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Phenylthiourea (CID 676454) - Compound BioActivity Data
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BioActivity Outcomes:
Active(10)
 
 
Top Targets:
Tyrosinase(6)
 
 
NR LBD TR(1)
 
 
BioAssay Types:
Literature(9)
 
 
Summary(1)
 
 
BioActivity Types:
IC50(7)
 
 
Potency(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 9    Data Row: 10   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103565465]
IC50 1.5Inhibition of mushroom tyrosinase activity using L-tyrosine as substrate by spectrometric analysis [AID626570, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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2
[SID103565465]
IC50 1.8Inhibition of tyrosinase in alpha-MSH-induced mouse B16 cells [AID494974, Type: Literature]
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3
[SID103565465]
IC50 1.8Inhibition of tyrosinase [AID457969, Type: Literature]
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4
[SID103565465]
IC50 1.8Inhibition of mushroom tyrosinase [AID331282, Type: Literature]Polyphenol oxidase 2 [gi:6686057]
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5
[SID103565465]
IC50 5.4Inhibition of melanogenesis in mouse B16 cells [AID480030, Type: Literature]
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6
[SID46391587]
IC50 43Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, Catechol Oxidase From Ipomoea Batatas (Sweet Potatoes)- Inhibitor Complex With Phenylthiourea (Ptu) [gi:6137621]
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7
[SID46391587]
IC50 43Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, Catechol Oxidase From Ipomoea Batatas (Sweet Potatoes)- Inhibitor Complex With Phenylthiourea (Ptu) [gi:6137621]
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8
[SID144208880]
TR Potency (uM) 47.4909qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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9
[SID46391587]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Catechol Oxidase From Ipomoea Batatas (Sweet Potatoes)- Inhibitor Complex With Phenylthiourea (Ptu) [gi:6137621]
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10
[SID103565465]
Inhibition of tyrosinase in human HEMn-MP assessed as reduction of melanin level at 100 uM after 2 days by spectrophotometric analysis [AID492070, Type: Literature]Tyrosinase [gi:401235]
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