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imatinib (CID 5291) - Compound BioActivity Data
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Filters: All Data » IC50      
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BioActivity Outcomes:
Active(293)
 
 
Inconclusive(6)
 
 
Unspecified(472)
 
 
Top Targets:
7tm 4(30)
 
 
 
PTKc Abl(19)
 
 
PTKc Kit(9)
 
 
RhoGAP Bcr(7)
 
 
p450(7)
 
 
 
BioAssay Types:
Confirmatory(485)
 
 
 
Literature(286)
 
 
 
 
BioActivity Types:
IC50(771)
 
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 758    Data Row: 771   Total Pages: 39   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103245522]
IC50 0.0002Cytotoxicity against human EOL-1 cells after 72 hrs by alamar-blue cell viability assay [AID414750, Type: Literature]
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2
[SID103245522]
IC50 0.0011Inhibition of wild type Bcr-Abl [AID463630, Type: Literature]
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3
[SID103245522]
IC50 0.002Inhibition of PDGFRA (unknown origin) [AID767455, Type: Literature]Platelet-derived growth factor receptor alpha [gi:129892]
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4
[SID103245522]
IC50 0.00605Antiproliferative activity against human imatinib-resistant K562 cells [AID590031, Type: Literature]
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5
[SID103245522]
IC50 0.0108Inhibition of mouse recombinant N-terminal His6-tagged Abl by radiometric kinase assay [AID497611, Type: Literature]Tyrosine-protein kinase ABL1 [gi:59802613]
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6
[SID103245522]
IC50 0.013Cytotoxicity against human TF1 cells expressing c-KIT mutation assessed as cell viability [AID649625, Type: Literature]
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7
[SID103245522]
IC50 0.018Inhibition of PDGFRalpha by TR-FRET assay [AID407646, Type: Literature]
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8
[SID103245522]
IC50 0.0199Inhibition of human wild-type ABL (Ser229 to Gln513)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) preincubated for 30 to 60 mins prior to substrate addition by TR-FRET assay [AID759168, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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9
[SID103245522]
IC50 0.0216Inhibition of wild-type cKIT (unknown origin)-mediated phosphorylation of biotinylated poly-Glu-Tyr preincubated for 30 to 60 mins prior to substrate addition by TR-FRET assay [AID759167, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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10
[SID103245522]
IC50 0.027Antiproliferative activity against mouse BA/F3 Bcr-abl negative cells expressing Tel-PDGFRbeta kinase assessed as proliferation after 48 hrs by MTT assay [AID512773, Type: Literature]
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11
[SID103245522]
IC50 0.038Inhibition of v-Abl tyrosine kinase. [AID228823, Type: confirmatory]
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12
[SID103245522]
IC50 0.038Inhibitory concentration against v-Abl tyrosine kinase [AID254706, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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13
[SID103245522]
IC50 0.03802Inhibition of BCR-ABL kinase (unknown origin) [AID743664, Type: Literature]Breakpoint cluster region protein [gi:143811366]
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14
[SID103245522]
IC50 0.03802Inhibition of BCR-ABL kinase (unknown origin) [AID743664, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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15
[SID103245522]
IC50 0.039Inhibition of PDGFR [AID463623, Type: Literature]
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16
[SID103245522]
IC50 0.039Antiproliferative activity against PDGFRbeta transfected mouse BA/F3 cells [AID515836, Type: Literature]
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17
[SID103245522]
IC50 0.04Inhibition of Abl tyrosine kinase [AID228828, Type: Literature]
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18
[SID103245522]
IC50 0.04Inhibition of c-Abl [AID291752, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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19
[SID103245522]
IC50 0.04Inhibition of human MATE1-mediated [14]-metformin uptake expressed in polarized MDCK2 cells after 5 mins by liquid scintillation counting analysis [AID721746, Type: Literature]Multidrug and toxin extrusion protein 1 [gi:74731723]
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20
[SID103245522]
IC50 0.043Inhibition of autophosphorylation of DDR1 expressed in HEK293 cells by ELISA [AID515827, Type: Literature]
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