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Diflunisal (CID 3059) - Compound BioActivity Data
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Filters: All Data » IC50      
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BioActivity Outcomes:
Active(2)
 
 
Inactive(36)
 
 
Inconclusive(16)
 
 
Unspecified(119)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
 
7TM GPCR Srsx(15)
 
 
p450(7)
 
 
alpha CA I II..(3)
 
 
 
prostaglandin..(2)
 
 
BioAssay Types:
Confirmatory(36)
 
 
Literature(20)
 
 
 
 
BioActivity Types:
IC50(173)
 
 
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 168    Data Row: 173   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103235071]
IC50 2.7Inhibition of human carbonic anhydrase 2 esterase activity by spectrophotometry [AID349141, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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2
[SID103235071]
IC50 3.38Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometry [AID349140, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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3
[SID103235071]
IC50 0.85TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells [AID681160, Type: other]Solute carrier family 22 member 6 [gi:74762955]
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4
[SID103235071]
IC50 109Inhibition of mycophenolic acid (1 mM) glucuronidation by human UGT enzymes from liver microsomes [AID624662, Type: Literature]
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5
[SID103235071]
IC50 122Inhibition of mycophenolic acid (0.5 mM) glucuronidation by human kidney microsomes [AID624661, Type: Literature]
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6
[SID103235071]
IC50 DRUGMATRIX: Vascular Endothelinal Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) [AID625231, Type: other]Vascular endothelial growth factor receptor 1 [gi:143811474]
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7
[SID103235071]
IC50 DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) [AID625144, Type: other]Leukotriene C4 synthase [gi:239977155]
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8
[SID103235071]
IC50 DRUGMATRIX: Nicotinic Acetylcholine radioligand binding (ligand: [125I] Epibatidine) [AID625158, Type: other]
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9
[SID103235071]
IC50 DRUGMATRIX: Phosphodiesterase PDE3 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625165, Type: other]
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10
[SID103235071]
IC50 DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) [AID625161, Type: other]Delta-type opioid receptor [gi:311033488]
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11
[SID103235071]
IC50 DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) [AID625167, Type: other]cGMP-specific 3',5'-cyclic phosphodiesterase [gi:317373261]
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12
[SID103235071]
IC50 DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other]Prostaglandin G/H synthase 1 [gi:317373262]
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13
[SID103235071]
IC50 DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) [AID625147, Type: other]Melanocortin receptor 3 [gi:395398606]
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14
[SID103235071]
IC50 DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) [AID625172, Type: other]Progesterone receptor [gi:75071465]
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15
[SID103235071]
IC50 DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625249, Type: other]Cytochrome P450 2D6 [gi:84028191]
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16
[SID103235071]
IC50 DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) [AID625251, Type: other]Cytochrome P450 3A4 [gi:116241312]
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17
[SID103235071]
IC50 DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625162, Type: other]Kappa-type opioid receptor [gi:116242691]
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18
[SID103235071]
IC50 DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) [AID625204, Type: other]Beta-1 adrenergic receptor [gi:48429211]
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19
[SID103235071]
IC50 DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) [AID625148, Type: other]Melanocortin receptor 4 [gi:60392672]
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20
[SID103235071]
IC50 DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625247, Type: other]Cytochrome P450 2C19 [gi:60416369]
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21
[SID103235071]
IC50 DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) [AID625223, Type: other]Sigma non-opioid intracellular receptor 1 [gi:74752153]
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22
[SID103235071]
IC50 DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) [AID625227, Type: other]Substance-K receptor [gi:229462950]
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23
[SID103235071]
IC50 DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) [AID625229, Type: other]Thromboxane-A synthase [gi:254763392]
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24
[SID103235071]
IC50 DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) [AID625178, Type: other]Matrix metalloproteinase-9 [gi:269849668]
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25
[SID103235071]
IC50 DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) [AID625205, Type: other]Beta-2 adrenergic receptor [gi:296439450]
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26
[SID103235071]
IC50 DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) [AID625268, Type: other]
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27
[SID103235071]
IC50 DRUGMATRIX: Imidazoline I2, Central radioligand binding (ligand: [3H] Idazoxan) [AID625272, Type: other]
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28
[SID103235071]
IC50 DRUGMATRIX: Leukotriene, BLT (LTB4) radioligand binding (ligand: [3H]LTB4) [AID625275, Type: other]
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29
[SID103235071]
IC50 DRUGMATRIX: GABAA, Muscimol, Central radioligand binding (ligand: [3H] Muscimol) [AID625260, Type: other]
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30
[SID103235071]
IC50 DRUGMATRIX: GABAA, Flunitrazepam, Central radioligand binding (ligand: [3H] Flunitrazepam) [AID625261, Type: other]
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31
[SID103235071]
IC50 DRUGMATRIX: GABAA, Chloride Channel, TBOB radioligand binding (ligand: [3H] TBOB) [AID625262, Type: other]
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32
[SID103235071]
IC50 DRUGMATRIX: Glutamate, AMPA radioligand binding (ligand: [3H] AMPA) [AID625264, Type: other]
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33
[SID103235071]
IC50 DRUGMATRIX: Glutamate, NMDA, Agonism radioligand binding (ligand: [3H] CGP-39653) [AID625266, Type: other]
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34
[SID103235071]
IC50 DRUGMATRIX: Glutamate, NMDA, Phencyclidine radioligand binding (ligand: [3H] TCP) [AID625267, Type: other]
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35
[SID103235071]
IC50 DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) [AID625215, Type: other]
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36
[SID103235071]
IC50 DRUGMATRIX: Calcium Channel Type L, Dihydropyridine radioligand binding (ligand: [3H] Nitrendipine) [AID625216, Type: other]
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37
[SID103235071]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT3 radioligand binding (ligand: [3H] GR-65630) [AID625219, Type: other]
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38
[SID103235071]
IC50 DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil) [AID625224, Type: other]
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39
[SID103235071]
IC50 DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) [AID625225, Type: other]
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40
[SID103235071]
IC50 DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: other]
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41
[SID103235071]
IC50 DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625166, Type: other]
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42
[SID103235071]
IC50 DRUGMATRIX: Potassium Channel [KATP] radioligand binding (ligand: [3H] Glyburide) [AID625170, Type: other]
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43
[SID103235071]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) [AID625190, Type: other]
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44
[SID103235071]
IC50 DRUGMATRIX: Sodium/nucleoside co-transporter radioligand binding (ligand: nitrobenzylthioinosine) [AID625197, Type: other]
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45
[SID103235071]
IC50 DRUGMATRIX: ATPase, Na+/K+ enzyme inhibition (substrate: ATP) [AID625210, Type: other]
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46
[SID103235071]
IC50 DRUGMATRIX: beta-Lactamase enzyme inhibition (substrate: Nitrocefin) [AID625212, Type: other]
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47
[SID103235071]
IC50 DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) [AID625236, Type: other]Carbonic anhydrase 2 [gi:115456]
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48
[SID103235071]
IC50 DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) [AID625235, Type: other]Cannabinoid receptor 1 [gi:115562]
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49
[SID103235071]
IC50 DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) [AID625175, Type: other]Cathepsin G [gi:115725]
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50
[SID103235071]
IC50 DRUGMATRIX: Peptidase, Matrix Metalloproteinase-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) [AID625177, Type: other]Interstitial collagenase [gi:116852]
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