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muscarinic acetylcholine receptor M1 [Homo sa.. [gi:37622910] - Target BioActivity Data
Also known as: muscarinic acetylcholine receptor M1 [Homo sapiens].
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BioActivity Outcomes:
Active(6093)
 
 
BioAssay Types:
Screening(6066)
 
 
Confirmatory(7)
 
 
BioActivity Types:
EC50(6)
 
 
Potency(1)
 
 
Substance Types:
Chemical(6093)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 7    Data Row: 6093   Total Pages: 305   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID125305166]
[CID53382542]
Potency 0.968665Human M1 PAM Extended Characterization CounterScreen (CRC) [AID588744, Type: confirmatory]
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2
[SID125305166]
[CID53382542]
EC50_uM_1 0.969Chemical optimization of in vitro pharmacology and DMPK properties of the highly selective mAChR 4 (M4) Positive Allosteric Modulator (PAM) Series with Greatly Improved Human Receptor Activity (hM1 CounterScreen) [AID623924, Type: confirmatory]
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3
[SID164186754]
[CID71737709]
Average_EC50_uM 2.52Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M1 [AID743097, Type: confirmatory]
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4
[SID164186720]
[CID71737675]
Average_EC50_uM 3.97Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M1 [AID743097, Type: confirmatory]
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5
[SID164186737]
[CID71737692]
Average_EC50_uM 4.84Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M1 [AID743097, Type: confirmatory]
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6
[SID164186661]
[CID71737617]
Average_EC50_uM 5.28Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M1 [AID743097, Type: confirmatory]
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7
[SID164186717]
[CID71737672]
Average_EC50_uM 6.99Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M1 [AID743097, Type: confirmatory]
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8
[SID842130]
[CID2900108]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
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9
[SID842133]
[CID644388]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
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10
[SID842134]
[CID644390]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 1 (CHRM1) [AID588814, Type: screening]
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11
[SID842134]
[CID644390]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
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12
[SID842152]
[CID644408]
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1). [AID588819, Type: screening]
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13
[SID842269]
[CID644528]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
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14
[SID842272]
[CID644531]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
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15
[SID842318]
[CID644577]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
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16
[SID842323]
[CID644582]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
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17
[SID842620]
[CID644892]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View
18
[SID842621]
[CID644893]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 1 (CHRM1) [AID588814, Type: screening]
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19
[SID842795]
[CID645068]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View
20
[SID842857]
[CID645134]
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1). [AID588819, Type: screening]
View