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Mitogen-activated protein kinase kinase kinas.. [gi:6685617] - Target BioActivity Data
Also known as: Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5.
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BioActivity Outcomes:
Active(55)
 
 
BioAssay Types:
Literature(55)
 
 
BioActivity Types:
IC50(49)
 
 
Kd(4)
 
 
Ki(2)
 
 
Substance Types:
Chemical(55)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 8    Data Row: 55   Total Pages: 3   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID124975778]
[CID24944925]
IC50 0.014Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
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2
[SID163315227]
[CID59175651]
IC50 0.016Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
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3
[SID163318751]
[CID59175417]
IC50 0.021Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
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4
[SID163332581]
[CID59175292]
IC50 0.021Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
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5
[SID163318750]
[CID59175229]
IC50 0.022Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
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6
[SID163322186]
[CID59175598]
IC50 0.03Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
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7
[SID163339408]
[CID24944928]
IC50 0.032Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
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8
[SID163322185]
[CID59175648]
IC50 0.034Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
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9
[SID164133368]
[CID71717270]
Kd 0.07Binding constant for ASK1 kinase domain [AID625028, Type: Literature]
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10
[SID163328995]
[CID59175469]
IC50 0.07Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
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11
[SID163328994]
[CID59175319]
IC50 0.082Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
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12
[SID103243222]
[CID44299148]
Kd 0.11Binding constant for MAP3K5 kinase domain [AID435412, Type: Literature]
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13
[SID103243222]
[CID44299148]
Kd 0.11Binding constant for ASK1 kinase domain [AID625028, Type: Literature]
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14
[SID103243222]
[CID44299148]
Kd 0.12Average Binding Constant for MAP3K5; NA=Not Active at 10 uM [AID256579, Type: Literature]
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15
[SID163318752]
[CID59175460]
IC50 0.129Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
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16
[SID164130300]
[CID1589310]
IC50 0.2Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
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17
[SID164135938]
[CID1351628]
IC50 0.2Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
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18
[SID163318749]
[CID836391]
IC50 0.26Competitive inhibition of human recombinant N-terminal FLAG-tagged ASK1 expressed in baculovirus infected Sf2 cells after 60 mins by scintillation counting analysis in presence of [gamma-33P]ATP [AID717545, Type: Literature]
View
19
[SID164138747]
[CID1544033]
IC50 0.3Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
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20
[SID164133135]
[CID6064827]
IC50 0.3Inhibition of human ASK1 using MBP as substrate incubated for 10 mins prior to ATP addition measured after 20 mins by liquid scintillation counting analysis [AID740395, Type: Literature]
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