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Morphine (CID 5288826) - Compound BioActivity Data
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Filters: All Data » Inactive      
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BioActivity Outcomes:
Inactive(20)
 
 
Top Targets:
NAD binding 8(1)
 
 
BioAssay Types:
Literature(20)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 20    Data Row: 20   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103169185]
Opioid receptor antagonist activity as inhibiting binding of normorphine to guinea pig ileum [AID79203, Type: Literature]
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2
[SID103169185]
Compound was tested in vivo for narcotic antagonist activity (dose in sc, mg/kg) in mice using tail flick antagonism assay; I =inactive at 1, 10, 30 mg/kg [AID107611, Type: Literature]
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3
[SID103169185]
Compound was administered subcutaneously and was evaluated for opioid antagonist activity (versus morphine) by tail-flick (TF) antagonism test; I denotes Inactive at 30 mg/kg [AID108541, Type: Literature]
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4
[SID103169185]
Tested for antagonistic activity using Straub tail test in mice at 20 mg/kg upon subcutaneous administration; Inactive [AID114398, Type: Literature]
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5
[SID103169185]
aAntagonistic potency of the compound; not active [AID125811, Type: Literature]
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6
[SID103169185]
Antagonist action in tail-flick antagonism vs morphine, in rhesus monkeys, compound was injected subcutaneously; Not Active [AID127299, Type: Literature]
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7
[SID103169185]
Antinociceptive activity in Kunming mouse assessed as tail withdrawal latency at 2 mg/kg, iv by hot water tail-flick test in presence of naloxone [AID730852, Type: Literature]
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8
[SID103169185]
Toxicity in mouse hind paw incision model assessed as behavioral effects at 3 mg/kg, ip [AID448139, Type: Literature]
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9
[SID103169185]
Binding affinity to MOR/alpha2A adrenergic receptor heterodimer expressed in HEK293 cells coexpressing Gi protein assessed as Gi protein activation at 100 nM [AID507152, Type: Literature]
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10
[SID103169185]
Binding affinity to MOR/alpha2A adrenergic receptor heterodimer expressed in HEK293 cells coexpressing Gi protein assessed as effect on norepinephrine-induced Gi protein activation at 100 nM [AID507153, Type: Literature]
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11
[SID103169185]
Inhibition of MOR/alpha2A adrenergic receptor heterodimer expressed in HEK293 cells assessed as stimulation of ERK1/2 phosphorylation in presence of norepinephrine [AID507158, Type: Literature]
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12
[SID103169185]
Inhibition of alpha2A adrenergic receptor heterodimer expressed in HEK293 cells assessed as change in ERK1/2 activity [AID507159, Type: Literature]
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13
[SID103169185]
Antinociceptive activity in Sprague-Dawley rat chronic constriction model assessed as reduction in Von Frey filament-induced mechanical allodynia in ipsilateral hind paw at 2 umol/kg, iv administered as bolus injection 5 mins post-naloxone coadministration [AID695731, Type: Literature]
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14
[SID103169185]
Comparison of the antinociceptive agonist/antagonist profile of activity by Tail Flick vs morphine test.(sc administration) inactive up to 30 mg/kg [AID129468, Type: Literature]
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15
[SID103169185]
Opioid antagonist activity of compound was measured as inhibiting the binding of normorphine to mouse vas deferens; None [AID138524, Type: Literature]
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16
[SID103169185]
Evaluated for inhibitory activity against Opioid receptor kappa 1 of rabbit vas deferens (RVD); Inactive [AID148433, Type: Literature]
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17
[SID103169185]
Compound was evaluated for the opioid receptor agonistic activity at dose 1-10 mg/kg by intraperitoneal administration; Inactive [AID149062, Type: Literature]
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18
[SID103169185]
Antagonistic potency was evaluated as analgesic activity in presence of nalorphine; No [AID233518, Type: Literature]
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19
[SID103169185]
Antinociceptive activity against formalin-induced pain in ddY mouse assessed as reduction of paw licking response during neurogenic phase at 20 mg/kg, ip pretreated for 10 mins before formalin challenge in presence of Naloxone [AID381219, Type: Literature]
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20
[SID103169185]
Inhibition of human brain MAOA [AID409950, Type: Literature]Amine oxidase [flavin-containing] A [gi:113978]
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