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Acetylcholine (CID 187) - Compound BioActivity Data
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Filters: All Data » Neur chan LBD      
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BioActivity Outcomes:
Active(38)
 
 
Inconclusive(3)
 
 
Unspecified(30)
 
 
Top Targets:
Neur chan LBD(71)
 
 
 
 
BioAssay Types:
Literature(69)
 
 
 
 
BioActivity Types:
Ki(33)
 
 
 
 
EC50(16)
 
 
 
IC50(4)
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 46    Data Row: 71   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234160]
Ki 0.0076Displacement of [3H]-cytisine from Alpha4-beta2 Nicotinic acetylcholine receptor of rat brain homogenates [AID239589, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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2
[SID104234160]
Ki 0.0076Displacement of [3H]-cytisine from Alpha4-beta2 Nicotinic acetylcholine receptor of rat brain homogenates [AID239589, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
View
3
[SID104234160]
Ki 0.011Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID145983, Type: Literature]Neuronal acetylcholine receptor subunit alpha-2 [gi:2851491]
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4
[SID104234160]
Ki 0.011Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID145983, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
View
5
[SID104234160]
Ki 0.033Displacement of [3H]epibatidine from rat recombinant alpha4beta2 nAChR expressed in HEK293 cells after 4 hrs by scintillation counting analysis [AID724038, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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6
[SID104234160]
Ki 0.033Displacement of [3H]epibatidine from rat recombinant alpha4beta2 nAChR expressed in HEK293 cells after 4 hrs by scintillation counting analysis [AID724038, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
View
7
[SID104234160]
Ki 0.0377Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrs [AID536863, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
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8
[SID104234160]
Ki 0.0377Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrs [AID536863, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
View
9
[SID104234160]
Ki 0.039Displacement of [3H]cystisine from nicotinic alpha-4-beta-2 receptor in rat brain [AID320061, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
View
10
[SID104234160]
Ki 0.039Displacement of [3H]cystisine from nicotinic alpha-4-beta-2 receptor in rat brain [AID320061, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
View
11
[SID104234160]
Ki 0.041Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID146006, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
View
12
[SID104234160]
Ki 0.041Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID146006, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:113061]
View
13
[SID104234160]
Ki 0.045Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID146486, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
View
14
[SID104234160]
Ki 0.045Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID146486, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
View
15
[SID104234160]
Ki 0.058Displacement of [3H]epibatidine from rat recombinant alpha4beta4 nAChR expressed in HEK293 cells after 4 hrs by scintillation counting analysis [AID724035, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
View
16
[SID104234160]
Ki 0.058Displacement of [3H]epibatidine from rat recombinant alpha4beta4 nAChR expressed in HEK293 cells after 4 hrs by scintillation counting analysis [AID724035, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:113111]
View
17
[SID104234160]
Ki 0.083Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in HEK293 cells using [3H]EB as radioligand [AID146772, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:113111]
View
18
[SID104234160]
Ki 0.083Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in HEK293 cells using [3H]EB as radioligand [AID146772, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
View
19
[SID104234160]
Ki 0.62Displacement of [3H]epibatidine from rat recombinant alpha3beta4 nAChR expressed in HEK293 cells after 4 hrs by scintillation counting analysis [AID724036, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:113111]
View
20
[SID104234160]
Ki 0.62Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrs [AID536862, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:113111]
View
21
[SID104234160]
Ki 0.62Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrs [AID536862, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:113061]
View
22
[SID104234160]
Ki 0.62Displacement of [3H]epibatidine from rat recombinant alpha3beta4 nAChR expressed in HEK293 cells after 4 hrs by scintillation counting analysis [AID724036, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:113061]
View
23
[SID104234160]
Ki 0.82Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in HEK293 cells using [3H]EB as radioligand [AID146162, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:113061]
View
24
[SID104234160]
Ki 0.82Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in HEK293 cells using [3H]EB as radioligand [AID146162, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:113111]
View
25
[SID104234160]
Ki 0.881Displacement of [3H]epibatidine from Alpha3 Beta4 Nicotinic acetylcholine receptor of rat brain homogenates [AID239611, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:113061]
View
26
[SID104234160]
Ki 0.881Displacement of [3H]epibatidine from Alpha3 Beta4 Nicotinic acetylcholine receptor of rat brain homogenates [AID239611, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:113111]
View
27
[SID104234160]
EC50 1.6Partial agonist activity at human 2:3 alpha4beta2 nAChR expressed in Xenopus laevis oocytes after 1 min by two electrode voltage clamp technique [AID724032, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:1351848]
View
28
[SID104234160]
EC50 1.6Partial agonist activity at human 2:3 alpha4beta2 nAChR expressed in Xenopus laevis oocytes after 1 min by two electrode voltage clamp technique [AID724032, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:113105]
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29
[SID104234160]
EC50 3.12Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells assessed as calcium influx measured every 1 sec for 1 min followed by every 30 secs for 10 mins by FLIPR assay [AID684908, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:146345356]
View
30
[SID104234160]
Ki 3.16228Displacement of [125I]alpha-bungarotoxin from Lymnaea stagnalis His-tagged AchBP [AID415528, Type: Literature]Acetylcholine-binding protein [gi:14285341]
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31
[SID104234160]
Ki 3.509Displacement of [3H]alpha-bungaro-toxine from nicotinic alpha-7 receptor in rat brain [AID320062, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:146345356]
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32
[SID104234160]
Ki 6.30957Displacement of [3H]-epibatidine from histidine-tagged Lymnaea stagnalis AChBP expressed in Sf9 cells after 1.5 hrs by liquid scintillation counting [AID620032, Type: Literature]Acetylcholine-binding protein [gi:14285341]
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33
[SID104234160]
Ki 7.94328Displacement of [3H]-MLA from human alpha7 nAChR expressed in human SH-SY5Y cells after 1.5 hrs by liquid scintillation counting [AID620034, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
View
34
[SID104234160]
EC50 19Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in Xenopus oocytes [AID146770, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
View
35
[SID104234160]
EC50 19Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in Xenopus oocytes [AID146770, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:113111]
View
36
[SID104234160]
IC50 Antagonist activity at human alpha-7 nAChR in tsA201 cells coexpressed with Ric3 by FMP assay [AID297967, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
View
37
[SID104234160]
IC50 Antagonist activity at human alpha7nAChR co-expressed with human Ric3 in tsA201 cells by FMP assay [AID297990, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
View
38
[SID104234160]
Ki Agonist activity at rat alpha-3-beta-4 nAChR expressed in HEK293 cells by FMP assay [AID346671, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:113061]
View
39
[SID104234160]
EC50 69Agonist activity at human recombinant alpha7 nAChR expressed in Xenopus oocyte in presence of 6 uM (S)-ethyl 1-(2-cyanoethyl)pyrrolidine-2-carboxylate [AID580950, Type: other]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
View
40
[SID104234160]
EC50 70Agonist activity at human alpha-4-beta-2 nAChR expressed in Xenopus oocytes by two-electrode voltage clamp technique [AID346673, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:1351848]
View
41
[SID104234160]
EC50 83Agonist activity at human alpha-7 nAChR expressed in Xenopus oocytes by two-electrode voltage clamp technique [AID346675, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
View
42
[SID104234160]
EC50 87Agonist activity at human recombinant alpha7 nAChR expressed in Xenopus oocyte [AID580949, Type: other]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
View
43
[SID104234160]
EC50 87Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in Xenopus oocytes [AID146477, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
View
44
[SID104234160]
EC50 87Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in Xenopus oocytes [AID146477, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
View
45
[SID104234160]
EC50 144Agonist activity at human alpha-3-beta-4 nAChR expressed in Xenopus oocytes by two-electrode voltage clamp technique [AID346674, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:254763435]
View
46
[SID104234160]
Ki 170Displacement of [3H]MLA from rat nAChR alpha7 linked to ion channel portion of 5-HT3A receptor expressed in human tsA-201 cells after 2.5 hrs by scintillation counting analysis [AID724037, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:146345356]
View
47
[SID104234160]
EC50 217Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in Xenopus oocytes [AID146158, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:113111]
View
48
[SID104234160]
EC50 217Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in Xenopus oocytes [AID146158, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:113061]
View
49
[SID104234160]
EC50 443Effective concentration against Nicotinic acetylcholine receptor alpha3-beta2 expressed in xenopus oocytes [AID240235, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:113105]
View
50
[SID104234160]
EC50 443Effective concentration against Nicotinic acetylcholine receptor alpha3-beta2 expressed in xenopus oocytes [AID240235, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:254763435]
View