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BioActivity Data for Target Histone acetyltransferase p300 [gi:223590203]

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BioActivity Outcomes:
Active(15)
 
 
BioAssay Types:
Literature(15)
 
 
BioAssay Categories:
In vitro(11)
 
 
Biochemical(15)
 
 
Cell-based(13)
 
 
BioActivity Types:
IC50(1)
 
 
Substance Types:
Chemical(15)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 7    Data Row: 15   Total Pages: 1   
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID103581591]
[CID9875131]
IC50 5Inhibition of human recombinant His-tagged p300 HAT domain expressed in Escherichia coli BL21(DE3) cells using [14C]Ac-AoA and histone H4 as substrate after 5 mins by scintillation counting [AID639341, Type: Literature]
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2
[SID163330935]
[CID60201924]
Inhibition of P300 CH1 domain-mediated HIFalpha protein expression in human LN229-V6R cells at 100 uM incubated for 1 hr under normoxia followed by 24 hrs under hypoxia by Western blot analysis [AID699454, Type: Literature]
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3
[SID134442973]
[CID16097752]
Binding affinity to P300 in human LN229 cell nuclear extracts by Western blot analysis [AID700952, Type: Literature]
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4
[SID134442973]
[CID16097752]
Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity at 2.5 to 10 uM incubated for 1 hr under normoxia followed by 24 hrs under hypoxia by reporter gene assay [AID699450, Type: Literature]
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5
[SID134436763]
[CID53258302]
Inhibition of His6-tagged human KAT3B catalytic domain expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604133, Type: Literature]
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6
[SID134436763]
[CID53258302]
Inhibition of His6-tagged human full-length KAT3B expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604132, Type: Literature]
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7
[SID103563467]
[CID25066642]
Inhibition of His6-tagged human KAT3B catalytic domain expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604133, Type: Literature]
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8
[SID103563467]
[CID25066642]
Inhibition of His6-tagged human full-length KAT3B expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604132, Type: Literature]
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9
[SID103562803]
[CID44448303]
Inhibition of His6-tagged human KAT3B catalytic domain expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604133, Type: Literature]
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10
[SID103562803]
[CID44448303]
Inhibition of His6-tagged human full-length KAT3B expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604132, Type: Literature]
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11
[SID134448380]
[CID53258426]
Inhibition of His6-tagged human KAT3B catalytic domain expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604133, Type: Literature]
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12
[SID134448380]
[CID53258426]
Inhibition of His6-tagged human full-length KAT3B expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604132, Type: Literature]
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13
[SID194181050]
[CID17163601]
Inhibition of human recombinant histone acetyltransferase p300 assessed as acetylation of histone H3 at 0.6 mM [AID1067274, Type: Literature]
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14
[SID134444465]
[CID53258425]
Inhibition of His6-tagged human KAT3B catalytic domain expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604133, Type: Literature]
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15
[SID134444465]
[CID53258425]
Inhibition of His6-tagged human full-length KAT3B expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604132, Type: Literature]
View