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Estradiol (CID 5757) - Compound BioActivity Data
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Filters: All Data » IC50      
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BioActivity Outcomes:
Active(136)
 
 
Inactive(43)
 
 
Inconclusive(21)
 
 
Unspecified(118)
 
 
Top Targets:
NR LBD ER(88)
 
 
 
 
7TM GPCR Srx(16)
 
 
 
7TM GPCR Srsx(15)
 
 
p450(7)
 
 
MFS(5)
 
 
BioAssay Types:
Literature(161)
 
 
 
 
 
Confirmatory(157)
 
 
 
 
BioActivity Types:
IC50(318)
 
 
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 307    Data Row: 318   Total Pages: 16   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103189263]
IC50 1e-05In vitro inhibition of estrogen-stimulated MCF-7 cell proliferation [AID102598, Type: Literature]Estrogen receptor [gi:544257]
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2
[SID103189263]
IC50 1e-05In vitro inhibition of estrogen-stimulated MCF-7 cell proliferation [AID102598, Type: Literature]Estrogen receptor beta [gi:6166154]
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3
[SID103189263]
IC50 4.6e-05Antagonist activity at ERbeta (unknown origin) by cell-based assay [AID1061128, Type: Literature]Estrogen receptor beta [gi:6166154]
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4
[SID103189263]
IC50 0.0001Inhibition of chemoattractant-induced cell migration of human SK-BR-3 cells after 48 hrs by transwell migration assay [AID503166, Type: Literature]
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5
[SID103189263]
IC50 0.00032Effect on estradiol-stimulated MCF-7 cell proliferation [AID101612, Type: Literature]
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6
[SID103189263]
IC50 0.000354Inhibition of estradiol binding to estrogen receptor [AID69383, Type: Literature]Estrogen receptor [gi:119600]
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7
[SID103189263]
IC50 0.000354Inhibition of estradiol binding to estrogen receptor [AID69383, Type: Literature]Estrogen receptor beta [gi:6166156]
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8
[SID103189263]
IC50 0.0004Inhibition of chemoattractant-induced cell migration of human MCF7 cells after 48 hrs by transwell migration assay [AID503167, Type: Literature]
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9
[SID103189263]
IC50 0.0005Displacement of [3H]17-beta-estradiol from Estrogen receptor of rabbit uterine tissue [AID69240, Type: Literature]
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10
[SID103189263]
IC50 0.00057Binding affinity to estrogen receptor-alpha after 2 hrs by TR-FRET assay [AID614197, Type: Literature]
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11
[SID103189263]
IC50 0.0007Inhibitory activity against Estrogen receptor by displacement of [3H]17-beta-estradiol in ER-rich cytosol from rabbit uterine tissue [AID69241, Type: Literature]
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12
[SID103189263]
IC50 0.0007Binding affinity for estrogen receptor of rabbit uterine skeletal muscle tissue [AID69242, Type: Literature]
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13
[SID103189263]
IC50 0.00075Displacement of [3H]17beta-estradiol from recombinant human ERalpha expressed in 293T cells [AID257299, Type: Literature]Estrogen receptor [gi:544257]
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14
[SID103189263]
IC50 0.001Displacement of [3H]estradiol from full length human recombinant ERalpha after 3 hrs by scintillation proximity assay [AID306462, Type: Literature]Estrogen receptor [gi:544257]
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15
[SID103189263]
IC50 0.001Displacement of [3H]estradiol from full length human recombinant ERbeta after 3 hrs by scintillation proximity assay [AID306463, Type: Literature]Estrogen receptor beta [gi:6166154]
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16
[SID103189263]
IC50 0.0011Binding affinity for human estrogen receptor beta [AID70516, Type: Literature]Estrogen receptor beta [gi:6166154]
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17
[SID103189263]
IC50 0.0011Binding affinity for human estrogen receptor beta [AID70517, Type: Literature]Estrogen receptor beta [gi:6166154]
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18
[SID103189263]
IC50 0.0011Inhibition of binding to recombinant human estrogen receptor beta [AID241865, Type: Literature]Estrogen receptor beta [gi:6166154]
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19
[SID103189263]
IC50 0.0011Inhibition of estrogen receptor beta [AID241337, Type: Literature]Estrogen receptor beta [gi:6166154]
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20
[SID103189263]
IC50 0.0011Binding affinity for human estrogen receptor beta [AID240821, Type: Literature]Estrogen receptor beta [gi:6166154]
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