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Morphine (CID 5288826) - Compound BioActivity Data
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Filters: All Data » ABC MTABC3 MDL1 MDL2      
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BioActivity Outcomes:
Active(1)
 
 
Unspecified(8)
 
 
Top Targets:
ABC MTABC3 MD..(9)
 
 
 
BioAssay Types:
Literature(9)
 
 
 
BioActivity Types:
IC50(3)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 9    Data Row: 9   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103169185]
Effect on human recombinant Pgp-mediated ATP consumption assessed as increase in ATPase activity at 200 uM by Pgp-Glo assay [AID330418, Type: Literature]Multidrug resistance protein 1 [gi:238054374]
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2
[SID103169185]
IC50 50TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells [AID681122, Type: Literature]Multidrug resistance protein 1 [gi:238054374]
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3
[SID103169185]
IC50 50TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1b-expressing LLC-PK1 cells [AID681128, Type: Literature]Multidrug resistance protein 1B [gi:126927]
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4
[SID103169185]
IC50 50TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1a-expressing LLC-PK1 cells [AID681119, Type: Literature]Multidrug resistance protein 1A [gi:239938877]
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5
[SID103169185]
TP_TRANSPORTER: transepithelial transport (basal to apical) in mdr1a-expressing LLC-PK1 cell [AID678833, Type: Literature]Multidrug resistance protein 1A [gi:239938877]
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6
[SID103169185]
TP_TRANSPORTER: increase in brain concentration in mdr1a(-/-) mouse [AID679340, Type: Literature]Multidrug resistance protein 1A [gi:239938877]
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7
[SID103169185]
TP_TRANSPORTER: transepithelial transport of Morphine at a concentration of 1 uM in MDR1-expressing MDCK cells [AID679084, Type: Literature]Multidrug resistance protein 1 [gi:238054374]
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8
[SID103169185]
TP_TRANSPORTER: transepithelial transport of Morphine at a concentration of 1 uM in Caco-2 cells [AID679085, Type: Literature]Multidrug resistance protein 1 [gi:238054374]
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9
[SID103169185]
TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in Caco-2 cells [AID681120, Type: Literature]Multidrug resistance protein 1 [gi:238054374]
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