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Dopamine (CID 681) - Compound BioActivity Data
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Filters: All Data » 7TM GPCR Srx      
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BioActivity Outcomes:
Active(22)
 
 
Inactive(3)
 
 
Inconclusive(1)
 
 
Unspecified(5)
 
 
Top Targets:
7TM GPCR Srx(31)
 
 
 
 
 
BioAssay Types:
Literature(22)
 
 
 
 
Confirmatory(6)
 
 
 
BioActivity Types:
Ki(10)
 
 
 
 
Potency(6)
 
 
 
IC50(5)
 
 
EC50(3)
 
 
Kd(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 29    Data Row: 31   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103167911]
IC50 0.002Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTN [AID196429, Type: Literature]D(1B) dopamine receptor [gi:118251]
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2
[SID103167911]
IC50 0.002Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTN [AID196429, Type: Literature]D(1A) dopamine receptor [gi:118229]
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3
[SID103167911]
IC50 0.0021Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpiride [AID196428, Type: Literature]D(1B) dopamine receptor [gi:118251]
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4
[SID103167911]
IC50 0.0021Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpiride [AID196428, Type: Literature]D(1A) dopamine receptor [gi:118229]
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5
[SID103167911]
EC50 0.02Agonist activity at human D1 receptor assessed as cAMP accumulation [AID502879, Type: Literature]D(1A) dopamine receptor [gi:118228]
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6
[SID103167911]
EC50 0.035Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production [AID319298, Type: Literature]D(1A) dopamine receptor [gi:118228]
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7
[SID90341661]
Potency 0.0517HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Hit Validation in HTRF [AID624455, Type: confirmatory]dopamine D1 receptor [Homo sapiens] [gi:299681]
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8
[SID90341661]
Potency 0.1HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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9
[SID103167911]
EC50 0.12Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production [AID272394, Type: Literature]D(1A) dopamine receptor [gi:118228]
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10
[SID103167911]
Ki 0.15Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes [AID61510, Type: Literature]D(1A) dopamine receptor [gi:118229]
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11
[SID90341661]
Potency 0.2512HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Agonists [AID488981, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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12
[SID103167911]
Ki 0.44Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum [AID733807, Type: Literature]D(1A) dopamine receptor [gi:110832828]
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13
[SID103167911]
IC50 0.8Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum [AID63370, Type: Literature]D(1A) dopamine receptor [gi:118229]
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14
[SID103167911]
Kd 2.5Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells [AID61865, Type: Literature]D(1A) dopamine receptor [gi:118228]
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15
[SID103167911]
Ki 4.3Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand [AID61852, Type: Literature]D(1A) dopamine receptor [gi:110832828]
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16
[SID103167911]
Ki 4.3Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina [AID61855, Type: Literature]D(1A) dopamine receptor [gi:110832828]
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17
[SID103167911]
Ki 4.47Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells [AID709661, Type: Literature]D(1A) dopamine receptor [gi:118228]
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18
[SID103167911]
Ki 7.1Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells [AID107885, Type: other]Melatonin receptor type 1A [gi:1346544]
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19
[SID103167911]
Ki 9.1Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1B expressed in CHO cells [AID108050, Type: other]Melatonin receptor type 1B [gi:1346548]
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20
[SID103167911]
Ki 12Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells [AID675146, Type: Literature]D(1A) dopamine receptor [gi:118228]
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21
[SID103167911]
Intrinsic activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production relative to dopamine [AID272395, Type: Literature]D(1A) dopamine receptor [gi:118228]
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22
[SID103167911]
Low-affinity agonist dissociation constant against striatal Dopamine receptor D1A [AID61996, Type: Literature]D(1A) dopamine receptor [gi:118229]
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23
[SID103167911]
Ki 10Binding affinity towards 5-hydroxytryptamine 1A receptor by the displacement of [125I]trans-8-OH-PIPAT in membrane homogenates of hippocampal tissue of rat brain [AID4036, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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24
[SID103167911]
Percent stimulation of adenylate cyclase activity at dopamine receptor D1 of Rat Striatum at 1 uM [AID61342, Type: Literature]D(1A) dopamine receptor [gi:118229]
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25
[SID103167911]
Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390 [AID61674, Type: other]D(1A) dopamine receptor [gi:118229]
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26
[SID103167911]
log(1/Kd) value against recombinant Dopamine receptor D1A expressed in COS7 cell [AID61867, Type: Literature]D(1A) dopamine receptor [gi:118228]
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27
[SID103167911]
Intrinsic activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production [AID319300, Type: Literature]D(1A) dopamine receptor [gi:118228]
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28
[SID90341661]
Potency 0.082HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Potentiators [AID488982, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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29
[SID11111282]
Potency qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response [AID943, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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30
[SID11111282]
Potency qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Measurement of IP-One Response [AID944, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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31
[SID103167911]
Ki Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate [AID272392, Type: Literature]D(1A) dopamine receptor [gi:1706296]
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