Bookmark and Share
Dopamine (CID 681) - Compound BioActivity Data
.
Filters: All Data » 7TM GPCR Srsx      
Filter selected
BioActivity Outcomes:
Active(57)
 
 
Inactive(4)
 
 
Unspecified(15)
 
 
Top Targets:
7TM GPCR Srsx(76)
 
 
 
 
BioAssay Types:
Literature(72)
 
 
 
 
Screening(2)
 
 
Confirmatory(1)
 
 
BioActivity Types:
Ki(27)
 
 
EC50(22)
 
 
IC50(6)
 
 
Kd(1)
 
 
Potency(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 74    Data Row: 76   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103167911]
EC50 0.0011Agonist activity at rat D2 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR [AID274445, Type: Literature]D(2) dopamine receptor [gi:47117674]
View
2
[SID103167911]
Ki 0.00189Displacement of [3H]quinpirole from human dopamine D2A receptors expressed in LtK cells [AID61612, Type: Literature]D(2) dopamine receptor [gi:118206]
View
3
[SID103167911]
IC50 0.002Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTN [AID196429, Type: Literature]D(3) dopamine receptor [gi:118211]
View
4
[SID103167911]
IC50 0.002Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTN [AID196429, Type: Literature]D(2) dopamine receptor [gi:47117674]
View
5
[SID103167911]
IC50 0.0021Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpiride [AID196428, Type: Literature]D(3) dopamine receptor [gi:118211]
View
6
[SID103167911]
IC50 0.0021Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpiride [AID196428, Type: Literature]D(2) dopamine receptor [gi:47117674]
View
7
[SID103167911]
Ki 0.0029Displacement of [3H]spiperone from human dopamine D2 receptor at high affinity state expressed in HEK293 cells [AID458633, Type: Literature]D(2) dopamine receptor [gi:118206]
View
8
[SID103167911]
EC50 0.00476Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID461563, Type: Literature]D(3) dopamine receptor [gi:1169206]
View
9
[SID103167911]
EC50 0.00476Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID513742, Type: Literature]D(3) dopamine receptor [gi:1169206]
View
10
[SID103167911]
EC50 0.005Activity at rat dopamine D2L receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production [AID272396, Type: Literature]D(2) dopamine receptor [gi:47117674]
View
11
[SID103167911]
EC50 0.0058Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay [AID712282, Type: Literature]D(3) dopamine receptor [gi:1169206]
View
12
[SID103167911]
EC50 0.0061Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay [AID709655, Type: Literature]D(3) dopamine receptor [gi:1169206]
View
13
[SID103167911]
EC50 0.00853Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding [AID425420, Type: Literature]D(3) dopamine receptor [gi:1169206]
View
14
[SID103167911]
EC50 0.00853Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding [AID446402, Type: Literature]D(3) dopamine receptor [gi:1169206]
View
15
[SID103167911]
EC50 0.00853Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding [AID312287, Type: Literature]D(3) dopamine receptor [gi:1169206]
View
16
[SID103167911]
EC50 0.00853Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding [AID384700, Type: Literature]D(3) dopamine receptor [gi:1169206]
View
17
[SID103167911]
EC50 0.00857Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID690847, Type: Literature]D(3) dopamine receptor [gi:1169206]
View
18
[SID103167911]
Ki 0.0132Displacement of [3H]raclopride from Dopamine receptor D3 [AID65128, Type: Literature]D(3) dopamine receptor [gi:1169206]
View
19
[SID103167911]
Ki 0.0149Inhibition of [3H]YM-09151-2 binding to bovine retina membrane Dopamine receptor D2, high affinity site [AID64172, Type: Literature]D(2) dopamine receptor [gi:118205]
View
20
[SID103167911]
Ki 0.015Displacement of [3H]raclopride from human D3 receptor expressed in HEK293 cells [AID675148, Type: Literature]D(3) dopamine receptor [gi:1169206]
View
21
[SID103167911]
Ki 0.017Binding Affinity on High Affinity Site of Dopamine receptor D2S [AID64658, Type: Literature]D(2) dopamine receptor [gi:118206]
View
22
[SID103167911]
Ki 0.02Binding affinity on High Affinity Site of Dopamine receptor D2L [AID64329, Type: Literature]D(2) dopamine receptor [gi:118206]
View
23
[SID103167911]
Ki 0.02Displacement of [3H]YM-09151-2 from human dopamine D3 receptor expressed in CHOp cells [AID709660, Type: Literature]D(3) dopamine receptor [gi:1169206]
View
24
[SID103167911]
Ki 0.021Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells [AID733801, Type: Literature]D(3) dopamine receptor [gi:1169206]
View
25
[SID103167911]
EC50 0.043Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production [AID319299, Type: Literature]D(2) dopamine receptor [gi:118206]
View
26
[SID103167911]
Ki 0.05Binding Affinity was tested on the high affinity site of Dopamine receptor D3 [AID64971, Type: Literature]D(3) dopamine receptor [gi:1169206]
View
27
[SID103167911]
EC50 0.065Agonist activity at human dopamine D2 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay [AID709658, Type: Literature]D(2) dopamine receptor [gi:118206]
View
28
[SID103167911]
Ki 0.072Displacement of [3H]spiperone from human wild type D3 receptor expressed in human HEK293 cells [AID388686, Type: Literature]D(3) dopamine receptor [gi:1169206]
View
29
[SID103167911]
Ki 0.11Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cells [AID733804, Type: Literature]D(2) dopamine receptor [gi:118206]
View
30
[SID103167911]
Ki 0.19Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cells [AID733806, Type: Literature]D(2) dopamine receptor [gi:118206]
View
31
[SID103167911]
Ki 0.197Displacement of [3H]raclopride from rat dopamine D2short receptor expressed in CHO-K1 cells by liquid scintillation counting [AID427139, Type: Literature]D(2) dopamine receptor [gi:47117674]
View
32
[SID103167911]
EC50 0.209Agonist activity at human cloned dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID312285, Type: Literature]D(2) dopamine receptor [gi:118206]
View
33
[SID103167911]
EC50 0.209Agonist activity at human dopamine D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID461562, Type: Literature]D(2) dopamine receptor [gi:118206]
View
34
[SID103167911]
EC50 0.209Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID513741, Type: Literature]D(2) dopamine receptor [gi:118206]
View
35
[SID103167911]
EC50 0.209Activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID425418, Type: Literature]D(2) dopamine receptor [gi:118206]
View
36
[SID103167911]
EC50 0.209Agonist activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding [AID446400, Type: Literature]D(2) dopamine receptor [gi:118206]
View
37
[SID103167911]
EC50 0.209Agonist activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID384698, Type: Literature]D(2) dopamine receptor [gi:118206]
View
38
[SID103167911]
EC50 0.227Agonist activity at human cloned dopamine D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID690845, Type: Literature]D(2) dopamine receptor [gi:118206]
View
39
[SID103167911]
EC50 0.24Agonist activity at human cloned dopamine D2 receptor expressed in CHO cells by [35S]GTP gammaS binding assay [AID712284, Type: Literature]D(2) dopamine receptor [gi:118206]
View
40
[SID103167911]
Ki 0.24Displacement of [3H]spiperone from human D3 receptor expressed in CHO cells [AID388669, Type: Literature]D(3) dopamine receptor [gi:1169206]
View
41
[SID103167911]
Ki 0.36Displacement of [3H]spiperone from human D2short receptor expressed in CHO cells [AID388668, Type: Literature]D(2) dopamine receptor [gi:118206]
View
42
[SID103167911]
Ki 0.422Displacement of [3H]YM-09151-2 from human dopamine D2 receptor expressed in CHOp cells [AID709659, Type: Literature]D(2) dopamine receptor [gi:118206]
View
43
[SID103167911]
Ki 0.45Displacement of [3H]spiperone from human D2long receptor expressed in CHO cells [AID388667, Type: Literature]D(2) dopamine receptor [gi:118206]
View
44
[SID103167911]
Ki 0.572Inhibition of [3H]raclopride binding to Dopamine receptor D2 [AID63076, Type: Literature]D(2) dopamine receptor [gi:118206]
View
45
[SID103167911]
Ki 0.617Tested for binding affinity against Dopamine receptor D2 like from bovine striatum membranes by using [3H]YM-09151-2 radioligand [AID64170, Type: Literature]D(2) dopamine receptor [gi:118205]
View
46
[SID103167911]
Ki 0.759Displacement of [3H]raclopride from human dopamine D2A receptors expressed in LtK cells [AID61613, Type: Literature]D(2) dopamine receptor [gi:118206]
View
47
[SID103167911]
Ki 0.843Competitive binding assay against Dopamine receptor D2 in rat striatal membranes and [125I]-IBF radioligand [AID65751, Type: Literature]D(2) dopamine receptor [gi:47117674]
View
48
[SID103167911]
EC50 1.425Agonist activity at rat dopamine D2short receptor expressed in CHO-K1 cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting [AID427140, Type: Literature]D(2) dopamine receptor [gi:47117674]
View
49
[SID103167911]
IC50 1.5Displacement of [3H]- -spiperone from Dopamine receptor D2 in rat striatum [AID64282, Type: Literature]D(2) dopamine receptor [gi:47117674]
View
50
[SID103167911]
Ki 1.52Inhibition of [3H]YM-09151-2 binding to bovine retina membrane Dopamine receptor D2, low affinity site [AID64173, Type: Literature]D(2) dopamine receptor [gi:118205]
View