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Morphine (CID 5288826) - Compound BioActivity Data
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Filters: All Data » IC50      
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BioActivity Outcomes:
Active(97)
 
 
Inconclusive(19)
 
 
Unspecified(13)
 
 
Top Targets:
7TM GPCR Srx(24)
 
 
 
 
7TM GPCR Srsx(13)
 
 
ERG2 Sigma1R(4)
 
 
ABC MTABC3 MD..(3)
 
 
Esterase lipa..(1)
 
 
BioAssay Types:
Literature(126)
 
 
 
 
Confirmatory(3)
 
 
BioActivity Types:
IC50(129)
 
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 117    Data Row: 129   Total Pages: 7   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103169185]
IC50 2.7e-0550% Inhibition of stereospecific [3H]-naltrexone (10e-9 M) binding towards opiate receptor in rat brain homogenate [AID145933, Type: Literature]
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2
[SID103169185]
IC50 0.00013Inhibitory activity of compound in guinea pig ileum tissue [AID76209, Type: Literature]
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3
[SID103169185]
IC50 0.00014Inhibition of [3H]DAMGO radioligand binding to rat brain opioid receptor mu 1. [AID151440, Type: Literature]
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4
[SID103169185]
IC50 0.00057In vitro binding affinity against cloned human Opioid receptor mu 1 expressed in HEK 293S cells [AID150822, Type: Literature]
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5
[SID103169185]
IC50 0.00127Displacement of [3H]DAMGO from mu opioid receptor in ICR mouse whole brain [AID383161, Type: Literature]Mu-type opioid receptor [gi:1171911]
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6
[SID103169185]
IC50 0.00127Displacement of [3H]DAMGO from mu opioid receptor in mouse whole brain without cerebellum [AID411134, Type: Literature]Mu-type opioid receptor [gi:1171911]
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7
[SID103169185]
IC50 0.0016Opioid receptor activity in terms of inhibition of [3H]dihydromorphine binding in rat brain membrane [AID149177, Type: Literature]
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8
[SID103169185]
IC50 0.00182Inhibition of [3H]U-69593 radioligand binding to Guinea pig opioid receptor kappa 1. [AID148680, Type: Literature]Kappa-type opioid receptor [gi:730228]
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9
[SID103169185]
IC50 0.00194Inhibition of [3H]- DAMGO binding to Rat brain Opioid receptor mu 1 [AID151303, Type: Literature]Mu-type opioid receptor [gi:464314]
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10
[SID103169185]
IC50 0.00292Evaluated for the inhibition concentration in the guinea pig ileal longitudinal muscle preparation (GPI) [AID78284, Type: Literature]
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11
[SID103169185]
IC50 0.0039Displacement of [3H]- DAGO from opioid receptor mu in rat brain membrane [AID149290, Type: Literature]Mu-type opioid receptor [gi:464314]
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12
[SID103169185]
IC50 0.004Evaluated for the inhibition of [3H]DAGO binding to mu-receptor of guinea pig brain [AID224723, Type: Literature]Mu-type opioid receptor [gi:3024265]
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13
[SID103169185]
IC50 0.0042Displacement [3H]naloxone from rat-brain Opioid receptors [AID150397, Type: Literature]Mu-type opioid receptor [gi:464314]
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14
[SID103169185]
IC50 0.0042Displacement [3H]naloxone from rat-brain Opioid receptors [AID150397, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882051]
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15
[SID103169185]
IC50 0.0042Displacement [3H]naloxone from rat-brain Opioid receptors [AID150397, Type: Literature]Kappa-type opioid receptor [gi:464313]
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16
[SID103169185]
IC50 0.0042Displacement [3H]naloxone from rat-brain Opioid receptors [AID150397, Type: Literature]Delta-type opioid receptor [gi:464311]
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17
[SID103169185]
IC50 0.0043Agonist activity at human MOR expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins by cAMP EIA [AID707251, Type: Literature]Mu-type opioid receptor [gi:2851402]
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18
[SID103169185]
IC50 0.0045Inhibition of [3H]-Naloxone binding to rat brain membrane without NaCl [AID226060, Type: Literature]
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19
[SID103169185]
IC50 0.00564Displacement of [3H]DAMGO from mu opioid receptor from Wistar rat brain by liquid scintillation counting [AID479370, Type: Literature]Mu-type opioid receptor [gi:464314]
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20
[SID103169185]
IC50 0.00737Inhibition of [3H]DADLE radioligand binding to rat brain opioid receptor delta 1. [AID149520, Type: Literature]
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