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Morphine (CID 5288826) - Compound BioActivity Data
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Filters: All Data » IC50      
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BioActivity Outcomes:
Active(97)
 
 
Inconclusive(19)
 
 
Unspecified(13)
 
 
Top Targets:
7TM GPCR Srx(24)
 
 
 
 
7TM GPCR Srsx(13)
 
 
ERG2 Sigma1R(4)
 
 
ABC MTABC3 MD..(3)
 
 
Esterase lipa..(1)
 
 
BioAssay Types:
Literature(123)
 
 
 
 
BioActivity Types:
IC50(129)
 
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 117    Data Row: 129   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103169185]
IC50 2.7e-0550% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenate [AID145933, Type: Literature]
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2
[SID103169185]
IC50 0.00013Inhibitory activity of compound in guinea pig ileum tissue [AID76209, Type: Literature]
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3
[SID103169185]
IC50 0.00014Inhibition of [3H]DAMGO radioligand binding to rat brain opioid receptor mu 1. [AID151440, Type: Literature]
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4
[SID103169185]
IC50 0.00057In vitro binding affinity against cloned human Opioid receptor mu 1 expressed in HEK 293S cells [AID150822, Type: Literature]
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5
[SID103169185]
IC50 0.00127Displacement of [3H]DAMGO from mu opioid receptor in ICR mouse whole brain [AID383161, Type: Literature]Mu-type opioid receptor [gi:1171911]
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6
[SID103169185]
IC50 0.00127Displacement of [3H]DAMGO from mu opioid receptor in mouse whole brain without cerebellum [AID411134, Type: Literature]Mu-type opioid receptor [gi:1171911]
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7
[SID103169185]
IC50 0.0016Opioid receptor activity in terms of inhibition of [3H]dihydromorphine binding in rat brain membrane [AID149177, Type: Literature]
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8
[SID103169185]
IC50 0.00182Inhibition of [3H]U-69593 radioligand binding to Guinea pig opioid receptor kappa 1. [AID148680, Type: Literature]Kappa-type opioid receptor [gi:730228]
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9
[SID103169185]
IC50 0.00194Inhibition of [3H]- DAMGO binding to Rat brain Opioid receptor mu 1 [AID151303, Type: Literature]Mu-type opioid receptor [gi:464314]
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10
[SID103169185]
IC50 0.00292Evaluated for the inhibition concentration in the guinea pig ileal longitudinal muscle preparation (GPI) [AID78284, Type: Literature]
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11
[SID103169185]
IC50 0.0039Displacement of [3H]- DAGO from opioid receptor mu in rat brain membrane [AID149290, Type: Literature]Mu-type opioid receptor [gi:464314]
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12
[SID103169185]
IC50 0.004Evaluated for the inhibition of [3H]DAGO binding to mu-receptor of guinea pig brain [AID224723, Type: Literature]Mu-type opioid receptor [gi:3024265]
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13
[SID103169185]
IC50 0.0042Displacement [3H]naloxone from rat-brain Opioid receptors [AID150397, Type: Literature]Delta-type opioid receptor [gi:464311]
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14
[SID103169185]
IC50 0.0042Displacement [3H]naloxone from rat-brain Opioid receptors [AID150397, Type: Literature]Kappa-type opioid receptor [gi:464313]
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15
[SID103169185]
IC50 0.0042Displacement [3H]naloxone from rat-brain Opioid receptors [AID150397, Type: Literature]Mu-type opioid receptor [gi:464314]
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16
[SID103169185]
IC50 0.0042Displacement [3H]naloxone from rat-brain Opioid receptors [AID150397, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882051]
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17
[SID103169185]
IC50 0.0043Agonist activity at human MOR expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins by cAMP EIA [AID707251, Type: Literature]Mu-type opioid receptor [gi:2851402]
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18
[SID103169185]
IC50 0.0045Inhibition of [3H]-Naloxone binding to rat brain membrane without NaCl [AID226060, Type: Literature]
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19
[SID103169185]
IC50 0.00564Displacement of [3H]DAMGO from mu opioid receptor from Wistar rat brain by liquid scintillation counting [AID479370, Type: Literature]Mu-type opioid receptor [gi:464314]
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20
[SID103169185]
IC50 0.00737Inhibition of [3H]DADLE radioligand binding to rat brain opioid receptor delta 1. [AID149520, Type: Literature]
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21
[SID103169185]
IC50 0.0085Binding to mu opioid receptor by using [3H]DAMGO as radioligand in guinea pig brain minus cerebellum [AID138855, Type: other]Mu-type opioid receptor [gi:3024265]
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22
[SID103169185]
IC50 0.0086Inhibitory activity against opiate receptor in rat using [3H]naloxone as radioligand [AID145939, Type: Literature]
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23
[SID103169185]
IC50 0.01Inhibition of Opioid receptors with [3H]naloxone binding in the absence of NaCl [AID150234, Type: Literature]
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24
[SID103169185]
IC50 0.011Tested for In vitro binding constant for Opioid receptors by measuring the inhibition of stereospecific binding of [3H]naloxone in rat brain homogenates [AID150395, Type: Literature]
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25
[SID103169185]
IC50 0.022Displacement of [3H]naloxone from rat brain Opioid receptors [AID150260, Type: Literature]Delta-type opioid receptor [gi:464311]
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26
[SID103169185]
IC50 0.022Displacement of [3H]naloxone from rat brain Opioid receptors [AID150260, Type: Literature]Kappa-type opioid receptor [gi:464313]
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27
[SID103169185]
IC50 0.022Displacement of [3H]naloxone from rat brain Opioid receptors [AID150260, Type: Literature]Mu-type opioid receptor [gi:464314]
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28
[SID103169185]
IC50 0.022Displacement of [3H]naloxone from rat brain Opioid receptors [AID150260, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882051]
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29
[SID103169185]
IC50 0.024Evaluated the ability to protect against the irreversible antagonism of morphines effects by beta-FNA in guinea pig ileal longitudinal muscle. [AID148625, Type: Literature]
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30
[SID103169185]
IC50 0.024Tested for potent reversible agonist activity on electrically stimulated guinea pig ileal longitudinal muscle preparation [AID76379, Type: Literature]
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31
[SID103169185]
IC50 0.027Displacement of [3H]nalotrexone from rat-brain Opioid receptors [AID150396, Type: Literature]Delta-type opioid receptor [gi:464311]
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32
[SID103169185]
IC50 0.027Displacement of [3H]nalotrexone from rat-brain Opioid receptors [AID150396, Type: Literature]Kappa-type opioid receptor [gi:464313]
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33
[SID103169185]
IC50 0.027Displacement of [3H]nalotrexone from rat-brain Opioid receptors [AID150396, Type: Literature]Mu-type opioid receptor [gi:464314]
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34
[SID103169185]
IC50 0.027Displacement of [3H]nalotrexone from rat-brain Opioid receptors [AID150396, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882051]
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35
[SID103169185]
IC50 0.027Concentration required to inhibit [3H]naltrexone binding to Opioid receptors [AID150244, Type: Literature]
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36
[SID103169185]
IC50 0.028In vitro inhibitory activity against opioid receptor in Guinea pig ileum [AID148626, Type: Literature]
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37
[SID103169185]
IC50 0.029Compound was tested for irreversible antagonistic activity against opioid receptor in electrically stimulated longitudinal muscle of guinea pig ileum [AID148481, Type: Literature]
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38
[SID103169185]
IC50 0.0331Inhibition of opioid activity in electricaly stimulated myenteric plexus longitudinal muscle of guinea pig ileum(GPI) preparation [AID76095, Type: Literature]
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39
[SID103169185]
IC50 0.038Inhibition of opioid receptor mu in guinea pig ileum (GPI) [AID148991, Type: Literature]Mu-type opioid receptor [gi:3024265]
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40
[SID103169185]
IC50 0.0547Opioid receptor activity was evaluated using guinea pig ileum (GPI) assay [AID148474, Type: Literature]
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41
[SID103169185]
IC50 0.0573Mu opioid receptor agonist activity as inhibition of electrically stimulated mysenteric plexus in guinea pig ileum [AID79038, Type: Literature]Mu-type opioid receptor [gi:3024265]
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42
[SID103169185]
IC50 0.0586In vitro inhibition of contractions in the electrically stimulated guinea pig ileum. [AID78310, Type: Literature]
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43
[SID103169185]
IC50 0.0586Concentration inhibiting electrically induced contraction of guinea pig ileum(GPI) at an ED50 of 5.6(ug/kg). [AID78160, Type: Literature]
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44
[SID103169185]
IC50 0.0588Ability to inhibit electrically evoked contractions of isolated muscle preparations of guinea pig ileum (GPI, mu receptor) [AID226065, Type: Literature]Mu-type opioid receptor [gi:3024265]
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45
[SID103169185]
IC50 0.065In vitro opioid inhibitory activity against in guinea pig ileum [AID148482, Type: Literature]
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46
[SID103169185]
IC50 0.0682Opioid agonistic activity was measured in guinea pig ileum [AID76240, Type: Literature]
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47
[SID103169185]
IC50 0.0697Inhibitory concentration evaluated in electrically stimulated guinea pig myenteric plexus longitudinal muscle [AID76212, Type: Literature]
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48
[SID103169185]
IC50 0.07Inhibitory potency against Opioid receptor mu 1 in longitudinal muscle preparation of guinea pig ileum [AID149864, Type: Literature]Mu-type opioid receptor [gi:3024265]
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49
[SID103169185]
IC50 0.07Inhibition of electrically evoked contraction of guinea pig ileum (myenteric plexus:longitudinal muscle preparation) by antagonist action at mu 1 opioid receptors [AID149865, Type: Literature]Mu-type opioid receptor [gi:3024265]
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50
[SID103169185]
IC50 0.0716Evaluated for inhibitory activity against Opioid receptor mu 1 of guinea pig ileum (GPI) [AID149742, Type: Literature]Mu-type opioid receptor [gi:3024265]
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