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BioActivity Data for Target muscarinic acetylcholine receptor M1 [Homo sa.. [gi:37622910]

Also known as: muscarinic acetylcholine receptor M1 [Homo sapiens].
Filters: All Data » Active      
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BioActivity Outcomes:
Active(6093)
 
 
BioAssay Types:
Screening(6066)
 
 
Confirmatory(7)
 
 
BioAssay Categories:
Cell-based(6066)
 
 
In vitro(1)
 
 
BioActivity Types:
EC50(6)
 
 
Potency(1)
 
 
Substance Types:
Chemical(6093)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 7    Data Row: 6093   Total Pages: 305   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID125305166]
[CID53382542]
Potency 0.968665Human M1 PAM Extended Characterization CounterScreen (CRC) [AID588744, Type: confirmatory]
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2
[SID125305166]
[CID53382542]
EC50_uM_1 0.969Chemical optimization of in vitro pharmacology and DMPK properties of the highly selective mAChR 4 (M4) Positive Allosteric Modulator (PAM) Series with Greatly Improved Human Receptor Activity (hM1 CounterScreen) [AID623924, Type: confirmatory]
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3
[SID164186754]
[CID71737709]
Average_EC50_uM 2.52Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M1 [AID743097, Type: confirmatory]
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4
[SID164186720]
[CID71737675]
Average_EC50_uM 3.97Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M1 [AID743097, Type: confirmatory]
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5
[SID164186737]
[CID71737692]
Average_EC50_uM 4.84Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M1 [AID743097, Type: confirmatory]
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6
[SID164186661]
[CID71737617]
Average_EC50_uM 5.28Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M1 [AID743097, Type: confirmatory]
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7
[SID164186717]
[CID71737672]
Average_EC50_uM 6.99Discovery of Novel Positive Allosteric Modulators (PAMs) of Muscarinic Receptor M5: Counterscreen against human M1 [AID743097, Type: confirmatory]
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8
[SID49819752]
[CID4907031]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
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9
[SID49819751]
[CID4901695]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
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10
[SID49819672]
[CID24241272]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
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11
[SID49819606]
[CID24817963]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View
12
[SID49819499]
[CID24817878]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View
13
[SID49819498]
[CID24817877]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
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14
[SID49819485]
[CID2902453]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View
15
[SID49819460]
[CID24817872]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View
16
[SID49819453]
[CID16021607]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 1 (CHRM1) [AID588814, Type: screening]
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17
[SID49819428]
[CID2229174]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 1 (CHRM1) [AID588814, Type: screening]
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18
[SID49819413]
[CID24817867]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View
19
[SID49819379]
[CID2221584]
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1). [AID588819, Type: screening]
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20
[SID49819362]
[CID2965780]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]
View