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Estradiol (CID 5757) - Compound BioActivity Data
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Filters: All Data » NR LBD ER      
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BioActivity Outcomes:
Active(232)
 
 
Inactive(18)
 
 
Inconclusive(19)
 
 
Unspecified(335)
 
 
Top Targets:
NR LBD ER(604)
 
 
 
 
 
BioAssay Types:
Literature(549)
 
 
 
 
 
Confirmatory(19)
 
 
 
 
 
Summary(9)
 
 
 
 
Screening(3)
 
 
 
BioActivity Types:
IC50(88)
 
 
 
 
EC50(66)
 
 
Kd(36)
 
 
Potency(23)
 
 
 
 
Ki(15)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 421    Data Row: 604   Total Pages: 31   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103189263]
EC50 4e-06Activation of human ERalpha expressed in human U2-OS cells by luciferase reporter gene assay relative to untreated control [AID707063, Type: Literature]Estrogen receptor [gi:544257]
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2
[SID103189263]
ED50 4.56e-06Functional ERalpha receptor activity in transcriptional activation assay in MCF-7 cells [AID70194, Type: Literature]Estrogen receptor [gi:544257]
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3
[SID103189263]
EC50 7e-06Agonist effect on transcriptional activation in MCF-7 cells expressing estrogen receptor alpha [AID70188, Type: Literature]Estrogen receptor [gi:544257]
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4
[SID103189263]
EC50 1e-05Percent agonistic activity for estrogen-induced pS2 expression in MCF-7 cells [AID102436, Type: Literature]Estrogen receptor [gi:544257]
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5
[SID103189263]
EC50 1e-05Effect on ERalpha in MCF7 cell line transfected with ER responsive luciferase reporter [AID257302, Type: Literature]Estrogen receptor [gi:544257]
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6
[SID103189263]
IC50 1e-05In vitro inhibition of estrogen-stimulated MCF-7 cell proliferation [AID102598, Type: Literature]Estrogen receptor [gi:544257]
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7
[SID103189263]
EC50 1e-05Percent agonistic activity for estrogen-induced pS2 expression in MCF-7 cells [AID102436, Type: Literature]Estrogen receptor beta [gi:6166154]
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8
[SID103189263]
IC50 1e-05In vitro inhibition of estrogen-stimulated MCF-7 cell proliferation [AID102598, Type: Literature]Estrogen receptor beta [gi:6166154]
View
9
[SID103189263]
EC50 1e-05Activation of human ERbeta expressed in human U2-OS cells by luciferase reporter gene assay relative to untreated control [AID707072, Type: Literature]Estrogen receptor beta [gi:6166154]
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10
[SID103189263]
EC50 1.9e-05Transcriptional activation of estrogen receptor alpha in U2OS cell using estrogen-regulated luciferase reporter gene plasmid upon incubation for 20-30 mins at RT [AID254648, Type: Literature]Estrogen receptor [gi:544257]
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11
[SID103189263]
EC50 3.01e-05Induction of pS2 Gene expression in human MCF-7 cells [AID103551, Type: Literature]Estrogen receptor [gi:544257]
View
12
[SID103189263]
EC50 3.01e-05Induction of pS2 Gene expression in human MCF-7 cells [AID103551, Type: Literature]Estrogen receptor beta [gi:6166154]
View
13
[SID103189263]
EC50 3.98e-05Agonist activity at ER-beta (unknown origin) transfected in HEK293T cells after 24 hrs by Steady-Glo luciferase reporter gene assay [AID1077858, Type: confirmatory]Estrogen receptor beta [gi:6166154]
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14
[SID103189263]
IC50 4.6e-05Antagonist activity at ERbeta (unknown origin) by cell-based assay [AID1061128, Type: Literature]Estrogen receptor beta [gi:6166154]
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15
[SID103189263]
EC50 4.7e-05Estrogenic activity at estrogen receptor in human Ishikawa Var-1 cells assessed as stimulation of alkaline phosphatase activity measured by metabolism of p-nitrophenol phosphatase after 72 hrs [AID333509, Type: Literature]Estrogen receptor [gi:544257]
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16
[SID103189263]
ED50 6e-05Effective dose in immature rat uterotrophic growth assay [AID246833, Type: Literature]Estrogen receptor [gi:119600]
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17
[SID103189263]
ED50 6e-05Effective dose in immature rat uterotrophic growth assay [AID246833, Type: Literature]Estrogen receptor beta [gi:6166156]
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18
[SID103189263]
EC50 6.17e-05Transactivation of human ERbeta expressed in HEK293 cells after 18 hrs by luciferase reporter gene assay [AID478663, Type: Literature]Estrogen receptor beta [gi:6166154]
View
19
[SID103189263]
EC50 6.46e-05Transactivation of human ERalpha expressed in HEK293 cells after 18 hrs by luciferase reporter gene assay [AID478662, Type: Literature]Estrogen receptor [gi:544257]
View
20
[SID103189263]
EC50 7e-05Agonist effect on transcriptional activation in T47D cells expressing estrogen receptor alpha [AID70190, Type: Literature]Estrogen receptor [gi:544257]
View