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Glycine (CID 750) - Compound BioActivity Data
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Filters: All Data » IC50      
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BioActivity Outcomes:
Active(9)
 
 
Inconclusive(5)
 
 
Unspecified(122)
 
 
Top Targets:
7TM GPCR Srx(16)
 
 
7TM GPCR Srsx(15)
 
 
p450(7)
 
 
Neur chan LBD(3)
 
 
 
prostaglandin..(2)
 
 
BioAssay Types:
Literature(20)
 
 
 
 
BioActivity Types:
IC50(136)
 
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 136    Data Row: 136   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103204298]
IC50 0.086Tested for binding affinity against NMDA receptor, from rat synaptic membrane, using [3H]glycine as the radioligand. [AID143072, Type: Literature]
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2
[SID103204298]
IC50 0.2In vitro inhibition of [3H]glycine at NMDA receptor [AID145260, Type: Literature]
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3
[SID103204298]
IC50 0.223Inhibition of rat glutamate receptor [AID566258, Type: Literature]
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4
[SID103204298]
IC50 0.25In vitro inhibitory activity to inhibit [3H]glycine binding to NMDA receptor [AID143065, Type: Literature]
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5
[SID103204298]
IC50 0.69Binding affinity against glycine binding site associated with N-methyl-D-aspartate glutamate receptor of rat synaptic plasma membrane(SPM) determined using [3H]glycine as radioligand. [AID144598, Type: Literature]
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6
[SID103204298]
IC50 6Inhibition of binding of [3H]strychnine to glycine receptor in rat [AID143467, Type: Literature]
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7
[SID103204298]
IC50 6.2Inhibitory concentration required to inhibit [3H]strychnine binding to N-methyl-D-aspartate glutamate receptor 1 [AID143614, Type: Literature]
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8
[SID103204298]
IC50 15.8Displacement of [3H]strychnine from strychnine-sensitive glycine receptor in rat spinal cord [AID270051, Type: Literature]
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9
[SID103204298]
IC50 15.8Displacement of [3H]strychnine from glycine receptor in rat spinal cord synaptosomal membranes [AID286349, Type: Literature]
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10
[SID103204298]
IC50 1348.96Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cells [AID595475, Type: Literature]Sodium- and chloride-dependent GABA transporter 3 [gi:341942004]
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11
[SID103204298]
IC50 2238.72Inhibition of mouse GAT2-mediated [3H]GABA uptake expressed in human HEK cells [AID595474, Type: Literature]Sodium- and chloride-dependent GABA transporter 2 [gi:400623]
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12
[SID103204298]
IC50 3090.3Inhibition of mouse GAT4-mediated [3H]GABA uptake expressed in human HEK cells [AID595476, Type: Literature]
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13
[SID103204298]
IC50 50000Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay [AID695877, Type: Literature]
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14
[SID103204298]
IC50 50000Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay [AID695876, Type: Literature]
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15
[SID103204298]
IC50 DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) [AID625225, Type: other]
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16
[SID103204298]
IC50 DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: other]
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17
[SID103204298]
IC50 DRUGMATRIX: GABAA, Muscimol, Central radioligand binding (ligand: [3H] Muscimol) [AID625260, Type: other]
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18
[SID103204298]
IC50 DRUGMATRIX: GABAA, Flunitrazepam, Central radioligand binding (ligand: [3H] Flunitrazepam) [AID625261, Type: other]
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19
[SID103204298]
IC50 DRUGMATRIX: GABAA, Chloride Channel, TBOB radioligand binding (ligand: [3H] TBOB) [AID625262, Type: other]
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20
[SID103204298]
IC50 DRUGMATRIX: Glutamate, AMPA radioligand binding (ligand: [3H] AMPA) [AID625264, Type: other]
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21
[SID103204298]
IC50 DRUGMATRIX: ATPase, Na+/K+ enzyme inhibition (substrate: ATP) [AID625210, Type: other]
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22
[SID103204298]
IC50 DRUGMATRIX: beta-Lactamase enzyme inhibition (substrate: Nitrocefin) [AID625212, Type: other]
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23
[SID103204298]
IC50 DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) [AID625215, Type: other]
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24
[SID103204298]
IC50 DRUGMATRIX: Calcium Channel Type L, Dihydropyridine radioligand binding (ligand: [3H] Nitrendipine) [AID625216, Type: other]
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25
[SID103204298]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT3 radioligand binding (ligand: [3H] GR-65630) [AID625219, Type: other]
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26
[SID103204298]
IC50 DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil) [AID625224, Type: other]
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27
[SID103204298]
IC50 DRUGMATRIX: Nicotinic Acetylcholine radioligand binding (ligand: [125I] Epibatidine) [AID625158, Type: other]
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28
[SID103204298]
IC50 DRUGMATRIX: Phosphodiesterase PDE3 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625165, Type: other]
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29
[SID103204298]
IC50 DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625166, Type: other]
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30
[SID103204298]
IC50 DRUGMATRIX: Potassium Channel [KATP] radioligand binding (ligand: [3H] Glyburide) [AID625170, Type: other]
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31
[SID103204298]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) [AID625190, Type: other]
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32
[SID103204298]
IC50 DRUGMATRIX: Sodium/nucleoside co-transporter radioligand binding (ligand: nitrobenzylthioinosine) [AID625197, Type: other]
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33
[SID103204298]
IC50 DRUGMATRIX: Glutamate, NMDA, Agonism radioligand binding (ligand: [3H] CGP-39653) [AID625266, Type: other]
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34
[SID103204298]
IC50 DRUGMATRIX: Glutamate, NMDA, Phencyclidine radioligand binding (ligand: [3H] TCP) [AID625267, Type: other]
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35
[SID103204298]
IC50 DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) [AID625268, Type: other]
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36
[SID103204298]
IC50 DRUGMATRIX: Imidazoline I2, Central radioligand binding (ligand: [3H] Idazoxan) [AID625272, Type: other]
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37
[SID103204298]
IC50 DRUGMATRIX: Leukotriene, BLT (LTB4) radioligand binding (ligand: [3H]LTB4) [AID625275, Type: other]
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38
[SID103204298]
IC50 DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) [AID625147, Type: other]Melanocortin receptor 3 [gi:395398606]
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39
[SID103204298]
IC50 DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) [AID625172, Type: other]Progesterone receptor [gi:75071465]
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40
[SID103204298]
IC50 DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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41
[SID103204298]
IC50 DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: other]Alpha-1D adrenergic receptor [gi:1168244]
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42
[SID103204298]
IC50 DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) [AID625208, Type: other]Aldose reductase [gi:1168407]
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43
[SID103204298]
IC50 DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) [AID625237, Type: other]C-C chemokine receptor type 2 [gi:1168965]
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44
[SID103204298]
IC50 DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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45
[SID103204298]
IC50 DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) [AID625144, Type: other]Leukotriene C4 synthase [gi:239977155]
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46
[SID103204298]
IC50 DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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47
[SID103204298]
IC50 DRUGMATRIX: Cholecystokinin CCKA radioligand binding (ligand: [3H] L-364,718) [AID625242, Type: other]Cholecystokinin receptor type A [gi:416772]
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48
[SID103204298]
IC50 DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) [AID625206, Type: other]Beta-3 adrenergic receptor [gi:461604]
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49
[SID103204298]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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50
[SID103204298]
IC50 DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
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