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Diflunisal (CID 3059) - Compound BioActivity Data
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Filters: All Data » Active      
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BioActivity Outcomes:
Active(37)
 
 
Top Targets:
prostaglandin..(10)
 
 
HSD10-like SD..(4)
 
 
alpha CA(2)
 
 
alpha CA I II..(2)
 
 
ALBUMIN(1)
 
 
BioAssay Types:
Literature(21)
 
 
Confirmatory(8)
 
 
Screening(3)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(7)
 
 
IC50(4)
 
 
Kd(2)
 
 
Ki(2)
 
 
EC50(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 25    Data Row: 37   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103235071]
Kd 1.16Binding affinity to human recombinant TTR Y78F mutant after 5 mins by isothermal titration calorimetry [AID1054846, Type: Literature]
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2
[SID103235071]
Kd 1.23027Binding affinity to human serum albumin by PAMPA method [AID327170, Type: Literature]Serum albumin [gi:113576]
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3
[SID103235071]
IC50 2.7Inhibition of human carbonic anhydrase 2 esterase activity by spectrophotometry [AID349141, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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4
[SID103235071]
IC50 3.38Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometry [AID349140, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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5
[SID103235071]
IC50 6.3Inhibition of transthyretin V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of sodium acetate-mediated aggregation preincubated for 30 mins followed by sodium acetate addition measured after 96 hrs by thioflavin T assay [AID1074430, Type: Literature]
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6
[SID103235071]
Ki 8.45Inhibition of human carbonic anhydrase 1 esterase activity by noncompetitive Lineweaver-Burke plot [AID349142, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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7
[SID103235071]
Ki 9.37Inhibition of human carbonic anhydrase 2 esterase activity by non-competitive Lineweaver-Burke plot [AID349145, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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8
[SID144204149]
Potency-Replicate_1 11.3588qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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9
[SID11112675]
Potency 12.5893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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10
[SID11112675]
Potency 12.5893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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11
[SID170464956]
Potency-Replicate_1 13.3322qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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12
[SID855794]
Potency 15.1014qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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13
[SID103235071]
IC50 18Inhibition of human recombinant TTR Y78F mutant-mediated fibrillogenesis after 30 mins by turbidimetric assay [AID1054848, Type: Literature]
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14
[SID855794]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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15
[SID855794]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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16
[SID170464956]
qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743199, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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17
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: Literature]Prostaglandin G/H synthase 1 [gi:317373262]
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18
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: Literature]Prostaglandin G/H synthase 1 [gi:317373262]
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19
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: Literature]Prostaglandin G/H synthase 1 [gi:317373262]
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20
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: Literature]Prostaglandin G/H synthase 1 [gi:317373262]
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