 0.0022Average Binding Constant for ABL1; NA=Not Active at 10 uM [AID256665, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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4
[SID103245522]
Kd 0.0025Binding constant for ABL1(F317L)-non phosphorylated kinase domain [AID624981, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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5
[SID103245522]
Kd 0.0059Binding constant for ABL1(H396P)-non phosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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6
[SID103245522]
Kd 0.006Binding affinity to human active site of N-terminal hexahistidine-tagged ABL2 expressed in Trichoplusia ni infected Sf9 cells by isothermal titration calorimetric assay [AID593557, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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7
[SID103245522]
Kd 0.0083Binding constant for ABL1(F317I)-non phosphorylated kinase domain [AID624979, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
8
[SID103245522]
Kd 0.0085Binding constant for ABL1(M351T) kinase domain [AID435514, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
9
[SID103245522]
Kd 0.01Binding constant for ABL2 kinase domain [AID435777, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
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10
[SID103245522]
Kd 0.01Binding constant for ABL2 kinase domain [AID624993, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
View
11
[SID103245522]
IC50 0.0108Inhibition of mouse recombinant N-terminal His6-tagged Abl by radiometric kinase assay [AID497611, Type: Literature]Tyrosine-protein kinase ABL1 [gi:59802613]
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12
[SID103245522]
Kd 0.012Binding constant for ABL1 kinase domain [AID435775, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
13
[SID103245522]
Ki 0.013Inhibition of human recombinant Abl [AID317426, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
14
[SID103245522]
Ki 0.013Inhibition of human recombinant Abl by filter-binding assay [AID370599, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
15
[SID103245522]
Ki 0.013Inhibition of human recombinant c-Abl by filter-binding assay [AID595769, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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16
[SID103245522]
Kd 0.013Average Binding Constant for ABL2; NA=Not Active at 10 uM [AID256641, Type: Literature]Abelson tyrosine-protein kinase 2 [gi:1168268]
View
17
[SID103245522]
Kd 0.014Average Binding Constant for ABL1(M351T); NA=Not Active at 10 uM [AID256669, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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18
[SID103245522]
IC50 0.0199Inhibition of human wild-type ABL (Ser229 to Gln513)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) preincubated for 30 to 60 mins prior to substrate addition by TR-FRET assay [AID759168, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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19
[SID103245522]
Kd 0.021Binding constant for ABL1-phosphorylated kinase domain [AID624992, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View
20
[SID103245522]
Kd 0.021Binding constant for ABL1(Q252H) kinase domain [AID435515, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
View