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Diflunisal (CID 3059) - Compound BioActivity Data
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Filters: All Data » Active      
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BioActivity Outcomes:
Active(26)
 
 
Top Targets:
HSD10-like SD..(4)
 
 
alpha CA I II..(4)
 
 
prostaglandin..(2)
 
 
ALBUMIN(1)
 
 
B zip1(1)
 
 
BioAssay Types:
Literature(8)
 
 
Confirmatory(8)
 
 
Screening(3)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(7)
 
 
IC50(2)
 
 
Ki(2)
 
 
EC50(1)
 
 
Kd(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 22    Data Row: 26   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103235071]
Kd 1.23027Binding affinity to human serum albumin by PAMPA method [AID327170, Type: Literature]Serum albumin [gi:113576]
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2
[SID103235071]
IC50 2.7Inhibition of human carbonic anhydrase 2 esterase activity by spectrophotometry [AID349141, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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3
[SID103235071]
IC50 3.38Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometry [AID349140, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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4
[SID103235071]
Ki 8.45Inhibition of human carbonic anhydrase 1 esterase activity by noncompetitive Lineweaver-Burke plot [AID349142, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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5
[SID103235071]
Ki 9.37Inhibition of human carbonic anhydrase 2 esterase activity by non-competitive Lineweaver-Burke plot [AID349145, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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6
[SID144204149]
Potency-Replicate_1 11.3588qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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7
[SID11112675]
Potency 12.5893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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8
[SID11112675]
Potency 12.5893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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9
[SID170464956]
Potency-Replicate_1 13.3322qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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10
[SID855794]
Potency 15.1014qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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11
[SID855794]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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12
[SID855794]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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13
[SID855794]
HTS to identify Inhibitors of West Nile Virus NS2bNS3 Proteinase [AID577, Type: screening]unnamed protein product [West Nile virus] [gi:11528014]
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14
[SID855794]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7K cells) [AID431, Type: confirmatory]
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15
[SID103235071]
Inhibition of TNF-alpha-induced NF-kappaB activation in human HCT116 cells at 1 mM after 6 hrs by luciferase reporter gene assay [AID639952, Type: Literature]
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16
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: other]Prostaglandin G/H synthase 2 [gi:3915797]
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17
[SID103235071]
Cyclooxygenase inhibitor [AID742498, Type: other]Prostaglandin G/H synthase 1 [gi:317373262]
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18
[SID170464956]
qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743199, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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19
[SID855794]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Retesting of KCC2 cells with Ouabain [AID1717, Type: other]
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20
[SID855794]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Secondary Assay 2 with KCC2 cells [AID1715, Type: other]electroneutral potassium-chloride cotransporter KCC2 [Homo sapiens] [gi:12003227]
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21
[SID855794]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Primary Screen [AID1456, Type: other]electroneutral potassium-chloride cotransporter KCC2 [Homo sapiens] [gi:12003227]
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22
[SID855794]
HTS to identify compounds that promote myeloid differentiation with Validation compound set [AID588685, Type: screening] [geneid:3205]
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23
[SID855794]
Phenotypic HTS multiplex for antifungal efflux pump inhibitors with Validation compound Set [AID588506, Type: screening]
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24
[SID48415892]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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25
[SID103235071]
The first dissociation constant for binding to WT TTR determined by isothermal titration calorimetry (25 C, pH 8.0) [AID210956, Type: Literature]
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26
[SID103235071]
The second dissociation constant for binding to WT TTR determined by isothermal titration calorimetry (25 C, pH 8.0) [AID210957, Type: Literature]
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