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Prostaglandin G/H synthase 1; Cyclooxygenase-.. [gi:548481] - Target BioActivity Data
Also known as: Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1.
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BioActivity Outcomes:
Active(727)
 
 
BioAssay Types:
Literature(710)
 
 
BioActivity Types:
IC50(706)
 
 
Kd(5)
 
 
Ki(5)
 
 
Substance Types:
Chemical(727)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 126    Data Row: 727   Total Pages: 15   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID103168269]
[CID73324]
IC50 0.001Inhibitory activity (RA1) against Prostaglandin G/H synthase 1 was calculated relative to aspirin [AID162144, Type: Literature]
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2
[SID103168276]
[CID68215]
IC50 0.001Inhibitory activity (RA1) against Prostaglandin G/H synthase 1 was calculated relative to aspirin [AID162144, Type: Literature]
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3
[SID103168306]
[CID94776]
IC50 0.001Inhibitory activity (RA1) against Prostaglandin G/H synthase 1 was calculated relative to aspirin [AID162144, Type: Literature]
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4
[SID103635887]
[CID11649268]
IC50 0.001Inhibition of ovine COX1 [AID377009, Type: Literature]
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5
[SID103635900]
[CID11519421]
IC50 0.001Inhibition of ovine COX1 [AID377009, Type: Literature]
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6
[SID103635901]
[CID44583799]
IC50 0.001Inhibition of ovine COX1 [AID377009, Type: Literature]
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7
[SID103181002]
[CID2662]
IC50 0.0037Inhibition of COX1 [AID270013, Type: Literature]
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8
[SID103497297]
[CID16007065]
IC50 0.0038Inhibition of COX1 [AID270013, Type: Literature]
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9
[SID103163840]
[CID3715]
IC50 0.004Inhibition of ovine COX1 [AID271286, Type: Literature]
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10
[SID104244877]
[CID46934868]
IC50 0.004Inhibition of sheep COX1 by enzyme immunoassay [AID502274, Type: Literature]
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11
[SID103497298]
[CID16007066]
IC50 0.0041Inhibition of COX1 [AID270013, Type: Literature]
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12
[SID103163840]
[CID3715]
IC50 0.006Inhibition of ovine COX1 after 5 mins [AID492859, Type: Literature]
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13
[SID103163840]
[CID3715]
IC50 0.006Inhibition of ovine COX-1 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid by HPLC analysis [AID614601, Type: Literature]
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14
[SID103163840]
[CID3715]
IC50 0.0067Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 1 min prior to substrate addition measured for 25 secs by TMPD-based chromogenic assay [AID695143, Type: Literature]
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15
[SID103199497]
[CID4306515]
IC50 0.0085Inhibition of ovine COX1 by fluorescence assay [AID657242, Type: Literature]
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16
[SID103325387]
[CID22810]
IC50 0.01In vitro inhibitory activity against Prostaglandin G/H synthase 1 in sheep [AID162021, Type: Literature]
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17
[SID123101585]
[CID9945282]
IC50 0.01Inhibition of ovine COX1 by colorimetric assay [AID701950, Type: Literature]
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18
[SID103178857]
[CID3394]
IC50 0.011In vitro inhibitory activity against Prostaglandin G/H synthase 1 in sheep [AID162021, Type: Literature]
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19
[SID103178857]
[CID3394]
IC50 0.012Reverisible competitive inhibition of prostaglandin G/H synthase 1 [AID162150, Type: Literature]
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20
[SID103163840]
[CID3715]
IC50 0.0122IC50 value against ovine Prostaglandin G/H synthase 1 [AID162016, Type: Literature]
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21
[SID103325245]
[CID44336308]
IC50 0.014In vitro inhibitory activity against Prostaglandin G/H synthase 1 in sheep [AID162021, Type: Literature]
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22
[SID103519097]
[CID23627031]
IC50 0.015Inhibition of ovine COX1 by measuring PGE2 [AID289278, Type: Literature]
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23
[SID103568428]
[CID12206760]
IC50 0.018Inhibition of ovine COX1 assessed as PGF2alpha production by enzyme immunoassay [AID633796, Type: Literature]
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24
[SID103519102]
[CID23627032]
IC50 0.03Inhibition of ovine COX1 by measuring PGE2 [AID289278, Type: Literature]
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25
[SID103163840]
[CID3715]
IC50 0.03Inhibition of ovine COX1 [AID284324, Type: Literature]
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26
[SID136927755]
[CID56924661]
IC50 0.03Inhibition of ovine COX1 [AID648861, Type: Literature]
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27
[SID103325387]
[CID22810]
IC50 0.032Reverisible competitive inhibition of prostaglandin G/H synthase 1 [AID162150, Type: Literature]
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28
[SID103223949]
[CID3177]
IC50 0.0416Inhibition of ovine COX1 by fluorescence assay [AID657242, Type: Literature]
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29
[SID103183701]
[CID5352624]
IC50 0.05Inhibition of ovine COX1 after 5 mins [AID492859, Type: Literature]
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30
[SID103163840]
[CID3715]
IC50 0.05Inhibition of ovine COX1 [AID313773, Type: Literature]
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31
[SID103163840]
[CID3715]
IC50 0.05In vitro inhibitory activity against ovine Prostaglandin G/H synthase 1 (44 nM) using [14C]AA (50 uM) was determined [AID162019, Type: Literature]
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32
[SID103163840]
[CID3715]
IC50 0.05Inhibition concentration against Prostaglandin G/H synthase 1 [AID162141, Type: Literature]
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33
[SID103163840]
[CID3715]
IC50 0.05Inhibition of ovine COX1 by discontinuous radioactive TLC assay [AID729250, Type: Literature]
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34
[SID103163840]
[CID3715]
IC50 0.05Inhibition of ovine COX1 [AID464499, Type: Literature]
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35
[SID103163840]
[CID3715]
IC50 0.05Inhibition of ram seminal vesicle COX1 assessed as conversion of [14C]-arachidonic acid to [14C]-prostaglandins preincubated for 20 mins by thin-layer chromatography analysis [AID598196, Type: Literature]
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36
[SID103173431]
[CID4037]
IC50 0.05Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay [AID162143, Type: Literature]
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37
[SID103394754]
[CID44365958]
IC50 0.05Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay [AID162143, Type: Literature]
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38
[SID103278302]
[CID14762933]
IC50 0.058Inhibition of ovine COX1 for 17 mins pre-incubated before addition of [1-14C]arachidonic acid [AID325048, Type: Literature]
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39
[SID103394961]
[CID24825636]
IC50 0.06Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay [AID162143, Type: Literature]
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40
[SID103311557]
[CID24740875]
IC50 0.06In vitro inhibitory activity against ovine Prostaglandin G/H synthase 1 (44 nM) using [14C]AA (50 uM) was determined [AID162019, Type: Literature]
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41
[SID104244679]
[CID46934725]
IC50 0.061Inhibition of sheep COX1 by enzyme immunoassay [AID502274, Type: Literature]
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42
[SID103325205]
[CID44336299]
IC50 0.063In vitro inhibitory activity against Prostaglandin G/H synthase 1 in sheep [AID162021, Type: Literature]
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43
[SID103200153]
[CID10296709]
IC50 0.06457Inhibitory activity against prostaglandin G/H synthase 1 (COX-1) [AID162176, Type: Literature]
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44
[SID103191369]
[CID3033]
IC50 0.067Inhibition of ovine COX1 for 17 mins pre-incubated before addition of [1-14C]arachidonic acid [AID325048, Type: Literature]
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45
[SID103163840]
[CID3715]
IC50 0.067In vitro inhibition against Prostaglandin G/H synthase 1 from ram seminal vesicles [AID162177, Type: Literature]
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46
[SID103163840]
[CID3715]
IC50 0.067In vitro inhibitory activity against prostaglandin G/H synthase 1 from the microsomal fraction of ram seminal vesicles [AID162020, Type: Literature]
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47
[SID103163840]
[CID3715]
IC50 0.069Inhibition of ovine COX1 by enzyme immunoassay [AID397232, Type: Literature]
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48
[SID103163840]
[CID3715]
IC50 0.069Inhibition of sheep COX1 by enzyme immunoassay [AID502274, Type: Literature]
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49
[SID103394331]
[CID24825640]
IC50 0.07Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay [AID162143, Type: Literature]
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50
[SID103394750]
[CID44365956]
IC50 0.07Inhibition of the ovine Prostaglandin G/H synthase 1 was determined by thin-layer chromatography assay [AID162143, Type: Literature]
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