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Dopamine (CID 681) - Compound BioActivity Data
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Filters: All Data » EC50      
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BioActivity Outcomes:
Active(51)
 
 
Top Targets:
7TM GPCR Srsx(22)
 
 
7TM GPCR Srx(3)
 
 
FAM101(2)
 
 
Herpes DNAp a..(1)
 
 
BioAssay Types:
Literature(51)
 
 
BioActivity Types:
EC50(51)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 51    Data Row: 51   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103167911]
EC50 0.0011In vitro effective concentration tested on HEK293 cells co-transfected with rat Dopamine receptor D2 using FLIPR assay [AID61225, Type: Literature]
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2
[SID103167911]
EC50 0.0011Agonist activity at rat D2 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR [AID274445, Type: Literature]D(2) dopamine receptor [gi:47117674]
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3
[SID103167911]
EC50 0.0022Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR [AID274437, Type: Literature]D(4) dopamine receptor [gi:1345939]
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4
[SID103167911]
EC50 0.0022In vitro effective concentration tested on HEK293 cells co-transfected with human Dopamine receptor D4 using FLIPR assay [AID65928, Type: Literature]
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5
[SID103167911]
EC50 0.0024In vitro effective concentration tested on HEK293 cells co-transfected with rat Dopamine receptor D4 using FLIPR assay [AID63828, Type: Literature]
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6
[SID103167911]
EC50 0.0024Agonist activity at rat D4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR [AID274442, Type: Literature]D(4) dopamine receptor [gi:6226851]
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7
[SID103167911]
EC50 0.0027Agonist activity at ferret D4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR [AID274441, Type: Literature]
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8
[SID103167911]
EC50 0.0027In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D4 using FLIPR assay [AID63703, Type: Literature]
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9
[SID103167911]
EC50 0.00476Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID461563, Type: Literature]D(3) dopamine receptor [gi:1169206]
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10
[SID103167911]
EC50 0.00476Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID513742, Type: Literature]D(3) dopamine receptor [gi:1169206]
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11
[SID103167911]
EC50 0.005Activity at rat dopamine D2L receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production [AID272396, Type: Literature]D(2) dopamine receptor [gi:47117674]
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12
[SID103167911]
EC50 0.0058Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTP gammaS binding assay [AID712282, Type: Literature]D(3) dopamine receptor [gi:1169206]
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13
[SID103167911]
EC50 0.0061Agonist activity at human dopamine D3 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay [AID709655, Type: Literature]D(3) dopamine receptor [gi:1169206]
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14
[SID103167911]
EC50 0.008Agonist activity at ferret D2 receptor in HEK293 cells coexpressing Galphaqo5 by FLIPR [AID274444, Type: Literature]
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15
[SID103167911]
EC50 0.008In vitro effective concentration tested on HEK293 cells co-transfected with ferret Dopamine receptor D2 using FLIPR assay [AID61221, Type: Literature]
View
16
[SID103167911]
EC50 0.00853Agonist activity at human dopamine D3 receptor expressed in mouse ATt-20 cells assessed as stimulation of [35S]GTPgammaS binding [AID384700, Type: Literature]D(3) dopamine receptor [gi:1169206]
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17
[SID103167911]
EC50 0.00853Agonist activity at human cloned dopamine D3 receptor expressed in AtT-20 cells assessed as stimulation of [35S]GTP-gamma-S binding [AID312287, Type: Literature]D(3) dopamine receptor [gi:1169206]
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18
[SID103167911]
EC50 0.00853Activity at human dopamine D3 receptor expressed in AtT cells assessed as stimulation of [35S]GTPgammaS binding [AID425420, Type: Literature]D(3) dopamine receptor [gi:1169206]
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19
[SID103167911]
EC50 0.00853Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding [AID446402, Type: Literature]D(3) dopamine receptor [gi:1169206]
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20
[SID103167911]
EC50 0.00857Agonist activity at human cloned dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID690847, Type: Literature]D(3) dopamine receptor [gi:1169206]
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21
[SID103167911]
EC50 0.01Activity at human dopamine D4.4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production [AID272398, Type: Literature]D(4) dopamine receptor [gi:1345939]
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22
[SID103167911]
EC50 0.018In vitro effective concentration tested on HEK293 cells co-transfected with human Dopamine receptor D2 using FLIPR assay [AID62753, Type: Literature]
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23
[SID103167911]
EC50 0.02Agonist activity at human D1 receptor assessed as cAMP accumulation [AID502879, Type: Literature]D(1A) dopamine receptor [gi:118228]
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24
[SID103167911]
EC50 0.035Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production [AID319298, Type: Literature]D(1A) dopamine receptor [gi:118228]
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25
[SID103167911]
EC50 0.038Inhibition of the constrictor response to electrical stimulation in rabbit ear artery. [AID167290, Type: Literature]
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26
[SID103167911]
EC50 0.043Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production [AID319299, Type: Literature]D(2) dopamine receptor [gi:118206]
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27
[SID103167911]
EC50 0.065Agonist activity at human dopamine D2 receptor expressed in CHOp cells assessed as stimulation of mitogenesis incubated for 24 hrs by [3H]thymidine incorporation assay [AID709658, Type: Literature]D(2) dopamine receptor [gi:118206]
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28
[SID103167911]
EC50 0.073Ability to stimulate peripheral prejunctional dopaminergic receptors by 50% inhibition of vasoconstrictor response to field stimulation in isolated perfused rabbit ear artery [AID167710, Type: Literature]
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29
[SID103167911]
EC50 0.076Ability to relax the electrically stimulated rabbit ear artery was determined [AID167274, Type: Literature]
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30
[SID103167911]
EC50 0.1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1 [AID63211, Type: Literature]
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31
[SID103167911]
EC50 0.12Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production [AID272394, Type: Literature]D(1A) dopamine receptor [gi:118228]
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32
[SID103167911]
EC50 0.17Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D2 [AID62748, Type: Literature]
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33
[SID103167911]
EC50 0.209Agonist activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID384698, Type: Literature]D(2) dopamine receptor [gi:118206]
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34
[SID103167911]
EC50 0.209Activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID425418, Type: Literature]D(2) dopamine receptor [gi:118206]
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35
[SID103167911]
EC50 0.209Agonist activity at human cloned dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID312285, Type: Literature]D(2) dopamine receptor [gi:118206]
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36
[SID103167911]
EC50 0.209Agonist activity at human dopamine D2L receptor expressed in CHO cells assessed as stimulation of [35S]GTPgamma binding [AID446400, Type: Literature]D(2) dopamine receptor [gi:118206]
View
37
[SID103167911]
EC50 0.209Agonist activity at human dopamine D2 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID513741, Type: Literature]D(2) dopamine receptor [gi:118206]
View
38
[SID103167911]
EC50 0.209Agonist activity at human dopamine D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID461562, Type: Literature]D(2) dopamine receptor [gi:118206]
View
39
[SID103167911]
EC50 0.227Agonist activity at human cloned dopamine D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID690845, Type: Literature]D(2) dopamine receptor [gi:118206]
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40
[SID103167911]
EC50 0.24Agonist activity at human cloned dopamine D2 receptor expressed in CHO cells by [35S]GTP gammaS binding assay [AID712284, Type: Literature]D(2) dopamine receptor [gi:118206]
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41
[SID103167911]
EC50 1.425Agonist activity at rat dopamine D2short receptor expressed in CHO-K1 cells assessed as stimulation of [35S]GTPgammaS binding by liquid scintillation counting [AID427140, Type: Literature]D(2) dopamine receptor [gi:47117674]
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42
[SID103167911]
EC50 1.5Effective concentration for increasing potency rate in guinea pig isolated right atria [AID73727, Type: Literature]
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43
[SID103167911]
EC50 1.7Effective concentration for increasing potency force in guinea pig isolated left atria [AID73725, Type: Literature]
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44
[SID103167911]
EC50 3.5Adenylase cyclase activity in rat striatal membranes [AID175327, Type: Literature]
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45
[SID103167911]
EC50 3.5Central dopaminergic activity was determined by testing compound for dopamine agonist activity mediated by adenylase cyclase in rat [AID175474, Type: Literature]
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46
[SID103167911]
EC50 3.5In vitro dose stimulating D-1 adenylate cyclase in rat caudate nuclei [AID175841, Type: Literature]
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47
[SID103167911]
EC50 3.5Effective concentration that gives maximal stimulation of cyclic AMP production over the concentration range tested. [AID220051, Type: Literature]
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48
[SID103167911]
EC50 3.5Tested for ability to stimulate dopamine sensitive adenylate cyclase in rat caudate homogenate [AID34440, Type: Literature]
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49
[SID103167911]
EC50 3.5Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes [AID63378, Type: Literature]
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50
[SID103167911]
EC50 4.8Agonist activity at D2-like receptor in pig striatal membrane assessed as [35S]GTPgammaS binding [AID515606, Type: Literature]
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