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Histone acetyltransferase p300; p300 HAT; E1A.. [gi:223590203] - Target BioActivity Data
Also known as: Histone acetyltransferase p300; p300 HAT; E1A-associated protein p300.
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BioActivity Outcomes:
Active(26)
 
 
BioAssay Types:
Literature(25)
 
 
BioActivity Types:
IC50(13)
 
 
Substance Types:
Chemical(26)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 7    Data Row: 26   Total Pages: 1   
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#StructureSubstanceCompoundActivityBioAssayLinks
OutcomeTypeValue [μM]
1
[SID103581591]
[CID9875131]
IC50 5Inhibition of human recombinant His-tagged p300 HAT domain expressed in Escherichia coli BL21(DE3) cells using [14C]Ac-AoA and histone H4 as substrate after 5 mins by scintillation counting [AID639341, Type: Literature]
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2
[SID163313709]
[CID60201930]
IC50 5Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity incubated for 1 hr under normoxia followed by 24 hrs under hypoxia by reporter gene assay [AID699451, Type: Literature]
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3
[SID163313710]
[CID60202084]
IC50 5Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity incubated for 1 hr under normoxia followed by 24 hrs under hypoxia by reporter gene assay [AID699451, Type: Literature]
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4
[SID163320613]
[CID60201925]
IC50 5Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity incubated for 1 hr under normoxia followed by 24 hrs under hypoxia by reporter gene assay [AID699451, Type: Literature]
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5
[SID163323985]
[CID60201927]
IC50 5Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity incubated for 1 hr under normoxia followed by 24 hrs under hypoxia by reporter gene assay [AID699451, Type: Literature]
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6
[SID163323986]
[CID60202085]
IC50 5Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity incubated for 1 hr under normoxia followed by 24 hrs under hypoxia by reporter gene assay [AID699451, Type: Literature]
View
7
[SID163327451]
[CID60201926]
IC50 5Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity incubated for 1 hr under normoxia followed by 24 hrs under hypoxia by reporter gene assay [AID699451, Type: Literature]
View
8
[SID163330935]
[CID60201924]
IC50 5Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity incubated for 1 hr under normoxia followed by 24 hrs under hypoxia by reporter gene assay [AID699451, Type: Literature]
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9
[SID163330936]
[CID60201929]
IC50 5Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity incubated for 1 hr under normoxia followed by 24 hrs under hypoxia by reporter gene assay [AID699451, Type: Literature]
View
10
[SID163330937]
[CID60202086]
IC50 5Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity incubated for 1 hr under normoxia followed by 24 hrs under hypoxia by reporter gene assay [AID699451, Type: Literature]
View
11
[SID163334423]
[CID60201928]
IC50 5Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity incubated for 1 hr under normoxia followed by 24 hrs under hypoxia by reporter gene assay [AID699451, Type: Literature]
View
12
[SID163334424]
[CID60202083]
IC50 5Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity incubated for 1 hr under normoxia followed by 24 hrs under hypoxia by reporter gene assay [AID699451, Type: Literature]
View
13
[SID163334425]
[CID60202087]
IC50 5Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity incubated for 1 hr under normoxia followed by 24 hrs under hypoxia by reporter gene assay [AID699451, Type: Literature]
View
14
[SID103562803]
[CID44448303]
Inhibition of His6-tagged human full-length KAT3B expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604132, Type: Literature]
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15
[SID103562803]
[CID44448303]
Inhibition of His6-tagged human KAT3B catalytic domain expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604133, Type: Literature]
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16
[SID103563467]
[CID25066642]
Inhibition of His6-tagged human full-length KAT3B expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604132, Type: Literature]
View
17
[SID103563467]
[CID25066642]
Inhibition of His6-tagged human KAT3B catalytic domain expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604133, Type: Literature]
View
18
[SID163330935]
[CID60201924]
Inhibition of P300 CH1 domain-mediated HIFalpha protein expression in human LN229-V6R cells at 100 uM incubated for 1 hr under normoxia followed by 24 hrs under hypoxia by Western blot analysis [AID699454, Type: Literature]
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19
[SID134436763]
[CID53258302]
Inhibition of His6-tagged human full-length KAT3B expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604132, Type: Literature]
View
20
[SID134436763]
[CID53258302]
Inhibition of His6-tagged human KAT3B catalytic domain expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604133, Type: Literature]
View
21
[SID134442973]
[CID16097752]
Inhibition of P300 CH1 domain-mediated HIF1 transcriptional activity in human LN229-V6R cells assessed as reduction in luciferase activity at 2.5 to 10 uM incubated for 1 hr under normoxia followed by 24 hrs under hypoxia by reporter gene assay [AID699450, Type: Literature]
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22
[SID134442973]
[CID16097752]
Binding affinity to P300 in human LN229 cell nuclear extracts by Western blot analysis [AID700952, Type: other]
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23
[SID134444465]
[CID53258425]
Inhibition of His6-tagged human full-length KAT3B expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604132, Type: Literature]
View
24
[SID134444465]
[CID53258425]
Inhibition of His6-tagged human KAT3B catalytic domain expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604133, Type: Literature]
View
25
[SID134448380]
[CID53258426]
Inhibition of His6-tagged human full-length KAT3B expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604132, Type: Literature]
View
26
[SID134448380]
[CID53258426]
Inhibition of His6-tagged human KAT3B catalytic domain expressed in Sf9 cells pre-incubated with acetyl-CoA and histone H4 peptide for 20 mins measured after 15 mins by fluorescent spectrofluorimeter analysis [AID604133, Type: Literature]
View