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Dopamine (CID 681) - Compound BioActivity Data
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Filters: All Data » IC50      
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BioActivity Outcomes:
Active(40)
 
 
Inconclusive(16)
 
 
Unspecified(11)
 
 
Top Targets:
7TM GPCR Srsx(6)
 
 
7TM GPCR Srx(5)
 
 
MFS(4)
 
 
Herpes DNAp a..(2)
 
 
SLC6sbd DAT1(2)
 
 
BioAssay Types:
Literature(60)
 
 
 
 
BioActivity Types:
IC50(67)
 
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 59    Data Row: 67   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103167911]
IC50 8e-09Agonist required to inhibit Dopamine receptor D2 photoinactivation by 50% with Iodazidoclebopride using [3H]-Spiperone [AID62635, Type: Literature]
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2
[SID103167911]
IC50 0.002Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTN [AID196429, Type: Literature]D(3) dopamine receptor [gi:118211]
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3
[SID103167911]
IC50 0.002Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTN [AID196429, Type: Literature]D(1A) dopamine receptor [gi:118229]
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4
[SID103167911]
IC50 0.002Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTN [AID196429, Type: Literature]D(1B) dopamine receptor [gi:118251]
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5
[SID103167911]
IC50 0.002Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTN [AID196429, Type: Literature]D(4) dopamine receptor [gi:6226851]
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6
[SID103167911]
IC50 0.002Inhibitory concentration half-maximal displacement of 1.0 nM [3H]NPA specific binding from rat striatal membranes using 10e-5 (+/-)ADTN [AID196429, Type: Literature]D(2) dopamine receptor [gi:47117674]
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7
[SID103167911]
IC50 0.0021Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpiride [AID196428, Type: Literature]D(1A) dopamine receptor [gi:118229]
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8
[SID103167911]
IC50 0.0021Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpiride [AID196428, Type: Literature]D(4) dopamine receptor [gi:6226851]
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9
[SID103167911]
IC50 0.0021Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpiride [AID196428, Type: Literature]D(1B) dopamine receptor [gi:118251]
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10
[SID103167911]
IC50 0.0021Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpiride [AID196428, Type: Literature]D(3) dopamine receptor [gi:118211]
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11
[SID103167911]
IC50 0.0021Inhibitory concentration for half-maximal displacement of 1.0 nM [3H]ADTN specific binding from rat striatal membranes using 10E-5 sulpiride [AID196428, Type: Literature]D(2) dopamine receptor [gi:47117674]
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12
[SID103167911]
IC50 0.0037Tested for binding to dopamine receptor using [3H]- ADTN as radioligand in calf caudate nucleus homogenates. [AID62451, Type: Literature]
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13
[SID103167911]
IC50 0.0045Tested for binding to dopamine receptor using [3H]apomorphine as radioligand in calf caudate nucleus homogenates. [AID62452, Type: Literature]
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14
[SID103167911]
IC50 0.00663Inhibition of [3H]norepinephrine uptake in HEK cells expressing human NET [AID145556, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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15
[SID103167911]
IC50 0.015The IC50 value was reported as apparent, since [3H]NCA was purported to be irreversible. Result indicates the mean of two separate experiments, each performed in triplicate. [AID62573, Type: Literature]
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16
[SID103167911]
IC50 0.029Compound concentration required to reduce specific binding of tritiated dopamine to rat brain striatal membrane by 50 % was reported [AID195878, Type: Literature]
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17
[SID103167911]
IC50 0.061Concentration that produces 50 % displacement of specific [3H]clonidine binding to Alpha adrenergic receptor in rat brain cortical membrane preparations. [AID33127, Type: Literature]
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18
[SID103167911]
IC50 0.064Inhibition of [3H]dopamine binding to Dopamine receptor in calf caudate nuclei. [AID62445, Type: Literature]
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19
[SID103167911]
IC50 0.2In vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand [AID61147, Type: other]
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20
[SID103167911]
IC50 0.2Inhibition of dopamine transporter-mediated [3H]dopamine uptake in Wistar rat striatal synaptosomes by liquid scintillation spectrometry [AID359909, Type: Literature]Sodium-dependent dopamine transporter [gi:128613]
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21
[SID103167911]
IC50 0.46Inhibition of [3H]dopamine uptake in HEK cells expressing human DAT [AID63033, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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22
[SID103167911]
IC50 0.51Inhibitory binding activity against dopamine receptor using [3H]ADTN as the radioligand in striatal tissue of calf brain. [AID62448, Type: Literature]
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23
[SID103167911]
IC50 0.8Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum [AID63370, Type: Literature]D(1A) dopamine receptor [gi:118229]
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24
[SID103167911]
IC50 1.2Compound was for its ability to displace [3H]haloperidol binding to rat striatal Dopamine receptor D2 [AID61560, Type: Literature]
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25
[SID103167911]
IC50 1.5Displacement of [3H]- -spiperone from Dopamine receptor D2 in rat striatum [AID64282, Type: Literature]D(2) dopamine receptor [gi:47117674]
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26
[SID103167911]
IC50 1.7Inhibition of [3H]haloperidol binding to Dopamine receptor in calf caudate nuclei. [AID62446, Type: Literature]
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27
[SID103167911]
IC50 1.7Inhibition of [3H](S)-sulpiride binding in striatal homogenates of rat brain [AID64439, Type: Literature]
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28
[SID103167911]
IC50 1.86Inhibition of 0.1 nM of [125I]- (S)-N-(1-Ethyl-pyrrolidin-2-ylmethyl)-5-iodo-2-methoxy-benzamide binding in striatal homogenates of rat brain [AID64438, Type: Literature]
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29
[SID103167911]
IC50 2.2Compound was evaluated for the inhibition of [3H]spiperone binding to Dopamine receptor D2 of rat striatal membranes [AID61554, Type: Literature]
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30
[SID103167911]
IC50 3Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes [AID61036, Type: Literature]
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31
[SID103167911]
IC50 3.045Ability to inhibit the specific binding of [3H]- dihydromorphine to opiate receptors in rat brain membrane preparation by 50% [AID145934, Type: Literature]
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32
[SID103167911]
IC50 3.045Neuroleptic activity in terms of [3H]spiroperidol binding in rat striatal membrane to Dopamine receptor D2 [AID64600, Type: Literature]
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33
[SID103167911]
IC50 3.5Inhibitory activity against [3H]spiperone in Rat Striatal membrane [AID64460, Type: Literature]
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34
[SID103167911]
IC50 3.7Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane [AID61192, Type: Literature]
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35
[SID103167911]
IC50 4.7Displacement of [3H]spiroperidol from homogenized bovine pituitary Dopamine receptor D2 [AID62165, Type: Literature]D(2) dopamine receptor [gi:118205]
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36
[SID103167911]
IC50 5Stimulation of Adenylate cyclase from rat striatal membranes [AID34315, Type: Literature]
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37
[SID103167911]
IC50 5.34Tested for Dopamine receptor activity by the inhibition against spiroperidol binding to rat caudate tissue. [AID62878, Type: Literature]
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38
[SID103167911]
IC50 5.34Concentration that produces 50 % displacement of specific [3H]spiroperidol binding to rat caudate membrane preparations. [AID64279, Type: Literature]
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39
[SID103167911]
IC50 8In vitro binding affinity towards Dopamine D2 receptor using [3H]spiperone as radioligand [AID61305, Type: other]
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40
[SID103167911]
IC50 10Compound concentration that causes inhibition of [3H]-acetyl choline release by 50% was determined using reserpine-alpha MPT treated mice striatal slices [AID132337, Type: Literature]
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41
[SID103167911]
IC50 10Tested for binding to dopamine receptor using [3H]spiroperidol as radioligand in calf caudate nucleus homogenates. [AID62453, Type: Literature]
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42
[SID103167911]
IC50 30Inhibition of [3H]5-HT uptake in HEK cells expressing human SERT [AID6428, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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43
[SID103167911]
IC50 62TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in OCT3-expressing HRPE cells [AID682029, Type: other]Solute carrier family 22 member 3 [gi:24212062]
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44
[SID103167911]
IC50 90Ability to displace [3H]WB-4101 from rat brain alpha-1 adrenergic receptor [AID36587, Type: Literature]
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45
[SID103167911]
IC50 100Inhibition of soybean lipoxygenase [AID548956, Type: Literature]
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46
[SID103167911]
IC50 100Inhibition of peptide EPQ (pY) EEIPI binding to Fyn protein kinase SH2 domain at 100 uM (no inhibition) [AID72275, Type: other]
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47
[SID103167911]
IC50 150Inhibitory binding activity against dopamine receptor using [3H]spiperone as the radioligand in striatal tissue of calf brain. [AID62450, Type: Literature]
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48
[SID103167911]
IC50 300Inhibition of CMG2 (40 to 217) C175A and R40C double mutant (unknown origin) interaction to full length PA E733C mutant expressed in Escherichia coli by FRET assay [AID725981, Type: Literature]
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49
[SID103167911]
IC50 384TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM) in OCT3-expressing HRPE cells [AID678784, Type: other]Solute carrier family 22 member 3 [gi:24212062]
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50
[SID103167911]
IC50 2300TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM) in OCT2-expressing HRPE cells [AID681591, Type: other]Solute carrier family 22 member 2 [gi:81872789]
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