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metabotropic glutamate receptor 5 precursor [.. [gi:8393490] - Target BioActivity Data
Also known as: metabotropic glutamate receptor 5 precursor [Rattus norvegicus].
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BioActivity Outcomes:
Probe(22)
 
 
Active(63)
 
 
BioAssay Types:
Confirmatory(82)
 
 
 
BioActivity Types:
EC50(60)
 
 
 
IC50(2)
 
 
Substance Types:
Chemical(85)
 
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 9    Data Row: 85   Total Pages: 2   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID126920341]
[CID53384864]
Average_IC50_uM 0.00483533mGluR5_3H_methoxyPEPy_Binding [AID588710, Type: confirmatory]
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2
[SID160963303]
[CID70789094]
Ki_uM 0.01Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: 3pt binding Assay [AID652191, Type: confirmatory]
View
3
[SID160963303]
[CID70789094]
Average_Ki_uM 0.0182Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: full Ki determination [AID652196, Type: confirmatory]
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4
[SID144241536]
[CID4384110]
Average_EC50_uM 0.049Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay) [AID651835, Type: confirmatory]
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5
[SID144241535]
[CID1364364]
Average_EC50_uM 0.051Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay) [AID651835, Type: confirmatory]
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6
[SID125305189]
[CID53382545]
Average_IC50_uM 0.0575mGluR5_3H_methoxyPEPy_Binding [AID588710, Type: confirmatory]
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7
[SID144241562]
[CID60210908]
Average_EC50_uM 0.085Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay) [AID651835, Type: confirmatory]
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8
[SID160963303]
[CID70789094]
Average_EC50_MICROMOLAR 0.1363Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: Fold-shift Assay [AID652198, Type: confirmatory]
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9
[SID144241527]
[CID60210882]
Average_EC50_uM 0.298Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay) [AID651835, Type: confirmatory]
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10
[SID144241541]
[CID60210914]
Average_EC50_uM 0.427Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay) [AID651835, Type: confirmatory]
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11
[SID144241540]
[CID60210915]
Average_EC50_uM 0.944Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay) [AID651835, Type: confirmatory]
View
12
[SID144241561]
[CID60210917]
Average_EC50_uM 1.393Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay) [AID651835, Type: confirmatory]
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13
[SID144241537]
[CID60210899]
Average_EC50_uM 1.688Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay) [AID651835, Type: confirmatory]
View
14
[SID144241539]
[CID60210911]
Average_EC50_uM 1.744Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay) [AID651835, Type: confirmatory]
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15
[SID144241564]
[CID1318633]
Average_EC50_uM 2.411Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay) [AID651835, Type: confirmatory]
View
16
[SID144241560]
[CID60210894]
Average_EC50_uM 2.456Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay) [AID651835, Type: confirmatory]
View
17
[SID144241551]
[CID60210906]
Average_EC50_uM 3.619Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay) [AID651835, Type: confirmatory]
View
18
[SID144241538]
[CID60210913]
Average_EC50_uM 4.395Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay) [AID651835, Type: confirmatory]
View
19
[SID144241553]
[CID60210918]
Average_EC50_uM 4.435Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay) [AID651835, Type: confirmatory]
View
20
[SID144241542]
[CID3433401]
Average_EC50_uM 4.53Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay) [AID651835, Type: confirmatory]
View
21
[SID144241549]
[CID60210910]
Average_EC50_uM 5.445Identification of a glycine sulfonamide based non-MPEP site positive allosteric potentiator (PAM) of mGlu5 (calcium_assay) [AID651835, Type: confirmatory]
View
22
[SID144241527]
[CID60210882]
ML332 Competition in Radioligand Binding assays (Ricerca) [AID651827, Type: other]
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23
[SID160963300]
[CID70789087]
Ki_uM 0.00382Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: 3pt binding Assay [AID652191, Type: confirmatory]
View
24
[SID160963301]
[CID70789102]
Ki_uM 0.00442Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: 3pt binding Assay [AID652191, Type: confirmatory]
View
25
[SID160963305]
[CID70789077]
Ki_uM 0.00483Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: 3pt binding Assay [AID652191, Type: confirmatory]
View
26
[SID160963305]
[CID70789077]
Average_Ki_uM 0.0054Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: full Ki determination [AID652196, Type: confirmatory]
View
27
[SID125311645]
[CID53384859]
Average EC50 0.006Optimization of novel mGluR5 positive allosteric modulators with different mechanisms of action and modes of efficacy [AID588715, Type: confirmatory]
View
28
[SID125311644]
[CID53384845]
Average EC50 0.008Optimization of novel mGluR5 positive allosteric modulators with different mechanisms of action and modes of efficacy [AID588715, Type: confirmatory]
View
29
[SID125305189]
[CID53382545]
Average EC50 0.009Optimization of novel mGluR5 positive allosteric modulators with different mechanisms of action and modes of efficacy [AID588715, Type: confirmatory]
View
30
[SID125311652]
[CID53384866]
Ki_uM 0.01Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: 3pt binding Assay [AID652191, Type: confirmatory]
View
31
[SID160963307]
[CID70789097]
Ki_uM 0.01Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: 3pt binding Assay [AID652191, Type: confirmatory]
View
32
[SID125311636]
[CID53384878]
Average EC50 0.012Optimization of novel mGluR5 positive allosteric modulators with different mechanisms of action and modes of efficacy [AID588715, Type: confirmatory]
View
33
[SID125311652]
[CID53384866]
Average_Ki_uM 0.0121Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: full Ki determination [AID652196, Type: confirmatory]
View
34
[SID125311639]
[CID53384879]
Average EC50 0.013Optimization of novel mGluR5 positive allosteric modulators with different mechanisms of action and modes of efficacy [AID588715, Type: confirmatory]
View
35
[SID160963300]
[CID70789087]
Average_Ki_uM 0.0187Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: full Ki determination [AID652196, Type: confirmatory]
View
36
[SID160963307]
[CID70789097]
Average_Ki_uM 0.019Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: full Ki determination [AID652196, Type: confirmatory]
View
37
[SID160963294]
[CID70789103]
Ki_uM 0.02Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: 3pt binding Assay [AID652191, Type: confirmatory]
View
38
[SID125311642]
[CID53384847]
Average EC50 0.025Optimization of novel mGluR5 positive allosteric modulators with different mechanisms of action and modes of efficacy [AID588715, Type: confirmatory]
View
39
[SID161003825]
[CID70789306]
Average_Ki_uM 0.0296Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: full Ki determination [AID652196, Type: confirmatory]
View
40
[SID125311643]
[CID53384835]
Average EC50 0.035Optimization of novel mGluR5 positive allosteric modulators with different mechanisms of action and modes of efficacy [AID588715, Type: confirmatory]
View
41
[SID160963288]
[CID70789079]
Ki_uM 0.04Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: 3pt binding Assay [AID652191, Type: confirmatory]
View
42
[SID161003825]
[CID70789306]
Ki_uM 0.04Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: 3pt binding Assay [AID652191, Type: confirmatory]
View
43
[SID160963295]
[CID70789092]
Average_Ki_uM 0.0487Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: full Ki determination [AID652196, Type: confirmatory]
View
44
[SID160963288]
[CID70789079]
Average_Ki_uM 0.0516Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: full Ki determination [AID652196, Type: confirmatory]
View
45
[SID160963285]
[CID70789093]
Average_Ki_uM 0.0677Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: full Ki determination [AID652196, Type: confirmatory]
View
46
[SID160963295]
[CID70789092]
Ki_uM 0.07Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: 3pt binding Assay [AID652191, Type: confirmatory]
View
47
[SID160963285]
[CID70789093]
Ki_uM 0.07Discovery of Novel Silent Allosteric Modulators (SAM) of the Metabotropic Glutamate Receptor 5: 3pt binding Assay [AID652191, Type: confirmatory]
View
48
[SID125311634]
[CID53384852]
Average EC50 0.071Optimization of novel mGluR5 positive allosteric modulators with different mechanisms of action and modes of efficacy [AID588715, Type: confirmatory]
View
49
[SID125311632]
[CID51346799]
Average EC50 0.073Optimization of novel mGluR5 positive allosteric modulators with different mechanisms of action and modes of efficacy [AID588715, Type: confirmatory]
View
50
[SID125311648]
[CID53384839]
Average EC50 0.09Optimization of novel mGluR5 positive allosteric modulators with different mechanisms of action and modes of efficacy [AID588715, Type: confirmatory]
View