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Microtubule-associated protein tau; Neurofibr.. [gi:334302961] - Target BioActivity Data
Also known as: Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau.
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BioActivity Outcomes:
Active(90)
 
 
BioAssay Types:
Literature(73)
 
 
Confirmatory(5)
 
 
BioActivity Types:
IC50(18)
 
 
Ki(7)
 
 
Kd(4)
 
 
Substance Types:
Chemical(90)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 23    Data Row: 90   Total Pages: 5   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID163339664]
[CID71463212]
IC50 0.00141Displacement of thiazine red R from human Tau aggregate expressed in Escherichia coli after 30 mins by fluorimetric analysis [AID718586, Type: Literature]
View
2
[SID103169156]
[CID3883]
Ki 0.0025Binding affinity to heparin induced human Tau 441 at 50 pM to 500 nM after 30 mins [AID712328, Type: confirmatory]
View
3
[SID163329269]
[CID71457851]
IC50 0.0051Displacement of thiazine red R from human Tau aggregate expressed in Escherichia coli after 30 mins by fluorimetric analysis [AID718586, Type: Literature]
View
4
[SID160685844]
[CID70688786]
Ki 0.017Binding affinity to human Tau aggregates after 30 mins by Thioflavin-S-based fluorescence assay [AID677224, Type: Literature]
View
5
[SID160668297]
[CID56950117]
Kd 0.0448Binding affinity to recombinant human tau expressed in Escherichia coli after 30 mins by fluorescence assay [AID663428, Type: confirmatory]
View
6
[SID160693422]
[CID7083]
Ki 0.069Inhibition of recombinant tau (unknown origin) aggregation [AID729973, Type: Literature]
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7
[SID160693422]
[CID7083]
IC50 0.069Inhibition of tau protein aggregation (unknown origin) at 5:1 compound to protein concentration by Western blot analysis [AID748711, Type: Literature]
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8
[SID103709786]
[CID65043]
IC50 0.069Inhibition of tau protein aggregation (unknown origin) at 5:1 compound to protein concentration by Western blot analysis [AID748711, Type: Literature]
View
9
[SID103745049]
[CID13735]
IC50 0.069Inhibition of tau protein aggregation (unknown origin) at 5:1 compound to protein concentration by Western blot analysis [AID748711, Type: Literature]
View
10
[SID174505162]
[CID54581735]
IC50 0.08Inhibition of tau protein aggregation (unknown origin) [AID748699, Type: Literature]
View
11
[SID160707358]
[CID70697093]
Ki 0.112Binding affinity to human Tau aggregates after 30 mins by Thioflavin-S-based fluorescence assay [AID677224, Type: Literature]
View
12
[SID163332133]
[CID16049314]
IC50 0.246Displacement of thiazine red R from human Tau aggregate expressed in Escherichia coli after 30 mins by fluorimetric analysis [AID718586, Type: Literature]
View
13
[SID160689667]
[CID56950118]
IC50 0.256Displacement of Thioflavin S from recombinant human tau expressed in Escherichia coli after 30 mins by fluorescence assay [AID663425, Type: confirmatory]
View
14
[SID174521858]
[CID72202169]
Kd 0.3Binding affinity to recombinant human tau (441 amino acid residues) aggregates expressed in Escherichia coli assessed as apparent dissociation constant after 30 mins by fluorescence spectroscopic analysis [AID749289, Type: Literature]
View
15
[SID174510207]
[CID1588443]
IC50 0.38Inhibition of tau protein aggregation (unknown origin) [AID748699, Type: Literature]
View
16
[SID174501256]
[CID73350446]
Kd 0.45Binding affinity to recombinant human tau (441 amino acid residues) aggregates expressed in Escherichia coli assessed as apparent dissociation constant after 30 mins by fluorescence spectroscopic analysis [AID749289, Type: Literature]
View
17
[SID160669871]
[CID57176479]
Ki 0.599Binding affinity to human Tau aggregates after 30 mins by Thioflavin-S-based fluorescence assay [AID677224, Type: Literature]
View
18
[SID174516898]
[CID73354961]
IC50 0.97Inhibition of tau protein aggregation (unknown origin) [AID748699, Type: Literature]
View
19
[SID103258907]
[CID5281672]
IC50 1.2Inhibition of human recombinant brain tau protein (412 amino acid residues) filament assembly expressed in Escherichia coli BL21(DE3) by electron microscopic analysis in presence of heparin [AID748713, Type: Literature]
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20
[SID160680540]
[CID70686684]
Ki 1.428Binding affinity to human Tau aggregates after 30 mins by Thioflavin-S-based fluorescence assay [AID677224, Type: Literature]
View