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Diflunisal (CID 3059) - Compound BioActivity Data
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Filters: All Data » IC50      
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BioActivity Outcomes:
Active(4)
 
 
Inactive(36)
 
 
Inconclusive(16)
 
 
Unspecified(119)
 
 
Top Targets:
7tm 4(31)
 
 
 
p450(7)
 
 
prostaglandin..(2)
 
 
alpha CA I II..(2)
 
 
 
STKc ERK1 2 l..(2)
 
 
BioAssay Types:
Confirmatory(152)
 
 
 
Literature(23)
 
 
 
 
BioActivity Types:
IC50(175)
 
 
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 170    Data Row: 175   Total Pages: 9   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103235071]
IC50 2.7Inhibition of human carbonic anhydrase 2 esterase activity by spectrophotometry [AID349141, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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2
[SID103235071]
IC50 3.38Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometry [AID349140, Type: Literature]Carbonic anhydrase 1 [gi:115449]
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3
[SID103235071]
IC50 6.3Inhibition of transthyretin V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of sodium acetate-mediated aggregation preincubated for 30 mins followed by sodium acetate addition measured after 96 hrs by thioflavin T assay [AID1074430, Type: Literature]
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4
[SID103235071]
IC50 18Inhibition of human recombinant TTR Y78F mutant-mediated fibrillogenesis after 30 mins by turbidimetric assay [AID1054848, Type: Literature]
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5
[SID103235071]
IC50 0.85TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells [AID681160, Type: Literature]Solute carrier family 22 member 6 [gi:74762955]
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6
[SID103235071]
IC50 109Inhibition of mycophenolic acid (1 mM) glucuronidation by human UGT enzymes from liver microsomes [AID624662, Type: Literature]
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7
[SID103235071]
IC50 122Inhibition of mycophenolic acid (0.5 mM) glucuronidation by human kidney microsomes [AID624661, Type: Literature]
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8
[SID103235071]
IC50 DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) [AID625231, Type: confirmatory]Vascular endothelial growth factor receptor 1 [gi:143811474]
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9
[SID103235071]
IC50 DRUGMATRIX: Imidazoline I2, Central radioligand binding (ligand: [3H] Idazoxan) [AID625272, Type: confirmatory]
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10
[SID103235071]
IC50 DRUGMATRIX: Leukotriene, BLT (LTB4) radioligand binding (ligand: [3H]LTB4) [AID625275, Type: confirmatory]
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11
[SID103235071]
IC50 DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) [AID625161, Type: confirmatory]Delta-type opioid receptor [gi:311033488]
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12
[SID103235071]
IC50 DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) [AID625167, Type: confirmatory]cGMP-specific 3',5'-cyclic phosphodiesterase [gi:317373261]
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13
[SID103235071]
IC50 DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: confirmatory]Prostaglandin G/H synthase 1 [gi:317373262]
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14
[SID103235071]
IC50 DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) [AID625147, Type: confirmatory]Melanocortin receptor 3 [gi:395398606]
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15
[SID103235071]
IC50 DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: confirmatory]Alpha-2B adrenergic receptor [gi:613504690]
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16
[SID103235071]
IC50 DRUGMATRIX: Nicotinic Acetylcholine radioligand binding (ligand: [125I] Epibatidine) [AID625158, Type: confirmatory]
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17
[SID103235071]
IC50 DRUGMATRIX: Phosphodiesterase PDE3 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625165, Type: confirmatory]
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18
[SID103235071]
IC50 DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625166, Type: confirmatory]
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19
[SID103235071]
IC50 DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) [AID625172, Type: confirmatory]Progesterone receptor [gi:75071465]
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20
[SID103235071]
IC50 DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625249, Type: confirmatory]Cytochrome P450 2D6 [gi:84028191]
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