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Morphine (CID 5288826) - Compound BioActivity Data
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Filters: All Data » EC50      
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BioActivity Outcomes:
Active(34)
 
 
Inconclusive(2)
 
 
Top Targets:
7TM GPCR Srx(28)
 
 
 
7TM GPCR Srsx(1)
 
 
BioAssay Types:
Literature(36)
 
 
 
BioActivity Types:
EC50(36)
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 36    Data Row: 36   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103169185]
EC50 0.003Inhibition of MOR/alpha2A adrenergic receptor heterodimer expressed in HEK293 cells assessed as stimulation of ERK1/2 phosphorylation [AID507157, Type: Literature]
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2
[SID103169185]
EC50 0.0037Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF assay [AID669685, Type: Literature]Mu-type opioid receptor [gi:2851402]
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3
[SID103169185]
EC50 0.006Activation of human mu opioid receptor expressed in HEK293a cells co-expressing YFP-labelled alphai1 and CFP-labelled beta1gamma2 Gi subunits assessed as Gi protein activation by fluorescence resonance energy transfer [AID327877, Type: Literature]Mu-type opioid receptor [gi:2851402]
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4
[SID103169185]
EC50 0.0064Activation of human mu opioid receptor expressed in HEK293a cells coexpressing YFP-labelled alphai1 and CFP-labelled beta-1-gamma-2 Gi subunits assessed as decrease in fluorescence resonance energy transfer signal at 10 uM [AID327872, Type: Literature]Mu-type opioid receptor [gi:2851402]
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5
[SID103169185]
EC50 0.007Activation of human mu opioid receptor expressed in HEK293a cells by [35S]GTP-gamma-S binding assay [AID327873, Type: Literature]Mu-type opioid receptor [gi:2851402]
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6
[SID103169185]
EC50 0.0156Stimulation of [35S]GTPgammaS binding to human recombinant MOR [AID269575, Type: Literature]Mu-type opioid receptor [gi:2851402]
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7
[SID103169185]
EC50 0.0156Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding [AID298634, Type: Literature]Mu-type opioid receptor [gi:2851402]
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8
[SID103169185]
EC50 0.0156Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID395302, Type: Literature]Mu-type opioid receptor [gi:2851402]
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9
[SID103169185]
EC50 0.0156Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins [AID577264, Type: Literature]Delta-type opioid receptor [gi:311033488]
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10
[SID103169185]
EC50 0.0213Compound was tested for its ability to stimulate [35S]GTP-gamma-S, binding to membranes from C6 glioma cells stably expressing rat mu opioid receptor [AID224581, Type: Literature]
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11
[SID103169185]
EC50 0.0236Displacement of [3H]etorphine from opioid receptor in rat cerebrum [AID320417, Type: Literature]
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12
[SID103169185]
EC50 0.03Agonist activity at mouse MOR assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by cell based TR-FRET assay [AID765836, Type: Literature]Mu-type opioid receptor [gi:1171911]
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13
[SID103169185]
EC50 0.03981Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluorescence assay [AID779596, Type: Literature]Mu-type opioid receptor [gi:2851402]
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14
[SID103169185]
EC50 0.05Agonist activity at human MOR assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by cell based TR-FRET assay [AID765841, Type: Literature]Mu-type opioid receptor [gi:2851402]
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15
[SID103169185]
EC50 0.051Inhibition of the electrically induced muscle contractions was determined using the guinea pig ileum [AID78840, Type: Literature]
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16
[SID103169185]
EC50 0.0855Agonist activity at mu opioid receptor in Swiss albino mouse ileum assessed as inhibition of electrically-stimulated muscle contraction [AID479373, Type: Literature]Mu-type opioid receptor [gi:1171911]
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17
[SID103169185]
EC50 0.1235Agonist activity at rat mu opioid receptor assessed as stimulation of [35]SGTPgammaS binding [AID452021, Type: Literature]Mu-type opioid receptor [gi:464314]
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18
[SID103169185]
EC50 0.1274Inhibition of isolated guinea pig ileum contraction induced by electrical stimulation [AID246131, Type: Literature]
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19
[SID103169185]
EC50 0.142Displacement of 3.0 nM [3H]etorphine from opioid receptor in rat cerebrum [AID320419, Type: Literature]
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20
[SID103169185]
EC50 0.194Agonist activity at rat MOR expressed in rat C6 cells assessed as stimulation of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting analysis [AID729038, Type: Literature]Mu-type opioid receptor [gi:464314]
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