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BioActivity Data for Target muscarinic acetylcholine receptor M1 [Homo sa.. [gi:37622910]

Also known as: muscarinic acetylcholine receptor M1 [Homo sapiens].
Filters: All Data » Active      
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BioActivity Outcomes:
Active(6093)
 
 
BioAssay Types:
Screening(6066)
 
 
Confirmatory(7)
 
 
BioAssay Categories:
Cell-based(6066)
 
 
In vitro(1)
 
 
BioActivity Types:
EC50(6)
 
 
Potency(1)
 
 
Substance Types:
Chemical(6093)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 7    Data Row: 6093   Total Pages: 305   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID125305166]
[CID53382542]
Potency 0.968665Human M1 PAM Extended Characterization CounterScreen (CRC) [AID588744, Type: confirmatory]
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2
[SID125305166]
[CID53382542]
EC50_uM_1 0.969Chemical optimization of in vitro pharmacology and DMPK properties of the highly selective mAChR 4 (M4) Positive Allosteric Modulator (PAM) Series with Greatly Improved Human Receptor Activity (hM1 CounterScreen) [AID623924, Type: confirmatory]
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3
[SID164186754]
[CID71737709]
Average_EC50_uM 2.52Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M1 [AID743097, Type: confirmatory]
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4
[SID164186720]
[CID71737675]
Average_EC50_uM 3.97Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M1 [AID743097, Type: confirmatory]
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5
[SID164186737]
[CID71737692]
Average_EC50_uM 4.84Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M1 [AID743097, Type: confirmatory]
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6
[SID164186661]
[CID71737617]
Average_EC50_uM 5.28Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M1 [AID743097, Type: confirmatory]
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7
[SID164186717]
[CID71737672]
Average_EC50_uM 6.99Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M1 [AID743097, Type: confirmatory]
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8
[SID49671206]
[CID4796206]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
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9
[SID49671213]
[CID2738290]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
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10
[SID49671222]
[CID5703613]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View
11
[SID49671243]
[CID2795752]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View
12
[SID49671291]
[CID4796915]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View
13
[SID49671047]
[CID4581175]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View
14
[SID49670977]
[CID17385245]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View
15
[SID49670904]
[CID24761624]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View
16
[SID49670859]
[CID16453923]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View
17
[SID49670566]
[CID20956353]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View
18
[SID49670559]
[CID2832015]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View
19
[SID49670438]
[CID2900517]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View
20
[SID49670370]
[CID6295221]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View