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Acetylcholine (CID 187) - Compound BioActivity Data
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Filters: All Data » IC50      
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BioActivity Outcomes:
Active(12)
 
 
Inconclusive(4)
 
 
Unspecified(4)
 
 
Top Targets:
Neur chan LBD(4)
 
 
 
CAP ED(1)
 
 
BioAssay Types:
Literature(20)
 
 
 
 
BioActivity Types:
IC50(20)
 
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 20    Data Row: 20   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234160]
IC50 0.012In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex muscarinic receptor. [AID141531, Type: Literature]
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2
[SID104234160]
IC50 0.012Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]OXO-M as radioligand [AID141545, Type: Literature]
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3
[SID104234160]
IC50 0.012The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]oxotremorine-M from rat cerebral cortex; Value ranges from 7-20 [AID141812, Type: Literature]
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4
[SID104234160]
IC50 1Vasorelaxant activity in Wistar rat endothelium-intact aortic rings assessed as inhibition of phenylephrine-induced contractions after 10 to 30 mins [AID602907, Type: Literature]
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5
[SID104234160]
IC50 1Vasorelaxant activity in Wistar rat endothelium-intact thoracic aortic ring assessed as inhibition of phenylephrine-induced contraction measured after 60 mins [AID662198, Type: Literature]
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6
[SID104234160]
IC50 24Compound was tested in vitro for its binding affinity to muscarinic acetylcholine receptor from rat cortical homogenates using [3H]QNB as radioligand [AID141546, Type: Literature]
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7
[SID104234160]
IC50 24In vitro displacement of [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortex muscarinic receptor. [AID141534, Type: Literature]
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8
[SID104234160]
IC50 24The compound was tested in vitro for central muscarinic acetylcholine receptor affinity to displace [3H]quinuclidinyl benzilate from rat cerebral cortex; Value ranges from 12000-50000 [AID141819, Type: Literature]
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9
[SID104234160]
IC50 Antagonist activity at human alpha-7 nAChR in tsA201 cells coexpressed with Ric3 by FMP assay [AID297967, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
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10
[SID104234160]
IC50 Antagonist activity at human alpha7nAChR co-expressed with human Ric3 in tsA201 cells by FMP assay [AID297990, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
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11
[SID104234160]
IC50 Displacement of [3H]epibatidine from chimeric human alpha7-5-HT3A receptor expressed in HEK293 cells after 2 hrs by scintillation counter analysis [AID689290, Type: Literature]
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12
[SID104234160]
IC50 Antagonist activity at rat alpha3beta4 nAChR expressed in HEK293 cells by FMP assay [AID297968, Type: Literature]
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13
[SID104234160]
IC50 Antagonist activity at human alpha7nAChR Y93A mutant co-expressed with human Ric3 in tsA201 cells by FMP assay [AID297991, Type: Literature]
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14
[SID104234160]
IC50 Antagonist activity at human alpha7 nAChR W149Y mutant co-expressed with human Ric3 in tsA201 cells by FMP assay [AID297993, Type: Literature]
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15
[SID104234160]
IC50 Antagonist activity at human alpha-7 nAChR Y188A mutant coexpressed with human Ric3 in tsA201 cells by FMP assay [AID297994, Type: Literature]
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16
[SID104234160]
IC50 Antagonist activity at human alpha-7 nAChR Y195A mutant coexpressed with human Ric3 in tsA201 cells by FMP assay [AID297995, Type: Literature]
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17
[SID104234160]
IC50 Antagonist activity at human rho1 GABAc receptor in HEK293 cells by FMP assay [AID297970, Type: Literature]
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18
[SID104234160]
IC50 Inhibition of human ERG expressed in CHO cells after 30 mins by Rb+ flux assay [AID672167, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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19
[SID104234160]
IC50 Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay [AID297971, Type: Literature]Glycine receptor subunit alpha-1 [gi:116242495]
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20
[SID104234160]
IC50 Antagonist activity at human 5HT3A receptor expressed in HEK293 cells by FMP assay [AID297969, Type: Literature]5-hydroxytryptamine receptor 3A [gi:1168222]
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