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Morphine (CID 5288826) - Compound BioActivity Data
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Filters: All Data » 7TM GPCR Srx      
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BioActivity Outcomes:
Active(87)
 
 
Inconclusive(3)
 
 
Unspecified(51)
 
 
Top Targets:
7TM GPCR Srx(141)
 
 
 
 
BioAssay Types:
Literature(137)
 
 
 
 
BioActivity Types:
Ki(41)
 
 
 
IC50(24)
 
 
 
 
EC50(22)
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 129    Data Row: 141   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103169185]
Ki 0.00088Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells [AID259394, Type: Literature]Mu-type opioid receptor [gi:2851402]
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2
[SID103169185]
Ki 0.00088Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID670110, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
3
[SID103169185]
Ki 0.001Inhibition of [3H]DAMGO binding to mu opioid receptor of rat brain membranes [AID151606, Type: Literature]Mu-type opioid receptor [gi:464314]
View
4
[SID103169185]
Ki 0.0011Displacement of [3H]DAMGO from human recombinant MOR expressed in CHO cells [AID269569, Type: Literature]Mu-type opioid receptor [gi:2851402]
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5
[SID103169185]
Ki 0.0011Displacement of [3H]DAMGO from human cloned mu opioid receptor [AID298631, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
6
[SID103169185]
IC50 0.00127Displacement of [3H]DAMGO from mu opioid receptor in ICR mouse whole brain [AID383161, Type: Literature]Mu-type opioid receptor [gi:1171911]
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7
[SID103169185]
IC50 0.00127Displacement of [3H]DAMGO from mu opioid receptor in mouse whole brain without cerebellum [AID411134, Type: Literature]Mu-type opioid receptor [gi:1171911]
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8
[SID103169185]
Ki 0.0018Binding affinity against mu opioid receptor in mouse hot plate test [AID238659, Type: Literature]Mu-type opioid receptor [gi:1171911]
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9
[SID103169185]
Ki 0.0018Displacement of [3H]DPDPE from delta opioid receptor in rat brain membranes [AID601797, Type: Literature]Delta-type opioid receptor [gi:464311]
View
10
[SID103169185]
IC50 0.00194Inhibition of [3H]- DAMGO binding to Rat brain Opioid receptor mu 1 [AID151303, Type: Literature]Mu-type opioid receptor [gi:464314]
View
11
[SID103169185]
Ki 0.0022Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK-293 cells by scintillation counting [AID669684, Type: other]Mu-type opioid receptor [gi:2851402]
View
12
[SID103169185]
Ki 0.0025Binding affinity towards opioid receptor mu 2 [AID152210, Type: Literature]Mu-type opioid receptor [gi:6093615]
View
13
[SID103169185]
Ki 0.00255Displacement of [125I]IOXY from human mu opioid receptor expressed in CHO cells coexpressing human recombinant MOR after 2 hrs by liquid scintillation counting [AID607794, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
14
[SID103169185]
Ki 0.00255Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cells [AID440049, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
15
[SID103169185]
Ki 0.0026Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cells after 2 hrs by liquid scintillation counting [AID612049, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
16
[SID103169185]
Ki 0.0026Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO cells membrane after 2 hrs by liquid scintillation counting [AID647794, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
17
[SID103169185]
Ki 0.0028Inhibition of [3H]DAMGO binding to rat brain homogenat Opioid receptor mu 1 [AID151750, Type: Literature]Mu-type opioid receptor [gi:464314]
View
18
[SID103169185]
Ki 0.003Inhibition of [3H]dihydromorphine (1 nM) binding to mu opioid receptor of rat brain homogenate [AID141761, Type: other]Mu-type opioid receptor [gi:464314]
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19
[SID103169185]
EC50 0.0037Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF assay [AID669685, Type: other]Mu-type opioid receptor [gi:2851402]
View
20
[SID103169185]
IC50 0.0039Displacement of [3H]- DAGO from opioid receptor mu in rat brain membrane [AID149290, Type: Literature]Mu-type opioid receptor [gi:464314]
View
21
[SID103169185]
Ki 0.00396Binding affinity for Opioid receptor mu 1 [AID152069, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
22
[SID103169185]
Ki 0.004Displacement of [3H]naloxone from human mu poioid receptor expressed in HEK293 cells [AID327878, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
23
[SID103169185]
IC50 0.0042Displacement [3H]naloxone from rat-brain Opioid receptors [AID150397, Type: Literature]Mu-type opioid receptor [gi:464314]
View
24
[SID103169185]
IC50 0.0042Displacement [3H]naloxone from rat-brain Opioid receptors [AID150397, Type: Literature]Delta-type opioid receptor [gi:464311]
View
25
[SID103169185]
IC50 0.0043Agonist activity at human MOR expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins by cAMP EIA [AID707251, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
26
[SID103169185]
Ki 0.0048mu-2 receptor binding affinity in rat brain by 3H [d-Ala2, (N-Me)Phe4, Gly5-ol] enkephalin displacement. [AID152212, Type: Literature]Mu-type opioid receptor [gi:464314]
View
27
[SID103169185]
IC50 0.00564Displacement of [3H]DAMGO from mu opioid receptor from Wistar rat brain by liquid scintillation counting [AID479370, Type: Literature]Mu-type opioid receptor [gi:464314]
View
28
[SID103169185]
EC50 0.006Activation of human mu opioid receptor expressed in HEK293a cells co-expressing YFP-labelled alphai1 and CFP-labelled beta1gamma2 Gi subunits assessed as Gi proteiin activation by fluorescence resonance energy transfer [AID327877, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
29
[SID103169185]
Ki 0.0063Displacement of [3H]diprenorphine from rat MOR expressed in rat C6 cells after 1 hr by liquid scintillation counting analysis [AID729035, Type: Literature]Mu-type opioid receptor [gi:464314]
View
30
[SID103169185]
EC50 0.0064Activation of human mu opioid receptor expressed in HEK293a cells coexpressing YFP-labelled alphai1 and CFP-labelled beta-1-gamma-2 Gi subunits assessed as decrease in fluorescence resonance energy transfer signal at 10 uM [AID327872, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
31
[SID103169185]
Ki 0.00655Displacement of [3H]DAMGO from mu opioid receptor in Sprague-Dawley rat brain membrane by liquid scintillation counting [AID577077, Type: Literature]Mu-type opioid receptor [gi:464314]
View
32
[SID103169185]
Ki 0.0069Displacement of [3H]diprenorphine from human kappa receptor expressed in CHO cells by scintillation counting [AID452018, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
33
[SID103169185]
EC50 0.007Activation of human mu opioid receptor expressed in HEK293a cells by [35S]GTP-gamma-S binding assay [AID327873, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
34
[SID103169185]
Ki 0.0139Displacement of radiolabeled NalBzOH from kappa3 opioid receptor in Hartley guinea pig brain [AID268680, Type: Literature]Nociceptin receptor [gi:1352647]
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35
[SID103169185]
Ki 0.015Inhibition of [3H]-[D-Pen2, D-Pen5]-enkephalin (2 nM) to Opioid receptor delta 1 of male Sprague-Dawley rat brain homogenate [AID149932, Type: other]Delta-type opioid receptor [gi:464311]
View
36
[SID103169185]
EC50 0.0156Stimulation of [35S]GTPgammaS binding to human recombinant MOR [AID269575, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
37
[SID103169185]
EC50 0.0156Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding [AID298634, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
38
[SID103169185]
EC50 0.0156Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID395302, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
39
[SID103169185]
EC50 0.0156Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins [AID577264, Type: Literature]Delta-type opioid receptor [gi:311033488]
View
40
[SID103169185]
IC50 0.022Displacement of [3H]naloxone from rat brain Opioid receptors [AID150260, Type: Literature]Delta-type opioid receptor [gi:464311]
View
41
[SID103169185]
IC50 0.022Displacement of [3H]naloxone from rat brain Opioid receptors [AID150260, Type: Literature]Mu-type opioid receptor [gi:464314]
View
42
[SID103169185]
Ki 0.024Displacement of [3H]-U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID670111, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
43
[SID103169185]
Ki 0.024Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cells [AID259396, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
44
[SID103169185]
IC50 0.027Displacement of [3H]nalotrexone from rat-brain Opioid receptors [AID150396, Type: Literature]Mu-type opioid receptor [gi:464314]
View
45
[SID103169185]
IC50 0.027Displacement of [3H]nalotrexone from rat-brain Opioid receptors [AID150396, Type: Literature]Delta-type opioid receptor [gi:464311]
View
46
[SID103169185]
Ki 0.036Binding affinity for mu opioid receptor was evaluated by displacing [3H]- diprenorphine [AID224586, Type: Literature]Mu-type opioid receptor [gi:464314]
View
47
[SID103169185]
ED50 0.037Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID443807, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
48
[SID103169185]
ED50 0.037Agonist activity at human mu opioid receptor expressed in CHO cells by [35S]GTP-gamma-S assay [AID296734, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
49
[SID103169185]
Ki 0.0469Displacement of [3H]U-69593 from human cloned kappa opioid receptor [AID298632, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View
50
[SID103169185]
Ki 0.0469Displacement of [3H]U-69593 from human recombinant KOR expressed in CHO cells [AID269573, Type: Literature]Kappa-type opioid receptor [gi:116242691]
View