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Acetylcholine (CID 187) - Compound BioActivity Data
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Filters: All Data » EC50      
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BioActivity Outcomes:
Active(25)
 
 
Unspecified(21)
 
 
Top Targets:
Neur chan LBD(16)
 
 
 
7TM GPCR Srx(6)
 
 
S100PBPR(2)
 
 
BioAssay Types:
Literature(44)
 
 
 
BioActivity Types:
EC50(46)
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 41    Data Row: 46   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104234160]
EC50 0.0011Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay [AID511592, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:113118]
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2
[SID104234160]
EC50 0.0011Agonist activity at human M1 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining [AID672151, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:113118]
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3
[SID104234160]
EC50 0.0012Agonist activity at human muscarinic M5 receptor expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining [AID672153, Type: Literature]Muscarinic acetylcholine receptor M5 [gi:543761]
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4
[SID104234160]
EC50 0.0012Agonist activity at human muscarinic M5 receptor expressed in BHK-21 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay [AID511603, Type: Literature]Muscarinic acetylcholine receptor M5 [gi:543761]
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5
[SID104234160]
EC50 0.0032Agonist activity at human muscarinic M3 receptor expressed in BHK-21 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay [AID511597, Type: Literature]Muscarinic acetylcholine receptor M3 [gi:113125]
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6
[SID104234160]
EC50 0.0032Agonist activity at human muscarinic M3 receptor expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining [AID672157, Type: Literature]Muscarinic acetylcholine receptor M3 [gi:113125]
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7
[SID104234160]
EC50 0.01Agonist activity at muscarinic human M4 receptor expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining [AID672155, Type: Literature]Muscarinic acetylcholine receptor M4 [gi:23503039]
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8
[SID104234160]
EC50 0.01Agonist activity at human muscarinic M4 receptor expressed in BHK-21 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay [AID511600, Type: Literature]Muscarinic acetylcholine receptor M4 [gi:23503039]
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9
[SID104234160]
EC50 0.22Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells coexpressing Galpha16 subunit assessed as increase of acetylcholine-induced calcium flux by FLIPR assay [AID511594, Type: Literature]Muscarinic acetylcholine receptor M2 [gi:113122]
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10
[SID104234160]
EC50 0.22Agonist activity at human muscarinic M2 receptor expressed in CHO-K1 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining [AID672159, Type: Literature]Muscarinic acetylcholine receptor M2 [gi:113122]
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11
[SID104234160]
EC50 0.63Agonistic activity against muscarinic acetylcholine receptor M5 expressed in NIH 3T3 cells. [AID142144, Type: Literature]
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12
[SID104234160]
EC50 1Agonist activity at alpha4beta2 nAChR high sensitivity form [AID705812, Type: Literature]
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13
[SID104234160]
EC50 1.6Partial agonist activity at human 2:3 alpha4beta2 nAChR expressed in Xenopus laevis oocytes after 1 min by two electrode voltage clamp technique [AID724032, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:113105]
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14
[SID104234160]
EC50 1.6Partial agonist activity at human 2:3 alpha4beta2 nAChR expressed in Xenopus laevis oocytes after 1 min by two electrode voltage clamp technique [AID724032, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:1351848]
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15
[SID104234160]
EC50 3.12Agonist activity at rat alpha7 nAChR expressed in GH4C1 cells assessed as calcium influx measured every 1 sec for 1 min followed by every 30 secs for 10 mins by FLIPR assay [AID684908, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:146345356]
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16
[SID104234160]
EC50 5Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype TE671 (muscle) [AID145357, Type: Literature]
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17
[SID104234160]
EC50 19Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in Xenopus oocytes [AID146770, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
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18
[SID104234160]
EC50 19Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in Xenopus oocytes [AID146770, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:113111]
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19
[SID104234160]
EC50 19Agonist activity at alpha3beta4 nAChR expressed in HEK293 cells by FLIPR membrane potential assay [AID410748, Type: Literature]
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20
[SID104234160]
EC50 20Agonistic activity against M1 muscarinic receptor expressed in NIH 3T3 cells. [AID141035, Type: Literature]
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21
[SID104234160]
EC50 20Effective concentration against Nicotinic acetylcholine receptor alpha4-beta4 expressed in xenopus oocytes [AID240238, Type: Literature]
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22
[SID104234160]
EC50 27Agonist activity at human muscarinic M1 receptor Y381A mutant expressed in CHO-K1 cells assessed as increase of acetylcholine-induced calcium flux by FLIPR assay [AID511611, Type: Literature]
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23
[SID104234160]
EC50 27Agonist activity at human muscarinic M1 receptor Y381A mutant expressed in BHK-21 cells assessed as calcium mobilization for 6 mins by Calcium4-based staining [AID672161, Type: Literature]
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24
[SID104234160]
EC50 30Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype IMR-32 (ganglionic) [AID145356, Type: Literature]
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25
[SID104234160]
EC50 40Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor subtype PC12 (ganglionic) [AID145657, Type: Literature]
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26
[SID104234160]
EC50 50Activation of human alpha-9/rat alpha-10 nACHR expressed in Xenopus oocytes assessed as increase of acetylcholine-induced current [AID623138, Type: Literature]
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27
[SID104234160]
EC50 68Effective concentration against Nicotinic acetylcholine receptor alpha4-beta2 expressed in xenopus oocytes [AID240233, Type: Literature]
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28
[SID104234160]
EC50 69Agonist activity at human recombinant alpha7 nAChR expressed in Xenopus oocyte in presence of 6 uM (S)-ethyl 1-(2-cyanoethyl)pyrrolidine-2-carboxylate [AID580950, Type: other]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
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29
[SID104234160]
EC50 70Agonist activity at human alpha-4-beta-2 nAChR expressed in Xenopus oocytes by two-electrode voltage clamp technique [AID346673, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:1351848]
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30
[SID104234160]
EC50 83Agonist activity at human alpha-7 nAChR expressed in Xenopus oocytes by two-electrode voltage clamp technique [AID346675, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
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31
[SID104234160]
EC50 83Effective concentration against Nicotinic acetylcholine receptor alpha2-beta4 expressed in xenopus oocytes [AID240234, Type: Literature]
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32
[SID104234160]
EC50 87Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in Xenopus oocytes [AID146477, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:6226548]
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33
[SID104234160]
EC50 87Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in Xenopus oocytes [AID146477, Type: Literature]Neuronal acetylcholine receptor subunit alpha-4 [gi:8469182]
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34
[SID104234160]
EC50 87Agonist activity at human recombinant alpha7 nAChR expressed in Xenopus oocyte [AID580949, Type: other]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
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35
[SID104234160]
EC50 100Agonist activity at alpha4beta2 nAChR low sensitivity form [AID705813, Type: Literature]
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36
[SID104234160]
EC50 144Agonist activity at human alpha-3-beta-4 nAChR expressed in Xenopus oocytes by two-electrode voltage clamp technique [AID346674, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:254763435]
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37
[SID104234160]
EC50 155Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha7 [AID146779, Type: Literature]
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38
[SID104234160]
EC50 180Effective concentration against Nicotinic acetylcholine receptor alpha 7 expressed in xenopus oocytes [AID240211, Type: Literature]
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39
[SID104234160]
EC50 203Effective concentration against Nicotinic acetylcholine receptor alpha3-beta4 expressed in xenopus oocytes [AID240236, Type: Literature]
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40
[SID104234160]
EC50 217Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in Xenopus oocytes [AID146158, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:113061]
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41
[SID104234160]
EC50 217Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in Xenopus oocytes [AID146158, Type: Literature]Neuronal acetylcholine receptor subunit beta-4 [gi:113111]
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42
[SID104234160]
EC50 230Effective concentration that causes inhibition of alpha-7 nAChR, was determined. Values are expressed as EC50 +/- SEM. [AID220451, Type: Literature]
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43
[SID104234160]
EC50 270Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor alpha4-beta2 [AID146316, Type: Literature]
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44
[SID104234160]
EC50 443Effective concentration against Nicotinic acetylcholine receptor alpha3-beta2 expressed in xenopus oocytes [AID240235, Type: Literature]Neuronal acetylcholine receptor subunit beta-2 [gi:113105]
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45
[SID104234160]
EC50 443Effective concentration against Nicotinic acetylcholine receptor alpha3-beta2 expressed in xenopus oocytes [AID240235, Type: Literature]Neuronal acetylcholine receptor subunit alpha-3 [gi:254763435]
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46
[SID104234160]
EC50 30000Antagonist activity at human alpha7nAChR W149A mutant co-expressed with human Ric3 in tsA201 cells by FMP assay [AID297992, Type: Literature]
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