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Iodoquinol (CID 3728) - Compound BioActivity Data
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Filters: All Data » Active      
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BioActivity Outcomes:
Active(100)
 
 
Top Targets:
zf-Tim10 DDP(4)
 
 
NR LBD ROR li..(4)
 
 
M18(3)
 
 
3a0801s02tim2..(2)
 
 
zf-RanBP(2)
 
 
BioAssay Types:
Screening(43)
 
 
Confirmatory(34)
 
 
Summary(5)
 
 
Literature(1)
 
 
BioActivity Types:
Potency(25)
 
 
IC50(9)
 
 
AC50(6)
 
 
EC50(5)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 88    Data Row: 100   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID855609]
Potency 0.1995qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
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2
[SID103293005]
IC50 0.294DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) [AID625181, Type: other]Mitogen-activated protein kinase 1 [gi:119554]
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3
[SID855609]
AC50_uM 0.314Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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4
[SID26746925]
Potency 0.3548qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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5
[SID103293005]
IC50 0.364DRUGMATRIX: Protein Serine/Threonine Kinase, p38alpha enzyme inhibition (substrate: Myelin Basic Protein) [AID625182, Type: other]Mitogen-activated protein kinase 14 [gi:2499600]
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6
[SID855609]
AC50_uM 0.391HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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7
[SID855609]
EC50_MICROM 0.7Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits [AID2745, Type: confirmatory]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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8
[SID26746925]
Potency 0.7079VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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9
[SID103293005]
IC50 0.906DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) [AID625173, Type: other]Angiotensin-converting enzyme [gi:2822103]
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10
[SID103293005]
IC50 0.933DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: other]Adenosine receptor A3 [gi:1351831]
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11
[SID103293005]
IC50 1.571DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625185, Type: other]Tyrosine-protein kinase Fyn [gi:125370]
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12
[SID103293005]
IC50 1.889DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625184, Type: other]Epidermal growth factor receptor [gi:2811086]
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13
[SID103293005]
IC50 2.461DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625187, Type: other]Tyrosine-protein kinase Lck [gi:125474]
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14
[SID855609]
Potency 2.5119qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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15
[SID855609]
Potency 3.6626qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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16
[SID855609]
Potency 4.4668VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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17
[SID855609]
AC50_uM 4.87HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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18
[SID103293005]
IC50 5.264DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) [AID625180, Type: other]Mitogen-activated protein kinase 3 [gi:232066]
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19
[SID144204374]
Potency-Replicate_1 6.007qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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20
[SID855609]
EC50 7.36Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7K cells) [AID431, Type: confirmatory]
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21
[SID855609]
AC50_uM 7.46ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_Dose_CherryPick_Activity [AID651703, Type: confirmatory]transforming acidic coiled-coil-containing protein 3 [Homo sapiens] [gi:5454102]
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22
[SID855609]
AC50_uM 7.46ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_Dose_CherryPick_Activity [AID651703, Type: confirmatory]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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23
[SID855609]
Potency 7.9433qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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24
[SID104171357]
Potency 8.0875S16 Schwann cell PMP22 intronic element firefly luciferase assay [AID624032, Type: confirmatory]peripheral myelin protein 22 [Rattus norvegicus] [gi:8393992]
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25
[SID144204374]
TR Potency (uM) 8.41267qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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26
[SID103293005]
IC50 8.577DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625186, Type: other]Receptor tyrosine-protein kinase erbB-2 [gi:119533]
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27
[SID144204374]
Potency-Replicate_1 10.5909qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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28
[SID104171357]
Potency 10.691Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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29
[SID144204374]
Potency-Replicate_1 11.8832qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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30
[SID144204374]
AhR Potency (uM) 13.3332qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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31
[SID144204374]
Potency-Replicate_1 13.3332qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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32
[SID26746925]
Potency 14.1254qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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33
[SID144204374]
Ratio Potency (uM) 15.089qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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34
[SID144204374]
Ratio Potency (uM) 16.7855qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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35
[SID855609]
EC50 17.1Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7 cells) [AID430, Type: confirmatory]
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36
[SID170465640]
Potency-Replicate_1 21.13qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway [AID743215, Type: confirmatory]peroxisome proliferator-activated receptor delta [Homo sapiens] [gi:216409690]
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37
[SID170465640]
Potency-Replicate_1 21.3138qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway [AID743223, Type: confirmatory]vitamin D (1,25- dihydroxyvitamin D3) receptor [Homo sapiens] [gi:216409708]
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38
[SID144204374]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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39
[SID104171357]
Potency 35.4813Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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40
[SID855609]
AC50_uM 49.5ARNT-TACC3: counter AlphaScreen Measured in Biochemical System Using Plate Reader - 2158-02_Inhibitor_Dose_CherryPick_Activity [AID651705, Type: confirmatory]
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41
[SID855609]
Potency 50.1187qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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42
[SID26746925]
Potency 50.1187qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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43
[SID855609]
Potency 56.2341qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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44
[SID855609]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
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45
[SID855609]
Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID504621, Type: screening]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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46
[SID855609]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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47
[SID855609]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]BRCA1-associated RING domain protein 1 [gi:116241265]
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48
[SID855609]
uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504690, Type: screening]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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49
[SID855609]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID504803, Type: screening]HTRA1 protein [gi:121945198]
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50
[SID855609]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID540248, Type: other]HTRA1 protein [gi:121945198]
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