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Inhibitor of nuclear factor kappa-B kinase su.. [gi:317373368] - Target BioActivity Data
Also known as: Inhibitor of nuclear factor kappa-B kinase subunit alpha; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B inhibitor kinase alpha; NFKBIKA; Transcription factor 16; TCF-16.
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BioActivity Outcomes:
Active(172)
 
 
BioAssay Types:
Literature(172)
 
 
BioActivity Types:
IC50(141)
 
 
Kd(15)
 
 
Ki(1)
 
 
Substance Types:
Chemical(172)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 31    Data Row: 172   Total Pages: 4   Display: Page     
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID103243222]
[CID44299148]
Kd 0.0058Binding constant for IKK-alpha kinase domain [AID624832, Type: Literature]
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2
[SID164133368]
[CID71717270]
Kd 0.009Binding constant for IKK-alpha kinase domain [AID624832, Type: Literature]
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3
[SID103652167]
[CID44591575]
IC50 0.01259Inhibition of human recombinant IKK1 [AID354255, Type: Literature]
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4
[SID103476101]
[CID44406565]
IC50 0.03Inhibitory activity against IKK1 [AID258073, Type: Literature]
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5
[SID103476152]
[CID44406586]
IC50 0.03Inhibitory activity against IKK1 [AID258073, Type: Literature]
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6
[SID103476152]
[CID44406586]
IC50 0.03Inhibitory activity against IKK complex isolated from HeLa cells [AID258074, Type: Literature]
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7
[SID103652012]
[CID44591532]
IC50 0.03162Inhibition of human recombinant IKK1 [AID354255, Type: Literature]
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8
[SID103243222]
[CID44299148]
IC50 0.039Inhibition of human recombinant IKK-alpha expressed in insect Sf21 cells using phospho-Ulight-IkappaB-alpha as substrate at 30 uM [AID590191, Type: Literature]
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9
[SID103476101]
[CID44406565]
IC50 0.04Inhibitory activity against IKK complex isolated from HeLa cells [AID258074, Type: Literature]
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10
[SID103476285]
[CID44406635]
IC50 0.04Inhibitory activity against IKK complex isolated from HeLa cells [AID258074, Type: Literature]
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11
[SID103694306]
[CID11409972]
Kd 0.041Binding constant for IKK-alpha kinase domain [AID624832, Type: Literature]
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12
[SID103476214]
[CID44406614]
IC50 0.05Inhibitory activity against IKK complex isolated from HeLa cells [AID258074, Type: Literature]
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13
[SID103652088]
[CID23648953]
IC50 0.05012Inhibition of human recombinant IKK1 [AID354255, Type: Literature]
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14
[SID103476099]
[CID9549298]
IC50 0.07Inhibitory activity against IKK complex isolated from HeLa cells [AID258074, Type: Literature]
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15
[SID103522292]
[CID16047968]
IC50 0.07943Inhibition of human recombinant GST-IKKalpha by TR-FRET assay [AID290819, Type: Literature]
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16
[SID103475883]
[CID44406419]
IC50 0.08Inhibitory activity against IKK complex isolated from HeLa cells [AID258074, Type: Literature]
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17
[SID103476289]
[CID44406636]
IC50 0.1Inhibitory activity against IKK complex isolated from HeLa cells [AID258074, Type: Literature]
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18
[SID103476284]
[CID44406634]
IC50 0.1Inhibitory activity against IKK1 [AID258073, Type: Literature]
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19
[SID103596121]
[CID11213558]
Kd 0.12Binding constant for IKK-alpha kinase domain [AID624832, Type: Literature]
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20
[SID103652090]
[CID24983829]
IC50 0.12589Inhibition of human recombinant IKK1 [AID354255, Type: Literature]
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21
[SID103652164]
[CID44591574]
IC50 0.12589Inhibition of human recombinant IKK1 [AID354255, Type: Literature]
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22
[SID103476284]
[CID44406634]
IC50 0.15Inhibitory activity against IKK complex isolated from HeLa cells [AID258074, Type: Literature]
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23
[SID103475883]
[CID44406419]
IC50 0.15Inhibitory activity against IKK1 [AID258073, Type: Literature]
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24
[SID103367595]
[CID44353987]
IC50 0.155Inhibitory activity against IKK1 [AID93201, Type: Literature]
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25
[SID103652007]
[CID23648921]
IC50 0.15849Inhibition of human recombinant IKK1 [AID354255, Type: Literature]
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26
[SID103652089]
[CID24985283]
IC50 0.15849Inhibition of human recombinant IKK1 [AID354255, Type: Literature]
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27
[SID136944791]
[CID11427553]
Kd 0.18Binding constant for IKK-alpha kinase domain [AID624832, Type: Literature]
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28
[SID103476285]
[CID44406635]
IC50 0.2Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cells [AID258076, Type: Literature]
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29
[SID103476285]
[CID44406635]
IC50 0.2Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cells [AID258077, Type: Literature]
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30
[SID103476285]
[CID44406635]
IC50 0.2Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cells [AID258078, Type: Literature]
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31
[SID103476081]
[CID44406549]
IC50 0.2Inhibitory activity against IKK complex isolated from HeLa cells [AID258074, Type: Literature]
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32
[SID103476099]
[CID9549298]
IC50 0.2Inhibitory activity against IKK1 [AID258073, Type: Literature]
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33
[SID103522545]
[CID16663529]
IC50 0.23Inhibition of IKK1 [AID290163, Type: Literature]
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34
[SID103367625]
[CID44353995]
IC50 0.245Inhibitory activity against IKK1 [AID93201, Type: Literature]
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35
[SID103476100]
[CID44406564]
IC50 0.25Inhibitory activity against IKK complex isolated from HeLa cells [AID258074, Type: Literature]
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36
[SID103651885]
[CID23648890]
IC50 0.25119Inhibition of human recombinant IKK1 [AID354255, Type: Literature]
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37
[SID103476099]
[CID9549298]
IC50 0.3Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cells [AID258077, Type: Literature]
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38
[SID103476099]
[CID9549298]
IC50 0.3Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cells [AID258078, Type: Literature]
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39
[SID103476099]
[CID9549298]
IC50 0.3Inhibition of LPS-induced TNFalpha release from human PBMC [AID258083, Type: Literature]
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40
[SID103475818]
[CID44406379]
IC50 0.3Inhibitory activity against IKK complex isolated from HeLa cells [AID258074, Type: Literature]
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41
[SID103475883]
[CID44406419]
IC50 0.3Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cells [AID258076, Type: Literature]
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42
[SID103652010]
[CID44591531]
IC50 0.31623Inhibition of human recombinant IKK1 [AID354255, Type: Literature]
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43
[SID103652165]
[CID24984774]
IC50 0.31623Inhibition of human recombinant IKK1 [AID354255, Type: Literature]
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44
[SID103367720]
[CID44354029]
IC50 0.331Inhibitory activity against IKK1 [AID93201, Type: Literature]
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45
[SID103675770]
[CID22285027]
IC50 0.39Inhibition of IKK1 [AID290163, Type: Literature]
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46
[SID103652008]
[CID24856835]
IC50 0.39811Inhibition of human recombinant IKK1 [AID354255, Type: Literature]
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47
[SID103522274]
[CID15979284]
IC50 0.39811Inhibition of human recombinant GST-IKKalpha by TR-FRET assay [AID290819, Type: Literature]
View
48
[SID103476289]
[CID44406636]
IC50 0.4Inhibition of TNF-alpha-stimulated expression of E-selectin in HUVEC cells [AID258076, Type: Literature]
View
49
[SID103475883]
[CID44406419]
IC50 0.4Inhibition of TNF-alpha-stimulated expression of ICAM1 in HUVEC cells [AID258077, Type: Literature]
View
50
[SID103475883]
[CID44406419]
IC50 0.4Inhibition of TNF-alpha-stimulated expression of VCAM1 in HUVEC cells [AID258078, Type: Literature]
View