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Acetylcholine (CID 187) - Compound BioActivity Data
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Filters: All Data » Ki      
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BioActivity Outcomes:
Active(34)
 
 
Inconclusive(2)
 
 
Unspecified(2)
 
 
Top Targets:
Neur chan LBD(33)
 
 
 
 
7TM GPCR Srsx(1)
 
 
BioAssay Types:
Literature(38)
 
 
 
 
BioActivity Types:
Ki(38)
 
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 25    Data Row: 38   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234160]
Ki 0.0076Displacement of [3H]-cytisine from Alpha4-beta2 Nicotinic acetylcholine receptor of rat brain homogenates [AID239589, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
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2
[SID104234160]
Ki 0.0076Displacement of [3H]-cytisine from Alpha4-beta2 Nicotinic acetylcholine receptor of rat brain homogenates [AID239589, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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3
[SID104234160]
Ki 0.011Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID145983, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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4
[SID104234160]
Ki 0.011Binding affinity towards rat nicotinic acetylcholine receptor alpha2-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID145983, Type: Literature]Neuronal acetylcholine receptor subunit alpha-2 [gi:2851491]
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5
[SID104234160]
Ki 0.033Displacement of [3H]epibatidine from rat recombinant alpha4beta2 nAChR expressed in HEK293 cells after 4 hrs by scintillation counting analysis [AID724038, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
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6
[SID104234160]
Ki 0.033Displacement of [3H]epibatidine from rat recombinant alpha4beta2 nAChR expressed in HEK293 cells after 4 hrs by scintillation counting analysis [AID724038, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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7
[SID104234160]
Ki 0.0377Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrs [AID536863, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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8
[SID104234160]
Ki 0.0377Displacement of [3H]epibatidine from rat alpha4beta2 nAChR expressed in HEK292 cells after 3 hrs [AID536863, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
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9
[SID104234160]
Ki 0.039Displacement of [3H]cystisine from nicotinic alpha-4-beta-2 receptor in rat brain [AID320061, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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10
[SID104234160]
Ki 0.039Displacement of [3H]cystisine from nicotinic alpha-4-beta-2 receptor in rat brain [AID320061, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
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11
[SID104234160]
Ki 0.041Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID146006, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:113061]
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12
[SID104234160]
Ki 0.041Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID146006, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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13
[SID104234160]
Ki 0.043Binding affinity towards rat forebrain nicotinic acetylcholine receptor using [3H]EB as radioligand [AID145685, Type: Literature]
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14
[SID104234160]
Ki 0.045Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID146486, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
View
15
[SID104234160]
Ki 0.045Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK293 cells using [3H]EB as radioligand [AID146486, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
View
16
[SID104234160]
Ki 0.058Displacement of [3H]epibatidine from rat recombinant alpha4beta4 nAChR expressed in HEK293 cells after 4 hrs by scintillation counting analysis [AID724035, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:113111]
View
17
[SID104234160]
Ki 0.058Displacement of [3H]epibatidine from rat recombinant alpha4beta4 nAChR expressed in HEK293 cells after 4 hrs by scintillation counting analysis [AID724035, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
View
18
[SID104234160]
Ki 0.083Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in HEK293 cells using [3H]EB as radioligand [AID146772, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
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19
[SID104234160]
Ki 0.083Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in HEK293 cells using [3H]EB as radioligand [AID146772, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:113111]
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20
[SID104234160]
Ki 0.085Displacement of [3H]oxotremorine from muscarinic receptor in rat brain [AID320063, Type: Literature]
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21
[SID104234160]
Ki 0.18Binding affinity towards rat alpha2-beta4 nACh receptor expressed in HEK293 cells using [3H]EB as radioligand [AID225720, Type: Literature]
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22
[SID104234160]
Ki 0.62Displacement of [3H]epibatidine from rat recombinant alpha3beta4 nAChR expressed in HEK293 cells after 4 hrs by scintillation counting analysis [AID724036, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:113061]
View
23
[SID104234160]
Ki 0.62Displacement of [3H]epibatidine from rat recombinant alpha3beta4 nAChR expressed in HEK293 cells after 4 hrs by scintillation counting analysis [AID724036, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:113111]
View
24
[SID104234160]
Ki 0.62Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrs [AID536862, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:113061]
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25
[SID104234160]
Ki 0.62Displacement of [3H]epibatidine from rat alpha3beta4 nAChR expressed in HEK292 cells after 3 hrs [AID536862, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:113111]
View
26
[SID104234160]
Ki 0.82Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in HEK293 cells using [3H]EB as radioligand [AID146162, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:113061]
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27
[SID104234160]
Ki 0.82Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in HEK293 cells using [3H]EB as radioligand [AID146162, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:113111]
View
28
[SID104234160]
Ki 0.881Displacement of [3H]epibatidine from Alpha3 Beta4 Nicotinic acetylcholine receptor of rat brain homogenates [AID239611, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:113111]
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29
[SID104234160]
Ki 0.881Displacement of [3H]epibatidine from Alpha3 Beta4 Nicotinic acetylcholine receptor of rat brain homogenates [AID239611, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:113061]
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30
[SID104234160]
Ki 3.16228Displacement of [125I]alpha-bungarotoxin from Lymnaea stagnalis His-tagged AchBP [AID415528, Type: Literature]Acetylcholine-binding protein [gi:14285341]
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31
[SID104234160]
Ki 3.509Displacement of [3H]alpha-bungaro-toxine from nicotinic alpha-7 receptor in rat brain [AID320062, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:146345356]
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32
[SID104234160]
Ki 6.30957Displacement of [3H]-epibatidine from histidine-tagged Lymnaea stagnalis AChBP expressed in Sf9 cells after 1.5 hrs by liquid scintillation counting [AID620032, Type: Literature]Acetylcholine-binding protein [gi:14285341]
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33
[SID104234160]
Ki 7.94328Displacement of [3H]-MLA from human alpha7 nAChR expressed in human SH-SY5Y cells after 1.5 hrs by liquid scintillation counting [AID620034, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
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34
[SID104234160]
Ki Agonist activity at rat alpha-3-beta-4 nAChR expressed in HEK293 cells by FMP assay [AID346671, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:113061]
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35
[SID104234160]
Ki 50.1187Displacement of [3H]epibatidine from histidine-tagged Aplysia californica AChBP expressed in Sf9 cells after 1.5 hrs by liquid scintillation counting [AID620033, Type: Literature]
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36
[SID104234160]
Ki 170Displacement of [3H]MLA from rat nAChR alpha7 linked to ion channel portion of 5-HT3A receptor expressed in human tsA-201 cells after 2.5 hrs by scintillation counting analysis [AID724037, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:146345356]
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37
[SID104234160]
Ki Displacement of [3H]raclopride from human D2L receptor expressed in CHO cells after 60 mins by scintillation proximity assay [AID672168, Type: Literature]D(2) dopamine receptor [gi:118206]
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38
[SID104234160]
Ki Displacement of [3H]epibatidine from Lymnaea stagnalis AChBP linked to ion channel portion of 5-HT3A receptor expressed in HEK293 cells after 4 hrs by scintillation counting analysis [AID724039, Type: Literature]Acetylcholine-binding protein [gi:14285341]
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