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Rutin (CID 5280805) - Compound BioActivity Data
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Filters: All Data » Active      
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BioActivity Outcomes:
Active(42)
 
 
Top Targets:
alkPPc(2)
 
 
Sialidase(1)
 
 
RRM eIF4H(1)
 
 
RRM1 I PABPs(1)
 
 
Pyr redox dim(1)
 
 
BioAssay Types:
Literature(26)
 
 
Confirmatory(9)
 
 
Screening(6)
 
 
BioActivity Types:
IC50(16)
 
 
Potency(5)
 
 
Ki(2)
 
 
EC50(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 42    Data Row: 42   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103516775]
Ki 0.009Binding affinity to adrenergic alpha2c receptor [AID478695, Type: Literature]
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2
[SID103516775]
Ki 0.009Binding affinity to adrenergic alpha2A receptor [AID478696, Type: Literature]
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3
[SID103516775]
IC50 1.17Antioxidant activity assessed as nitric oxide scavenging activity by fluorescent triazofluorescein formation assay [AID453282, Type: Literature]
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4
[SID103516775]
I50 1.886Inhibition of beef heart mitochondrial NADH oxidase assessed per mg of protein [AID338027, Type: Literature]
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5
[SID103516775]
IC50 2.53Antioxidant activity assessed as nitric oxide scavenging activity by spectrophotometry [AID515378, Type: Literature]
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6
[SID26719694]
Potency 3.1623qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen [AID2100, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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7
[SID103516775]
IC50 3.66Nitric oxide scavenging activity assessed as inhibition of DAF2 oxidation [AID289333, Type: Literature]
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8
[SID103516775]
ID50 7.27Inhibition of Moloney murine leukemia virus reverse transcriptase using (riboadenylic acid)n(deoxythymidylic acid)12-18 as template primer by liquid scintillation counting [AID339056, Type: Literature]
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9
[SID103516775]
ID50 7.33Inhibition of Moloney murine leukemia virus reverse transcriptase using (ribocytidylic acid)n(deoxyguanylic acid)12-18 as template primer by liquid scintillation counting [AID339057, Type: Literature]
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10
[SID26719694]
Potency 8.9125qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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11
[SID103516775]
IC50 10.6Antioxidant activity assessed as superoxide-scavenging activity by nitrite method [AID399341, Type: Literature]
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12
[SID103516775]
IC50 12.3Antioxidant activity assessed as DPPH radical scavenging activity [AID333567, Type: Literature]
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13
[SID103516775]
IC50 12.34Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins [AID356577, Type: Literature]
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14
[SID103516775]
IC50 13Inhibition of aldose reductase in rat lens homogenates by fluorophotometer [AID335838, Type: Literature]Aldose reductase [gi:1168407]
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15
[SID26719694]
Potency 14.1254qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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16
[SID29216321]
Potency 23.7781qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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17
[SID49681540]
EC50_uM 27.96Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity [AID434954, Type: confirmatory]glycogen synthase kinase-3 beta isoform 1 [Homo sapiens] [gi:21361340]
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18
[SID144205498]
Potency-Replicate_1 29.8493qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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19
[SID103516775]
IC50 30.9Inhibition of Clostridium perfringens neuraminidase [AID455702, Type: Literature]Sialidase [gi:127825]
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20
[SID103516775]
IC50 34.4Noncompetitive inhibition of recombinant influenza A virus rvH1N1 A/Bervig_Mission/1/18 neuraminidase [AID455703, Type: Literature]
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21
[SID103516775]
IC50 38.7Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by microplate reader [AID736009, Type: Literature]
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22
[SID103516775]
IC50 41.9Antiglycation activity of compound assessed as inhibition of BSA-derived advance glycated end product formation after 7 days by spectrofluorimeter [AID395278, Type: Literature]
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23
[SID103516775]
IC50 41.9Inhibition of glycation of bovine serum albumin assessed as advanced glycated end product measured after 7 days by spectrofluorimeter in presence of glucose anhydrous [AID721628, Type: Literature]Serum albumin [gi:1351907]
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24
[SID49681540]
uHTS Luminescent assay for identification of inhibitors of mouse intestinal alkaline phosphatase [AID2806, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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25
[SID49681540]
uHTS Luminescent assay for identification of inhibitors of human intestinal alkaline phosphatase [AID2544, Type: screening]Alkaline phosphatase, intestinal [Homo sapiens] [gi:124376142]
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26
[SID49681540]
HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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27
[SID103516775]
Inhibition of AMPK-mediated adipocyte differentiation in mouse 3T3L1 cells [AID517389, Type: Literature]
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28
[SID103516775]
Inhibition of PPAR-gamma-mediated adipocyte differentiation in mouse 3T3L1 cells [AID517390, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432235]
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29
[SID103516775]
Stimulation of BALB/c mouse cloned 3T3/A31 cells proliferation at 0.01 to 10 ug/mL [AID379096, Type: Literature]
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30
[SID103516775]
Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality treated with drug after 2 hrs of TNFalpha treatment [AID402483, Type: Literature]
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31
[SID103516775]
Potentiation of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality treated with drug after 2 hrs of TNFalpha treatment [AID402484, Type: Literature]
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32
[SID103516775]
Stability in phosphate buffer at pH 7.4 after 90 mins by spectrophotometry [AID441661, Type: Literature]
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33
[SID103516775]
Antioxidant activity assessed as DPPH radical scavenging activity after 20 min [AID293297, Type: Literature]
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34
[SID103516775]
IC50 Antioxidant activity assessed as inhibition of superoxide production by xanthine/xanthine oxidase method [AID293298, Type: Literature]
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35
[SID103516775]
Antioxidant activity in BALB/c mouse BM cells assessed as inhibition of ROS production [AID293299, Type: Literature]
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36
[SID48421832]
DSSTox (NCTRER) National Center for Toxicological Research Estrogen Receptor Binding Database [AID1204, Type: screening]
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37
[SID48414436]
DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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38
[SID26719694]
IC50 uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) [AID2014, Type: confirmatory]polyadenylate-binding protein 1 [Homo sapiens] [gi:46367787]
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39
[SID26719694]
IC50 uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) [AID2012, Type: confirmatory]Eukaryotic translation initiation factor 4H [Homo sapiens] [gi:45219878]
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40
[SID26719694]
QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID1822, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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41
[SID26719694]
uHTS Identification of Diaphorase Inhibitors and Chemcical Oxidizers: Counter Screen for Diaphorase-based Primary Assays [AID1217, Type: screening]Dihydrolipoamide dehydrogenase [Homo sapiens] [gi:17391426]
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42
[SID26719694]
IC50 HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. [AID1209, Type: confirmatory]MPI protein [Homo sapiens] [gi:16878311]
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