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Glycine (CID 750) - Compound BioActivity Data
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Filters: All Data » IC50      
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BioActivity Outcomes:
Active(10)
 
 
Inconclusive(5)
 
 
Unspecified(122)
 
 
Top Targets:
7tm 4(30)
 
 
p450(7)
 
 
Neur chan LBD(3)
 
 
 
prostaglandin..(2)
 
 
NR LBD ER(2)
 
 
BioAssay Types:
Confirmatory(116)
 
 
Literature(21)
 
 
 
 
BioActivity Types:
IC50(137)
 
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 137    Data Row: 137   Total Pages: 7   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103204298]
IC50 0.086Tested for binding affinity against NMDA receptor, from rat synaptic membrane, using [3H]glycine as the radioligand. [AID143072, Type: Literature]
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2
[SID103204298]
IC50 0.2In vitro inhibition of [3H]glycine at NMDA receptor [AID145260, Type: Literature]
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3
[SID103204298]
IC50 0.223Inhibition of rat glutamate receptor [AID566258, Type: Literature]
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4
[SID103204298]
IC50 0.25In vitro inhibitory activity to inhibit [3H]glycine binding to NMDA receptor [AID143065, Type: Literature]
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5
[SID103204298]
IC50 0.69Binding affinity against glycine binding site associated with N-methyl-D-aspartate glutamate receptor of rat synaptic plasma membrane(SPM) determined using [3H]glycine as radioligand. [AID144598, Type: Literature]
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6
[SID103204298]
IC50 6Inhibition of binding of [3H]strychnine to glycine receptor in rat [AID143467, Type: Literature]
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7
[SID103204298]
IC50 6.2Inhibitory concentration required to inhibit [3H]strychnine binding to N-methyl-D-aspartate glutamate receptor 1 [AID143614, Type: Literature]
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8
[SID103204298]
IC50 15.8Displacement of [3H]strychnine from strychnine-sensitive glycine receptor in rat spinal cord [AID270051, Type: Literature]
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9
[SID103204298]
IC50 15.8Displacement of [3H]strychnine from glycine receptor in rat spinal cord synaptosomal membranes [AID286349, Type: Literature]
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10
[SID103204298]
IC50 31.6Inhibition of GlyT1 (unknown origin) assessed as inhibition of [14C]glycine uptake [AID1070046, Type: Literature]Sodium- and chloride-dependent glycine transporter 1 [gi:302393807]
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11
[SID103204298]
IC50 1348.96Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cells [AID595475, Type: Literature]Sodium- and chloride-dependent GABA transporter 3 [gi:341942004]
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12
[SID103204298]
IC50 2238.72Inhibition of mouse GAT2-mediated [3H]GABA uptake expressed in human HEK cells [AID595474, Type: Literature]Sodium- and chloride-dependent GABA transporter 2 [gi:400623]
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13
[SID103204298]
IC50 3090.3Inhibition of mouse GAT4-mediated [3H]GABA uptake expressed in human HEK cells [AID595476, Type: Literature]
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14
[SID103204298]
IC50 50000Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay [AID695876, Type: Literature]
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15
[SID103204298]
IC50 50000Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay [AID695877, Type: Literature]
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16
[SID103204298]
IC50 Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay [AID297971, Type: Literature]Glycine receptor subunit alpha-1 [gi:116242495]
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17
[SID103204298]
IC50 DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) [AID625144, Type: confirmatory]Leukotriene C4 synthase [gi:239977155]
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18
[SID103204298]
IC50 DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) [AID625145, Type: confirmatory]Cysteinyl leukotriene receptor 1 [gi:20138087]
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19
[SID103204298]
IC50 DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) [AID625146, Type: confirmatory]Arachidonate 15-lipoxygenase [gi:126397]
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20
[SID103204298]
IC50 DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) [AID625147, Type: confirmatory]Melanocortin receptor 3 [gi:395398606]
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